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BSG


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Symbol:BSG
Name(s):basigin (Ok blood group)
Type:protein-coding
Organism:Homo sapiens
Synonyms:5F7, CD147, EMMPRIN, M6, OK, TCSF
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18223224 The expression of EMMPRIN confers resistance to radiotherapy. Therefore, EMMPRIN expression in cervical cancer may be regarded both as a prognostic factor and a therapeutic target.
18048771 Coincubation of platelets with monocytes induced EMMPRIN-mediated nuclear factor kappaB activation in monocytes with increased MMP-9, interleukin-6, and tumor necrosis factor-alpha secretion by monocytes
18160808 EMMPRIN was preferentially expressed in most NSCLCs. High levels of expression were associated with early T stage and well-differentiated adenocarcinoma
18035727 EMMPRIN and MMP-2 are the major determinants of malignancy in cancers.
17725804 Multidrug resistant breast cancer cells with p-glycoprotein substrates could affect outcome through modulating the production of MMP9.
17962725 Low EMPRINN expression was found more often in serous tumors than in other types of epithelial ovarian cancer. It was associated with a better prognosis.
17441962 CD147 may assume a dual role, since it had intrinsic stimulative effects on breast cabcer tumor invasion in vitro as well as increasing resistance to P-gp substrate drugs.
16425263 The colocalization of EMMPRIN, MT1-MMP and TIMP-2 in human cervical carcinomas seems to be involved in a specific distribution pattern of tumor cell bound MMP-2, which is related with local proteolytic activity.
15823273 ECM remodeling is under the control of induction and inhibition of matrix degrading protease and the novel MMP inducer, EMMPRIN may play a role in influx and differentiation of monocytes and destabilizing atheroma
15904490 expression of CD147 is upregulated during the differentiation of monocyte THP-1 cells to macrophage cells, and CD147 induces the secretion and activation of MMP-2 and MMP-9 and enhances the invasive ability of THP-1 cells

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCD147solute carrier family 16, member 1--Pubmed
HPRDCD147solute carrier family 16, member 3--Pubmed
HPRDbasiginSolute carrier family 16, member 1--Pubmed
HPRDbasiginMonocarboxylate transporter 3--Pubmed
HPRDbasiginmatrix metalloproteinase 1 preproprotein--Pubmed
HPRDbasiginmatrix metalloproteinase 1 preproprotein--Pubmed
HPRDbasigin isoform 1 precursorSolute carrier family 16, member 1--Pubmed
HPRDbasigin isoform 1 precursorMonocarboxylate transporter 3--Pubmed
HPRDbasigin isoform 1 precursormatrix metalloproteinase 1 preproprotein--Pubmed

Recent Publications on BSG:

Pubmed Logo
EMMPRIN expression in tongue squamous cell carcinoma.
BACKGROUND: Extracellular matrix metalloproteinase inducer (EMMPRIN) is...
30th October, 2009
Department of Oral and Maxillfacial Surgery, The Second Affiliated J Oral Pathol Med. 2009 Jul;38(6):518-23. Epub 2009 Apr 13.
DOI Direct Link
Comprehensive profiling of the cell surface proteome of Sy5Y neuroblastoma cells yields a subset of proteins associated with tumor differentiation.
Neuroblastoma tumors are derived from the neural crest and exhibit...
9th October, 2009
Children's Hospital and Research Center at Oakland, California 94609, USA. J Proteome Res. 2009 Aug;8(8):3791-6.
DOI Direct Link
Upregulation of caveolin-1 and CD147 expression in nasopharyngeal carcinoma enhanced tumor cell migration and correlated with poor prognosis of the patients.
Expression of caveolin-1 (Cav-1) and extracellular matrix...
22nd September, 2009
State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Int J Cancer. 2009 Oct 15;125(8):1832-41.
DOI Direct Link
The diagnosis and treatment of Crohn's disease and ulcerative colitis.
INTRODUCTION: Crohn's disease and ulcerative colitis are chronic...
17th September, 2009
Medizinische Klinik mit Schwerpunkt Gastroenterologie und Hepatologie, Dtsch Arztebl Int. 2009 Feb;106(8):123-33. Epub 2009 Feb 20.
DOI Direct Link
Increased expression of extracellular matrix metalloproteinase inducer is associated with matrix metalloproteinase-1 and -2 in gingival tissues from patients with periodontitis.
BACKGROUND AND OBJECTIVE: Extracellular matrix metalloproteinase inducer...
16th September, 2009
Key Laboratory for Oral Biomedical Engineering of Ministry of Education, J Periodontal Res. 2009 Feb;44(1):125-32.
DOI Direct Link

