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SNCA
| Symbol: | SNCA | | Name(s): | synuclein, alpha (non A4 component of amyloid precursor) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | MGC110988, NACP, PARK1, PARK4, PD1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18070888 |
monoubiquitylation by SIAH1 and SIAH2 represents a possible trigger event for alpha-synuclein aggregation and Lewy body formation |
| 18210157 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18211709 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18322262 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18005258 |
Data showed that that alphaB-crystallin interrupted alpha-synuclein aggregation at its earliest stages, most likely by binding to partially folded monomers and thereby preventing their aggregation into fibrillar structures. |
| 18036154 |
the transcriptome and proteome of nitrated alpha-syn activated microglia, shown provide new potential insights into Parkinson disease mechanisms. |
| 18211709 |
No mutations were found in SNCA in Parkinson disease patients from Portugal. |
| 18179253 |
alpha-synuclein forms a high affinity lipid binding intermediate species during fibril formation. Oligomeric alpha-syn is known to be toxic & the high affinity binding species described here may correspond to a toxic species involved in Parkinson disease. |
| 11173882 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11207390 |
Observational study of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Recent Publications on SNCA: |  |
Association study of GATA-2 transcription factor gene (GATA2) polymorphism and Parkinson's disease.
It was shown that high levels of alpha-synuclein in substantia nigra are... | 30th October, 2009
| Department of Experimental and Clinical Pharmacology, Pomeranian Medical
| Parkinsonism Relat Disord. 2009 Oct 26.
DOI Direct Link |
alpha-Synuclein modulation of Ca signaling in human neuroblastoma (SH-SY5Y) cells.
Parkinson's disease (PD) is characterized in part by the presence of... | 29th October, 2009
| Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of
| J Neurochem. 2009 Oct 5.
DOI Direct Link |
Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.
Genetic variability across the SNCA locus has been repeatedly associated... | 17th October, 2009
| Institute for Genome Sciences & Policy, Duke University Medical Center,
| PLoS One. 2009 Oct 16;4(10):e7480.
DOI Direct Link |
alpha-Synuclein multiplication analysis in Italian familial Parkinson disease.
The alpha-synuclein gene (SNCA) multiplication causes autosomal dominant... | 17th October, 2009
| Parkinson Institute, Istituti Clinici di Perfezionamento, via Bignami 1,
| Parkinsonism Relat Disord. 2009 Oct 13.
DOI Direct Link |
From QTL to candidate gene: a genetic approach to alcoholism research.
A major focus of research in alcohol-related disorders is to identify the... | 17th October, 2009
| Department of Psychiatry, Indiana University School of Medicine, Institute
| Curr Drug Abuse Rev. 2009 May;2(2):127-34.
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→View more research publications. |
SNCA results (if any) from reagent suppliers | 
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Snca antibody, alpha-Synuclein (clone 5C2) Antibody, Mouse ...
Buy quality mouse Snca antibody (interacts with human), anti-Snca, alpha- Synuclein (clone 5C2) antibody, mouse monoclonal antibody, alpha-Synuclein (
clone ...
http://www.genwaybio.com/product_info.php?products_id=35023...
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Alpha-synuclein Antibody (N-term)
... PARK1 antibody; PARK4 antibody; Parkinson disease familial 1 antibody; PD 1 antibody; PD1 antibody; SNCA antibody; Synuclein alpha antibody ...
http://www.abgent.com/products/catalog_no/AP6401a...
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SNCA protein, alpha-Synuclein Delta-NAC recombinant protein
Buy quality SNCA protein (n/a), SNCA, alpha-Synuclein Delta-NAC recombinant protein, (n/an/a). alpha-Synuclein Delta-NAC, Human, Recombinant, E Coli; ...
http://www.genwaybio.com/product_info.php?products_id=38065...
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S3062 Anti-α-Synuclein antibody produced in rabbit IgG fraction of ...
Synonym: Anti-SNCA. MDL number: MFCD02095740 ... microarray: suitable. Gene Information, human ... SNCA(6622). rat ... Snca(29219). storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=S306...
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alpha Synuclein antibody, alpha Synuclein Antibody, Rabbit ...
Rabbit polyclonal to alpha Synuclein; 6622; SNCA; 127750; P37840; MGC110988; NACP; PARK1; PARK4; PD1;; Alpha-synuclein, SYUA_HUMAN. [ N/A NP_000336.1 P37840
...
http://www.genwaybio.com/product_info.php?products_id=196445...
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Antibodies to Parkinson's Disease
human ... SNCA(6622) rat ... Snca(29219), rat, human, ARR, IHC (p), WB, pricing ... human ... SNCA(6622), mouse, rat zebrafish, human, IHC, IP, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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ALPHA SYNUCLEIN antibody, ALPHA SYNUCLEIN Antibody, Goat ...
SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease.
...
http://www.genwaybio.com/product_info.php?products_id=76340...
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