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CXCL12
| Symbol: | CXCL12 | | Name(s): | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | PBSF, SCYB12, SDF-1a, SDF-1b, SDF1, SDF1A, SDF1B, TLSF-a, TLSF-b, TPAR1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17724466 |
Gene silencing increases metastasis in breast carcinoma. |
| 17916907 |
bone marrow-derived-SDF-1alpha enhances the invasiveness of lung cancer cells by increasing MMP-9 expression through the CXCR4/ERK/NF-kappaB signal transduction pathway |
| 18205260 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18223219 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18060801 |
The frequency of the SDF-1A allele was significantly different between cases and controls: 0.32 vs. 0.20, respectively (OR 1.81; 95% CI 1.25-2.60; p=0.007). |
| 18223219 |
study found that low plasma SDF-1 is an independent host-derived predictive marker of distant metastasis in breast cancer |
| 17805324 |
The CXCL12-G801A polymorphism did not associate with disease outcome or presence of extramedullary disease in acute myeloid leukemia. |
| 18206727 |
Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease |
| 18317966 |
SDF-1alpha might serve as a possible marker for predicting or monitoring distant metastasis in gastric carcinoma |
| 17914737 |
CXCL12 may have a role in leukaemic cell proliferation and survival during childhood ALL. | →View more information from publications. |
Recent Publications on CXCL12: |  |
Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells.
As the induction of contact hypersensitivity is the result of a series of... | 3rd November, 2009
| Departments of Dermatology, VU University Medical Centre, Amsterdam, The
| Toxicol In Vitro. 2009 Oct 27.
DOI Direct Link |
Strong expression of chemokine receptor CXCR4 by renal cell carcinoma cells correlates with metastasis.
The chemokine receptor CXCR4 is involved in the metastasis of many... | 28th October, 2009
| Department of Urology, Changhai Hospital, Second Military Medical
| Clin Exp Metastasis. 2009 Oct 27.
DOI Direct Link |
A chemokine targets the nucleus: Cxcl12-gamma isoform localizes to the nucleolus in adult mouse heart.
Chemokines are extracellular mediators of complex regulatory circuits... | 28th October, 2009
| Viral Vector Facility, Technical Unit of Gene Targeting, Fundacion CNIC
| PLoS One. 2009 Oct 27;4(10):e7570.
DOI Direct Link |
Sequence analysis, characterization and mRNA distribution of channel catfish (Ictalurus punctatus Rafinesque, 1818) chemokine (C-X-C motif) receptor 4 (CXCR4) cDNA.
Chemokine receptor CXCR4, a member of the G protein-coupled receptor... | 27th October, 2009
| United States Department of Agriculture, Agricultural Research Service,
| Vet Immunol Immunopathol. 2009 Oct 2.
DOI Direct Link |
Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4.
The chemokine Stromal cell-derived factor-1 (SDF-1/CXCL12) and its... | 20th October, 2009
| The University of Tokyo, Japan;
| J Biol Chem. 2009 Oct 18.
DOI Direct Link |
→View more research publications. |
CXCL12 results (if any) from reagent suppliers | 
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CXCL12 Antibody (N-term)
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CXCL12 antibody (N-term) (Cat.#AP7779a), which was peroxidase-conjugated to ...
http://www.abgent.com/products/catalog_no/AP7779a_CXCL12_Ant...
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mouse/rat CXCL12 beta subunit antibody, Affinity Purified conjugate
eBioscience technical data sheet for product 14-7991 Polyclonal anti-mouse/rat CXCL12 beta subunit (SDF-1b, SDF1b) Polyclonal antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_14/14-...
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CXCL12 antibody, CXCL12 Antibody, Rabbit Polyclonal Antibody
Buy quality rabbit CXCL12 antibody (interacts with rat and mouse - not yet tested in other species), anti-CXCL12, CXCL12 antibody, rabbit polyclonal ...
http://www.genwaybio.com/product_info.php?products_id=198013...
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mouse/rat CXCL12 alpha subunit antibody, Affinity Purified conjugate
eBioscience technical data sheet for product 14-7992 Polyclonal anti-mouse/rat CXCL12 alpha subunit (SDF-1a, SDF1a) Polyclonal antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_14/14-...
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Human CXCL12 ELISA Kit
This assay employs an antibody specific for human CXCL12 coated on a ... anti- human CXCL12 antibody is added. After washing away unbound biotinylated ...
http://www.cellsciences.com/PDF/CKH184.pdf...
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ORDERING INFORMATION
Mature human and mouse CXCL12 differ only by 1 amino acid. Preparation ... The ND50 for this lot of anti-CXCL12 antibody was determined to be approximately ...
http://www.rndsystems.com/pdf/MAB310.pdf...
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Mouse CXCL12 ELISA Kit
anti-mouse CXCL12 antibody is added. After washing away unbound ... linked immunosorbent assay for the quantitative measurement of mouse CXCL12 in ...
http://www.cellsciences.com/PDF/CKM061.pdf...
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