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SIAH1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18070888 |
monoubiquitylation by SIAH1 and SIAH2 represents a possible trigger event for alpha-synuclein aggregation and Lewy body formation |
| 16752048 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18089810 |
SIAH may offer a novel therapeutic target to halt tumor growth and ameliorate RAS-mediated pancreatic cancer. |
| 17420721 |
Siah-1S (splice variant S) displays a promotion effect on cells tumorigenicity |
| 16752048 |
genetic alterations of SIAH-1 do not significantly contribute to the pathogenesis of Parkinson disease |
| 12557228 |
SIAH1 has been identified as a putative tumor suppressor gene for human hepatocellular carcinomas, with a correlation between its suppressed expression and tumor size and differentiation. |
| 14506261 |
Siah-1 was found to abrogate the inhibitory effects of synphilin-1 on dopamine release |
| 15326481 |
Siah-1L represents a new member of the human Siah family that is induced in response to p53 and plays an important role in the regulation of beta-catenin activity in tumor cells |
| 16615911 |
analysis of the substrate binding site of Siah ubiquitin ligase |
| 15163637 |
SIAH-mediated down regulation of alternative splicing may be an important developmental difference between otherwise highly conserved T-STAR proteins. | →View more information from publications. |
Recent Publications on SIAH1: |  |
SIAH1 induced apoptosis by activation of the JNK pathway and inhibited invasion by inactivation of the ERK pathway in breast cancer cells.
Seven in absentia homolog 1 (SIAH1), a homologue of Drosophila seven in... | 25th September, 2009
| Department of Pathology, First Affiliated Hospital and College of Basic
| Cancer Sci. 2009 Sep 2.
DOI Direct Link |
Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-{alpha}2 deficiency.
Laminin alpha2-deficient Congenital Muscular Dystrophy, called MDC1A, is a... | 18th September, 2009
| 1 Santhera Pharmaceuticals;
| J Pharmacol Exp Ther. 2009 Sep 16.
DOI Direct Link |
Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor.
Protein ubiquitination is critical for many cellular processes, through... | 12th September, 2009
| IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
| Oncogene. 2009 Aug 20;28(33):2959-68. Epub 2009 Jun 22.
DOI Direct Link |
Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1.
Homeodomain-interacting protein kinase 2 (HIPK2) induces apoptosis and,... | 13th June, 2009
| Department of Biological Science, Sungkyunkwan University, 300
| Cancer Lett. 2009 Jul 8;279(2):177-84. Epub 2009 Feb 27.
DOI Direct Link |
The molecular programme of tumour reversion: the steps beyond malignant transformation.
How cells become malignant has preoccupied scientists for over a century.... | 12th March, 2009
| LBPA, UMR 8113, Ecole Normale Superieure, 61 Avenue du President Wilson,
| Nat Rev Cancer. 2009 Mar;9(3):206-16. Epub 2009 Jan 30.
DOI Direct Link |
→View more research publications. |
SIAH1 results (if any) from reagent suppliers | 
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