Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18063705 |
we focus on the SHh signaling pathway and its role in gastrointestinal (GI) tract development and maintenance and consider the diseases resulting from aberrant SHh activity--REVIEW |
| 11857543 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 15249145 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17895245 |
Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells |
| 17914115 |
Snail and SHH are overexpressed in a large subset of neuroendocrine tumors of the ileum. |
| 17628016 |
Expression of Shh ligand by glioblastoma multiforme cells is a mechanism for Hh pathway activation. Shh mRNA was found in many primary tumor samples, the highest level of expression being in the tumor with the most elevated Gli1 level. |
| 17761145 |
Activin B is a potent inducer of Pdx1 as well as Shh in differentiating embryonic stem cell derived embryoid bodies |
| 17353904 |
Results suggest that the SHH pathway may be a target to overcome MDR and increase chemotherapeutic response. |
| 17390043 |
The stronger Shh expression in intestinal metaplasia and gastric adenoma indicates that hedgehog protein is involved at an early phase of gastric carcinogenesis. |
| 17611415 |
Shh signaling enhanced K-Ras-mediated pancreatic tumorigenesis and reduced the dependence of tumor cells on the sustained activation of Ras-stimulated signaling pathways. |
| 16571640 |
Shh is an important regulator of human putative epidermal stem cell proliferation in the basal layer of fetal epidermis and modulates the cell responsiveness to EGF |
| 17414057 |
The quantitative expression of sHh signaling detected by Western blotting in pancretic cancer. |
| 12533514 |
The Tbx1 regulatory region was responsive to signaling by Sonic hedgehog (Shh) in vivo. |
| 15292211 |
sonic hedgehog mutations have a role in holoprosencephaly |
| 12783258 |
Adriamycin influences the Shh signalling pathway, resulting in disruption of normal development of the foregut. |
| 17461467 |
Shh-Ptch1-Gli1 signaling pathway may play a role in the progression of colorectal tumor. |
| 12495844 |
REVIEW: Hedgehog signaling in human disease |
| 12632368 |
Aberrant Shh signaling may play a critical role in the pathogenesis of esophageal atresia with tracheoesophageal fistula in humans. |
| 15470048 |
Shh down-regulated in the precursor cell population the expression of IL-7R as well as stromal-derived factor-1 chemokine receptor, CXCR4, and inhibited IL-7-dependent STAT5 phosphorylation. |
| 16701100 |
Increased expression of SHh mRNA in human colonic adenocarcinomas and in a colorectal cell line. |
| 16786128 |
beta-catenin might be involved in the Hh signaling pathway via enhancement of the transcriptional activity of GLI |
| 16244652 |
SHH gene therapy may have considerable therapeutic potential in individuals with acute and chronic myocardial ischemia. |
| 17152067 |
Mutations within ZRS of sonic hedgehog appear to be a common cause of familial triphalangeal thumb and preaxial polydactyly. |
| 12514186 |
induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase |
| 16159933 |
Shh might maintain pituitary cells in nonproliferative state. Shh is newly described hypophysiotropic cytokine and its down-regulation may be involved in pathogenesis of pituitary adenomas. |
| 16778137 |
SHH morphogens are associated with microvesicles (MVs) shed from the plasma membrane of apoptotic/stimulated T cells. |
| 11983699 |
role in activating poliovirus receptor/CD155 gene |
| 15502857 |
SHH signaling in inflammatory diseases of the gut acts to ensure stem cell restitution of damaged mucosal epithelium. |
| 14520411 |
a wide range of digestive tract tumours, including most of those originating in the oesophagus, stomach, biliary tract and pancreas, but not in the colon, display increased Hh pathway activity, which is suppressible by cyclopamine, a Hh pathway antagonist |
| 16540513 |
Transgenic SHH signals cooperate with those of FGF9 to regulate mesenchymal proliferation in distinct submesothelial and subepithelial regions of developing lung. |
| 17102592 |
Dignaling is clearly upregulated in gastrointestinal neuroendocrine carcinomas in a Gli1-dependent manner. |
| 17378681 |
The metabolic pathway of SHH might have been responsible for the left side-restricted multiple fetal abnormalities reported. |
| 17392427 |
Melanomas require SHH-GLI signaling regulated by interactions bewteen GLI1 and the RAS-MEK/AKT pathways. |
| 12926841 |
In gray matter from brains of multiple sclerosis (MS) victims, the total amount of Shh was less than normals and the signaling 20 kDa protein was greatly reduced. |
| 15221788 |
Thirteen novel SHH mutations found in a cohort of Holoprosencephaly patinets. |
| 14691301 |
Decreased expression of the Shh pathway in atrophic gastritis and gastric cancer might reflect altered differentiation processes within the gastric unit and contributes to the development of gastric atrophy. |
| 16282375 |
