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Gene DB Home
Symbol:BTC
Name(s):betacellulin
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15793259 Observational study of gene-disease association. (HuGE Navigator)
15936459 Observational study of gene-disease association. (HuGE Navigator)
16306376 Observational study of gene-disease association. (HuGE Navigator)
16683131 Observational study of gene-disease association. (HuGE Navigator)
16869959 Observational study of gene-disease association. (HuGE Navigator)
17962208 1st report of BTC expression in breast cancer. Its expression was lower in lobular breast cancers than in ductal carcinomas.
17895248 the ADAM10 prodomain inhibits betacellulin shedding, demonstrating that it could be of potential use as a therapeutic agent to treat cancer.
17525275 In vivo, EGFR signaling is hyperactive in tumor cells of skin SCC but not of BCC, and in nearby asymptomatic epidermis of both tumor types. Hyperactivation is due to upregulation of EGFR ligands AREG, HBEGF and TGFA, and downregulation of BTC
17479438 Variants in the betacellulin gene do not play a major role in the development of type 2 diabetes in an Amish Caucasian populations
12074582 The solution structure of the EGF-like domain of betacellulin has been determined using two-dimensional nuclear magnetic resonance spectroscopy

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBetacellulinepidermal growth factor receptor oncogene homolog, avian)--Pubmed
HPRDbetacellulinEGF receptor--Pubmed
HPRDbetacellulinv-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog--Pubmed
HPRDbetacellulinv-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog--Pubmed
HPRDbetacellulinmatrix metalloproteinase 9 preproprotein--Pubmed
HPRDbetacellulinmatrix metalloproteinase 9 preproprotein--Pubmed
HPRDbetacellulinv-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed
HPRDbetacellulinv-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor--Pubmed

Recent Publications on BTC:

Pubmed Logo
Inhibitors of the Mitochondrial Citrate Transport Protein: Validation of the Role of Substrate Binding Residues and Discovery of the First Purely Competitive Inhibitor.
The mitochondrial citrate transport protein (CTP) is critical to energy...
22nd October, 2009
Rosalind Franklin University of Medicine and Science. Mol Pharmacol. 2009 Oct 20.
DOI Direct Link
Mitochondrial reticulation in shoot apical meristem cells of Arabidopsis provides a mechanism for homogenization of mtDNA prior to gamete formation.
Plant mitochondria are typically portrayed as being small, oval...
21st October, 2009
Instituto para la Conservacion y Mejora de la Agrodiversidad Valenciana Plant Signal Behav. 2009 Mar;4(3):168-71.
Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiae.
Acetylcholinesterases (AChEs) and their genes from susceptible and...
20th October, 2009
Department of Entomology and Plant Pathology, Oklahoma State University, Insect Biochem Mol Biol. 2009 Sep;39(9):646-53. Epub 2009 Jul 14.
DOI Direct Link
Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice.
Insulin deficiency in type 1 diabetes leads to disruptions in glucose,...
13th October, 2009
Division of Diabetes, Endocrinology, and Metabolism, Department of Endocrinology. 2009 Nov;150(11):4863-73. Epub 2009 Oct 9.
DOI Direct Link
Poly(bisthiophene-carbazole-fullerene) double-cable polymer as new donor-acceptor material: preparation and electrochemical and spectroscopic characterization.
A new donor-acceptor dyad, namely, a 3,6-bis(thiophen-2-yl)carbazole...
10th October, 2009
INAC, UMR 5819-SPrAM (CEA-CNRS-Univ. J. Fourier-Grenoble I), Laboratoire J Phys Chem B. 2009 Oct 29;113(43):14087-93.
DOI Direct Link

View more research publications.

Press Releases on BTC:

BioPortfolio Logo
Health Robotics Announces Worldwide Launch of the "i.v. Room of the Future" Concept at Las Vegas' ASHP 18th November, 2009

BOZEN, Italy, November 18 /PRNewswire/ -- Health Robotics today announced the worldwide presentation and launch of its revolutionary vision for "The i.v. Room of the Future" at the

Actress and Mom Alison Sweeney Teams Up With the American Pharmacists Association to Help Fellow Allergy Sufferers Find Relief This Spring 2nd April, 2009 American Pharmacists Association

- TV Host Explains How Talking to a Pharmacist Helped Her Manage Her Congestion so She Can Get Back to Her Busy Schedule -

WASHINGTON, D.C.

BioNews Results for BTC

: RSS Logo
BioPortfolio Logo
BERGHOF Products + Instruments GmbH: Greater Flexibility and Variety
PRO-4-PRO:  Oct 20 2009 4:27PM Matching: btc
Which is promising as therapeutic targets in patients with biliary tract cancer? EGFR or HER2?
EurekAlert!:  Oct 19 2009 7:18AM Matching: btc
Research study on EGFR and HER2 expressions in BTC
News-Medical.Net:  Oct 19 2009 11:32AM Matching: btc
EGFR or HER2: Which to target in patients with advanced biliary tract cancer
News-Medical.Net:  Oct 19 2009 10:36AM Matching: btc
Which is promising as therapeutic targets in patients with biliary tract cancer? EGFR or HER2?
PhysOrg.com:  Oct 17 2009 12:06AM Matching: btc
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
BTC Neuropsychological Database

Patents:

Patents logo
US Patent No.Title
7528105 Heterodimeric chain synthetic heparin-binding growth factor analogs
7545718 Method and apparatus for establishing manufacturer-specific test writing parameters for writing of writable optical storage media
7550433 Erythropoietin receptor peptide formulations and uses
7550565 G-CSF conjugates
7550566 G-CSF conjugates

View more patents.

BTC results (if any) from reagent suppliers

Google CSE Logo
BTC (C-16) Antibody sc-5800
BTC shRNA (h) Lentiviral Particles, sc-39414-V, 200 µl ... See how others have used BTC (C-16): sc-5800 antibody and or BTC (C-16) antibody conjugates. ...
http://www.scbt.com/datasheet-5800-btc-c-16-antibody.html...

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Betacellulin antibody [34362.11] (ab10417) | Abcam
Betacellulin (BTC) is a heparin-binding member of the EGF family of growth ... Betacellulin (BTC) was originally isolated as a 32 kDa glycoprotein from the ...
http://www.abcam.com/Betacellulin-antibody-34362-11-ab10417....

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BTC Antibody / BTC Antibodies
BTC Antibody / BTC Antibodies. ... BTC specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-btc.html...

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Betacellulin/BTC - R&D Systems
At the amino acid sequence level, human mature BTC protein exhibits 80% identity with mouse BTC protein. BTC is expressed in most tissues including kidney, ...
http://www.rndsystems.com/molecule_detail.aspx?m=1101...

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BTC (T-16) Antibody sc-5802
BTC (T-16): sc-5802. Immunofluorescence staining of methanol-fixed A-431 cells ... Western blot analysis of BTC expression in rat pancreas tissue extract. ...
http://www.scbt.com/datasheet-5802-btc-t-16-antibody.html...

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690872 Basolite™ F300 Fe-BTC produced by BASF
690872 Basolite F300 produced by BASF MOF (metal organic framework)
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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BTC (34362.11) Antibody sc-57045
mouse monoclonal IgG1, 100µg/ml; raised against full length BTC of human origin; recommended for detection of BTC of human origin by WB and ELISA; ...
http://www.scbt.com/datasheet-57045-btc-34362-11-antibody.ht...

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