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BMP6


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Gene DB Home
Symbol:BMP6
Name(s):bone morphogenetic protein 6
Type:protein-coding
Organism:Homo sapiens
Synonyms:VGR, VGR1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18070108 The crystal structure of human BMP-6 was determined to a resolution of 2.1 A.
16604289 Observational study of gene-disease association. (HuGE Navigator)
16886151 Observational study of gene-disease association. (HuGE Navigator)
18187665 Observational study of gene-disease association. (HuGE Navigator)
17924656 presents the crystal structure of BMP-6
17899540 A functional bone morphogenetic protein 6 (BMP-6) signalling pathway is present in adult pre-T-leukemia lymphoma cell line Jurkat TAg.
17574840 BMP-6 promoter methylation status is correlated with estrogen receptor status in breast cancer
17575215 BMP-6 promoter methylation may be a potential new biomarker of risk prediction in DLBCL.
13130469 the presence of BMP-6 in adult human articular cartilage indicates a functional role for this growth factor in the maintenance of joint integrity.
15861517 To analyze the expression of bone morphogenetic proteins (BMPs) in prostate and breast cancers with established metastasis in bone

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDactivin A receptor, type IIA precursorbone morphogenetic protein 6 preproprotein--Pubmed
HPRDactivin A receptor, type IIA precursorbone morphogenetic protein 6 preproprotein--Pubmed
HPRDBone morphogenetic protein 6bone morphogenetic protein receptor, type IB precursor--Pubmed
HPRDBone morphogenetic protein 6bone morphogenetic protein receptor type II precursor--Pubmed
HPRDBone morphogenetic protein 6sclerostin domain containing 1 precursor--Pubmed
HPRDBone morphogenetic protein 6BMP-binding endothelial regulator precursor protein--Pubmed
HPRDbone morphogenetic protein 6 preproproteinBone morphogenetic protein receptor, type IB--Pubmed
HPRDbone morphogenetic protein 6 preproproteinBMP receptor, type 2--Pubmed
HPRDbone morphogenetic protein 6 preproproteinbone morphogenetic protein receptor, type IA precursor--Pubmed
HPRDbone morphogenetic protein 6 preproproteinbone morphogenetic protein receptor, type IA precursor--Pubmed

Recent Publications on BMP6:

Pubmed Logo
BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.
Impaired regulation of hepcidin expression in response to iron loading...
23rd October, 2009
Inserm, Toulouse, France. Blood. 2009 Sep 17;114(12):2515-20. Epub 2009 Jul 21.
DOI Direct Link
Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis.
BACKGROUND AND AIMS: Mutations in HFE are the most common cause of the...
16th October, 2009
Division of Nephrology, Center for Systems Biology, Massachusetts General Gastroenterology. 2009 Oct;137(4):1489-97. Epub 2009 Jul 7.
DOI Direct Link
Regulation of GNRH production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells.
Recent studies have shown that bone morphogenetic proteins (BMPs) are...
6th October, 2009
Department of Medicine and Clinical Science, Okayama University Graduate J Endocrinol. 2009 Oct;203(1):87-97. Epub 2009 Jul 27.
DOI Direct Link
Iron-induced expression of BMP6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo.
BACKGROUND & AIMS:: Recent studies identified bone-morphogenic-protein 6...
30th September, 2009
Institute of Pathology, University of Regensburg, D-93042 Regensburg, Gastroenterology. 2009 Sep 25.
DOI Direct Link
[BMP6: a key player in iron metabolism]
BACKGROUND & AIMS:: Recent studies identified bone-morphogenic-protein 6...
22nd September, 2009
Med Sci (Paris). 2009 Aug-Sep;25(8-9):678-80.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7041641 Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
7268208 Morphogen solubilizing peptides
7285532 Therapeutic method for treating bone formation diseases
7306903 Methods and compositions for identifying morphogen analogs
7308364 Diagnosis of multiple myeloma on gene expression profiling

View more patents.

BMP6 results (if any) from reagent suppliers

Google CSE Logo
BMP6 antibody [morph-6.1] (ab15640) | Buy from Abcam
Mouse monoclonal [morph-6.1] to BMP6. Bone Morphogenetic Proteins (BMP) are members of the TGF beta superfamily of cytokines that affect bone and cartilage
...
http://www.abcam.com/BMP6-antibody-morph-6-1-ab15640.html...

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BMP6 Antibody Bone Morphogenetic Protein 6
BMP6 Antibody 49-650, ... Immunogen. BMP6 antibody was raised against amino acids 40 to 55 of BMP6. (Human). Application. BMP6 antibody can be used for ...
http://www.prosci-inc.com/shop/catalog1/BMP6-Antibody-p-3344...

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BMP-6 (N-19) Antibody sc-7406
See how others have used BMP-6 (N-19): sc-7406 antibody and or BMP-6 ... BMP6 is axonally transported by motoneurons and supports their survival in vitro. ...
http://www.scbt.com/datasheet-7406-bmp-6-n-19-antibody.html...

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Human BMP-6 Affinity Purified Polyclonal Ab
The ND50 for this lot of anti-human BMP-6 antibody was determined to be approximately ... Human BMP-6 induces alkaline phosphatase expression by a mouse
...
http://www.rndsystems.com/pdf/af507.pdf...

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BMP-6 (D-19) Antibody sc-27409
BMP-6 shRNA (h) Lentiviral Particles, sc-37066-V, 200 µl ... See how others have used BMP-6 (D-19): sc-27409 antibody and or BMP-6 (D-19) antibody ...
http://www.scbt.com/datasheet-27409-bmp-6-d-19-antibody.html...

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Human BMP6 ELISA Kit
This assay employs an antibody specific for human BMP6 coated on a 96-well plate . ... anti-human BMP6 antibody is added. After washing away unbound ...
http://www.cellsciences.com/PDF/CKH126.pdf...

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BMP-6 siRNA (m) sc-37067
Click here for details. suitable control antibody: BMP-6 (N-19): sc-7406; sqRT- PCR Primer also available: BMP-6 (m)-PR: sc-37067-PR, 20 µl ...
http://www.scbt.com/datasheet-37067-bmp-6-sirna-m.html...

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