Wednesday November 25 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

VAMP2


Suggest Content
Advertise Here
Gene DB Home
Symbol:VAMP2
Name(s):vesicle-associated membrane protein 2 (synaptobrevin 2)
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ11460, SYB2, VAMP-2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17356306 Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17001002 addition of PIP2 to Stx4/SNAP23 vesicles inhibited the fusion reaction, and its addition to VAMP2 vesicles was stimulatory
17313651 VAMP2 can be phosphorylated by activated PKCzeta in vitro and the presence of ProF increases the PKCzeta-dependent phosphorylation of VAMP2 in vitro
17331077 Results indicate that the sorting determinants of synaptic vesicle proteins can operate independently of a neuronal context and implicate the association of VAMP2 with synaptophysin I in the specification of the pathway of synaptic vesicle biogenesis.
12517971 VAMP-2 mediates exocytosis of specific and tertiary granules of neutrophils through its interaction with Q-SNARE/R-SNARE complexes located at the neutrophil plasma membrane.
11842301 SNAP-23 and syntaxin-4 are expressed in human eosinophils and are likely candidates for association with VAMP-2 during docking, which is followed by exocytosis
16195891 VAMP-2 can be one of the v-SNAREs for constitutive exocytosis
17196367 The vesicular distribution may be attributed in part to the direct interaction between PKD3 and vesicle-associated membrane protein VAMP2, through which PKD3 may regulate VAMP2 vesicle trafficking by facilitating its recruitment to the target membrane.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDSynaptosomal associated protein,25Kdvesicle-associated membrane protein 2--Pubmed
HPRDsynaptosomal-associated protein 25 isoform SNAP25ASynaptobrevin 2--Pubmed
HPRDSyntaxin 4Avesicle-associated membrane protein 2--Pubmed
HPRDsyntaxin 4Synaptobrevin 2--Pubmed
HPRDSyntaxin binding protein 2vesicle-associated membrane protein 2--Pubmed
HPRDsyntaxin binding protein 2Synaptobrevin 2--Pubmed
HPRDSynaptobrevin 2transient receptor potential cation channel, subfamily C, member 3--Pubmed
HPRDSynaptobrevin 2synaptosomal-associated protein 23 isoform SNAP23A--Pubmed
HPRDSynaptobrevin 2Rab acceptor 1--Pubmed
HPRDSynaptobrevin 2complexin 1--Pubmed

Recent Publications on VAMP2:

Pubmed Logo
Identifying Genes for Establishing a Multigenic Test for Hepatocellular Carcinoma Surveillance in Hepatitis C Virus-Positive Cirrhotic Patients.
In this study, we used the Affymetrix HG-U133A version 2.0 GeneChips to...
29th October, 2009
1Department of Biostatistics, 2Massey Cancer Center, 3Division of Cancer Epidemiol Biomarkers Prev. 2009 Oct 27.
DOI Direct Link
Vesicle-associated membrane protein 2 mediates trafficking of alpha5beta1 integrin to the plasma membrane.
Integrins are major receptors for cell adhesion to the extracellular...
14th October, 2009
Department of Biochemistry and Molecular Biology, University of Louisville Exp Cell Res. 2009 Oct 12.
DOI Direct Link
A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapse.
Synapses relay information through the release of neurotransmitters stored...
10th October, 2009
MRC Centre for Developmental Neurobiology, King's College London, London, Nat Neurosci. 2009 Jun;12(6):751-8. Epub 2009 May 10.
DOI Direct Link
Evidence that Electrostatic Interactions between VAMP2 and Acidic Phospholipids May Modulate the Fusion of Transport Vesicles with the Plasma Membrane.
Monitoring Editor: Thomas F.J. Martin The juxtamembrane domain of VAMP2...
9th October, 2009
Department of Medicine and Molecular Pharmacology, Albert Einstein College Mol Biol Cell. 2009 Oct 7.
DOI Direct Link
CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions.
Ca(2+)-dependent activator protein for secretion (CAPS) is an essential...
7th October, 2009
Department of Biochemistry, University of Wisconsin, Madison, WI 53706, Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17308-13. Epub 2009 Sep 29.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7135292 Analysis and modification of gene expression in marine invertebrate cells
6946293 Progenitor cells, methods and uses related thereto
6713444 Buforin I as a specific inhibitor and therapeutic agent for botulinum toxin B and tetanus neurotoxins

View more patents.

VAMP2 results (if any) from reagent suppliers

Google CSE Logo
VAMP2 antibody (ab3347) | Abcam
Rabbit polyclonal to VAMP2. VAMP2 (Synaptobrevin 2) is a small integral membrane protein found specifically in synaptic vesicles in neurons.
http://www.abcam.com/vamp2-antibody-ab3347.html...

Thumbshot
Anti-VAMP2 Polyclonal Antibody
Polyclonal Antibody against VAMP2 for use in Immunoprecipitation, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

Thumbshot
VAMP-2 (3E5) Antibody sc-69706
VAMP-2 shRNA (h) Lentiviral Particles, sc-43519-V, 200 µl ... VAMP-2 (3E5): sc- 69706. Western blot analysis of VAMP-2 expression in non-transfected: ...
http://www.scbt.com/datasheet-69706-vamp-2-3e5-antibody.html...

Thumbshot
Anti-VAMP2 Polyclonal Antibody
PA1-766 detects vesicle associated membrane protein 2 (VAMP-2) from rat ... kDa protein representing VAMP-2 from rat brain whole protein extract. ...
http://www.bioreagents.com/products/printProductDetail/print...

Thumbshot
VAMP2 antibodies: Signal Transduction > Protein Trafficking ...
VAMP2 antibodies. ... VAMP2 antibody. IHC-P, WB, IHC-Fr. Sheep polyclonal. Reacts with: Hu, Ms, Rat. ab53407 · VAMP2 antibody [clone 3E5]. WB, ELISA ...
http://www.abcam.com/index.html?t=10946&pt=1&c=2247&ei=&mu=r...

Thumbshot
VAMP-1/2 (4H302) Antibody sc-58310
Western blot analysis of VAMP-2 expression in non-transfected: sc-117752 (A) and human VAMP-2 transfected: sc-115139 (B) 293T whole cell lysates. ...
http://www.scbt.com/datasheet-58310-vamp-1-2-4h302-antibody....

Thumbshot
VAMP2 peptide (ab4958) | Abcam
VAMP2 peptide. VAMP2 (Synaptobrevin 2) is a small integral membrane protein found specifically in synaptic vesicles in neurons.
http://www.abcam.com/VAMP2-peptide-ab4958.html...

Thumbshot

Search Bioportfolio and other Life Science Sites for VAMP2, or search for VAMP2 on BioPortfolio's antibody search engine.
This page has been viewed 136 times
Recent Search Terms used to find this page:
vamp2 vesicle | VAMP2 phosphorylation exocytosis | synaptobrevin 2 PCR control | synaptobrevin 2 | synaptobrevin2 | synaptobrevin2 | synaptobrevin2 | VAMP2 antibody ab18014 | glucose VAMP2 | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.