Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18029192 |
BMP-7 but not BMP-2 and BMP-4 prevents the loss of primitive hematopoietic progenitor cells cultured in SFM plus SF3. |
| 17003840 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17264867 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17497692 |
BMP7 promotes the adipogenic and not the osteogenic or chondrogenic lineage development of human stem cells |
| 17415633 |
Immunohistochemistry of cirrhotic human liver demonstrated upregulated BMP7 protein expression in hepatocytes as compared with normal human liver. |
| 17724140 |
Results suggest that bone morphogenic protein 7 controls and preserves the epithelial phenotype in the human prostate and underscore a decisive role of the tumor microenvironment in mediating the therapeutic response of BMP7. |
| 17909016 |
In breast cancer, bone morphogenetic protein 7 (BMP7) is a novel target gene regulated by the p53 family and mediates the cell survival function of the basal physiologically relevant level of p53. |
| 17018615 |
BMP7 expression was almost completely absent at the invasive margin of esophageal tumors, but present in the central area. It may antagonize TGF-beta1's role in invasiveness. |
| 17478078 |
Proinvasive activity of BMP7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells is reported. |
| 12925612 |
Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage. |
| 15929982 |
the prodomain of BMP-7 has a role in targeting the BMP-7 complex to the extracellular matrix |
| 17264867 |
These results indicate that mutations are rare in FGF8 and FGFR2 in hypospadias, but gene variants may influence the risk. |
| 14587033 |
OP-1 stimulated cell proliferation and mRNA expression of several biochemical markers in this ligament cell culture model |
| 12385776 |
age related decline in level may contribute to the elevated susceptibility of cartilage to the degenerative process. |
| 12811818 |
BMP-7 plays an important role in the regulation of anti-inflammatory response in the adult gut tissue. |
| 16831023 |
Osteogenic protein-1 (OP-1 has shown particular potential in clinical trials as a bone graft substitute . |
| 15100360 |
Stimulation of kidney cells with BMP-7 induced hyaluronan synthase 2 mRNA expression and decreased the expression of Hyal1 and Hyal2. |
| 15861517 |
To analyze the expression of bone morphogenetic proteins (BMPs) in prostate and breast cancers with established metastasis in bone |
| 12478660 |
BMP-7 signaling is inhibited by glypican 3 in hepatocellular carcinoma cells |
| 16126463 |
BMPs influence the formation of the osteolytic prostate cancer metastases, and treatment modalities that inhibit BMP activity may limit the progression of the lytic component of prostate cancer metastases. |
| 16686760 |
BMP7 could restore the homeostatic balance of pSmad signaling found in normal kidneys, thereby preventing or reversing the development of chronic allograft nephropathy. |
| 16846353 |
Recombinant human BMP-7 plays a role in the migration of bone-forming cells. |
| 16899516 |
maintenance of renal BMP-7 during the evolution of diabetic nephropathy reduces diabetic renal injury, especially podocyte dropout. The findings also establish a role for endogenous glomerular BMP-7 as an autocrine regulator of podocyte integrity in vivo. |
| 11769973 |
Transforming growth factor-beta1 supports the rapid morphogenesis of heterotopic endochondral bone initiated by human osteogenic protein-1 via the synergistic upregulation of molecular markers |
| 15574511 |
The effect of BMP-7 on TGF-beta1 synthesis in TNF-alpha-stimulated cells was abrogated by disruption of CD44-hyaluronan interactions, suggesting that it was due to increased monocyte binding to hyaluronan on the cell surface. |
| 16807538 |
BMP-7 expression in the adult human kidney appears to be more restricted than in the fetal situation and predominantly found in the distal nephron. |
| 17262821 |
strong BMP staining is seen in maturing chondrocytes, and thus may play a role in chondrocyte differentiation and/or apoptosis; BMP release by osteoclasts may promote osteoblastic differentiation at sites of bone remodeling |
| 17522432 |
induction of BMP7 expression is frequent in melanomas and may serve as a novel prognostic marker of progression in melanoma patients |
| 12594282 |
BMP-7 inhibits constitutive and IL-1 beta-induced expression of monocyte chemoattractant protein-1 in mesangial cells, partly through suppression of c-Jun N-terminal kinase activity and AP-1 binding activity. |
| 16419056 |
Our results are suggesting a possible functional role for BMP7 in breast cancer development. |
| 12734180 |
IGF-1 and OP-1 could be key physiological regulators of MMP-13 gene expression |
| 12478285 |
crystal structure of the antagonist Noggin bound to BMP-7, which shows that Noggin inhibits BMP signalling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors |
| 14981086 |
results suggest expression of the Ihh gene, which contains multiple Smad binding sites, may be finely regulated by a gradient of bone morphogenetic protein BMP7 |
| 16646979 |
Measurement of OP-1 in joint fluid may have value in the clinical evaluation of joint diseases. |
| 17530715 |
BMP-7 was more potent than BMP-2 in inducing chondrogenesis, but the properties of the differentiated tissue were similar in each case |
| 17530716 |
The presence of BMP-7 and IL-1Ra antagonized the anti-anabolic effects of lipopolysaccharide |
| 14751565 |
In the extraskeletal model, newly formed bone was evident in the presence of rhBMP-7 |
| 12740218 |
In pulmonary artery smooth muscle cells from pulmonary hypertension patients, the BMP-2- or BMP-7-induced apoptosis was significantly inhibited compared with PASMCs from patients with secondary pulmonary hypertension. |
| 12919879 |
Overall decrease in endogenous OP-1 in degenerated and OA tissue suggests that OP-1 could be one of the factors responsible for normal homeostasis and matrix integrity in cartilage. |
| 15994952 |
BMP7 induced Smad phosphorylation in a dose-dependent manner, with Smad activation clearly demonstrable in prostate adenocarcinoma. |
| 16719933 |
Topical and differential expression of BMP-2/4 and BMP-7 mRNA and protein was found in bursa tissue. |
| 12792780 |
BMP-7 is expressed in various breast cancer cell lines in a cell line-specific manner |
| 12667445 |
crystal structure of BMP7 in complex with the extracellular domain (ECD) of the activin type II receptor |
