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BMP4


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Symbol:BMP4
Name(s):bone morphogenetic protein 4
Type:protein-coding
Organism:Homo sapiens
Synonyms:BMP2B, BMP2B1, ZYME
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18317771 Observational study of gene-disease association. (HuGE Navigator)
18029192 BMP-7 but not BMP-2 and BMP-4 prevents the loss of primitive hematopoietic progenitor cells cultured in SFM plus SF3.
18252212 Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways.
12404109 Observational study of gene-disease association. (HuGE Navigator)
16604289 Observational study of gene-disease association. (HuGE Navigator)
17003840 Observational study of gene-disease association. (HuGE Navigator)
17847004 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18076106 Mutations in BMP4,are infrequently found in patients with congenital cardiac septal defects
17989347 A BMP4/growth differentiation factor 5 (GDF5) selective binding protein exists in human pulmonary artery smooth muscle cells.
17516553 BMP4 induces epithelial-mesenchymal transition through MSX2 induction on pancreatic cancer cell line.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBone morphogenetic protein 4bone morphogenetic protein receptor, type IB precursor--Pubmed
HPRDBone morphogenetic protein 4bone morphogenetic protein 8B preproprotein--Pubmed
HPRDBone morphogenetic protein 4bone morphogenetic protein receptor, type IA precursor--Pubmed
HPRDBone morphogenetic protein 4noggin precursor--Pubmed
HPRDBone morphogenetic protein 4BMP-binding endothelial regulator precursor protein--Pubmed
HPRDbone morphogenetic protein 4 preproproteinBone morphogenetic protein receptor, type IB--Pubmed
HPRDbone morphogenetic protein 4 preproproteinBMP receptor, type IA--Pubmed
HPRDbone morphogenetic protein 4 preproproteinNoggin--Pubmed
HPRDbone morphogenetic protein 4 preproproteinBone morphogenetic protein 8B--Pubmed
BINDbone morphogenetic protein 4 preproprotein-BMP4 interacts with an unspecified isoform of CHRD (Chd). This interaction was modeled on a demonstrated interaction between BMP4 from an unspecified species and CHRD from an unspecified species.-Pubmed

Recent Publications on BMP4:

Pubmed Logo
A common SNP near BMP2 is associated with severity of the iron burden in HFE p.C282Y homozygous patients: A follow-up study.
Background and Objectives. It is now generally admitted that penetrance of...
3rd November, 2009
IRD - UR010, Paris, France. Blood Cells Mol Dis. 2009 Oct 29.
DOI Direct Link
An Hh-Dependent Pathway in Lateral Plate Mesoderm Enables the Generation of Left/Right Asymmetry.
Breaking bilateral symmetry is critical for vertebrate morphogenesis. In...
3rd November, 2009
Department of Molecular and Cellular Biology and Harvard Stem Cell Curr Biol. 2009 Oct 28.
DOI Direct Link
Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.
In a transient 90-min middle cerebral artery occlusion (MCAO) model of...
29th October, 2009
Department of Molecular and Cellular Physiology, Graduate School of J Cereb Blood Flow Metab. 2009 Oct 28.
DOI Direct Link
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Hedgehog signaling is aberrantly activated in glioma, medulloblastoma,...
29th October, 2009
M & M Medical Bioinformatics, Hongo 113-0033, Japan. Curr Mol Med. 2009 Sep;9(7):873-86.
Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain.
Accumulating evidence suggests that Sonic hedgehog (Shh) signaling plays a...
27th October, 2009
Department of Anatomy and Developmental Biology, Yoshida, Sakyo-ku, Kyoto Mech Dev. 2009 Oct 22.
DOI Direct Link

View more research publications.

Press Releases on BMP4:

BioPortfolio Logo
Scientists Discover Why Teeth Form in a Single Row 26th February, 2009 University of Rochester Medical Center

Same Study Uncovers How Each Tooth Signals the Next to Start Growing

ROCHESTER, N.Y., Feb. 26 /PRNewswire-USNewswire/ -- A system of opposing genetic forces determines why mammals

Clinical Trials:

Clinical Trials Logo
The Role of TBX3 in Human ES Cell Differentiation

Patents:

Patents logo
US Patent No.Title
7459291 Chordin-like molecules and uses thereof
7510876 Definitive endoderm
7510881 Method and kit for the quantitative and/or qualitative detection of components in a sample
7511012 Myostatin binding agents
7514260 Feeder independent extended culture of embryonic stem cells

View more patents.

BMP4 results (if any) from reagent suppliers

Google CSE Logo
BMP4 antibody [66119.11] (ab6296) | Abcam
Mouse monoclonal [66119.11] to BMP4. BMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurally related signaling proteins.
http://www.abcam.com/BMP4-antibody-66119-11-ab6296.html...

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BMP4 Antibody Bone Morphogenetic Protein 4
BMP4 Antibody 49-648, ... Immunogen. BMP4 antibody was raised against amino acids 20 to 34 of BMP4. (Human). Application. BMP4 antibody can be used for ...
http://www.prosci-inc.com/shop/catalog1/BMP4-Antibody-p-3343...

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The Abcam catalog
BMP4 antibodies. ... BMP4 antibody [66119.11]. Neut, WB, I-ELISA. Specific publication references. Mouse monoclonal. Reacts with: ...
http://www.abcam.com/index.html?t=8587&pt=1&c=3516...

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BMP-4 (9H4) Antibody sc-81000
mouse monoclonal IgG2b, 200µg/ml; raised against recombinant BMP-4 of human origin ... BMP-4 (9H4): sc-81000. Western blot analysis of BMP-4 expression in
...
http://www.scbt.com/datasheet-81000-bmp-4-9h4-antibody.html...

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Anti-BMP-4 Monoclonal Antibody
Monoclonal Antibody against BMP-4 for use in ELISA, Inhibition Assays, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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BMP-4 (N-16) Antibody sc-6896
BMP-4 shRNA (h) Lentiviral Particles, sc-39744-V, 200 µl ... See how others have used BMP-4 (N-16): sc-6896 antibody and or BMP-4 (N-16) antibody conjugates ...
http://www.scbt.com/datasheet-6896-bmp-4-n-16-antibody.html...

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BioVendor R&D - Antibodies \ Bone morphogenetic protein 4(BMP4 ...
Bone morphogenetic protein 4(BMP4) Human, Rabbit Polyclonal Antibody. Other names: BMP4, Distributed product. Product: Size: New: LF-PA0093, 100ul ...
http://www.biovendor.com/product/antibodies/bone-morphogenet...

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