Tuesday November 24 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

BID


Suggest Content
Advertise Here
Gene DB Home
Symbol:BID
Name(s):BH3 interacting domain death agonist
Type:protein-coding
Organism:Homo sapiens
Synonyms:FP497, MGC15319, MGC42355
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18173728 activation of Bid is required for inducing apoptosis in this experimental model
17534194 Observational study of gene-disease association. (HuGE Navigator)
18166654 We conclude that unconventional ubiquitination and proteasome-dependent degradation of tBid-N is required to unleash the proapoptotic activity of tBid-C.
18089817 BH3 profiling reveals that mitochondrial BCL-2 is primed by death signals after egf receptor inhibition in lung cancer cells.
17549073 Existence of Bid activation pathways in eosinophils other than those mediated by the classic initiator caspases.
17855051 Bax translocation by UV irradiation is a Bid-independent event and inhibited by overexpression of Bcl-x(L).
16077201 Cathepsin B substrate, BID, serves as molecular switch between apotosis and autophagy in camptothecin treated breast cancer cells.
17431792 Bid cleavage occurs prior to the activation of caspase-8 during TRAIL-mediated apoptosis in U2OS cells
17635912 mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release
17226776 These findings indicate that phosphorylation of PLS3 by PKC-delta induces PLS3 activation to facilitate mitochondrial targeting of tBid and apoptosis.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBCL2 antagonist killer 1BH3 interacting domain death agonist isoform 2--Pubmed
BINDBCL2-associated X protein isoform alphaBH3 interacting domain death agonist isoform 2Bax interacts with Bid.-Pubmed
HPRDBcl 2BH3 interacting domain death agonist isoform 2--Pubmed
BIND-BH3 interacting domain death agonist isoform 2Bid interacts with Bcl-2.-Pubmed
HPRDB-cell lymphoma protein 2 alpha isoformBH3 interacting domain death agonist--Pubmed
BINDB-cell lymphoma protein 2 alpha isoformBH3 interacting domain death agonist isoform 2Bid interacts with Bcl-2.-Pubmed
HPRDBCL2 related protein A1BH3 interacting domain death agonist isoform 2--Pubmed
HPRDBCL2-related protein A1 isoform 1BH3 interacting domain death agonist--Pubmed
BINDBCL2-related protein A1 isoform 1BH3 interacting domain death agonist isoform 2Bid interacts with A1. This interaction was modelled on a demonstrated interaction between human Bid and mouse A1.-Pubmed
BINDBCL2-like 1 isoform 1-Bcl-XL interacts with Bid. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bid.-Pubmed

Recent Publications on BID:

Pubmed Logo
Two Dosages of Oral Fluoropyrimidine S-1 of 35 and 40 mg/m2 bid: Comparison of the Pharmacokinetic Profiles in Korean Patients with Advanced Gastric Cancer.
OBJECTIVE: In this study, we compared the pharmacokinetic profiles of...
3rd November, 2009
1 Cancer Metastasis Research Center, Yonsei University College of Jpn J Clin Oncol. 2009 Oct 31.
DOI Direct Link
A Semi-Mechanistic Model of CP-690,550-Induced Reduction in Neutrophil Counts in Patients With Rheumatoid Arthritis.
CP-690,550, a selective inhibitor of the Janus kinase family, is being...
3rd November, 2009
Inc. J Clin Pharmacol. 2009 Oct 30.
DOI Direct Link
Response to budesonide among atopic and non-atopic infants/preschoolers with recurrent wheezing.
BACKGROUND: The treatment in non-atopic young children with recurrent...
31st October, 2009
Department of Pediatrics, Universidad de Antofagasta, Antofagasta, Chile. Allergol Immunopathol (Madr). 2009 Oct 27.
DOI Direct Link
A coumarin derivative (RKS262) inhibits cell-cycle progression, causes pro-apoptotic signaling and cytotoxicity in ovarian cancer cells.
Coumarin derivative RKS262 belongs to a new class of potential anti-tumor...
30th October, 2009
Molecular Therapeutics Laboratory, Program in Women's Oncology, Department Invest New Drugs. 2009 Oct 29.
DOI Direct Link
Attenuation of phencyclidine-induced object recognition deficits by the combination of atypical antipsychotic drugs with pimavanserin (ACP 103), a 5-hydroxytryptamine2A receptor inverse agonist.
Sub-chronic administration of the NMDA receptor antagonist, phencyclidine...
30th October, 2009
1 Vanderbilt Medical Center; J Pharmacol Exp Ther. 2009 Oct 28.
DOI Direct Link

View more research publications.

Press Releases on BID:

BioPortfolio Logo
Axelar AB Presents the New Anticancer Agent AXL1717 at The AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston, Massachusetts, USA 13th November, 2009 Karolinska Development AB

STOCKHOLM, November 13 /PRNewswire/ -- Axelar AB today announced that promising data from the ongoing Phase I/II clinical trial concerning their lead anticancer product AXL1717, an insulin-like

INFORM-1 Results: Robust Antiviral Suppression Achieved with Combination of Nucleoside Analog Polymerase Inhibitor RG7128 and Protease Inhibitor RG7227 3rd November, 2009 Pharmasset, Inc.

