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ABCC8
| Symbol: | ABCC8 | | Name(s): | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17919176 |
ABCC8 mutations cause PNDM, TNDM or permanent diabetes diagnosed outside the neonatal period. |
| 18290324 |
Alanine in HI: a silent mutation cries out! |
| 11318841 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11692183 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12118200 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12540637 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 12879777 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14728986 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15579791 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15840308 |
Observational study of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | crystallin, beta B1 | ATP binding cassette, subfamily C, member 8 | - | - | Pubmed |
| HPRD | endosulfine alpha isoform 3 | ATP-binding cassette, sub-family C, member 8 | - | - | Pubmed |
| HPRD | potassium inwardly-rectifying channel J8 | ATP-binding cassette, sub-family C, member 8 | - | - | Pubmed |
| HPRD | potassium inwardly-rectifying channel J8 | ATP-binding cassette, sub-family C, member 8 | - | - | Pubmed |
| HPRD | potassium inwardly-rectifying channel J11 | ATP binding cassette, subfamily C, member 8 | - | - | Pubmed |
Recent Publications on ABCC8: |  |
Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.
OBJECTIVE: In the pancreatic beta-cell, ATP-sensitive K(+) (K(ATP))... | 24th October, 2009
| Department of Pharmacology, Alberta Diabetes Institute, University of
| Diabetes. 2009 Oct;58(10):2419-24. Epub 2009 Jul 8.
DOI Direct Link |
Influence of genetic polymorphisms on the pharmacokinetics and pharmaco-dynamics of sulfonylurea drugs.
Sulfonylurea drugs including chlorpropamide, gliclazide, tolbutamide,... | 6th October, 2009
| Faculty of Pharmacy, The University of Sydney, NSW, Australia.
| Curr Drug Metab. 2009 Jul;10(6):643-58.
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Mutations in the ABCC8 gene can cause autoantibody-negative insulin-dependent diabetes.
Activating mutations in genes KCNJ11 and ABCC8, which form the... | 18th September, 2009
| Endocrinology, Nutrition and Diabetes Department, Pitie-Salpetriere
| Diabetes Metab. 2009 Jun;35(3):233-5. Epub 2009 Apr 1.
DOI Direct Link |
Differential K(ATP) channel pharmacology in intact mouse heart.
Classically, cardiac sarcolemmal K(ATP) channels have been thought to be... | 12th September, 2009
| Department of Biomedical Engineering, Washington University, St. Louis, MO
| J Mol Cell Cardiol. 2009 Sep 8.
DOI Direct Link |
The spectrum of ABCC8 mutations in Norwegian patients with congenital hyperinsulinism of infancy.
Potassium channels in the plasma membrane of the pancreatic beta cells are... | 2nd September, 2009
| aSection for Pathology, The Gade Institute, and bSection for Pediatrics,
| Clin Genet. 2009 May;75(5):440-8.
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→View more research publications. |
ABCC8 results (if any) from reagent suppliers | 
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SUR-1 (C-16) Antibody sc-5789
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ABCC8, 6833, 11p15.1, NM_000352 ...
http://www.scbt.com/datasheet-5789-sur-1-c-16-antibody.html...
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Abgent - Cell and Function Antibodies
AT1009a, ABCC8 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H. AT1010a, ABCF2 monoclonal antibody (M01), ELISA,IHC-P,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...
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SUR-1/2 (D-18) Antibody sc-5791
Human, ABCC8, 6833, 11p15.1, NM_000352 · Q09428 · 610374. Human, ABCC9, 10060, 12p12.1, NM_005691, NM_020297, NM_020298 · O60706 ...
http://www.scbt.com/ko/datasheet-5791-sur-1-2-d-18-antibody....
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Gene Scanning by High-Resolution Melt (HRM) on a LightCycler® 480 ...
follows: A) ABCC8, SNP class 1, A/G mutation; B) CYP19A1, SNP class 2, C/G mutation; C) UGT1A1, SNP class 3, G/T mutation; D) ABCC1, SNP class 4, A/T ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/RNAi/P...
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SUR-1 (H-80) Antibody sc-25683
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, ABCC8, 6833, 11p15.1, NM_000352 ...
http://www.scbt.com/ja/datasheet-25683-sur-1-h-80-antibody.h...
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