Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18318428 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18192296 |
The presence of long SHBG(TAAAA)n alleles is associated with increased risk for polycystic ovary syndrome and in combination with short androgen receptor(CAG)n alleles may influence the hyperandrogenic phenotype of PCOS. |
| 11140838 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 14671199 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14764814 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15199113 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15634719 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15668497 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15879463 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15894658 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16251630 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16331562 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16896040 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16926255 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16982738 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17077994 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17176215 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17220347 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17315164 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17411440 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17507624 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17706202 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18056923 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18188141 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18192296 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18047273 |
analysis of human follicular fluid samples of patients undergoing controlled ovarian hyper stimulation for in vitro fertilization therapy identified SHBG and INHA |
| 17992261 |
monosaccharide-induced lipogenesis reduced hepatic HNF-4alpha levels, which in turn attenuated SHBG expression. |
| 17890489 |
plasma adiponectin has a role in regulating sex hormone and insulin-like growth factor levels, including SHBG, c-peptide, and IGFBP-1 |
| 17077994 |
SHBG, but not CYP17, CYP1B1, or COMT polymorphisms are associated with different sex hormone levels in post-menopausal breast cancer survivors |
| 17893265 |
SHBG may serve as a predictive marker of IR in women with hyperandrogenic syndrome, particularly in those who are obese. |
| 17884445 |
Low SHBG may be an important independent factor for cardiometabolic risk |
| 17684316 |
SHBG is internalized by brain cells, which may be affected by the presence of estrogen receptor beta |
| 15894658 |
Finds variant SHBG Asn allele (Asp327Asn) associated with reduced breast cancer risk in postmenopausal women [OR, 0.73; 95% CI (95% CI), 0.53-0.99], but not in premenopausal women [OR, 1.03; 95% CI, 0.82-1.27). |
| 17027360 |
Although certain parameters of insulin status and serum SHBG demonstrated statistically significant correlation coefficients, these relationships are weak and SHBG cannot be used as a predictor of insulin resistance. |
| 17027364 |
The present study demonstrated a time and operation effect decline in plasma DHEAS levels. In contrast, the time x operation interaction on SHBG levels exhibited an increase toward postoperative day 7. |
| 12054810 |
2.35 A and 1.7 A crystal structures of the amino-terminal LG domain of SHBG. Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site. |
| 12065592 |
binds steroid ligands in specific orientations producing distinct changes in protein conformation |
| 14568572 |
IGFBP-1 and SHBG are equally sensitive to ambient insulin concentrations in human hepatoma cell cultures, and the production of both proteins is also attenuated by the IGFs. |
| 15664449 |
SHBG interacts with cell membranes and causes inhibition of the anti-apoptotic effect of estradiol. |
| 16926255 |
Polymorphisms in the SHBG promoter predict serum levels of SHBG, androgens, and glucuronidated androgen metabolites, and hip Bone Mineral Density in men. |
| 15193539 |
SHBG may play a key role in male patients with idiopathic or secondary osteoporosis. |
| 16394089 |
Low SHBG and/or androgen deficiency may provide early warning signs for cardiovascular risk and an opportunity for early intervention in nonobese men. |
| 12081841 |
serum concentrations are elevated in kwashiorkor and anorexia nervosa but not in marasmus; marker of nutritional status in anorexia nervosa and kwashiorkor |
| 15146368 |
SHBG androgen sensitivity test is a simple diagnostic tool for the detection of androgen receptor malfunction in gonadal dysgenesis. |
