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CCL5


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Symbol:CCL5
Name(s):chemokine (C-C motif) ligand 5
Type:protein-coding
Organism:Homo sapiens
Synonyms:D17S136E, MGC17164, RANTES, SCYA5, SISd, TCP228
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18186796 Human CCL5/RANTES gene promoter polymorphisms are not associated with the different types of bronchial asthma in Spanish population
18217191 Observational study of gene-disease association. (HuGE Navigator)
18306985 Observational study of gene-disease association. (HuGE Navigator)
18361934 Observational study of gene-disease association. (HuGE Navigator)
18060801 The frequency of the RANTES-403G allele was significantly higher in patients with stenosis >70% (OR, 2.45; 95% CI 1.12-5.71; p=0.015).
17426779 In this review we focus on the known polymorphisms of two chemokines: CCL2, CCL5 and their corresponding receptors (CCR2, CCR5) and we also discuss their associations with susceptibility and progression to selected immune-mediated diseases [REVIEW]
17678915 Women with endometriosis had increased peritoneal mRNA expression of RANTES and VCAM-1 during menstrual compared with luteal phase.
16078996 Observational study of gene-disease association. (HuGE Navigator)
11125885 Observational study of gene-environment interaction. (HuGE Navigator)
11197694 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCC chemokine receptor type 1small inducible cytokine A5 precursor--Pubmed
HPRDchemokine receptor 1CCL5--Pubmed
HPRDCC chemokine receptor 3small inducible cytokine A5 precursor--Pubmed
HPRDCC chemokine receptor 3small inducible cytokine A5 precursor--Pubmed
HPRDchemokine receptor 4small inducible cytokine A5 precursor--Pubmed
HPRDchemokine receptor 4small inducible cytokine A5 precursor--Pubmed
HPRDchemokine receptor 5small inducible cytokine A5 precursor--Pubmed
HPRDchemokine receptor 5small inducible cytokine A5 precursor--Pubmed
HPRDchemokine binding protein 2small inducible cytokine A5 precursor--Pubmed
HPRDchemokine binding protein 2small inducible cytokine A5 precursor--Pubmed

Recent Publications on CCL5:

Pubmed Logo
Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells.
Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are found in diesel...
3rd November, 2009
Department of Air Pollution and Noise, Division of Environmental Medicine, Toxicol Appl Pharmacol. 2009 Oct 28.
DOI Direct Link
Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells.
As the induction of contact hypersensitivity is the result of a series of...
3rd November, 2009
Departments of Dermatology, VU University Medical Centre, Amsterdam, The Toxicol In Vitro. 2009 Oct 27.
DOI Direct Link
Use of different DMSO concentrations for cryopreservation of autologous peripheral blood stem cell grafts does not have any major impact on levels of leukocyte-and platelet-derived soluble mediators.
Background aims Infusion of stem cell autografts can be associated with...
3rd November, 2009
Blood Bank. Cytotherapy. 2009 Oct 27;11(6):749-760.
I-TAC is a dominant chemokine in controlling skin intragraft inflammation via recruiting CXCR3(+) cells into the graft.
Chemokines play a critical role in the acute transplant rejection. In...
31st October, 2009
Department of Immunology, Institute for Immunobiology, Shanghai Medical Cell Immunol. 2009 Sep 11.
DOI Direct Link
Pancreatic cancer cells activate CCL5 expression in mesenchymal stromal cells through the insulin-like growth factor-I pathway.
Mesenchymal stromal cells (MSCs) have a critical role in cancer...
31st October, 2009
Department of Stem Cell Biology and Histology, Tohoku University Graduate FEBS Lett. 2009 Oct 27.
DOI Direct Link

View more research publications.

Press Releases on CCL5:

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Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice 5th January, 2009 Carolus Therapeutics Inc.

San Diego-Based Carolus Therapeutics Focuses on Discovery and Development of Anti-Inflammatory Drugs Based on Collaborators' Findings at RWTH Aachen University in Germany

BioNews Results for CCL5

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BioPortfolio Logo
Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD
British Journal of the Thorax:  Oct 28 2009 10:41PM Matching: ccl5
Increased CCL5 and CXCL7 chemokine expression is associated with neutrophil activation in severe stable COPD
British Journal of the Thorax:  Oct 14 2009 11:05PM Matching: ccl5
Monoclonal Antibodies: Study data from P. Portales and co-authors update knowledge of monoclonal antibodies
NewsRX:  Oct 9 2009 6:32PM Matching: ccl5

Clinical Trials:

Clinical Trials Logo
IMD-1041 Chronic Obstructive Pulmonary Disease: Proof of Concept (POC) Study

Patents:

Patents logo
US Patent No.Title
7118988 Vertically wired integrated circuit and method of fabrication
7307081 Piperidine derivatives useful as CCR5 antagonists
7335580 Lamellar-derived microelectronic component array and method of fabrication
7338794 Amended recombinant cells for the production and delivery of gamma interferon as an antiviral agent, adjuvant and vaccine accelerant
7384964 Synthesis of epothilones, intermediates thereto, analogues and uses thereof

View more patents.

CCL5 results (if any) from reagent suppliers

Google CSE Logo
CCL5 Monoclonal Antibody Chemokine
CCL5 monoclonal antibody can be used for detection of CCL5 by ELISA (minimum working concentration: 2 μg/ml maximum working concentration: 4 μg/ml), ...
http://www.prosci-inc.com/shop/catalog1/CCL5-Monoclonal-Anti...

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Purified Anti-RANTES CCL5 Antibody - BioLegend
Purified Anti-RANTES CCL5 Antibody - RANTES (CCL5) is a member of the CC chemokine family.
http://www.biolegend.com/purified-anti-rantes-ccl5-antibody-...

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mouse/rat CCL5 antibody, Affinity Purified conjugate
eBioscience technical data sheet for product 14-7993 Polyclonal anti-mouse/rat CCL5 (RANTES) Polyclonal antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_14/14-...

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Alexa Fluor 647 Anti-human RANTES CCL5 Antibody Anti-RANTES ...
Alexa Fluor 647 Anti-human RANTES CCL5 Antibody Anti-RANTES - RANTES (CCL5) is a member of the CC chemokine family.
http://www.biolegend.com/alexa-fluor-647-anti-human-rantes-c...

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Cotton Rat CCL5/RANTES Affinity Purified Polyclonal Ab
Anti-cotton rat RANTES/CCL5 Antibody. FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS. R&D Systems, Inc. 1-800-343-7475. AF1010 1 of 2 ...
http://www.rndsystems.com/pdf/af1010.pdf...

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Recombinant Human RANTES/CCL5 Carrier Free - BioLegend
Recombinant Human RANTES/CCL5 Carrier Free - RANTES is a CC chemokine and directs the migration of leukocytes in immune and inflammatory responses.
http://www.biolegend.com/recombinant-human-rantes-ccl5-carri...

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Monoclonal Anti-human CCL5/RANTES-PerCP
human CCL5 (rhCCL5). The IgG fraction from ascites fluids ... CCL5/RANTES ( Catalog # IC278C, filled histogram) or isotype control ...
http://www.rndsystems.com/pdf/IC278C.pdf...

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