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TACC1


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Symbol:TACC1
Name(s):transforming, acidic coiled-coil containing protein 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp686K18126, Ga55, KIAA1103
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16496324 Splice variants can be localized to different subcellular compartments in a cell-and tissue-specific manner.
11903063 Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells
12165861 Down regulation of tacc1 controls mrna homeostasis in polarized cells and participates in oncogenic processes in human cancers
12547166 Splicing pattern of its mRNA is altered in stomach cancer
12389629 REVIEW: genetics, expression, gene expression regulation, and function studies
15064709 TACC1 and the mitotic kinase Aurora B belong to the same complex during cytokinesis.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDGCN5 general control of amino-acid synthesis 5-like 2transforming, acidic coiled-coil containing protein 1TACC1 interacts with hGCN5L2.-Pubmed
HPRDsmall nuclear ribonucleoprotein polypeptide Gtransforming, acidic coiled-coil containing protein 1--Pubmed
HPRDSerine/threonine protein kinase 6transforming, acidic coiled-coil containing protein 1--Pubmed
HPRDtransforming, acidic coiled-coil containing protein 1aurora kinase B--Pubmed
HPRDtransforming, acidic coiled-coil containing protein 1glioma-amplified sequence-41--Pubmed
HPRDtransforming, acidic coiled-coil containing protein 1U6 snRNA-associated Sm-like protein LSm7--Pubmed

Recent Publications on TACC1:

Pubmed Logo
Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer.
Cross-resistance to molecules used in endocrine therapy is among the main...
14th April, 2009
Universite de Lyon, 69008 Lyon, France Universite Lyon 1, ISPB, Faculte de J Mol Endocrinol. 2009 Feb;42(2):87-103. Epub 2008 Nov 4.
DOI Direct Link
Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2.
The BRCA1-associated ring domain protein 1 (BARD1) interacts with BRCA1...
24th March, 2009
Department of Gynecology and Obstetrics, Molecular Gynecology and Cancer Res. 2009 Feb 1;69(3):1125-34. Epub 2009 Jan 27.
DOI Direct Link
The TACC proteins: TACC-ling microtubule dynamics and centrosome function.
A major quest in cell biology is to understand the molecular mechanisms...
7th October, 2008
Cell and Developmental Biology Program, Centre for Genomic Regulation Trends Cell Biol. 2008 Aug;18(8):379-88. Epub 2008 Jul 23.
DOI Direct Link
Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas.
The mortality rate for patients with ovarian carcinomas is high and the...
17th September, 2008
Department of Oncology, University of Gothenburg, Gothenburg, Sweden. Int J Cancer. 2008 Nov 1;123(9):2130-7.
DOI Direct Link
Interaction of TACC proteins with the FHL family: implications for ERK signaling.
The Transforming acidic coiled coil (TACC) proteins play a conserved role...
16th May, 2008
Department of Physical Sciences, Arkansas Tech University, 1701 N Boulder J Cell Commun Signal. 2007 Jun;1(1):5-15. Epub 2007 Mar 28.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598080 Diagnostic assay for source of inflammation
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
6924358 121P1F1: a tissue specific protein highly expressed in various cancers
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6753154 Human AZU-1 gene, variants thereof and expressed gene products

View more patents.

TACC1 results (if any) from reagent suppliers

Google CSE Logo
TACC1 (G-18) Antibody sc-5881
goat polyclonal IgG, 200 µg/ml; epitope mapping near the N-terminus of TACC1 of human origin; recommended for detection of TACC1 of human origin by WB, ...
http://www.scbt.com/datasheet-5881-tacc1-g-18-antibody.html...

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Purified Anti-ch-TOG Antibody - BioLegend
Ch-TOG is believed to function in spindle microtubule organization and has been shown to interact with TACC1, TACC3,and tubulin. The Poly6204 antibody has ...
http://www.biolegend.com/purified-anti-ch-tog-antibody-2191....

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TACC Antibody / TACC Antibodies
TACC1 (G-18) Antibody, sc-5881, goat IgG, N-terminus (h), WB, IF, ELISA, human ... TACC1 shRNA Plasmid (m): sc-154042-SH. TACC1 shRNA (m) ...
http://www.scbt.com/table-tacc.html...

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A8914 Anti-Rabbit IgG (whole molecule)−Agarose antibody produced ...
reference, Cowell, J., et al., Interaction of the transforming acidic coiled- coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A891...

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TACC1 siRNA (h) sc-37499
Click here for details. suitable control antibody: TACC1 (C-18): sc-5882; sqRT- PCR Primer also available: TACC1 (h)-PR: sc-37499-PR, 20 µl ...
http://www.scbt.com/ko/datasheet-37499-tacc1-sirna-h.html...

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MONOCLONAL ANTIBODY TO HUMAN AURORA-A KINASE (CROSS REACTIVE WITH ...
Conte, N et al; TACC1-chTOG-Aurora A protein complex in breast cancer. Oncogene 2003, 22: 8102. HM5007. Monoclonal antibody against Human BPDE-DNA, ...
http://www.hbt.nl/HM2123.pdf...

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TACC Antibody / TACC Antibodies
TACC1 (G-18) 抗体, sc-5881, goat IgG, N-terminus (h), WB, IF, ELISA, human. TACC1 (C-18) 抗体 ... TACC1 shRNA Plasmid (m): sc-154042-SH. TACC1 shRNA (m) ...
http://www.scbt.com/ja/table-tacc.html...

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