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SLC16A1
| Symbol: | SLC16A1 | | Name(s): | solute carrier family 16, member 1 (monocarboxylic acid transporter 1) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | FLJ36745, MCT, MCT1, MGC44475 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17701893 |
These studies show that promoter-activating mutations in exercise-induced hyperinsulinism induce SLC16A1 expression in beta cells, permitting pyruvate uptake and pyruvate-stimulated insulin release despite ensuing hypoglycemia. |
| 17016429 |
Targeting the Map kinase signal transduction cascademay provide a potential therapeutic approach in lymphomas and related malignancies that exhibit high levels of the MCT-1 protein. |
| 17082373 |
A single bout of high-intensity exercise decreased both MCT relative abundance (MCT1 and MCT4) in membrane preparations. |
| 15901598 |
Distinct MCT isoforms may be involved in short-chain fatty acid transport across the apical or basolateral membranes in polarized colonic epithelial cells. |
| 11953883 |
Carcinoma samples displaying reduced levels of MCT1 were found to express the high affinity glucose transporter, GLUT1, suggesting that there is a switch from butyrate to glucose as an energy source in colonic epithelia during transition to malignancy |
| 15135232 |
studies demonstrate that the opposing plasma membranes of human syncytiotrophoblast are polarized with respect to both monocarboxylate transporter MCT1 and MCT4 activity and expression |
| 15804185 |
MCT1 is functionally active and is the only MCT isoform involved in the apical uptake of monocarboxylates by retinal pigmented epithelial ARPE-19 cells |
| 17182800 |
DL-2-Hydroxy-(4-methylthio)butanoic acid is transported into the colonic cancer cell line cell membrane by a transport mechanissm involving MCT1. |
| 16370372 |
The inhibition of MCT1 during T lymphocyte activation results in selective and profound inhibition of the extremely rapid phase of T cell division essential for an effective immune response. |
| 11882670 |
substrate-induced regulation of human colonic MCT1. The basis of this regulation is a butyrate-induced increase in mRNA abundance, resulting from the dual control of gene transcription and stability of the transcript | →View more information from publications. |
Recent Publications on SLC16A1: |  |
Genetic Variations in the MCT1 (SLC16A1) Gene in the Chinese Population of Singapore.
MCT1(SLC16A1) is the first member of the monocarboxylate transporter (MCT)... | 3rd November, 2009
| Department of Pharmacology, Yong Loo Lin School of Medicine, National
| Drug Metab Pharmacokinet. 2009;24(5):469-74.
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Regulation of Gene Expression in Brain Tissues of Rats Chronically Treated by The Highly Abused Opioid Agonist, Oxycodone: Microarray Profiling and Gene Mapping Analysis.
Although oxycodone is the most often used opioid agonist, it remains one... | 30th September, 2009
| 1 School of Pharmacy, University of Maryland, Baltimore;
| Drug Metab Dispos. 2009 Sep 28.
DOI Direct Link |
The genetic basis of congenital hyperinsulinism.
Congenital hyperinsulinism (CHI) is biochemically characterised by the... | 26th September, 2009
| London Centre for Paediatric Endocrinology and Metabolism, Hospital for
| J Med Genet. 2009 May;46(5):289-99. Epub 2009 Mar 1.
DOI Direct Link |
Endogenous gene and protein expression of drug transporting proteins in cell lines routinely used in drug discovery programs.
The aim of this study was to investigate the gene and protein expression... | 11th September, 2009
| Department of Pharmacy.
| Drug Metab Dispos. 2009 Sep 9.
DOI Direct Link |
miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1.
Given that miR-124 is preferentially expressed in differentiating and... | 9th September, 2009
| Department of Anatomical and Cellular Pathology, The Chinese University of
| Hum Pathol. 2009 Sep;40(9):1234-43. Epub 2009 May 7.
DOI Direct Link |
→View more research publications. |
SLC16A1 results (if any) from reagent suppliers | 
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CD147 antibody, CD147 [MEM-M6/1] Antibody, Mouse Monoclonal Antibody
May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to ... Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a ...
http://www.genwaybio.com/product_info.php?products_id=192051...
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MCT1 (C-20) Antibody sc-14916
The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol. Pharmacol. 70: 2108-2115.
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http://www.scbt.com/datasheet-14916-mct1-c-20-antibody.html...
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Abgent - Stem Cell
AP1478a, MCFD2 Antibody (N-term), IHC, E, H. AP2753b, MCT1 (SLC16A1) Antibody (C -term), WB, E, H. AP2753c, MCT1 (SLC16A1) Antibody (Center), WB, E, H ...
http://www.abgent.com/products/category/stem_cell...
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Cell Surface Molecules / GPCRs
Semaphorin 4D (SEMA4D, CD100) polyclonal antibody, PAB-10202, $190.00. Solute carrier family 16 member 1 (SLC16A1) polyclonal antibody, PAB-10124, $190.00 ...
http://www.orbigen.com/dictionary/cat1089.htm...
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MCT1 (H-70) Antibody sc-50324
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, SLC16A1, 6566, 1p13.2, NM_003051 ...
http://www.scbt.com/datasheet-50324-mct1-h-70-antibody.html...
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