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BMP7


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Gene DB Home
Symbol:BMP7
Name(s):bone morphogenetic protein 7 (osteogenic protein 1)
Type:protein-coding
Organism:Homo sapiens
Synonyms:OP-1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18029192 BMP-7 but not BMP-2 and BMP-4 prevents the loss of primitive hematopoietic progenitor cells cultured in SFM plus SF3.
17003840 Observational study of gene-disease association. (HuGE Navigator)
17264867 Observational study of gene-disease association. (HuGE Navigator)
17497692 BMP7 promotes the adipogenic and not the osteogenic or chondrogenic lineage development of human stem cells
17415633 Immunohistochemistry of cirrhotic human liver demonstrated upregulated BMP7 protein expression in hepatocytes as compared with normal human liver.
17724140 Results suggest that bone morphogenic protein 7 controls and preserves the epithelial phenotype in the human prostate and underscore a decisive role of the tumor microenvironment in mediating the therapeutic response of BMP7.
17909016 In breast cancer, bone morphogenetic protein 7 (BMP7) is a novel target gene regulated by the p53 family and mediates the cell survival function of the basal physiologically relevant level of p53.
17018615 BMP7 expression was almost completely absent at the invasive margin of esophageal tumors, but present in the central area. It may antagonize TGF-beta1's role in invasiveness.
17478078 Proinvasive activity of BMP7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells is reported.
12925612 Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDactivin A type I receptor precursorbone morphogenetic protein 7 precursor--Pubmed
HPRDactivin A type I receptor precursorbone morphogenetic protein 7 precursor--Pubmed
HPRDActivin A receptor, type IIbone morphogenetic protein 7 precursor--Pubmed
HPRDactivin A receptor, type IIA precursorBone morphogenetic protein 7--Pubmed
HPRDActivin A receptor, type IIBbone morphogenetic protein 7 precursor--Pubmed
HPRDactivin A type IIB receptor precursorBone morphogenetic protein 7--Pubmed
HPRDBone morphogenetic protein 7bone morphogenetic protein receptor, type IB precursor--Pubmed
HPRDBone morphogenetic protein 7bone morphogenetic protein receptor type II precursor--Pubmed
HPRDbone morphogenetic protein 7 precursorBMP receptor, type 2--Pubmed
HPRDbone morphogenetic protein 7 precursorBone morphogenetic protein receptor, type IB--Pubmed

Recent Publications on BMP7:

Pubmed Logo
Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.
In a transient 90-min middle cerebral artery occlusion (MCAO) model of...
29th October, 2009
Department of Molecular and Cellular Physiology, Graduate School of J Cereb Blood Flow Metab. 2009 Oct 28.
DOI Direct Link
A Genomewide Association Study of Citalopram Response in Major Depressive Disorder.
BACKGROUND: Antidepressant response is likely influenced by genetic...
23rd October, 2009
Department of Psychiatry and Institute for Human Genetics, University of Biol Psychiatry. 2009 Oct 19.
DOI Direct Link
PRDC regulates placode neurogenesis in chick by modulating BMP signalling.
The epibranchial placodes generate the neurons of the geniculate,...
20th October, 2009
MRC Centre for Developmental Neurobiology, 4th Floor New Hunts House, Dev Biol. 2009 Oct 15.
DOI Direct Link
Trps1 functions downstream of Bmp7 in kidney development.
During embryonic development, the mesenchyme of the lungs, gut, kidneys,...
13th October, 2009
First Department of Pathology, Wakayama Medical University Medical School, J Am Soc Nephrol. 2009 Nov;20(11):2403-11. Epub 2009 Oct 9.
DOI Direct Link
BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism.
The iterative formation of nephrons during embryonic development relies on...
2nd October, 2009
Department of Molecular Medicine, Maine Medical Center Research Institute, Development. 2009 Nov;136(21):3557-66. Epub 2009 Sep 30.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-Articular OP-1 in Subjects With Osteoarthritis of the Knee

Patents:

Patents logo
US Patent No.Title
7141239 Growth/differentiation factor of the TGF-.beta. family
7371725 Spondyloarthropathies
7374760 Methods and compositions for nerve regeneration
7381409 Antibodies specific for sclerostin and methods of screening and use therefor
7390657 Method for generating primate trophoblasts

View more patents.

BMP7 results (if any) from reagent suppliers

Google CSE Logo
BMP7 antibody (ab27569) | Abcam
Rabbit polyclonal to BMP7. Bone Morphogenetic Protein 7 (BMP7), also known as osteogenic protein 1 (OP1), is produced from a DNA sequence encoding the human
...
http://www.abcam.com/BMP7-antibody-ab27569.html...

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BMP7 Antibody
fected or transfected with mouse BMP7, using BMP7 Antibody. ■ 100 µl. (10 Western mini-blots) ... transfected levels of total mouse BMP7 protein. It only
...
http://www.cellsignal.com/pdf/4693.pdf...

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BMP-7 (4E7) Antibody sc-53917
BMP-7 shRNA (h) Lentiviral Particles, sc-39748-V, 200 µl ... BMP-7 (4E7): sc- 53917. Western blot analysis of BMP-7 expression in F9 whole cell lysate. ...
http://www.scbt.com/datasheet-53917-bmp-7-4e7-antibody.html...

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BMP7 Antibody #4693
BMP7 Antibody detects transfected levels of total mouse BMP7 protein. It only recognizes the BMP7 precursor protein (49 kDa), not the mature secreted from ...
http://www.cellsignal.com/products/4693.html...

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Bmp7 Antibody (N-term)
(RIGHT)Immunofluorescence analysis of Bmp7 Antibody (N-term) (Cat.#AP1718a) in HeLa cells. 0.025 mg/ml primary antibody was followed by ...
http://www.abgent.com/products/catalog_no/AP1718a_Bmp7_Antib...

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BMP-7 (L-19) Antibody sc-9305
See how others have used BMP-7 (L-19): sc-9305 antibody and or BMP-7 (L-19) antibody ... Western blot analysis of BMP-7 expression in F9 whole cell lysate.
...
http://www.scbt.com/datasheet-9305-bmp-7-l-19-antibody.html...

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The Abcam catalog
BMP7 antibodies. ... BMP7 antibody (Biotin). WB, ELISA, sELISA. Rabbit polyclonal. Biotin conjugated. Reacts with: Hu. Terms and conditions · Legal ...
http://www.abcam.com/index.html?t=8589&pt=1&c=3284...

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