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BRAF


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Gene DB Home
Symbol:BRAF
Name(s):v-raf murine sarcoma viral oncogene homolog B1
Type:protein-coding
Organism:Homo sapiens
Synonyms:B-raf 1, BRAF1, MGC126806, MGC138284, RAFB1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18224685 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18199160 A worse clinical outcome was found for CIMP-high, microsatellite stable colorectal cancer with KRAS/BRAF mutation but not for those lacking KRAS/BRAF mutation.
17940185 BRAF mutation represents a novel indicator of the progression and aggressiveness of papillary thyroid cancer (Review)
18098337 BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations.
14722037 Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
15824163 Observational study of gene-disease association. (HuGE Navigator)
15904951 Observational study of gene-disease association. (HuGE Navigator)
15968271 Observational study of gene-disease association. (HuGE Navigator)
15994075 Observational study of gene-disease association. (HuGE Navigator)
16015629 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAKT1v-raf murine sarcoma viral oncogene homolog B1--Pubmed
HPRDserine/threonine protein kinaseB-Raf--Pubmed
HPRDB-Raftyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide--Pubmed
HPRDB-Raftyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptide--Pubmed
HPRDB-Raftyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide--Pubmed
HPRDB-Rafv-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 1--Pubmed
HPRDB-Raftyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide--Pubmed
HPRDB-Rafmuscle RAS oncogene homolog--Pubmed
HPRDB-Rafmitogen-activated protein kinase kinase 2--Pubmed
HPRDv-raf murine sarcoma viral oncogene homolog B1H-Ras--Pubmed

Recent Publications on BRAF:

Pubmed Logo
BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells.
In colorectal cancer, BRAF and KRAS oncogenes are mutated in about 15% and...
3rd November, 2009
Laboratory of Signal Mediated Gene Expression, Institute of Biological Neoplasia. 2009 Nov;11(11):1116-31.
Cytostatic Activity of Adenosine Triphosphate-Competitive Kinase Inhibitors in BRAF Mutant Thyroid Carcinoma Cells.
Context: The V600E mutation accounts for the vast majority of thyroid...
3rd November, 2009
Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Istituto J Clin Endocrinol Metab. 2009 Oct 30.
DOI Direct Link
Oncogenic BRAFv600einduces expression of neuronal differentiation marker map2 in melanoma cells by promoter demethylation and downregulation of transcription repressor HES1.
MAP2 is a neuron-specific microtubule associated protein that binds and...
3rd November, 2009
University of Wisconsin-Madison, United States. J Biol Chem. 2009 Oct 30.
DOI Direct Link
ROLE OF NF-kappaB IN THYROID CANCER.
Thyroid cancer is the most common neoplasia of the endocrine system and...
3rd November, 2009
Istituto di Endocrinologia e Oncologia Sperimentale, CNR. Mol Cell Endocrinol. 2009 Oct 29.
DOI Direct Link
Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations.
ABSTRACT: BACKGROUND: Thyroid carcinomas show a high prevalence of...
3rd November, 2009
BMC Cancer. 2009 Oct 31;9(1):387.
DOI Direct Link

View more research publications.

Press Releases on BRAF:

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MDOUTLOOK(R) Quick Polls Report on Clinical Integration of Key Oncology Developments Following ASCO 2009 24th June, 2009 The Arcas Group

ATLANTA, June 24 /PRNewswire/ -- MDOUTLOOK(R), the innovative oncology intelligence platform, today announced the results from its Quick Poll research, which was launched immediately following

Exosome Diagnostics and DxS Diagnostic Innovations Collaborate to Develop Blood-Based Tests for Key Cancer Mutations 22nd June, 2009 Exosome Diagnostics, Inc.

NEW YORK, June 22 /PRNewswire/ -- Exosome Diagnostics, Inc. ("ExosomeDX") and DxS Ltd. ("DxS") today announced that they will collaborate on the development of blood-based

Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service 1st June, 2009 Quest Diagnostics Incorporated

EGFR Pathway Test analyzes in sequential reflex fashion more mutations potentially inhibiting anti-EGFR therapy response in metastatic colorectal cancer patients

MADISON, N

Micromet Presents Update on BiTE Antibody Pipeline and Reviews Key AACR Presentations at R&D Day 24th April, 2009 Micromet, Inc.