View more research publications.

Press Releases on BSG:

BioPortfolio Logo
MMR Seeks Its Slice of the Billion-Dollar Stimulus Pie 24th February, 2009 MMR Information Systems, Inc.

Flexibility and Plug and Play Capability of MyMedicalRecords Pro to be Showcased For More Than 28,000 Healthcare Technology Experts Expected at HIMSS09

LOS ANGELES, Feb. 24

BioNews Results for BSG

: RSS Logo
BioPortfolio Logo
GASTRO 2009 Press Conferences
Medicexchange.com:  Nov 4 2009 5:11AM Matching: bsg
Medical News: Invitation To Gastro 2009 Press Conference, UK
Medical News Today:  Nov 3 2009 12:10PM Matching: bsg
Binge drinking should be tackled regionally, research suggest
Nursing Times:  Oct 19 2009 10:01AM Matching: bsg
Eleven companies honored for workplace strengths
MySanAntonio:  Oct 12 2009 8:44PM Matching: bsg

Clinical Trials:

Clinical Trials Logo
Biomarkers and Genetic Factors Related to Emphysema

Patents:

Patents logo
US Patent No.Title
7579681 Super high density module with integrated wafer level packages
7587694 System and method for utilizing meta-cells
7588767 Microorganisms for therapy
7588771 Microorganisms for therapy
7589365 Dual capacitor structure for imagers

View more patents.

BSG results (if any) from reagent suppliers

Google CSE Logo
CD147 antibody, CD147 [MEM-M6/1] Antibody, Mouse Monoclonal Antibody
Mouse monoclonal [MEM - M6 / 1] to CD147; 682; BSG; 109480; P35613; 5F7; CD147; EMMPRIN; M6; OK; TCSF;; 682; BSG; 109480; P35613; 5F7; CD147; EMMPRIN; M6; ...
http://www.genwaybio.com/product_info.php?products_id=192051...

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Basigin Monoclonal Antibody Basigin
Background. Basigin (BSG) Mouse anti-Human Monoclonal (HIM6) Antibody. Additional Names. BSG, 5F7, BASIGIN, CD147, EMMPRIN, M6, OK, TCSF, basigin ...
http://www.prosci-inc.com/shop/catalog1/Basigin-Monoclonal-A...

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Bacteria, Viruses, and Infectious Diseases(330) - GeneTex Inc ...
BSG antibody (basigin (Ok blood group)), GTX100915, Rabbit PAb, WB, 100 μl, USD $239.00, -. BST1 antibody (bone marrow stromal cell antigen 1), GTX112704 ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...

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Antibodies to Extracellular Matrix Proteins
E4154, Anti-EMMPRIN antibody produced in goat, (polyclonal), affinity isolated antibody, mouse ... Bsg(12215), mouse, ELISA (i), WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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EMMPRIN (T-18) Antibody sc-9756
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Bsg, 12215, 10 C1, P18572 ...
http://www.scbt.com/datasheet-9756-emmprin-t-18-antibody.htm...

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CD147 antibody (ab24813) | Abcam
CD147 interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. CD147 also interacts with ATP1B2, ...
http://www.abcam.com/CD147-antibody-ab24813.html...

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EMMPRIN (8D6) Antibody sc-21746
... Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, BSG, 682, 19p13.3, NM_001728, NM_198589, NM_198590, NM_198591 · P35613 ...
http://www.scbt.com/datasheet-21746-emmprin-8d6-antibody.htm...

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