BOSTON, Nov. 3 /PRNewswire-FirstCall/ -- Pharmasset, Inc (Nasdaq: VRUS) and InterMune, Inc. (Nasdaq: ITMN) today announced results from all patient cohorts of the INFORM-1 trial, an

Orexigen(R) Therapeutics Releases New Efficacy Data for Contrave(R) in Late Breaker Presentations at the 27th Annual Scientific Meeting of The Obesity Society 27th October, 2009 Orexigen Therapeutics, Inc.
-- Obese patients on Contrave demonstrated significant improvements in important markers of cardiometabolic risk including waist circumference, HDL and triglycerides

Orexigen(R) Therapeutics Presents New Data Showing Weight Loss with Contrave Significantly Improves Important Markers of Cardiometabolic Risk 24th October, 2009 Orexigen Therapeutics, Inc.
-- There was no evidence of increased abuse liability.

"These data show that Contrave provides obese patients with meaningful reduction in weight

Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 24th September, 2009 Amylin Pharmaceuticals, Inc.
-- Poster: Presentation #795, Oct. 1, 12:45-1:45 p.m. CEST "Changes in Adipokines in Type 2 Diabetic Patients Treated with Exenatide versus Glimepiride on Metformin

BioNews Results for BID

: RSS Logo
BioPortfolio Logo
Cancer service bid data may be flawed
Dudley News:  Nov 14 2009 4:45PM Matching: bid
Cancer service bid data may be flawed
Halesowen News:  Nov 14 2009 4:40PM Matching: bid
Cancer service bid data may be flawed
Bromsgrove Advertiser:  Nov 14 2009 4:35PM Matching: bid
Catalyst Receives Guidance from Nasdaq Regarding Minimum Bid Price Requirement
KOTA Territory News:  Nov 14 2009 11:05PM Matching: bid
Catalyst Receives Guidance from Nasdaq Regarding Minimum Bid Price Requirement
Montana's News Station:  Nov 14 2009 5:59PM Matching: bid
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
A 12-Month Study Comparing Fluticasone Propionate/Salmeterol (ADVAIR) DISKUS Combination Product 250/50mcg Twice Daily To Fluticasone Propionate (FLOVENT) DISKUS 250 Mcg Twice Daily In Symptomatic Patients With Asthma

Patents:

Patents logo
US Patent No.Title
7606401 System and method for processing tokenless biometric electronic transmissions using an electronic rule module clearinghouse
7610011 Providing alternative programming on a radio in response to user input
7610217 Automatic auction method and system on server-client system
7610219 System and methods for assembly of a web site for an online store by a seller
7610220 Systems and methods for contingency-based options and futures for playoff tickets based upon individual athletes

View more patents.

BID results (if any) from reagent suppliers

Google CSE Logo
Bid antibody (ab2388) | Abcam
Rabbit polyclonal to Bid. Bid, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive ...
http://www.abcam.com/Bid-antibody-ab2388.html...

Thumbshot
BID Antibody (Mouse Specific) #2003
The BH3 domain-only protein, BID, a death agonist member of the Bcl-2/Bcl-xL family (1), is localized in the cytosolic fraction of cells as an inactive ...
http://www.cellsignal.com/products/2003.html...

Thumbshot
The Abcam catalog
Bid antibodies. ... Bid antibody. IP, WB, IHC-Fr. Rabbit polyclonal ... Bid antibody [Y8]. Flow Cyt, IP, WB, ICC/IF, IHC-P ...
http://www.abcam.com/index.html?t=49106&pt=1&c=299...

Thumbshot
BID Antibody (Human Specific) #2002
BID Antibody (Human Specific) detects endogenous levels of both the full length (22 kDa) and cleaved large fragment (15 kDa) of human BID. ...
http://www.cellsignal.com/products/2002.html...

Thumbshot
BID Antibody / BID Antibodies
BID Antibody / BID Antibodies. ... BID specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-bid.html...

Thumbshot
BID Antibody
Specific antibody for the gene product of BID, the protein BH3 interacting domain death agonist. Validated for specificity by gene-silencing with siRNA ...
http://www.piercenet.com/products/browse.cfm?fldID=7FC75E6B-...

Thumbshot
p-BID (Ser 65) Antibody sc-130180
rabbit polyclonal IgG, 100µg/ml; recommended for detection of Ser 65 phosphorylated BID of human origin by WB, IP, IF, IHC(P) and ELISA ...
http://www.scbt.com/datasheet-130180-p-bid-ser-65-antibody.h...

Thumbshot

Search Bioportfolio and other Life Science Sites for BID, or search for BID on BioPortfolio's antibody search engine.
This page has been viewed 524 times
Recent Search Terms used to find this page:
interacting with death | BH3 interactive domain | Mitochondria-mediated tumstatin peptide-induced HepG2 cell apoptosis | BH3 gene | hepG2 abcam bcl 2 | t-bid antibody | bh3 profiling us patent | interacting domain | bid suggest link.html | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.