Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17960657 |
Cotransfection of mesenchymal stem cells with the combination of the CTLA4Ig and the BMP2 gene stimulates osteoblastic cell differentiation in vitro. |
| 18029192 |
BMP-7 but not BMP-2 and BMP-4 prevents the loss of primitive hematopoietic progenitor cells cultured in SFM plus SF3. |
| 15240857 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16432645 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16453284 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16604289 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16753015 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17726567 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17847004 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 18059158 |
BMP2 downregulates PTEN via RAS/ERK in a SMAD4-null environment that contributes to cell growth, and constitutes a SMAD4-independent but BMP-responsive signaling pathway. |
| 17824831 |
STRO-1 selected rat dental pulp stem cells transfected with adenoviral-mediated human BMP2 gene show enhanced odontogenic differentiation. |
| 17437303 |
Results show that cells contacting 316L steel are exposed to increased concentrations of Ni which suffice to impair BMP-2-induced ALP activity. |
| 17726567 |
Variation in BMP2 masy play a previously unidentified role in aspects of bone density, which may be age- and site-dependent. |
| 17711857 |
BMP2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization. |
| 17681894 |
PKA signaling pathway would be the main intracellular signaling pathway of the EP4 for the anabolic effect of bone and mineral metabolisms |
| 17847004 |
interactive effect on serum ferritin level of rs235756 in BMP2 and a SNP in HJV, with a small additive effect of a SNP in BMP4 |
| 17919499 |
Statins induce apoptosis in colorectal tumor cells through induction of BMP2. Statin therapy may only be effective in SMAD4-expressing tumors and may have adverse effects in SMAD4-negative tumors. |
| 17617489 |
Glycidyl methacrylated dextran gelatin scaffolds containing micospheres loaded with BMP2 enhanced periodontal regeneration. |
| 17401695 |
BMP-2, TGF-beta2, and TGF-beta3 are involved in bone formation in heterotopic ossifications. |
| 17519894 |
BMP2 augmentation might be critically important in achieving this effect |
| 17504062 |
We conclude that the controlled release of BMP-2 for a certain time period was essential to inducing the osteoinductive potential of BMP-2. |
| 11854297 |
BMP-2 and TGF-beta activate both Ras/MAPK/AP-1 and Smad signaling in osteoblasts with Smads modulating AP-1 activity. |
| 12925611 |
In cell culture, IL-1beta and TNF-alpha increased BMP-2 mRNA and protein levels by eightfold and fifteenfold, respectively, whereas IGF-1 and TGF-beta1 had no effect. In cartilage explant cultures, IL-1beta and TNF-alpha increased BMP-2 levels. |
| 16261446 |
data indicate that BMP-2 can utilize a new signal transduction pathway in the NF-kappaB activation system, which plays a crucial role in the survival of the N1511 chondrocytic cell line |
| 16157126 |
The principal finding of this study was that BMP2 is up-regulated in the chorioamniotic membranes in labor and histologic chorioamnionitis. |
| 16672363 |
structure of the ternary complex representing the signaling competent complex of BMP-2 bound to the entire extracellular domains of both its type I receptor, BMPR-Ia, & its type II receptor, ActRII, at a resolution of 2.2 angstroms |
| 11748585 |
promotes chondrogenic differentiation of multipotential mesenchymal cells |
| 14587031 |
the effect of MGP on calcification and osteogenic differentiation is determined by availability of BMP-2 |
| 15042598 |
Decreased BMP2 expression associated with progression to prostate cancer; loss of BMP2 and Smad4 related to progression to a more aggressive phenotype |
| 16598384 |
autocrine BMP production is necessary for the RUNX2 transcription factor to be active and that BMPs and RUNX2 cooperatively interact to stimulate osteoblast gene expression. |
| 16615932 |
Finally, two inhibitors of cyclin-dependent kinase 9 (a dominant negative CDK9 and flavopiridol) repressed activity from the MR and BMPR2 promoters |
| 12856332 |
Results suggest that rHuIL-11 acts synergistically with rHuBMP-2 to more rapidly stimulate bone formation compared with rHuBMP-2 alone. |
| 17120779 |
Biglycan is a positive modulator of BMP-2 induced osteoblast differentiation |
| 13678785 |
BMP-2 stimulated Placental growth factor secretion from MG63 osteosarcoma and mesenchymal stem cells |
| 14699493 |
BMP2 acts as a tumor suppressor promoting apoptosis in mature colonic epithelial cells. |
