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BRCA1


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Symbol:BRCA1
Name(s):breast cancer 1, early onset
Type:protein-coding
Organism:Homo sapiens
Synonyms:BRCAI, BRCC1, IRIS, PSCP, RNF53
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18257128 review of BRCA1/2 associated hereditary breast cancer [review]
18083712 PGE(2) via EP(2) and EP(4) activates the cAMP-->PKA-->CREB pathway leading to enhanced CYP19 transcription and increased aromatase activity through BRCA1 and p300
18205043 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18242166 Observational study of genetic testing. (HuGE Navigator)
18256760 Observational study of genotype prevalence. (HuGE Navigator)
18279628 Observational study of genotype prevalence. (HuGE Navigator)
18284688 Observational study of gene-disease association. (HuGE Navigator)
18286383 Observational study of genotype prevalence. (HuGE Navigator)
18288416 Observational study of gene-disease association. (HuGE Navigator)
18355772 Meta-analysis of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDacetyl-Coenzyme A carboxylase alphabreast cancer 1, early onset isoform 1BRCA1 interacts with acetyl-CoA carboxylase.-Pubmed
HPRDacetyl-Coenzyme A carboxylase alpha isoform 1breast cancer 1, early onset isoform 1--Pubmed
HPRDacetyl-Coenzyme A carboxylase alpha isoform 1breast cancer 1, early onset isoform 1--Pubmed
HPRDandrogen receptor isoform 1breast cancer 1, early onset isoform 1--Pubmed
HPRDandrogen receptor isoform 1breast cancer 1, early onset isoform 1--Pubmed
HPRDactivating transcription factor 1breast cancer 1, early onset isoform 1--Pubmed
HPRDactivating transcription factor 1breast cancer 1, early onset isoform 1--Pubmed
HPRDataxia telangiectasia mutated protein isoform 1breast cancer 1, early onset isoform 1--Pubmed
HPRDataxia telangiectasia mutated protein isoform 1breast cancer 1, early onset isoform 1--Pubmed
BINDataxia telangiectasia and Rad3 related proteinbreast cancer 1, early onset isoform 1BRCA1 physically and functionally interacts with ATR during genotoxic stress-Pubmed

Recent Publications on BRCA1:

Pubmed Logo
The emerging role of the distal Fallopian tube and p53 in pelvic serous carcinogenesis.
In their paper in this issue of the Journal, Xian et al have analysed in...
3rd November, 2009
Bute Medical School, University of St Andrews and Department of Pathology, J Pathol. 2009 Sep 25.
DOI Direct Link
BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer.
Expression profiling of BRCA1-deficient tumours has identified a pattern...
3rd November, 2009
Department of Oncology, Centre for Cancer Research and Cell Biology, Breast Cancer Res Treat. 2009 Oct 31.
DOI Direct Link
Regulatory mechanism of the initiation step of DNA replication by CDK in budding yeast.
Cyclin-dependent kinases (CDKs) regulate the progression of the cell cycle...
3rd November, 2009
Division of Microbial Genetics, National Institute of Genetics, Research Biochim Biophys Acta. 2009 Oct 29.
DOI Direct Link
Analysis of BRCA1 and BRCA2 Mutations in Southern Iranian Breast Cancer Patients.
The germline mutations of breast cancer susceptibility genes 1 (BRCA1) and...
3rd November, 2009
Shiraz Institute for Cancer Research, Shiraz University of Medical Arch Iran Med. 2009 Nov;12(6):584-7.
Breast cancer immunohistochemical features in young women with BRCA 1/2 mutations.
Breast cancer among young women is a rare pathology. In most studies...
3rd November, 2009
Kyiv City Exp Oncol. 2009 Sep;31(3):174-8.

View more research publications.

Press Releases on BRCA1:

BioPortfolio Logo
Reportlinker Adds Direct-To-Consumer Genetic Testing: Business Prospects in the United States 26th October, 2009 Reportlinker

NEW YORK, Oct. 26 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue.

