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SHH
| Symbol: | SHH | | Name(s): | sonic hedgehog homolog (Drosophila) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18063705 |
we focus on the SHh signaling pathway and its role in gastrointestinal (GI) tract development and maintenance and consider the diseases resulting from aberrant SHh activity--REVIEW |
| 11857543 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 15249145 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17895245 |
Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells |
| 17914115 |
Snail and SHH are overexpressed in a large subset of neuroendocrine tumors of the ileum. |
| 17628016 |
Expression of Shh ligand by glioblastoma multiforme cells is a mechanism for Hh pathway activation. Shh mRNA was found in many primary tumor samples, the highest level of expression being in the tumor with the most elevated Gli1 level. |
| 17761145 |
Activin B is a potent inducer of Pdx1 as well as Shh in differentiating embryonic stem cell derived embryoid bodies |
| 17353904 |
Results suggest that the SHH pathway may be a target to overcome MDR and increase chemotherapeutic response. |
| 17390043 |
The stronger Shh expression in intestinal metaplasia and gastric adenoma indicates that hedgehog protein is involved at an early phase of gastric carcinogenesis. |
| 17611415 |
Shh signaling enhanced K-Ras-mediated pancreatic tumorigenesis and reduced the dependence of tumor cells on the sustained activation of Ras-stimulated signaling pathways. | →View more information from publications. |
Recent Publications on SHH: |  |
The evolution of gnathostome development: Insight from chondrichthyan embryology.
Chondrichthyans (cartilaginous fishes) represent one of the two lineages... | 3rd November, 2009
| Department of Organismal Biology and Anatomy, University of Chicago,
| Genesis. 2009 Oct 30.
DOI Direct Link |
Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway.
The Hedgehog (Hh) signaling pathway plays crucial roles in embryonic... | 3rd November, 2009
| Department of Gene Technology, Tallinn University of Technology, Akadeemia
| Exp Cell Res. 2009 Oct 21.
DOI Direct Link |
The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors.
Pitrm1 is a zinc metalloendopeptidase that has been implicated in... | 31st October, 2009
| The University of Queensland, Institute for Molecular Bioscience,
| Dev Dyn. 2009 Oct 29.
DOI Direct Link |
The molecular basis of oral-facial-digital syndrome, type 1.
Oral-facial-digital syndrome type 1 (OFDI; OFD1; OMIM 311200) is a rare... | 31st October, 2009
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| Am J Med Genet C Semin Med Genet. 2009 Oct 28;151C(4):318-325.
DOI Direct Link |
Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh.
Recently, it was reported that Hh signaling is activated in tumor stromal... | 29th October, 2009
| Department of Cancer Therapy and Research, Graduate School of Medical
| Cancer Immunol Immunother. 2009 Oct 28.
DOI Direct Link |
→View more research publications. |
Press Releases on SHH:
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| Midwest Hospital Recognized for Green Initiatives |
17th July, 2008 |
Sacred Heart Hospital |
EAU CLAIRE, Wis., July 17 /PRNewswire/ -- Many hospitals are taking steps
to be environmentally friendly, but Sacred Heart Hospital (SHH) continues to
lead by example to do what is best for the
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SHH results (if any) from reagent suppliers | 
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