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BRCA2


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Symbol:BRCA2
Name(s):breast cancer 2, early onset
Type:protein-coding
Organism:Homo sapiens
Synonyms:BRCC2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18257128 review of BRCA1/2 associated hereditary breast cancer [review]
18256760 Observational study of genotype prevalence. (HuGE Navigator)
18270339 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
18279628 Observational study of genotype prevalence. (HuGE Navigator)
18284688 Observational study of gene-disease association. (HuGE Navigator)
18286383 Observational study of genotype prevalence. (HuGE Navigator)
18288416 Observational study of gene-disease association. (HuGE Navigator)
18355772 Meta-analysis of gene-disease association. (HuGE Navigator)
18182994 Since BRCA1/2 mutation carrier status is associated with more aggressive disease, it is a prognostic factor for PRCA outcome.
17549502 The output 3D molecular structure from the combination between BRCA2-RAD51 is derived

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDbreast cancer 1, early onset isoform 1breast cancer 2, early onset--Pubmed
HPRDbreast cancer 1, early onset isoform 1breast cancer 2, early onset--Pubmed
BINDbreast cancer 1, early onset isoform 1breast cancer 2, early onsetBRCA1 interacts with BRCA2.-Pubmed
HPRDBRCA2tumor protein p53--Pubmed
HPRDBRCA2BUB1 budding uninhibited by benzimidazoles 1 homolog beta--Pubmed
HPRDBRCA2RAD51 homolog protein isoform 1--Pubmed
HPRDBRCA2signal transducer and activator of transcription 5A--Pubmed
HPRDbreast cancer 2, early onsetRAD51--Pubmed
HPRDbreast cancer 2, early onsetp53--Pubmed
HPRDbreast cancer 2, early onsetMitotic checkpoint kinase MAD3L--Pubmed

Recent Publications on BRCA2:

Pubmed Logo
Analysis of BRCA1 and BRCA2 Mutations in Southern Iranian Breast Cancer Patients.
The germline mutations of breast cancer susceptibility genes 1 (BRCA1) and...
3rd November, 2009
Shiraz Institute for Cancer Research, Shiraz University of Medical Arch Iran Med. 2009 Nov;12(6):584-7.
Breast cancer immunohistochemical features in young women with BRCA 1/2 mutations.
Breast cancer among young women is a rare pathology. In most studies...
3rd November, 2009
Kyiv City Exp Oncol. 2009 Sep;31(3):174-8.
The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers.
Integrins containing the beta(3) subunit are key players in tumor growth...
31st October, 2009
IHCC (International Hereditary Cancer Centre), Department of Genetics and Breast Cancer Res Treat. 2009 Oct 30.
DOI Direct Link
Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase.
The breast and ovarian cancer suppressor protein BRCA2 controls the RAD51...
31st October, 2009
The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Nucleic Acids Res. 2009 Oct 29.
DOI Direct Link
Cancer genetics and reproduction.
Cancers of the reproductive organs (i.e., ovaries, uterus and testes),...
30th October, 2009
Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, UK. Best Pract Res Clin Obstet Gynaecol. 2009 Oct 26.
DOI Direct Link

View more research publications.

Press Releases on BRCA2:

BioPortfolio Logo
Reportlinker Adds Direct-To-Consumer Genetic Testing: Business Prospects in the United States 26th October, 2009 Reportlinker

NEW YORK, Oct. 26 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue.

