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SNCG


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Symbol:SNCG
Name(s):synuclein, gamma (breast cancer-specific protein 1)
Type:protein-coding
Organism:Homo sapiens
Synonyms:BCSG1, SR
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
11585599 Observational study of gene-disease association. (HuGE Navigator)
14556204 Observational study of gene-disease association. (HuGE Navigator)
17373700 Observational study of gene-disease association. (HuGE Navigator)
17681534 A comparison of the structural and dynamic properties of the free states of all three synucleins, is reported in order to shed light on differences that may help to explain their different propensities to aggregate.
17534899 SNCG is a new unfavorable prognostic marker for breast cancer progression and a potential target for breast cancer treatment.
17369845 tobacco exposure induces the abnormal expression of SNCG in lung cancer cells through downregulation of DNMT3B
16821081 This study suggests that the expression of SNCG is an independent predictive marker for recurrence and metastasis in breast cancer progression.
16596223 Inducing demethylation of SNCG by hepatocarcinogens may represent one underlying mechanism for the aberrant expression of SNCG in hepatoma.
15596044 Up-regulation of gamma-synuclein is associated with bladder cancer
12121974 role in promoting cancer cell survival and inhibition of stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDMitotic checkpoint kinase MAD3Lsynuclein, gamma--Pubmed
HPRDBUB1 budding uninhibited by benzimidazoles 1 homolog betasynuclein, gamma--Pubmed
HPRDG protein coupled receptor kinase 5synuclein, gamma--Pubmed
HPRDG protein-coupled receptor kinase 5Synuclein, gamma--Pubmed
HPRDmitogen-activated protein kinase 8 isoform JNK1 alpha2synuclein, gamma--Pubmed
HPRDmitogen-activated protein kinase 8 isoform JNK1 alpha2synuclein, gamma--Pubmed

Recent Publications on SNCG:

Pubmed Logo
Applications of novel monoclonal antibodies specific for synuclein-gamma in evaluating its levels in sera and cancer tissues from colorectal cancer patients.
Overexpressions of synuclein-gamma (SNCG) in different cancers display...
23rd October, 2008
The Key Laboratory of Ministry of Education for Cancer Research and its Cancer Lett. 2008 Sep 28;269(1):148-58. Epub 2008 Jun 30.
DOI Direct Link
A candidate molecular signature associated with tamoxifen failure in primary breast cancer.
ABSTRACT: INTRODUCTION: Few markers are available to predict response to...
22nd October, 2008
Breast Cancer Res. 2008 Oct 17;10(5):R88.
DOI Direct Link
Relationship of SNCG, S100A4, S100A9 and LCN2 gene expression and DNA methylation in bladder cancer.
Microarray analysis of paired cultures of normal and cancerous urothelial...
23rd September, 2008
Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany. Int J Cancer. 2008 Sep 19;123(12):2798-2807.
DOI Direct Link
BCSG1 methylation status and BCSG1 expression in breast tissues derived from Chinese women with breast cancer.
OBJECTIVE: To investigate the role of DNA methylation in the regulation of...
23rd July, 2008
Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Oncology. 2008;74(1-2):61-8. Epub 2008 Jun 11.
DOI Direct Link
Porcine gamma-synuclein: molecular cloning, expression analysis, chromosomal localization and functional expression.
The gamma-synuclein protein is involved in breast carcinogenesis and has...
8th May, 2008
Department of Genetics and Biotechnology, Faculty of Agricultural Mol Biol Rep. 2008 May 7.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
6610484 Identifying material from a breast duct

SNCG results (if any) from reagent suppliers

Google CSE Logo
HPA014404 Anti SNCG antibody produced in rabbit Prestige ...
HPA014404 Anti-SNCG antibody produced in rabbit Prestige Antibodies™ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol ...
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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Alpha Diagnostic Intl Inc., 6203 Woodlake Center Dr, San Antonio ...
isoform termed γ-synuclein (SNCG) or breast cancer gene 1. (BCG1) has been cloned (human 127 aa (chrm 10q23),. rat/mouse 123 aa). ...
https://www.4adi.com/objects/catalog/product/extras/SYN14-S-...

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pan Synuclein antibody (ab53726) datasheet | Abcam
High levels of expression have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor ...
http://www.abcam.com/index.html?datasheet=53726...

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S
HPA014404, Anti-SNCG antibody produced in rabbit New, affinity isolated antibody , human ... SNCG(6623), human, IHC (p), PA, WB ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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gamma Synuclein antibody [1H10D2] (ab47966) datasheet | Abcam
Ni-NTA purified truncated recombinant human SNCG expressed in E. Coli strain BL21 (DE3). Reacts with (species key). Hu, Rat. Tested applications (see key)
...
http://www.abcam.com/index.html?datasheet=47966...

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WB Control-Human Alpha Synuclein protein W. blot +ve control-Alpha ...
Recently a new isoform termed ¿-synuclein (SNCG) or breast cancer gene 1 (BCG1) ... Higher levels of expression of SNCG has been reported in advanced breast ...
https://www.4adi.com/ccpc2617-13137-human-alpha-synuclein--p...

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New Antibodies :: ProSci Incorporated
SNCG Monclonal Antibody · SOCS1 Antibody (CT) · SOCS1 Antibody (NT) · SORL1 Monclonal Antibody · SORL1 Monclonal Antibody ...
http://www.prosci-inc.com/new-antibodies.php...

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Molecular Biology, Synuclein, gamma CT Control Peptide
Recently a new isoform, termed g-synuclein (SNCG) or breast cancer gene 1 (BCG1) has been cloned (human 127aa, rat/mouse 123aa). All three synucleins shown ...
http://www.usbio.net/displayPage.php?ProdSku=S9502-10P...

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γ-synuclein siRNA (h) sc-42289
ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, SNCG, 6623, 10q23.2, NM_003087 · O76070 ...
http://www.scbt.com/datasheet-42289-gamma-synuclein-sirna-h....

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Molecular Biology, Synuclein, alpha, Point Mutation (A30P ...
Recently a new isoform termed g-synuclein (SNCG) or breast cancer gene 1 (BCG1) has ... Higher levels of expression of SNCG have been reported in advanced ...
http://www.usbio.net/displayPage.php?ProdSku=S9500-18H...

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