CAP Applauds SACGHS Recommendation to Create Exclusion From Gene Patent Infringement in Clinical Care

23rd October, 2009 College of American Pathologists

WASHINGTON, Oct. 23 /PRNewswire-USNewswire/ -- The College of American Pathologists today expressed its support for a key government advisory group's recommendation to create

June 2009 Mayo Clinic Health Letter Highlights Probiotics, Carotid Artery and Breast Cancer Treatments 7th July, 2009 Mayo Clinic

ROCHESTER, Minn., July 7 /PRNewswire-USNewswire/ -- Here are highlights from the June issue of Mayo Clinic Health Letter. You may cite this publication as often as you wish. Reprinting is

Video: Liberate The Breast Cancer Genes 13th May, 2009 American Civil Liberties Union

ACLU Releases Video Showing How Restrictive Gene Patents Hurt Women

NEW YORK, May 13 /PRNewswire/ -- Breast cancer survivor Genae Girard underwent genetic testing

United States Embassy Joins Forces With Susan G. Komen for the Cure(R) and the Cancer Society of the Bahamas for Historic Race in Support of Breast Cancer Awareness 8th November, 2008 Susan G. Komen for the Cure

NASSAU, Bahamas, Nov. 8 /PRNewswire/ -- The United States Embassy in the Bahamas, in partnership with the Cancer Society of the Bahamas and Susan G. Komen for the Cure(R) today made history

BioNews Results for BRCA1

: RSS Logo
BioPortfolio Logo
PHOTOS: Congresswoman and cancer survivor touts importance of protecting young women from breast cancer
Naples Daily News:  Nov 14 2009 3:50AM Matching: brca1
PHOTOS: Congresswoman and cancer survivor touts importance of protecting young women from breast cancer
Marco Eagle:  Nov 14 2009 3:42AM Matching: brca1
Type of arteriovenous fistula, NYHA class and apelin in hemodialyzed patients
Bioscience Technology Online:  Nov 13 2009 4:29AM Matching: brca1
Preclinical mouse models for BRCA1-associated breast cancer
Bioscience Technology Online:  Nov 12 2009 4:14PM Matching: brca1
Preclinical mouse models for BRCA1-associated breast cancer
British Journal of Cancer:  Nov 11 2009 2:22AM Matching: brca1
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
AZD2281 and Carboplatin in Treating Patients With BRCA1/BRCA2-Associated, Hereditary, or Triple Negative Metastatic or Unresectable Breast Cancer or Ovarian Epithelial Cancer

Patents:

Patents logo
US Patent No.Title
7572899 Compositions and methods for increasing bone mineralization
7585867 Substituted thiazolo[4,5-d]pyrimidin-2(3H)-one
7587078 Automated image analysis
7588767 Microorganisms for therapy
7588771 Microorganisms for therapy

View more patents.

BRCA1 results (if any) from reagent suppliers

Google CSE Logo
BRCA1 antibody (ab494) | Abcam
Mouse polyclonal to BRCA1. BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic
...
http://www.abcam.com/BRCA1-antibody-ab494.html...

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BRCA1 Antibody #9010
The breast cancer susceptibility proteins BRCA1 and BRCA2 are frequently mutated in cases of hereditary breast and ovarian cancers and have roles in ...
http://www.cellsignal.com/products/9010.html...

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BRCA1 Antibody
Specific antibody for the gene product of BRCA1, the protein Breast cancer 1 early onset. Validated for specificity by gene-silencing with siRNA followed by
...
http://www.piercenet.com/Products/browse.cfm?fldID=DFB3C2B6-...

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Phospho-BRCA1 (Ser1524) Antibody #9009
Western blot analysis of untreated and UV-treated (50 mJ/cm2,30 min) HeLa cells and HT-1376 cells, using Phospho-BRCA1 (Ser1524) Antibody (upper) and BRCA1 ...
http://www.cellsignal.com/products/9009.html...

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p-BRCA1 (Ser 1497) Antibody sc-12889
p-BRCA1 (Ser 1497) Antibody sc-12889 p-BRCA1 (Ser 1497) Antibody sc-12889. ... Western blot analysis of p-BRCA1 expression in HeLa (A) and UV-irradiated ...
http://www.scbt.com/datasheet-12889-p-brca1-ser-1497-antibod...

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BRCA1 Antibody
of human BRCA1. Antibodies are purified by protein A and ... enous levels of total BRCA1 protein. The antibody does not recognize BRCA2. ...
http://www.cellsignal.com/pdf/9010.pdf...

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Anti-BRCA1 Polyclonal Antibody
Polyclonal Antibody against BRCA1 for use in Immunohistochemistry, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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