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BMP2


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Gene DB Home
Symbol:BMP2
Name(s):bone morphogenetic protein 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:BMP2A
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17960657 Cotransfection of mesenchymal stem cells with the combination of the CTLA4Ig and the BMP2 gene stimulates osteoblastic cell differentiation in vitro.
18029192 BMP-7 but not BMP-2 and BMP-4 prevents the loss of primitive hematopoietic progenitor cells cultured in SFM plus SF3.
15240857 Observational study of gene-disease association. (HuGE Navigator)
16432645 Observational study of gene-disease association. (HuGE Navigator)
16453284 Observational study of gene-disease association. (HuGE Navigator)
16604289 Observational study of gene-disease association. (HuGE Navigator)
16753015 Observational study of gene-disease association. (HuGE Navigator)
17726567 Observational study of gene-disease association. (HuGE Navigator)
17847004 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18059158 BMP2 downregulates PTEN via RAS/ERK in a SMAD4-null environment that contributes to cell growth, and constitutes a SMAD4-independent but BMP-responsive signaling pathway.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDactivin A type I receptor precursorbone morphogenetic protein 2 preproprotein--Pubmed
HPRDactivin A type I receptor precursorbone morphogenetic protein 2 preproprotein--Pubmed
HPRDachaete-scute complex homolog-like 1bone morphogenetic protein 2 preproprotein--Pubmed
HPRDachaete-scute complex homolog-like 1bone morphogenetic protein 2 preproprotein--Pubmed
HPRDBone morphogenetic protein 2bone morphogenetic protein receptor, type IB precursor--Pubmed
HPRDBone morphogenetic protein 2bone morphogenetic protein receptor type II precursor--Pubmed
HPRDBone morphogenetic protein 2noggin precursor--Pubmed
HPRDBone morphogenetic protein 2BMP-binding endothelial regulator precursor protein--Pubmed
HPRDbone morphogenetic protein 2 preproproteinBone morphogenetic protein receptor, type IB--Pubmed
HPRDbone morphogenetic protein 2 preproproteinNoggin--Pubmed

Recent Publications on BMP2:

Pubmed Logo
A common SNP near BMP2 is associated with severity of the iron burden in HFE p.C282Y homozygous patients: A follow-up study.
Background and Objectives. It is now generally admitted that penetrance of...
3rd November, 2009
IRD - UR010, Paris, France. Blood Cells Mol Dis. 2009 Oct 29.
DOI Direct Link
Wnt Inhibitors Dkk1 and Sost are Downstream Targets of BMP Signaling Through the Type IA Receptor (BMPRIA) in Osteoblasts.
Abstract The BMP and Wnt signaling pathways both contribute essential...
31st October, 2009
J Bone Miner Res. 2009 Oct 29.
DOI Direct Link
Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.
In a transient 90-min middle cerebral artery occlusion (MCAO) model of...
29th October, 2009
Department of Molecular and Cellular Physiology, Graduate School of J Cereb Blood Flow Metab. 2009 Oct 28.
DOI Direct Link
Osteo-transcriptomics of human mesenchymal stem cells: Accelerated gene expression and osteoblast differentiation induced by vitamin D reveals c-MYC as an enhancer of BMP2-induced osteogenesis.
Bone marrow-derived human mesenchymal stem cells (hMSCs) have the in vitro...
28th October, 2009
Department of Applied Biology, Nijmegen Centre for Molecular Life Sciences Bone. 2009 Oct 24.
DOI Direct Link
TNF{alpha} represses BMP signaling by interfering with the DNA binding of smads through the activation of NF-{kappa}B.
Bone morphogenetic proteins (BMPs) induce not only bone formation in vivo...
27th October, 2009
Kyushu Dental College, Japan; J Biol Chem. 2009 Oct 23.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Spine Fusion Instrumented With BMP-2 vs Uninstrumented With Infuse BMP-2 Alone

Patents:

Patents logo
US Patent No.Title
7459437 Molecular determinants of myeloma bone disease and uses thereof
7501179 Block copolymer particles
7501281 Compositions, methods and kits related to thrombin, Notch signaling and stamatogenesis and growth of stem cells
7504099 Methods of inducing or enhancing connective tissue repair
7507709 Synergistic effects of OP/BMP morphogens and GDNF/NGF neurotrophic factors

View more patents.

BMP2 results (if any) from reagent suppliers

Google CSE Logo
BMP2 antibody (ab14933) | Abcam
Rabbit polyclonal to BMP2. BMP2 belongs to the transforming growth factor-beta ( TGFB) superfamily of secreted growth factors. It is a disulfide-linked ...
http://www.abcam.com/BMP2-antibody-ab14933.html...

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BMP-2 (N-14) Antibody sc-6895
See how others have used BMP-2 (N-14): sc-6895 antibody and or BMP-2 (N-14) antibody conjugates ... Western blot analysis of mature human recombinant BMP-2.
...
http://www.scbt.com/datasheet-6895-bmp-2-n-14-antibody.html...

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BMP2 Antibody Bone Morphogenetic Protein 2
BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the ...
http://www.prosci-inc.com/shop/catalog1/BMP2-Antibody-p-3343...

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Bmp2 Antibody (N-term)
Bmp2 Antibody (N-term). Purified Rabbit Polyclonal Antibody (Pab) ... Bmp2 Antibody (N-term). Formalin-fixed and paraffin-embedded human cancer tissue ...
http://www.abgent.com/products/catalog_no/AP1713a_Bmp2_Antib...

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BMP2 antibody - Differentiation marker (ab17885) | Abcam
Rabbit polyclonal to BMP2 - Differentiation marker. BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors.
http://www.abcam.com/BMP2-antibody-Differentiation-marker-ab...

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BMP2K antibody, BMP-2 Antibody, Rabbit Polyclonal Antibody
Buy quality rabbit BMP2K antibody (interacts with human), anti-BMP2K, BMP-2 antibody, rabbit polyclonal antibody, BMP-2 Antibody, Rabbit Polyclonal Antibody
...
http://www.genwaybio.com/product_info.php?products_id=78449...

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The Abcam catalog
BMP2 antibodies. ... BMP2 antibody - Differentiation marker. WB, ELISA. Rabbit polyclonal ... BMP2 antibody [65529.111]. I-ELISA, IHC-P, WB, ELISA ...
http://www.abcam.com/index.html?t=92930&pt=1&c=3529...

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