The effects of seven missense mutations associated with holoprosencephaly that affect the N-terminal signaling domain of SHH have been characterized |
| 12547712 |
Down-reuglation of this protein's expression in pulmonary hypoplasia is associated with congenital diaphragmatic hernia. |
| 12629553 |
Role for hedgehog signaling in regeneration and carcinogenesis of airway epithelium |
| 15314219 |
Data report expression of sonic hedgehog-GLI-1 pathway components in adult human prostate cancer, often with enhanced levels in tumors versus normal prostatic epithelia. |
| 12917489 |
model of the interactions between beta-catenin and hedgehog signaling in the epidermis in which SHH promotes proliferation of progenitors of the hair lineages whereas IHH stimulates proliferation of sebocyte precursors |
| 14520413 |
Hedgehog pathway may have an early and critical role in the genesis of pancreatic cancer; maintenance of hedgehog signalling is important for aberrant proliferation and tumorigenesis |
| 12709790 |
These studies are the first demonstration that mutations in SHH associated with human HPE (holoprosencephaly) perturb the in vivo patterning function of SHH in the developing nervous system. |
| 11857543 |
While the gene contributes to face development, it is not a frequent cause of cleft lip or palate. |
| 15905200 |
Elevated expression of hedgehog target genes human patched gene 1 (PTCH1) or Gli1 occurs in 63 of the 99 primary gastric cancers. |
| 16448649 |
A pattern of strong Shh expression with weak expression of Foxf1 in all cases of UIP (usual interstitial pneumonitis) and a complementary expression of Shh and Foxf1 in cases of nonspecific interstitial pneumonitis (NSIP-F). |
| 17409199 |
data support a direct molecular link between the Hh signaling pathway and SOX9 regulation, wherein SHH stimulates SOX9 through its mediator GLI1, and are consistent with a mechanism of SOX9 regulation through distal chromatin interactions |
| 15170664 |
SHH signalling can increase aberrant cell survival in colorectal tumour cells. |
| 15128061 |
signaling molecules might play a role in epithelial-mesenchymal interactions and cell proliferation in tooth development as well as in growth of [ameloblastomas] |
| 16003737 |
elevated expression of Shh and its target genes is quite common in esophageal cancers |
| 16322088 |
Hedgehog signaling is conserved in hepatic progenitors from fetal development through adulthood and may be a new therapeutic target in patients with liver damage. |
| 16528374 |
Rsults suggested that the increased and constitutive Shh expression is implicated in gastric carcinogenesis, and that promoter methylation may be an important regulatory mechanism of Shh expression. |
| 12421920 |
Shh-mediated signaling is a physiological component of T cell responses, which acts to modulate CD4+ T cell effector function. |
| 12773389 |
deregulated hedgehog signaling in the genesis of basaloid follicular hamartomas |
| 14733907 |
Shh signaling has a role in the cellular proliferation of oral squamous cell carcinoma cells |
| 15592520 |
ptc1 mutation enhances a downstream reporter of sonic hedgehog (shh)-ptc1 signaling. |
| 15675968 |
an intact EGF signaling axis cooperates with shh and is a critical mediator of matrix invasion in a tumor type characterized by disrupted shh. |
| 16300466 |
This review highlights the hypothesis of hedgehog pathway activation in damaged nerve tissue, inducing the repair process, as a potentially new approach to treatment of neurodegenerative diseases and dysfunction, including spinal cord injury. |
| 12394760 |
characterization of (SHH) expression in the human fetal prostate |
| 15939571 |
regulatory elements around the SHH gene may contribute to the maintenance of conserved synteny across human chromosome 7q36.3 |
| 15238528 |
Overexpression of a wild-type regulatory subunit of protein kinase A is sufficient to activate sonic hedgehog target gene transcription. |
| 15249678 |
Results identify REN(KCTD11) as a suppressor of Hedgehog signaling and suggest that its inactivation might lead to a deregulation of the tumor-promoting Hedgehog pathway in medulloblastoma. |
| 17007023 |
Expressions of Shh and Gli-1 were significantly higher in leiomyomas than in gastrointestinal stromal tumors. Expressions of Ptc and Smo did not correlate with histopathological differentiation. |
| 17035233 |
sFRP-1, a target gene of the hedgehog pathway, is involved in cross-talk between the hedgehog pathway and the Wnt pathway |
| 15521068 |
Taken together, our data suggest that the hedgehog pathway is weakly active in normal adult urothelial cells and of limited importance in transitional cell carcinoma. |
| 16945339 |
analysis of Hedgehog modulator properties after functional coupling of Smoothened to G15 |
| 17050669 |
The results presented in this study implicate p63 in the regulation of the Shh signaling pathway. |
| 12837695 |
mutations in a long-range Shh enhancer located in an intron of the limb region 1 gene result in preaxial polydactyly |