| 15292305 |
Serum SHBG appeared to be an independent positive predictor of bone turnover rate, which also positively associated with serum 25-hydroxyvitamin-D levels. |
| 12235141 |
Data show that human sex hormone-binding globulin (SHBG) transcripts containing an alternative exon 1 sequence are located specifically in the testicular germ cells of transgenic mice, whereas murine SHBG transcripts are confined to Sertoli cells. |
| 14764814 |
Polymorphism(s) within coding sequence and, potentially, in regulatory sequence of SHBG gene are associated with circulating SHBG levels and may represent part of genetic background of sex steroid hormone activity. |
| 15755867 |
Estimation of genetic and nongenetic influences on endogenous sex hormones (testosterone, estradiol, estrone, and SHBG) in a large sample of 532 adult white mono- and dizygotic male twins |
| 12603009 |
SHBG and sex steroids showed a negative correlation with serum lipids considered a cardiovascular risk |
| 12039072 |
Data suggest that O-glycosylation of sex hormone-binding gllobulin is essential for SHBG binding to a membrane receptor that is responsible for inhibiting the estradiol-induced proliferation of MCF-7 breast cancer cells. |
| 15574421 |
USF transcription factors repress SHBG transcription in Sertoli cells through an interaction with FP4 within its proximal promoter |
| 14671199 |
Novel (TAAAA)n allele found in low frequency, mainly in controls. May be genetic contribution to decreased SHBG levels frequently seen in polycystic ovary syndrome(PCOS). May act as susceptibility gene, genetic link for origin. |
| 12679434 |
study shows that for patients with polycystic ovary syndrome, sex hormone-binding globulin is an integrated marker of insulin resistance that may be of use to identify insulin-resistant individuals for targeted treatment |
| 12753385 |
sex-hormone-binding globulin has a role in modulating tyrosinase activity at the posttranslational level through the cell membrane signaling pathway of melanocytes |
| 16757555 |
SHBG may have a role in cardiovascular disease in women with polycystic ovary syndrome |
| 17411440 |
These data do not support a substantial association between common genetic variation in SHBG and ovarian cancer risk. |
| 12151349 |
polymorphisms in familial and sporadic breast cancer |
| 14694008 |
May be a marker for insulin resistance in type 2 diabetes. |
| 15879463 |
TAAAA repeat polymorphism in the promoter region provides evidence for a possible association of SHBG gene with age at menarche. |
| 12228253 |
Results describe the crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol. |
| 12800098 |
Plasma SHBG level may represent significant predictor of metabolic syndrome in men and premenopausal women. |
| 15862967 |
Interacts with prostatic proteins in a yeast two-hybrid system. |
| 15111517 |
Low total testosterone and SHBG levels independently predict development of the metabolic syndrome and diabetes in middle-aged men. |
| 15784702 |
Intrahepatic cholestasis of pregnancy is associated with blunted responses of SHBG to oral estrogen. |
| 17189294 |
the (TAAAA)(n) SHBG gene polymorphism might have a role in serum SHBG expression and in hyperandrogenaemic clinical presentation of PCOS |
| 17258903 |
D327N polymorphism of the SHBG gene does not influence susceptibility to polycystic ovary syndrome |
| 12861158 |
first-trimester sex hormone binding globulin levels were lower among women in whom gestational diabetes mellitus subsequently developed |
| 16155373 |
SHBG-immunoreactive neurons were observed in the supraoptic nucleus, the suprachiasmatic nucleus, the bed nucleus of the stria terminalis, paraventricular nucleus, arcuate nucleus, the perifornical region and the medial preoptic area in human brains. |
| 16949385 |
A study evaluating testosterone and estradiol (E2) levels among women in relation to 5 single nucleotide polymorphisms (SNPs) of the aromatase (CYP 19) gene in women of 4 ethnic/racial groups is presented. |
| 17315164 |
The current results suggested that the codon 327 Asn allele in the SHBG gene may be related to a reduced risk of endometrial cancer among postmenopausal women. |
| 12015315 |
observations are consistent with the hypothesis that SHBG, destined to participate in signaling at the cell membrane, is locally regulated and produced |
| 11473114 |
A (TAAAA)(n) pentanucleotide repeat, located within an alu sequence at the 5' boundary of the human SHBG promoter, influences its transcriptional activity in association with downstream elements, including an SP1-binding site |
