STX1A

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Symbol:	STX1A
Name(s):	syntaxin 1A (brain)
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	HPC-1, STX1, p35-1
Links:	Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
11719842	Observational study of gene-disease association. (HuGE Navigator)
17912268	Observational study of gene-disease association. (HuGE Navigator)
18065728	We have identified a new three-gene classifier that is independent of and improves on stage to stratify early-stage NSCLC patients with significantly different prognoses.
17032905	Norepinephrine transpossrter/syntaxin 1A complex rapidly redistributes, upon amphetamine treatment, when mechanisms supported by the transporter's NH2 terminus are eliminated.
16672225	Syntaxin-1A actions on sulfonylurea receptor 2A blocks acidic pH-induced cardiac K(ATP) channel activation
12114505	SNAP-25 traffics to the plasma membrane by a syntaxin-independent mechanism.
15316009	cleavage of APP but not syntaxin 1 is independent of cell surface regulation by extracellular ligands
15219469	A significant genetic association was found between schizophrenia and an intron 7 single nucleotide polymorphism (SNP) tested. Haplotype analysis supported the association with several significant values that appear to be driven by the intron 7 SNP.
12446681	interacts with CFTR protein differently from interactions with SNARE.
15339904	Syn-1A binds both NBFs of SUR1 and SUR2A but appears to exhibit distinct interactions with NBF2 of these SUR proteins in modulating the KATP channels in islet beta cells and cardiac myocytes
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	MINT1	syntaxin 1A	-	-	Pubmed
HPRD	amyloid beta A4 precursor protein-binding, family A, member 1	Syntaxin 1A	-	-	Pubmed
HPRD	Calcium channel voltage dependent, L type alpha 1D subunit	syntaxin 1A	-	-	Pubmed
HPRD	calcium channel, voltage-dependent, L type, alpha 1D subunit	Syntaxin 1A	-	-	Pubmed
HPRD	Cyclin dependent kinase 5	syntaxin 1A	-	-	Pubmed
HPRD	cyclin-dependent kinase 5	Syntaxin 1A	-	-	Pubmed
HPRD	cystic fibrosis transmembrane conductance regulator, ATP-binding cassette	syntaxin 1A	-	-	Pubmed
HPRD	cystic fibrosis transmembrane conductance regulator, ATP-binding cassette	syntaxin 1A	-	-	Pubmed
BIND	cystic fibrosis transmembrane conductance regulator, ATP-binding cassette	syntaxin 1A	Syntaxin 1A interacts with CFTR.	-	Pubmed
HPRD	KCNB1	syntaxin 1A	-	-	Pubmed

Recent Publications on STX1A:
Syntaxin 1A is required for normal in utero development. We have generated a syntaxin 1A knockout mouse by deletion of exons 3...	30th September, 2008	Department of Physiology and Biophysics, The Hotchkiss Brain Institute,	Biochem Biophys Res Commun. 2008 Oct 24;375(3):372-7. Epub 2008 Aug 17. DOI Direct Link
Search for genetic variants of the SYNTAXIN 1A (STX1A) gene: the -352 A>T variant in the STX1A promoter associates with impaired glucose metabolism in an Italian obese population. OBJECTIVE: To test if sequence variations of the SYNTAXIN 1A (STX1A) gene...	10th September, 2008	Department of Medical Sciences, Endocrinology and Metabolism, University	Int J Obes (Lond). 2008 Mar;32(3):413-20. Epub 2007 Oct 2. DOI Direct Link
Shiga toxin 2 causes apoptosis in human brain microvascular endothelial cells via C/EBP homologous protein. Shiga toxin 1 (Stx1) and Stx2 produced by Escherichia coli O157 are known...	8th August, 2008	Department of Bacteriology, Graduate School of Medical Sciences, Kyushu	Infect Immun. 2008 Aug;76(8):3679-89. Epub 2008 Jun 9. DOI Direct Link
Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism. Autism is a pervasive developmental disorder diagnosed in early childhood....	3rd July, 2008	Department of Psychiatry and Neurology, Hamamatsu University School of	Int J Neuropsychopharmacol. 2008 Jul 2:1-12. DOI Direct Link
No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population. Abnormalities in neural connections and the neurotransmitter system appear...	3rd June, 2008	Department of Psychiatry, Fujita Health University School of Medicine,	Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1327-31. DOI Direct Link
→View more research publications.

