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ADAM17
| Symbol: | ADAM17 | | Name(s): | ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CD156b, MGC71942, TACE, cSVP | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18276953 |
oxygen regulates the expression of TACE and TACE may be important for placental development during human pregnancy. |
| 17942404 |
TMEFF2 contributes to cell proliferation in an ADAM17-dependent autocrine fashion in cells expressing this protein |
| 18171982 |
disruption of ALCAM-mediated adhesion is a relevant step in ovarian cancer cell motility, and ADAM17/TACE takes part in this process, which may be relevant to invasive potential |
| 17608729 |
This review focuses on a subset of soluble proteins , which are cleaved by tumor necrosis factor alpha-converting enzyme (TACE)/ADAM17, and on their role in cancer. |
| 17786981 |
These data demonstrate that high-density lipoproteins alter the lipid raft structure, which in turn activates the ADAM17-dependent processing of transmembrane substrates. |
| 17999917 |
In conclusion, ADAM-17 plays an important role in cancer invasion probably through CD44 cleavage. |
| 17714581 |
Type 2 diabetes LDL lipoproteins increasin adhesion molecules by promoting increased expression of ADAM17. |
| 16912185 |
Highly malignant renal carcinoma cancer cells fail to form in vivo tumors in the absence of ADAM17. |
| 17438092 |
The proportion of active to total ADAM-17 increased progressively from normal breast tissue to primary breast cancer to lymph node metastases. |
| 12568494 |
Review. The activation of EGFR in response to smoke involves cleavage of amphiregulin by ADAM 17. | →View more information from publications. |
Recent Publications on ADAM17: |  |
Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice.
Tumor necrosis factor alpha-converting enzyme (TACE, also known as ADAM17)... | 31st October, 2009
| Department of Internal Medicine, University of Rome Tor Vergata, Rome,
| Hepatology. 2009 Aug 25.
DOI Direct Link |
The disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells.
Syndecans are cell surface proteoglycans that bind and modulate various... | 31st October, 2009
| Institute of Pharmacology and Toxicology, RWTH Aachen University, Germany;
| J Biol Chem. 2009 Oct 29.
DOI Direct Link |
Mitochondrial ROS Mediates GPCR-induced TACE-dependent TGF-{alpha} Shedding.
Monitoring Editor: J. Silvio Gutkind EGFR activation by GPCRs regulates... | 23rd October, 2009
| Department of Biochemistry and Biophysics and Lineberger Comprehensive
| Mol Biol Cell. 2009 Oct 21.
DOI Direct Link |
Gene expression analysis of an EGFR indirectly related pathway identified PTEN and MMP9 as reliable diagnostic markers for human glial tumor specimens.
In this study the mRNA levels of five EGFR indirectly related genes, EGFR,... | 17th October, 2009
| Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia,
| J Biomed Biotechnol. 2009;2009:924565. Epub 2009 Jul 30.
DOI Direct Link |
ADAM17_i33708A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study.
BACKGROUND AND AIMS: The disintegrin and metalloproteinase ADAM17, also... | 13th October, 2009
| Nutrition and Genomics Laboratory, JM-USDA-HNRCA at Tufts University, 711
| Nutr Metab Cardiovasc Dis. 2009 Oct 8.
DOI Direct Link |
→View more research publications. |
ADAM17 results (if any) from reagent suppliers | 
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ADAM17 antibody (ab2051) | Abcam
Rabbit polyclonal to ADAM17. ADAM17, also known as TNF alpha Convertase, or TACE , was first cloned from human epithelial cells.
http://www.abcam.com/ADAM17-antibody-ab2051.html...
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ADAM17 Antibody (CT) ADAM17 / TACE
ADAM17 antibody was raised against a synthetic peptide near the C-terminus of ADAM17.,
http://www.prosci-inc.com/shop/catalog1/ADAM17-Antibody-p-26...
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ADAM17 Antibody (C-term)
ADAM17 Antibody (C-term) Cell Function, ADAM17 Antibody (C-term) Neurosciences, ADAM17 Antibody (C-term) Stem Cell, ADAM17 Antibody (C-term) Cancer, ADAM17 ...
http://www.abgent.com/products/catalog_no/AP1492b...
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ADAM17 Antibody A Disintegrin And Metalloproteinase Domain 17
ADAM17 Antibody 49-524, ... Immunogen. ADAM17 antibody was raised against amino acids 807 to 823 of ADAM17. (Human). Application. ADAM17 antibody can be ...
http://www.prosci-inc.com/shop/catalog1/ADAM17-Antibody-p-33...
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ADAM17 antibody - Aminoterminal end catalytic domain (ab28233) | Abcam
Rabbit polyclonal to ADAM17 - Aminoterminal end catalytic domain. ADAM17, also known as TNF alpha Convertase, or TACE, was first cloned from human ...
http://www.abcam.com/ADAM17-antibody-Aminoterminal-end-catal...
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ADAM17 Antibody A Disintegrin And Metalloproteinase Domain 17
Left: Immunohistochemistry staining of ADAM17 in skeletal muscle (formalin-fixed paraffin embedded) using ADAM17 antibody. ...
http://www.prosci-inc.com/shop/catalog1/ADAM17-Antibody-p-32...
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Anti-ADAM17 Polyclonal Antibody
Polyclonal Antibody against ADAM17 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...
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