| 15037653 |
BMP-2 enhanced the angiogenic response in developing tumors |
| 12535648 |
results show that expression of a dominant negative type II TGFbeta receptor impairs BMP2 signaling in MDA-MB-231 breast cancer cells, resulting in an attenuation of the anti-proliferative effects of BMP2 on these cells |
| 15102076 |
BMP2 or 4 in pilomatricoma is responsible for induction of proalpha(1)(II) collagen mRNA in overlying epidermal cells resulting in deposition of type II collagen in dermo-epidermal junction. |
| 15150273 |
bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation requires menin, Smads and Runx2 |
| 15861517 |
To analyze the expression of bone morphogenetic proteins (BMPs) in prostate and breast cancers with established metastasis in bone |
| 16150699 |
findings identify functional cross-talk of Id1 expression between Wnt and BMP signaling and demonstrate a novel mechanism for Wnt regulation of the BMP-2 response, linking Id1 expression to Wnt/beta-catenin signaling |
| 16326713 |
Data show that phosphophoryn (PP) up-regulates bone morphogenetic protein 2 gene expression 12 h post-treatment with PP, much later than initial detection of Smad1 phosphorylation at 30 min. |
| 12531697 |
BMP2 and BMP4 differently affect activin A induction of erythropoiesis; follistatin and FLRG proteins downmodulate the effects of activin A and BMP2. |
| 12819188 |
expression of the mature BMP-2 protein is disregulated in the majority of NSCLC. BMP-2 enhancement of tumor cell migration and invasion, as well as stimulating tumor growth in vivo, suggests it has important biological activity in lung carcinomas. |
| 15322112 |
Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. |
| 16126463 |
BMPs influence the formation of the osteolytic prostate cancer metastases, and treatment modalities that inhibit BMP activity may limit the progression of the lytic component of prostate cancer metastases. |
| 16613856 |
BMP-2 stimulates Runx2 acetylation |
| 16621789 |
BMP-2 antagonizes Wnt-3a signaling in osteoblast progenitors by promoting an interaction between Smad1 and Dvl-1 that restricts beta-catenin activation |
| 16835229 |
TNF-alpha increases the stability of BMP-2 mRNA through the pentameric motifs via NF-kappaB |
| 11718007 |
BMP-2 gene transfection tends to accelerate HPDLFs into osteoblast-like cells. |
| 17553463 |
lysyl hydroxylases and lysyl oxidase/lysyl oxidase-like proteins are differentially responsive to BMP-induced osteoblast differentiation |
| 12126644 |
BMP2 binds to collagen II at a specific binding domain and has a role in embryo development, organogenesis, and regeneration of damaged tissues |
| 16247476 |
Forced expression of BMP-2 in A549 cells significantly enhanced tumor growth in the lungs following intravenous injection but not of subcutaneous tumors |
| 16442268 |
Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes |
| 16815889 |
BMP-2 significantly (>2-fold) upregulated mRNA expression of KCNA5, KCNA7, KCNA10, KCNC3, KCNC4, KCNF1, KCNG3, KCNS1, and KCNS3 but downregulated (at least 2-fold) KCNAB1, KCNA2, KCNG2, and KCNV2 in pulmonary artery smooth muscle |
| 17138967 |
Results show calcium-sensing receptor regulate BMP-2 synthesis and secretion required phosphatidylinositol 3-kinase activation. |
| 17255107 |
the BMP1 prodomain specifically binds and regulates signaling by BMP2 and BMP4 |
| 11968014 |
RT-PCR analysis of human bone marrow stromal cells during osteogenesis in vitro: the mRNA levels of bone morphogenetic protein-2 (BMP-2), bone sialoprotein-II (BSP), osteopontin (OP) and cbfa-1 increased with culture time in osteogenic medium. |
| 17518682 |
Increased mRNA expression of BMP-2 in bone marrow derived cultured human mesenchymal stem cells under cyclic tensile strain demonstrates the critical nature of mechanical factors in the osteogenic differentiation process. |
| 16000303 |
Osterix regulation by recombinant BMP-2 proceeds via protein kinase D and MAP kinase (p38 and JNK) signaling in human mesenchymal stem cells |
| 12933820 |
brief exposure to recombinant human bone morphogenetic protein-2 (rhBMP-2)is sufficient to induce irreversible commitment to mineralization in dexamethasone-treated osteoblast cultures |
| 12168799 |
BMP2 has a role in controlling normal and premature cranial ossification in humans [review] |
| 12489168 |
BMP2 can recruit progenitors to the cementoblastic lineage and regulate differentiation by inducing and enhancing the expression of cementum attachment protein, a cell lineage-specific regulator. |
| 15647840 |
BMP-2 inhibits DHT-induced growth of LNCaP cells through a decrease in E2F protein expression and suppression of E2F activity by hypophosphorylation of Rb |