Patents:
US Patent No.	Title
7341838	Polypeptides related to natriuretic peptides and methods of their identification and use
7135173	Antiviral activity of Shiga toxin
6727063	Single nucleotide polymorphisms in genes
6541013	Methods and compositions for suppressing bovine leukemia virus with a Shiga toxin polypeptide

STX1A results (if any) from reagent suppliers

Stx1a syntaxin 1A (brain) Stx1a; HPC-1; STX1A. Other Designations. syntaxin 1 a. Refseq ID(s). NM_016801. Accession No.(s). AK144399; BC023379; BC047133; BC057892; BC100446; more. ... http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...
Alternative names for Syntaxin 1a antibody [SP36] (ab73913) Alternative names for Syntaxin 1a antibody [SP36] (ab73913). Neuron specific antigen HPC1 antibody; STX1A antibody. ©1998-2008 Abcam plc. ... http://www.abcam.com/assets/popups/alternative-names.htm?int...
Primary Antibodies - GenWay Biotech Inc. Syntaxin; 6804; STX1A; 186590; Q16623; HPC-1; STX1; p35-1; ... Syntaxin; 116470; Stx1a; - Mouse monoclonal [1.B.663] to Syntaxin;, IgG Monoclonal ... https://www.genwaybio.com/all_primary_antibodies.php?fl=S&so...
Alternative names for Syntaxin 1a antibody [SP36], prediluted ... Alternative names for Syntaxin 1a antibody [SP36], prediluted (ab73915). Neuron specific antigen HPC1 antibody; STX1A antibody ... http://www.abcam.com/assets/popups/alternative-names.htm?int...
Syntaxin 1 (HPC-1) Antibody sc-12736 Number. Human, STX1A, 6804, 7q11.23, NM_004603 · Q16623 · 186590. Mouse, Stx1a, 20907, 5 G2, O35526, N/A. Ordering Information ... http://www.scbt.com/datasheet-12736-syntaxin-1-hpc-1-antibod...
S1172 Anti Syntaxin 1 antibody produced in rabbit IgG fraction of ... Stx1a(116470), Stx1b2(24923). storage temp. −20°C. References. Reference. Smith , D.B.and Johnson, K.S. Gene 67, 31, (1988) abstract. Bennet, M.K. et al. ... http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...
SNAP25 antibody (ab72396) datasheet \| Abcam It is part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. SNAP25 is involved in the molecular regulation of neurotransmitter release. ... http://www.abcam.com/index.html?datasheet=72396...
Antibodies to Neural Proteins ascites fluid, rat ... Stx1a(116470), bovine, rabbit, rat, ARR, ICC, WB. S1172, Anti-Syntaxin 1 antibody produced in rabbit, IgG fraction of antiserum ... http://www.sigmaaldrich.com/catalog/search/TablePage/9676594...
Syntaxin 1a antibody (ab37396) datasheet \| Abcam Haploinsufficiency of STX1A may be the cause of certain cardiovascular and musculo skeletal abnormalities observed in Williams-Beuren syndrome (WBS), ... http://www.abcam.com/index.html?datasheet=37396...
S0664 Monoclonal Anti Syntaxin antibody produced in mouse clone ... Stx1a(116470). shipped in. dry ice. storage temp. −20°C. References. Reference. Barnstable, C.J., et al. Dev. Brain Res. 20, 286, (1985). Inoue, A., et al. ... http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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STX1A

Gene Information from Publications

Interacting gene products

Recent Publications on STX1A:

Patents:

STX1A results (if any) from reagent suppliers