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AURKA


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Symbol:AURKA
Name(s):aurora kinase A
Type:protein-coding
Organism:Homo sapiens
Synonyms:AIK, ARK1, AURA, AURORA2, BTAK, MGC34538, STK15, STK6, STK7
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18027856 polymorphic variant of Aurora A does not appear to be associated with variation in colorectal cancer risk in HNPCC
18361427 Observational study of gene-disease association. (HuGE Navigator)
18043979 Perimembrane Aurora-A status was a significant factor to predict a poor prognosis in correction with enhanced proliferative activity in non-small cell lung cancer.
15087379 Observational study of gene-disease association. (HuGE Navigator)
15271853 Observational study of gene-disease association. (HuGE Navigator)
15271856 Observational study of gene-disease association. (HuGE Navigator)
15466974 Observational study of gene-disease association. (HuGE Navigator)
15598762 Observational study of gene-disease association. (HuGE Navigator)
15688402 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15867347 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCell cycle protein CDC20serine/threonine kinase 6--Pubmed
HPRDcell division cycle 20Serine/threonine protein kinase 6--Pubmed
HPRDNucleoside diphosphate kinase Aserine/threonine kinase 6--Pubmed
HPRDnon-metastatic cells 1, protein expressed in isoform bSerine/threonine protein kinase 6--Pubmed
BINDPML [human, mRNA, 2251 nt]-PML3 interacts with Aurora A.-Pubmed
HPRDprotein phosphatase 1, catalytic subunit, alpha isoform 3Serine/threonine protein kinase 6--Pubmed
BINDRAS p21 protein activator 1 isoform 1serine/threonine protein kinase 6RasGAP interacts with HsAIRK-1.-Pubmed
HPRDSerine/threonine protein kinase 6tumor protein p53--Pubmed
HPRDSerine/threonine protein kinase 6ubiquitin-conjugating enzyme E2N--Pubmed
HPRDSerine/threonine protein kinase 6methyl-CpG binding domain protein 3--Pubmed

Recent Publications on AURKA:

Pubmed Logo
Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells.
Analysis of centrosome number and structure has become one means of...
27th October, 2009
Genetics Branch, Center for Cancer Research, National Cancer Environ Mol Mutagen. 2009 Oct;50(8):672-96.
DOI Direct Link
Determinants for the efficiency of anticancer drugs targeting either Aurora-A or Aurora-B kinases in human colon carcinoma cells.
The mitotic Aurora kinases, including Aurora-A and Aurora- B, are...
20th October, 2009
Institute for Molecular Biology and Tumor Research, Philipps University Mol Cancer Ther. 2009 Jul;8(7):2046-56. Epub 2009 Jul 7.
DOI Direct Link
A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors.
Aurora kinase A (Aurora-A) belongs to a highly conserved family of...
8th October, 2009
Department of Dermatology, University of Colorado Denver at Anschutz Cancer Res. 2009 Sep 15;69(18):7207-15. Epub 2009 Sep 8.
DOI Direct Link
Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.
Genetic instability, which leads to an accumulation of various genetic...
3rd October, 2009
Department of Urology, Mayo Clinic College of Medicine, Rochester, J Clin Invest. 2009 Sep;119(9):2714-24. doi: 10.1172/JCI37405. Epub 2009
DOI Direct Link
Aurora A moonlights in neurite extension.
Aurora A, an integral mitotic kinase, is essential for microtubule...
23rd September, 2009
Nat Cell Biol. 2009 Sep;11(9):1053-4.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
A Phase 1 First-in-Human Study Evaluating AMG 900 in Advanced Solid Tumors

AURKA results (if any) from reagent suppliers

Google CSE Logo
Aurka antibody, AURORA-A KINASE Antibody, Rabbit Polyclonal Antibody
Buy quality rabbit Aurka antibody (interacts with human), anti-Aurka, AURORA-A KINASE antibody, rabbit polyclonal antibody, AURORA-A KINASE Antibody, ...
http://www.genwaybio.com/product_info.php?products_id=76670...

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Antibodies to Modifying Enzymes/Other
Aurka(20878) human ... AURKA(6790), mouse, human, ELISA (i), ICC, WB, pricing. L7293, Monoclonal Anti-LSD1 (AOF2) antibody produced in mouse, LSD1-12 ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Aurora Kinase Antibody (CT) Aurora kinase A / STK15
AURKA, aurora kinase A, AIK, ARK1, AURA, AURORA2, BTAK, MGC34538, STK15, STK6, STK7, IPL1-related kinase, aurora-A, aurora-related kinase 1, ...
http://www.prosci-inc.com/shop/catalog1/Aurora-Kinase-Antibo...

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A2606 Monoclonal Anti-Aurora-A Kinase−Biotin antibody produced in ...
indirect ELISA: suitable. isotype, IgG2b. Gene Information, human ... AURKA(6790 ). mouse ... Aurka(20878). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A260...

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ARK-1 (7F12) Antibody sc-81441
Human, AURKA, 6790, 20q13.2, NM_003600, NM_198433, NM_198434, NM_198435, NM_198436, NM_198437 · O14965 · 603072. Mouse, Aurka, 20878, 2 H3, P97477 ...
http://www.scbt.com/datasheet-81441-ark-1-7f12-antibody.html...

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Anti-Aurora A Monoclonal Antibody
AURKA is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome
...
http://www.bioreagents.com/products/productDetails/productDe...

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Ajuba antibody (ab67666) | Abcam
Arjuba plays a important role in the regulation of the kinase activity of AURKA/ Aurora A for mitotic commitment. Is also a component of the IL 1 signaling ...
http://www.abcam.com/Ajuba-antibody-ab67666.html...

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