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SOX9


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Symbol:SOX9
Name(s):SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
Type:protein-coding
Organism:Homo sapiens
Synonyms:CMD1, CMPD1, SRA1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18333897 SOX9 expression is a general feature of basal cell carcinomas and adnexal skin neoplasms, suggesting a contribution of SOX9 to the pathogenesis of these tumors.
18087279 The association of SOX9 hypermethylation with tumour progression and clinical outcome suggests its relevant clinical implications at stratifying patients affected with bladder cancer.
15266301 Observational study of gene-disease association. (HuGE Navigator)
17615267 SOX9 signaling is not essential for LE135-induced chondrogenesis in mesenchymal stem cells derived from osteoarthritis patients.
17532558 The embryonic male prostaglandin D synthase (Pgds)/SOX9 pathway is expressed at both the RNA and protein levels in different types of human ovarian tumors.
17702866 role of SOX9 in pigmentation emphasizes the impact of SOX proteins in adult tissues.
17360815 Sox9 transcriptionally regulates furin expression during chondrogenesis.
11754051 A chromosomally normal boy with ACD and his clinical follow-up up to the age of 2 years, in whom a heterozygous SOX9 missense mutation (H165Y) was identified.
12783851 Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia
15456769 SOX9 is a key regulator of CRTL1

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDnuclear receptor subfamily 5, group A, member 1transcription factor SOX9--Pubmed
HPRDnuclear receptor subfamily 5, group A, member 1transcription factor SOX9--Pubmed
HPRDheat shock 70kDa protein 1Atranscription factor SOX9--Pubmed
HPRDheat shock 70kDa protein 1Atranscription factor SOX9--Pubmed
HPRDKaryopherin beta 1transcription factor SOX9--Pubmed
HPRDkaryopherin beta 1SOX9--Pubmed
BINDkaryopherin beta 1transcription factor SOX9KPNB1 (importin beta) interacts with SOX9.-Pubmed
HPRDc-Maftranscription factor SOX9--Pubmed
HPRDv-maf musculoaponeurotic fibrosarcoma oncogene homolog isoform aSOX9--Pubmed
HPRDtranscription factor SOX9spen homolog, transcriptional regulator--Pubmed

Recent Publications on SOX9:

Pubmed Logo
Enhanced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells in Low Oxygen Environment Micropellet Cultures.
Chondrogenesis of mesenchymal stem cells (MSCs) is typically induced when...
3rd November, 2009
Cell Transplant. 2009 Oct 29.
DOI Direct Link
Genetic mechanisms underlying male sex determination in mammals.
Genetic control of gonadal development proceeds through either the male or...
31st October, 2009
Department of Comparative Anatomy, Institute of Zoology, Jagiellonian J Appl Genet. 2009;50(4):347-60.
Determination and Stability of Gonadal Sex.
The discovery that the SRY gene induces male sex in humans and other...
31st October, 2009
J Androl. 2009 Oct 29.
DOI Direct Link
Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein which recruits the KAP1 co-repressor machinery.
The sex determination transcription factor SRY is a cell fate-determining...
24th October, 2009
The Wistar Institute, United States; J Biol Chem. 2009 Oct 22.
DOI Direct Link
Nestin and SOX9 and SOX10 transcription factors are coexpressed in melanoma.
Please cite this paper as: Nestin and SOX9 and SOX10 transcription factors...
23rd October, 2009
Department of Dermatology, Ludwig-Maximilian University of Munich, Munich, Exp Dermatol. 2009 Oct 21.
DOI Direct Link

View more research publications.

BioNews Results for SOX9

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BioPortfolio Logo
Long-range regulation at the SOX9 locus in development and disease
Journal of Medical Genetics:  Oct 14 2009 11:27PM Matching: sox9
Long-range regulation at the SOX9 locus in development and disease [Review]
Journal of Medical Genetics:  Oct 2 2009 4:36AM Matching: sox9
Role of deleted in colon carcinoma in osteoarthritis and in chondrocyte migration
MDLinx:  Sep 14 2009 9:06AM Matching: sox9

Patents:

Patents logo
US Patent No.Title
5804388 Chromosome 9 and progressive rod-cone degeneration disease genetic markers and assays
6890897 Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6936417 Gene expression in bladder tumors
6964868 Human genes and gene expression products II

View more patents.

SOX9 results (if any) from reagent suppliers

Google CSE Logo
SOX9 antibody (ab3697) | Abcam
See below for SOX9 antibody images, references, products related to ab3697 ... Rabbit polyclonal antibody to Sox9 recognizes full length of Sox9 (left lane)
...
http://www.abcam.com/SOX9-antibody-ab3697.html...

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Sox-9 (H-90) Antibody sc-20095
See how others have used Sox-9 (H-90): sc-20095 antibody and or Sox-9 (H-90) ... Western blot analysis of Sox-9 expression in C3H/10T1/2 whole cell lysate. ...
http://www.scbt.com/datasheet-20095-sox-9-h-90-antibody.html...

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SOX9 antibody (ab26414) | Abcam
See below for SOX9 antibody images, references, products related to ab26414 and other tools. ... Contact Abcam with a Technical Enquiry about SOX9 antibody ...
http://www.abcam.com/SOX9-antibody-ab26414.html...

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SOX9 Antibody (Center)
SOX9 Antibody (Center) Nuclear Signaling, SOX9 Antibody (Center) Stem Cell, SOX9 Antibody (Center) Transcription Regulation.
http://www.abgent.com/products/catalog_no/AP1409c...

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SOX9 antibody (ab36748) | Abcam
See below for SOX9 antibody images, references, products related to ab36748 and other ... Human testis stained with Anti-SOX9 (ab36748) at 1/50 dilution by ...
http://www.abcam.com/SOX9-antibody-ab36748.html...

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Sox-9 (P-20) Antibody sc-17340
See how others have used Sox-9 (P-20): sc-17340 antibody and or Sox-9 (P-20) ... Western blot analysis of Sox-9 expression in non-transfected: sc-117752 (A) ...
http://www.scbt.com/datasheet-17340-sox-9-p-20-antibody.html...

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SOX9 Antibody (N-term)
SOX9 Antibody (N-term) Nuclear Signaling, SOX9 Antibody (N-term) Stem Cell, SOX9 Antibody (N-term) Transcription Regulation.
http://www.abgent.com/products/catalog_no/AP1409a...

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