Thursday November 26 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

SIX1


Suggest Content
Advertise Here
Gene DB Home
Symbol:SIX1
Name(s):SIX homeobox 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:BOS3, DFNA23, TIP39
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17637804 A novel SIX1 mutation suggests a slightly different clinical profile compared to EYA1-related branchio-oto-renal syndrome.
17519359 CSRP3, MUSTN1, SIX1, and FBXO32 expression changes in response to lengthening and shortening contractions in human muscle
17008870 Results showed that Six1 is frequently overexpressed in hepatocellular carcinoma (HCC) patients and elevated Six1 protein in HCC patients may be an indication of advanced stage and poor overall survival after hepatectomy.
16670092 SALL1 is a likely target gene for SIX1 during kidney development
15123840 Six1 overexpression reinstates an embryonic pathway of proliferation in breast cancer by up-regulating cyclin A1
16652090 SIX1 mutation may cause the enlargement of the vestibular aqueduct in patients diagnosed with branchio-oto syndrome.
17130831 Cell cycle regulation of Six1 occurs both transcriptionally and post-translationally via phosphorylation
15141091 Identification of SIX1 mutations as causing branchio-oto-renal syndrome offers insights into the molecular basis of otic and renal developmental diseases in humans

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDamino-terminal enhancer of split isoform bSIX homeobox 1SIX1 interacts with AES.-Pubmed
HPRDdachshund homolog 1 isoform aHomeobox protein SIX1--Pubmed
HPRDEYA 1SIX homeobox 1--Pubmed
HPRDeyes absent 1 isoform bHomeobox protein SIX1--Pubmed
HPRDeyes absent 2 isoform bSIX homeobox 1--Pubmed
HPRDeyes absent 3Homeobox protein SIX1--Pubmed
BINDSIX homeobox 1transducin-like enhancer protein 1SIX1 interacts with TLE1.-Pubmed
HPRDSIX homeobox 1SIX homeobox 1--Pubmed

Recent Publications on SIX1:

Pubmed Logo
The non-conserved C-terminal segments of Sine Oculis Homeobox (SIX) proteins confer functional specificity.
The Sine Oculis Homeobox (SIX) proteins play critical roles in...
3rd November, 2009
Department of Biology, Indiana University, Bloomington, Indiana 47405, Genesis. 2009 Aug;47(8):514-23.
DOI Direct Link
Vestigial-like 2 acts downstream of MyoD activation and is associated with skeletal muscle differentiation in chick myogenesis.
The co-factor Vestigial-like 2 (Vgl-2), in association with the...
17th October, 2009
CNRS, UMR7622, Biologie Moleculaire et Cellulaire du Developpement, Mech Dev. 2009 Oct 13.
DOI Direct Link
The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction.
Wnt signalling is required for neural crest (NC) induction; however, the...
15th October, 2009
Department of Cell and Developmental Biology, University College London, Development. 2009 Oct;136(19):3267-78.
DOI Direct Link
Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations.
Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental...
15th October, 2009
Program in Molecular Biology, University of Colorado Denver School of J Biol Chem. 2009 Jul 31;284(31):20781-90. Epub 2009 Jun 4.
DOI Direct Link
Effector gene screening allows unambiguous identification of Fusarium oxysporum f. sp. lycopersici races and discrimination from other formae speciales.
During infection of tomato, the fungus Fusarium oxysporum f. sp....
6th October, 2009
Scientia Terrae Research Institute, Sint-Katelijne-Waver, Belgium; FEMS Microbiol Lett. 2009 Nov;300(2):201-15. Epub 2009 Oct 4.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Integrative Medicine Approach to the Management of Asthma in Adults

Patents:

Patents logo
US Patent No.Title
7588767 Microorganisms for therapy
7049072 Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
6979557 Full-length cDNA
6936417 Gene expression in bladder tumors
6884578 Genes differentially expressed in secretory versus proliferative endometrium

View more patents.

SIX1 results (if any) from reagent suppliers

Google CSE Logo
SIX1 antibody (ab22072) | Abcam
Mouse polyclonal to SIX1. The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the
developing ...
http://www.abcam.com/SIX1-antibody-ab22072.html...

Thumbshot
Six1 (A-20) Antibody sc-9709
See how others have used Six1 (A-20): sc-9709 antibody and or Six1 (A-20) antibody conjugates ... The homeoprotein six1 transcriptionally activates
multiple ...
http://www.scbt.com/datasheet-9709-six1-a-20-antibody.html...

Thumbshot
SIX1 antibodies: Chromatin and Nuclear Signaling > Transcription ...
SIX1 antibodies. ... SIX1 antibodies. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication. ab22072 · SIX1 antibody ...
http://www.abcam.com/index.html?t=115701&pt=1&c=3424&ei=&mu=...

Thumbshot
Six1 (m): 293T Lysate sc-123562
100 µg protein in 200 µl SDS-PAGE buffer; suitable as Western Blotting control for Six1 antibodies; mouse Six1 transfected 293T lysate; suitable control ...
http://www.scbt.com/datasheet-123562-six1-m-293t-lysate.html...

Thumbshot
SensoLyte™ MMP-13 ELISA Kit
Perform six 1:3 serial dilutions by pipetting out 200 μL from the stock solution to get concentration of 2000, 666.7, 222.2, 74.07, 24.69, 8.23 ng/mL, ...
http://www.anaspec.com/pdfs/72104.pdf...

Thumbshot
Six1/2/4 (N-19) Antibody sc-9708
Six1/2/4 (N-19) P, sc-9708 P (peptide), 100 µg/0.5 ml, $58. Six1/2/4 (N-19) X ... Western blot analysis of Six1/2/4 expression in NIH/3T3 whole cell lysate.
...
http://www.scbt.com/ko/datasheet-9708-six1-2-4-n-19-antibody...

Thumbshot
SensoLyte™ MMP-1 ELISA Kit
Perform six 1:3 serial dilutions by pipetting out 200 μL from the stock solution to get concentration of 18000, 6000, 2000, 666.7, 222.2, 74.07, ...
http://www.anaspec.com/pdfs/72102.pdf...

Thumbshot

Search Bioportfolio and other Life Science Sites for SIX1, or search for SIX1 on BioPortfolio's antibody search engine.
This page has been viewed 466 times
Recent Search Terms used to find this page:
six1 antibody | six1.net | six1 chromatin structure muscle | Six1 protein | six1 vestibular aqueduct enlargement | six1 | six1.net | Six1 | Six1 | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.