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CCL2
| Symbol: | CCL2 | | Name(s): | chemokine (C-C motif) ligand 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18186797 |
A significant increase was noted for the risk of late acute rejection in renal allograft recipients who were homozygous for the MCP-1-2518G polymorphism |
| 18093183 |
These results showed the -2518 MCP-1 polymorphism is related to the susceptibility of plaque type psoriasis. |
| 18205260 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18230355 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17426779 |
In this review we focus on the known polymorphisms of two chemokines: CCL2, CCL5 and their corresponding receptors (CCR2, CCR5) and we also discuss their associations with susceptibility and progression to selected immune-mediated diseases. [REVIEW] |
| 18061474 |
Both IL-20 and IL-24 showed correlations to CCL2/MCP-1 in plasma from rheumatoid arthritis and spondyloarthropathy patients. |
| 17917677 |
preliminary evidence linking genetic variation in CCR2 to circulating levels of MCP-1 |
| 18208975 |
Upon MCP-1 stimulation, iPLA(2)beta is recruited to the membrane-enriched pseudopod; in contrast, cPLA(2)alpha is recruited to the endoplasmic reticulum. |
| 17694504 |
circulating levels of advanced glycation end products (AGEs) and soluble receptor for AGE are independent determinants of serum MCP-1 levels in patients with type 2 diabetes |
| 18042260 |
It is shown that human monocytes constitutively express p17Rs and that HIV-1 p17 selectively triggers these cells to produce MCP-1. | →View more information from publications. |
Recent Publications on CCL2: |  |
The chemokine CCL2 increases prostate tumor growth and bone metastasis through macrophage and osteoclast recruitment.
CC chemokine ligand 2 (CCL2, also known as monocyte chemoattractant... | 3rd November, 2009
| Department of Internal Medicine, University of Michigan School of
| Neoplasia. 2009 Nov;11(11):1235-42.
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Leukotriene B4 mediates {gamma}{delta} T lymphocyte migration in response to diverse stimuli.
Herein, we investigated the involvement of the 5-LO-derived lipid mediator... | 3rd November, 2009
| *Laboratorio de Farmacologia Aplicada, Farmanguinhos, Fundacao Oswaldo
| J Leukoc Biol. 2009 Oct 30.
DOI Direct Link |
B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice.
The treatment of primary biliary cirrhosis (PBC) with conventional... | 31st October, 2009
| Division of Rheumatology, Allergy and Clinical Immunology, University of
| Hepatology. 2009 Aug 10.
DOI Direct Link |
Plasma levels of chemokines during leprosy specific treatment.
Leprosy, whose etiologic agent is Mycobacterium leprae, is an illness of... | 31st October, 2009
| Laboratorio de Imunofarmacologia, Instituto de Ciencias Biologicas,
| Acta Trop. 2009 Oct 26.
DOI Direct Link |
CCL2 is induced by chemotherapy and protects prostate cancer cells from docetaxel-induced cytotoxicity.
BACKGROUND: Metastatic prostate cancer is either inherently resistant to... | 30th October, 2009
| Division of Hematology and Medical Oncology, Oregon Health & Science
| Prostate. 2009 Oct 28.
DOI Direct Link |
→View more research publications. |
Press Releases on CCL2:
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| Osprey Pharmaceuticals U.S.A., Inc. Initiates Phase Ib Clinical Trial in IgA Nephropathy |
14th April, 2009 |
Osprey Pharmaceuticals U.S.A., Inc. |
Trial to Evaluate Safety of CCL2-LPM for Inflammatory Kidney Disease
SAN FRANCISCO, April 14 /PRNewswire/ -- Osprey Pharmaceuticals U.S.A., Inc. announced today that patient
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| Osprey Pharmaceuticals U.S.A., Inc. Completes $11 Million Initial Private Financing |
3rd September, 2008 |
Osprey Pharmaceuticals U.S.A., Inc. |
SAN FRANCISCO, Sept. 3 /PRNewswire/ -- Osprey Pharmaceuticals U.S.A., a
privately-held company focused on developing novel protein therapeutics that
selectively target chemokine-activated
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CCL2 results (if any) from reagent suppliers | 
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Anti-CCL2 Monoclonal Antibody
Monoclonal Antibody against CCL2 for use in ELISA, Inhibition Assays, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...
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mouse CCL2 antibody, Cytokine Kits conjugate
eBioscience technical data sheet for product 88-7391 Mouse CCL2 (MCP-1, MCP1, MCAF) ELISA Ready-SET-Go! antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_88/88-...
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Anti-CCL2 Monoclonal Antibody
Monoclonal Antibody against CCL2 for use in ELISA, Inhibition Assays, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western
Blot.
http://www.bioreagents.com/products/productDetails/productDe...
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human CCL2 antibody, Affinity Purified conjugate
eBioscience technical data sheet for product 14-7099 Affinity Purified anti- human CCL2 (MCP-1, MCP1, MCAF) 5D3-F7 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_14/14-...
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Anti-CCL2 Polyclonal Antibody
Polyclonal Antibody against CCL2 for use in Inhibition Assays, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...
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mouse/rat/human CCL2 antibody, Affinity Purified conjugate
eBioscience technical data sheet for product 14-7096 Affinity Purified anti- mouse/human/rat CCL2 (MCP-1, MCP1, MCAF) 2H5 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_14/14-...
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Enzo Life Sciences: Monoclonal Antibody to CCL2 (human) (5D3-F7)
Monoclonal Antibody to CCL02 human 5D3-F7,Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products • Monoclonal Antibodies,Chemokines & Cytokines,CC ...
http://www.enzolifesciences.com/ALX-804-465/monoclonal-antib...
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