CAP Applauds SACGHS Recommendation to Create Exclusion From Gene Patent Infringement in Clinical Care

23rd October, 2009 College of American Pathologists

WASHINGTON, Oct. 23 /PRNewswire-USNewswire/ -- The College of American Pathologists today expressed its support for a key government advisory group's recommendation to create

June 2009 Mayo Clinic Health Letter Highlights Probiotics, Carotid Artery and Breast Cancer Treatments 7th July, 2009 Mayo Clinic

ROCHESTER, Minn., July 7 /PRNewswire-USNewswire/ -- Here are highlights from the June issue of Mayo Clinic Health Letter. You may cite this publication as often as you wish. Reprinting is

Video: Liberate The Breast Cancer Genes 13th May, 2009 American Civil Liberties Union

ACLU Releases Video Showing How Restrictive Gene Patents Hurt Women

NEW YORK, May 13 /PRNewswire/ -- Breast cancer survivor Genae Girard underwent genetic testing

United States Embassy Joins Forces With Susan G. Komen for the Cure(R) and the Cancer Society of the Bahamas for Historic Race in Support of Breast Cancer Awareness 8th November, 2008 Susan G. Komen for the Cure

NASSAU, Bahamas, Nov. 8 /PRNewswire/ -- The United States Embassy in the Bahamas, in partnership with the Cancer Society of the Bahamas and Susan G. Komen for the Cure(R) today made history

BioNews Results for BRCA2

: RSS Logo
BioPortfolio Logo
Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin
MDLinx:  Oct 14 2009 9:18AM Matching: brca2
Hereditary Breast and Ovarian Cancer
NWI Times:  Oct 14 2009 12:09AM Matching: brca2
Family matter: Sisters, young mothers battle breast cancer
Norton Mirror:  Oct 14 2009 6:51PM Matching: brca2
Genetic Testing Can Unveil Breast Cancer Risks
WFOR:  Oct 14 2009 12:06PM Matching: brca2
Don't Believe Breast Cancer Myths
Click2Houston.com:  Oct 14 2009 9:31AM Matching: brca2
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers

Patents:

Patents logo
US Patent No.Title
7517994 Heterocyclic inhibitors of MEK and methods of use thereof
7547544 Antibodies against GPR64 and uses thereof
7547687 Therapeutic treatment methods
7550141 Methods for imaging tumor vasculature using conjugates that bind to aminophospholipids
7553485 Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof

View more patents.

BRCA2 results (if any) from reagent suppliers

Google CSE Logo
BRCA2 Antibody #9012
The breast cancer susceptibility proteins BRCA1 and BRCA2 are frequently mutated in cases of hereditary breast and ovarian cancers and have roles in ...
http://www.cellsignal.com/products/9012.html...

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BRCA2 antibody (ab97) | Abcam
Mouse monoclonal to BRCA2. BRCA 2 is localized to chromosome 13q12 - q13. Loss of heterozygosity of 13q is observed in 25% of sporadic breast tumors, ...
http://www.abcam.com/BRCA2-antibody-ab97.html...

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BRCA2 Antibody
cycle-dependent phosphorylation of BRCA2 at Ser3291 by ... enous levels of total BRCA2 protein. The antibody does not recognize BRCA1. ...
http://www.cellsignal.com/pdf/9012.pdf...

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The Abcam catalog
BRCA2 antibodies. ... BRCA2 antibody. IP, WB, ICC/IF. Rabbit polyclonal ... BRCA2 antibody (Agarose). IP. Rabbit polyclonal. Agarose conjugated ...
http://www.abcam.com/index.html?t=9019&pt=1&c=4340...

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BRCA2 Monoclonal Antibody Anti-BRCA2
BRCA2 monoclonal antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. ...
http://www.prosci-inc.com/shop/catalog1/BRCA2-Monoclonal-Ant...

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BRCA2 (phospho T3349) antibody (ab36459) | Abcam
Rabbit polyclonal to BRCA2 (phospho T3349). BRCA 2 is localized to chromosome 13q12 - q13. Loss of heterozygosity of 13q is observed in 25% of sporadic ...
http://www.abcam.com/BRCA2-phospho-T3349-antibody-ab36459.ht...

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BRCA2 (H-299) Antibody sc-28235
See how others have used BRCA2 (H-299): sc-28235 antibody and or BRCA2 (H-299) ... Interference with BRCA2, which localizes to the centrosome during S and ...
http://www.scbt.com/datasheet-28235-brca2-h-299-antibody.htm...

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