| 16771708 |
TSG-6 is down-regulated during osteoblastic differentiation, and suppressed osteoblastic differentiation induced by both BMP-2 and osteogenic differentiation medium. |
| 17003113 |
GREMLIN 1 was expressed in the stroma of human basal cell carcinoma (BCC) tumors but not in normal skin in vivo. Bone morphogenetic protein (BMP) 2 and 4 are expressed by BCC cells. |
| 17472960 |
RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal |
| 11792561 |
Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2. |
| 12002771 |
REVIEW:Bone morphogenetic protein (BMP)-2 cell cycle arrest and apoptosis in human myeloma cells. |
| 14499589 |
These results indicate that the 73-92 peptide of bone morphogenetic protein-2 (BMP-2) may be a receptor-binding site and may stimulate bone precursor cells to induce calcification. |
| 14691541 |
a region on the short arm of Chromosome 20 contains a gene or genes that appear to be a major risk factor for osteoporosis and osteoporotic fractures, including BMP2 |
| 12620973 |
BMP2 exposure can regulate PTEN protein levels by decreasing PTEN's association with the degradative pathway |
| 15851600 |
(TNF)-alpha induced NF-kappaBeta activation and elicited significant increases in BMP-2 mRNA and protein in human umbilical vein endothelial cells |
| 16637042 |
Potential use of slow degrading silk fibroin 3-D scaffolds loaded with BMP-2 in combination with human bone marrow cells to induce osteogenesis. |
| 16893455 |
Bone morphogenetic protein 2 (BMP-2) mRNA was upregulated in injured articular cartilage explants |
| 17262821 |
strong BMP staining is seen in maturing chondrocytes, and thus may play a role in chondrocyte differentiation and/or apoptosis; BMP release by osteoclasts may promote osteoblastic differentiation at sites of bone remodeling |
| 17530715 |
BMP-2 induced the chondrogenic differentiation of synovial explants in a dose- and time-dependent manner under serum- and dexamethasone-free conditions |
| 17549388 |
BMP2 regulates the interaction of IGF-1 with growth plate chondrocytes. |
| 12527559 |
BMP-2 inhibits PDGF-stimulated proliferation of HASMCs through induction of p21. p21-mediated induction of cell cycle arrest by BMP-2 may initiate osteogenic differentiation of vascular smooth muscle cells, ultimately leading to vascular mineralization. |
| 12052447 |
Local application of recombinant human BMP2 from coated titanium implants significantly improves fracture healing, biomechanical torsional stability, and callus remodeling in a rat model. |
| 12740218 |
In pulmonary artery smooth muscle cells from pulmonary hypertension patients, the BMP-2- or BMP-7-induced apoptosis was significantly inhibited compared with PASMCs from patients with secondary pulmonary hypertension. |
| 12919699 |
Study evaluates several aspects of the osteogenic effect of human BMP-2 protein injected into quadriceps of female C57B1/6J SCID mice. |
| 15592496 |
The expression of tenascin-W is induced by BMP-2 in mammary canacer. |
| 15641068 |
In the presence of 10 microg rHuBMP-2, muscle-derived mesenchymal cells expressed type II collagen messenger RNA at 4 days after transplantation, and a mature cartilage mass was formed 5 weeks after transplantation in the diffusion chamber. |
| 16391828 |
identified several BMP-2-responsive genes in LNCaP cells, human prostate cancer cell line |
| 12872164 |
Data show that retinoid-induced expression of bone morphogenetic protein-2 is necessary and sufficient for apoptosis of retinoid-responsive cells. |
| 12082094 |
induces osteocalcin expression in osteoblasts |
| 15647827 |
BMP-2 upregulates the expression of alphavbeta integrins, and these integrins, in turn, play a critical role in BMP-2 function in osteoblasts |
| 14558086 |
BMP-2 and BMP-6 are expressed in arthritic synovium and are strongly up-regulated by proinflammatory cytokines. |
| 11642720 |
The expression signals of BMP-2 mRNA in malignant schwannoma were not lower than in benign lesions |
| 12210753 |
rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice |
| 16719933 |
Topical and differential expression of BMP-2/4 and BMP-7 mRNA and protein was found in bursa tissue. |
| 12854828 |
BMP-2 exerts both positive and negative effects on osteoblasts, possibly depending on the differentiation stage and/or the existing BMP signaling |
| 16754660 |
heparin enhances BMP-2-induced osteoblast differentiation in vitro and in vivo by protecting BMPs from degradation and inhibition by BMP antagonists |
| 15358784 |
The Bmp2 3' UTR contains essential regulatory elements that act post-transcriptionally |