Pivotal Trial Expected to Initiate in 2010 for Blinatumomab

NEW YORK, April 24 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells 22nd April, 2009 Micromet, Inc.

Study Presented at 2009 AACR Meeting Highlights Potential Therapeutic Approach to Treat Patients Unresponsive to Erbitux and Vectibix

DENVER, April 22 /PRNewswire-FirstCall/

BioNews Results for BRAF

: RSS Logo
BioPortfolio Logo
ArQule, Inc. to Present at Lazard Capital Markets Sixth Annual Healthcare Conference on November 17, 2009
SmartBrief:  Nov 11 2009 12:45AM Matching: braf
Qiagen Snags SABiosciences for $90M to Boost Diagnostic Capabilities
Genetic Engineering News:  Nov 11 2009 12:27AM Matching: braf
Thyroid Cancer Risk Doubled for Residents of Volcanic Areas
MedIndia:  Nov 10 2009 12:28PM Matching: braf
Findings May Spur Development of Drugs to Treat Brain Tumors in Infants
Biotech Daily:  Nov 9 2009 4:22PM Matching: braf
Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF
Bioscience Technology Online:  Nov 8 2009 12:12AM Matching: braf
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
AZD6244 in Cancers With BRAF Mutations

Patents:

Patents logo
US Patent No.Title
7354725 Kinase peptides and antibodies
7456027 Proteolytic biomarkers for traumatic injury to the nervous system
7465454 Yeast-based vaccines as immunotherapy
7476683 Glycinamide derivatives as raf-kinase inhibitors
7482334 Therapeutic treatment methods

View more patents.

BRAF results (if any) from reagent suppliers

Google CSE Logo
B Raf antibody [EP152Y] (ab33899) | Abcam
Rabbit monoclonal [EP152Y] to B Raf. The Raf kinases are important intermediates in signal transduction. Raf protein family members, including A Raf and B ...
http://www.abcam.com/B-Raf-antibody-EP152Y-ab33899.html...

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Phospho-B-Raf (Ser445) Antibody #2696
Western blot analysis of extracts from Raji and HeLa cells treated with TPA ( 200nM, 30 minutes) using Phospho-B-Raf (Ser445) Antibody (top) and total B-Raf
...
http://www.cellsignal.com/products/2696.html...

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B-RAF Antibody (T372)
B-RAF Antibody (T372) Apoptosis, B-RAF Antibody (T372) Cell Function, B-RAF Antibody (T372) Neurosciences, B-RAF Antibody (T372) Protein Modification, B-RAF
...
http://www.abgent.com/products/catalog_no/AP7810d...

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Purified Anti-Phospho-B-Raf Thr598/Ser601 Antibody - BioLegend
Purified Anti-Phospho-B-Raf Thr598/Ser601 Antibody - The Raf proteins are a family of serine/threonine-specific kinases that serve as a central intermediate
...
http://www.biolegend.com/purified-anti-phospho-b-raf-thr598-...

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B Raf (phospho S601) antibody (ab60997) | Abcam
Rabbit polyclonal to B Raf (phospho S601). The Raf kinases are important intermediates in signal transduction. Raf protein family members, including A
Raf ...
http://www.abcam.com/B-Raf-phospho-S601-antibody-ab60997.htm...

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Phospho-BRAF-S601 Antibody
Dot blot analysis of Phospho-BRAF-S601 Antibody (Cat. #AP3373a) and BRAF Non Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non
...
http://www.abgent.com/products/catalog_no/AP3373a_Phospho_BR...

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Phospho-B-Raf (Ser445) Antibody
body detects endogenous levels of B-Raf when phosphory- lated at serine 445. ... ine 445 of human B-Raf. Antibodies are purified by protein ...
http://www.cellsignal.com/pdf/2696.pdf...

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