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BMI1


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Symbol:BMI1
Name(s):BMI1 polycomb ring finger oncogene
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC12685, PCGF4, RNF51
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18269588 Neither EGFR nor BMI-1 had significant prognostic impact for basal-like phenotype of breast cancer.
17711569 Elevated Bmi-1 is associated with breast cancer
17625597 Bmi-1 may promote maintenance of suprabasal keratinocyte survival to prevent premature death during differentiation.
17974970 Examination of various growth-regulatory pathways suggested that Bmi-1 overexpression together with H-Ras promotes human mammary epithelial cell transformation and breast oncogenesis by deregulation of multiple growth-regulatory pathways.
17145814 Bmi1 overexpression was correlated with the malignant grades of human digestive precancerous tissues, which suggests that advanced Bmi1 dysregulation might predict malignant progression.
17145810 The oncogenic role of Bmi-1 in human primary breast carcinomas is not determined by its capacity to inhibit INK4a/ARF proteins(p16INK4a, p14ARF, or h-TERT) or to induce telomerase activity.
17597110 BMI-1 mediated repression of p16(ink4a) may contribute to an increased aggressive behavior of stem cell-like melanoma cells.
17360938 In a cohort of 64 CML patients, the level of BMI1 at diagnosis correlated with time to transformation to blast crisis, and the combination of low BMI1 and high proteinase-3 expression was associated with an improved overall survival
17454639 Bmi-1 seems to play a secondary role in chronic myeloid leukemia transformation
17134822 PcG protein BMI1 is associated with adverse pathological features and clinical PSA recurrence of prostate cancer.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDPolycomb complex protein BMI1E2F transcription factor 6 isoform 1--Pubmed
HPRDPolycomb complex protein BMI1ring finger protein 1--Pubmed
HPRDPolycomb complex protein BMI1polyhomeotic 1-like--Pubmed
HPRDPolycomb complex protein BMI1polyhomeotic 1-like--Pubmed
HPRDPolycomb complex protein BMI1myeloid/lymphoid or mixed-lineage leukemia--Pubmed
HPRDPolycomb complex protein BMI1promyelocytic leukemia zinc finger protein--Pubmed
HPRDPolycomb complex protein BMI1polyhomeotic-like 2 isoform a--Pubmed
HPRDBMI1 polycomb ring finger oncogeneRing Finger Protein 1--Pubmed
HPRDBMI1 polycomb ring finger oncogeneE2F transcription factor 6--Pubmed
HPRDBMI1 polycomb ring finger oncogeneMLL--Pubmed

Recent Publications on BMI1:

Pubmed Logo
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Hedgehog signaling is aberrantly activated in glioma, medulloblastoma,...
29th October, 2009
M & M Medical Bioinformatics, Hongo 113-0033, Japan. Curr Mol Med. 2009 Sep;9(7):873-86.
Knockdown of Bmi-1 impairs growth and invasiveness of human gastric carcinoma cells.
The effect of B cell-specific MLV integration site-1 (Bmi-1) RNA...
23rd October, 2009
Department of Gastroenterology and Hubei Provincial Center of Clinical Oncol Res. 2009;17(11-12):613-20.
GSK3beta regulates differentiation and growth arrest in glioblastoma.
Cancers are driven by a population of cells with the stem cell properties...
14th October, 2009
Laboratory of Molecular Neuro-Oncology, University Hospital Basel, Basel, PLoS One. 2009 Oct 13;4(10):e7443.
DOI Direct Link
Balancing dormant and self-renewing hematopoietic stem cells.
The mouse hematopoietic stem cell (HSC) is probably the best-understood...
9th October, 2009
Ludwig Institute for Cancer Research Ltd., Lausanne Branch, University of Curr Opin Genet Dev. 2009 Oct 5.
DOI Direct Link
Diagnostic importance of overexpression of Bmi-1 mRNA in early breast cancers.
Target molecules for a highly sensitive and specific diagnosis of breast...
2nd October, 2009
Department of Clinical Laboratory Medicine, Sapporo Medical University Int J Oncol. 2009 Sep;35(3):511-5.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598031 Method for the detection of gene transcripts in blood and uses thereof
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7049072 Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases

View more patents.

BMI1 results (if any) from reagent suppliers

Google CSE Logo
Bmi1 antibody [1.T.21] - ChIP Grade (ab14389) | Abcam
Mouse monoclonal [1.T.21] to Bmi1 - ChIP Grade. The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells.
http://www.abcam.com/Bmi1-antibody-1-T-21-ChIP-Grade-ab14389...

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Bmi1 Antibody #2830
Confocal immunofluorescent analysis of U2OS cells using Bmi1 Antibody (green). Actin filaments have been labeled with DY-554 phalloidin (red). ...
http://www.cellsignal.com/products/2830.html...

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Bmi-1 Antibody / Bmi-1 Antibodies
Bmi-1 Antibody / Bmi-1 Antibodies. ... Bmi-1 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-bmi-1.html...

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Bmi1 Antibody
Bmi1 protein. Antibodies are purified by peptide affinity chromatography. ... Bmi1 Antibody (green). Actin filaments have been labeled with ...
http://www.cellsignal.com/pdf/2830.pdf...

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The Abcam catalog
Bmi1 antibodies. ... Bmi1 antibody [1.T.21] - ChIP Grade. Flow Cyt, IP, WB, ICC/ IF, IHC-P, ChIP. Images · Customer Abreviews: 4 stars (out of 5) ...
http://www.abcam.com/index.html?t=13952&pt=1&c=3315...

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Anti-BMI-1 Polyclonal Antibody
Polyclonal Antibody against BMI-1 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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Bmi1 antibody (ab38295) | Abcam
Rabbit polyclonal to Bmi1. The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life
...
http://www.abcam.com/Bmi1-antibody-ab38295.html...

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