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TACR2


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Gene DB Home
Symbol:TACR2
Name(s):tachykinin receptor 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:NK2R, NKNAR, SKR, TAC2R
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18219665 NK2 receptors are involved in the neuroneuronal and neuromuscular processes regulating human colonic motility.
16893949 Observational study of gene-disease association. (HuGE Navigator)
17448763 Observational study of gene-disease association. (HuGE Navigator)
17532769 Increased proportion of alveolar macrophages expressing neurokinin 2 receptor may be involved in the pathogenesis of COPD.
17503489 Data indicate that presynaptic and postsynaptic neuroneuronal and neuromuscular regulatory processes mediated by tachykinins via NK2r may occur for modulating human colonic motility.
12801882 protease-activated receptor 2 agonists induced a contraction of murine intestinal smooth muscle that was mediated by nerves and requires both neurokinin 1 and 2 receptors
15294896 NK2 receptors are compartmentalized at the plasma membrane
12427486 Identification of a tachykinin NK(2) receptor splice variant.
11906947 Tachykinin NK2 receptors mediate smooth muscle contraction in human corpus cavernosum and spongiosum.
15690122 Preprotachykinin-I peptides mediate autocrine proliferation of the neuroblastoma cells through both NK-1 and NK-2 receptors.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDTachykinin 1tachykinin receptor 2--Pubmed
HPRDtachykinin 1 isoform beta precursorTachykinin receptor 2--Pubmed
HPRDTachykinin receptor 2tachykinin 3 isoform 2--Pubmed
HPRDTachykinin receptor 2tachykinin 4--Pubmed
HPRDtachykinin receptor 2Tachykinin 3--Pubmed
HPRDtachykinin receptor 2Tachykinin 4--Pubmed

Recent Publications on TACR2:

Pubmed Logo
Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus.
BACKGROUND: In the mouse uterus, pregnancy is accompanied by changes in...
12th September, 2009
Instituto de Investigaciones Quimicas, CSIC, Sevilla, Spain. Reprod Biol Endocrinol. 2009 Jul 23;7:77.
DOI Direct Link
No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease.
The Tachykinin Receptor 2 (TACR2) located at chromosome 10q21.3 belongs to...
21st April, 2009
Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry Neurobiol Aging. 2009 Apr 16.
DOI Direct Link
Expression of the tachykinin receptor mRNAs in healthy human colon.
Tachykinins are a family of neuropeptides, involved in a variety of...
7th January, 2009
Biovays, 3 Place Victor Hugo, F-13331, Marseille, France. Eur J Pharmacol. 2008 Dec 3;599(1-3):121-5. Epub 2008 Sep 26.
DOI Direct Link
Occurrence and pharmacological characterization of four human tachykinin NK2 receptor variants.
Tachykinin NK(2) receptor antagonists are potentially beneficial in...
6th September, 2008
AstraZeneca R&D, Molndal, Sweden. Biochem Pharmacol. 2008 Aug 15;76(4):476-81. Epub 2008 Jun 13.
DOI Direct Link
A role for tachykinins in the regulation of human sperm motility.
BACKGROUND: Tachykinins and tachykinin receptors are widely distributed in...
4th August, 2007
Instituto de Investigaciones Quimicas, CSIC-Universidad de Sevilla, 49 Hum Reprod. 2007 Jun;22(6):1617-25. Epub 2007 Apr 16.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7604936 Methods and compositions for diagnosis and monitoring auto immune and chronic inflammatory diseases
6727063 Single nucleotide polymorphisms in genes
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6969702 Compounds and methods for increasing neurogenesis
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

TACR2 results (if any) from reagent suppliers

Google CSE Logo
NK-2R (G-15) Antibody sc-22050
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, TACR2, 6865, 10q21.3, NM_001057 ...
http://www.scbt.com/datasheet-22050-nk-2r-g-15-antibody.html...

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Antibodies available - Antibodies | Imgenex
IMG-72123, Tachykinin Receptor 2, TACR2, NK-2R, NK2R, NKNAR, Purified, ... IMX- 30743, TACR2/Neurokinin 2 receptor, Purified, Peptide Affinity, N/A, ELISA ...
http://www.imgenex.com/alphabetic_antibody_list.php?key=T&do...

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NK-2R (G-15) Antibody sc-22050
Species, Nome del gene, Codice del gene, Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, TACR2, 6865,
10q21.3 ...
http://www.scbt.com/it/datasheet-22050-nk-2r-g-15-antibody.h...

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eHandbook 001_050.indd
TACR2 and TACR3, they are currently named by the acronyms NK1, NK2 and NK3. These receptors are coupled through Gq and G11 to phospholipase C. The agonist
...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/RBI_Hand...

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NK-2R (G-15) Antibody sc-22050
Humano, TACR2, 6865, 10q21.3, NM_001057 · P21452 · 162321. Ratón, Tacr2, 21337, 10 B4, P30549, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-22050-nk-2r-g-15-antibody.h...

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SelectScreen® Cell-based GPCR Profiling Services
Tachykinin, TACR2, NFAT-bla CHO-K1. Tachykinin, TACR3, U2OS. Vasopressin & Oxytocin, AVPR1A, NFAT-bla CHO-K1. Vasopressin & Oxytocin, AVPR2, CRE-bla CHO-K1
...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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Cell-Based GPCR Reporter Assays
Tachykinin, TACR1, PDF Download · K1801, X. Tachykinin, TACR2, PDF Download · K1844, X, Ca²+(Fluo-4), Phospho-ERK2. Tachykinin, TACR3, PDF Download ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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