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SLC9A1
| Symbol: | SLC9A1 | | Name(s): | solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | APNH, FLJ42224, NHE1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18003619 |
Data support a novel molecular function of Daxx as an upstream regulator of NHE1 in ischemic cell death. |
| 12905871 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17981808 |
Model structure of the Na+/H+ exchanger 1 in human and E. coli |
| 17913870 |
These data provide the first evidence that both EGF and S1P stimulate NHE activity in the syncytiotrophoblast; they appear to do so predominantly by activating the NHE1 isoform. |
| 17916606 |
NHE1 activity generates a proton gradient at the cell surface accompanied by the cells' ability to respond to changes in pH in melanoma |
| 17894388 |
Epidermal growth factor upregulates NHE1 by post-translational regulation that is important for cervical cancer cell invasiveness. |
| 17982256 |
Three MAPKs exhibit unique interrelationships with the Na(+)/H(+) exchanger, NHE1, after osmotic cell shrinkage:ERK1/2, JNK1/2 and p38 MAPK. |
| 17662110 |
Results support the view that the multiple charged residues identified in this study, along with several basic residues reported previously, participate in the regulation of the intracellular pH sensing of Na+/H+ exchanger 1. |
| 15772858 |
NHE activity in the microvillus of syncytiotrophoblasts is attributable predominantly to NHE1. |
| 15823043 |
The results suggest that PP1 is an important regulatory phosphatase of NHE1, that it can bind to and dephosphorylate the protein, and that it regulates NHE1 activity in vivo. | →View more information from publications. |
Recent Publications on SLC9A1: |  |
Genetic susceptibility to febrile seizures: Case-control association studies.
Objective: A genetic predisposition to febrile seizures (FS) has long been... | 27th October, 2009
| Department of Pediatrics, Graduate School of Medical Sciences, Kyushu
| Brain Dev. 2009 Oct 22.
DOI Direct Link |
Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives.
In our efforts to discover more potent and lasting NHE1 inhibitors, we... | 15th October, 2009
| Department of Medicinal Chemistry, China Pharmaceutical University,
| Eur J Med Chem. 2009 Sep;44(9):3771-6. Epub 2009 May 5.
DOI Direct Link |
Interferon-gamma suppresses Na+ -H+ exchanger in cultured human endolymphatic sac epithelial cells.
Adequate regulation of endolymphatic pH is essential for maintaining inner... | 14th October, 2009
| Department of Otorhinolaryngology, Yonsei University College of Medicine,
| J Cell Biochem. 2009 Aug 1;107(5):965-72.
DOI Direct Link |
Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin.
Blood-brain barrier (BBB) Na transporters are essential for brain water... | 22nd September, 2009
| Department of Physiology and Membrane Biology, University of California,
| Am J Physiol Cell Physiol. 2009 Aug;297(2):C278-89. Epub 2009 May 20.
DOI Direct Link |
Phenylephrine and sustained acidosis activate the neonatal rat cardiomyocyte Na+/H+ exchanger through phosphorylation of amino acids Ser770 and Ser771.
The mammalian Na(+)/H(+) exchanger isoform 1 (NHE1) is a ubiquitously... | 2nd September, 2009
| Department of Biochemistry, University of Alberta, Edmonton, Alberta,
| Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H846-58. Epub 2009 Jun
DOI Direct Link |
→View more research publications. |
SLC9A1 results (if any) from reagent suppliers | 
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NHE-1 (C-20) Antibody sc-16097
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, SLC9A1, 6548, 1p36.11, NM_003047 ...
http://www.scbt.com/datasheet-16097-nhe-1-c-20-antibody.html...
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Nhe-1 Antibody (IN) Sodium-hydrogen exchanger 1
Additional Names. Nhe-1 (IN), Sodium-hydrogen exchanger 1, solute carrier family 9 member 1, SLC9A1, Na+/H+ antiporter ...
http://www.prosci-inc.com/shop/catalog1/Nhe-1-Antibody-p-659...
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A7410 Amiloride hydrochloride hydrate ≥98% (TLC), powder
Abp1(76507), Accn1(11418), Accn2(11419), Plau(18792), Scnn1a(20276), Scnn1b( 20277), Scnn1d(140501), Scnn1g(20278), Slc9a1(20544) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A741...
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SLC9A6/NHE6 | MBL International
Genet. 36, 759-766 (1999) 3) Numata, M., et al., J. Biol. Chem. 273, 6951-6959 ( 1998). Related Products: BMP023 anti- SLC9A1/NHE1 (polyclonal) ...
http://www.mblintl.com/product/bmp049...
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A9561 5-(N,N-Hexamethylene)amiloride HMA
Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a3(24784). mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A956...
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SLC9A7 | MBL International
BMP023 anti-SLC9A1/NHE1 (polyclonal) BMP049 anti-SLC9A6/NHE6 (polyclonal). Intended Use: For Research use only. Not for use in diagnostic procedure. ...
http://www.mblintl.com/product/bmp043...
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A3085 5-(N-Ethyl-N-isopropyl)amiloride EIPA
Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785). mouse ... Scnn1a(20276), Scnn1b(20277), ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A308...
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