Friday November 27 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

TACR1


Suggest Content
Advertise Here
Gene DB Home
Symbol:TACR1
Name(s):tachykinin receptor 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:NK1R, NKIR, SPR, TAC1R
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16893949 Observational study of gene-disease association. (HuGE Navigator)
17443717 Observational study of gene-disease association. (HuGE Navigator)
17448763 Observational study of gene-disease association. (HuGE Navigator)
18180429 Observational study of gene-disease association. (HuGE Navigator)
17713785 Evidence was also obtained that the proper clustering of the receptor in these microdomains was important for effective agonist-induced NK1-R signaling and for its interaction with beta-arrestin2.
18187929 T-2328 is a potent, centrally active NK(1) antagonist.
18085301 NK1R expressing neurons in different subregions of the ventral respiratory group have diverse roles and provide insight on the modulatory role of substance P.
17602742 Changes in SP receptor expression during chronic inflammation suggest that SP receptors are potential targets for therapeutic regulation of the inflammatory bowel disease.
17667845 NK1 receptor mRNA and protein expression were enhanced in obstructive sleep apnea.
17443717 studied gene variants of Tachykinin Receptor 1 in 167 suicide attempters (affective spectrum n = 107, schizophrenia spectrum n = 35, borderline personality disorder n = 25), 92 individuals who committed suicide and 312 healthy subjects

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDG protein-coupled receptor kinase 5tachykinin receptor 1 isoform long--Pubmed
HPRDG protein-coupled receptor kinase 5tachykinin receptor 1 isoform long--Pubmed
HPRDtachykinin 1 isoform beta precursortachykinin receptor 1 isoform long--Pubmed
HPRDtachykinin 1 isoform beta precursortachykinin receptor 1 isoform long--Pubmed
HPRDtachykinin 3 isoform 2tachykinin receptor 1 isoform long--Pubmed
HPRDTachykinin receptor 1tachykinin 4--Pubmed
HPRDtachykinin receptor 1 isoform longTachykinin 4--Pubmed

Recent Publications on TACR1:

Pubmed Logo
Behavioural and neurochemical abnormalities in mice lacking functional tachykinin-1 (NK1) receptors: a model of attention deficit hyperactivity disorder.
In rodent behavioural screens, such as the forced swim or...
15th September, 2009
Department of Neuroscience, Physiology & Pharmacology, University College Neuropharmacology. 2009 Dec;57(7-8):627-35. Epub 2009 Sep 10.
DOI Direct Link
Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus.
BACKGROUND: In the mouse uterus, pregnancy is accompanied by changes in...
12th September, 2009
Instituto de Investigaciones Quimicas, CSIC, Sevilla, Spain. Reprod Biol Endocrinol. 2009 Jul 23;7:77.
DOI Direct Link
Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.
Several neurotransmitters act through G-protein-coupled receptors to evoke...
20th March, 2009
Department of Biology, University of Pennsylvania, 415 S. University Nature. 2009 Feb 5;457(7230):741-4. Epub 2008 Dec 17.
DOI Direct Link
Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder.
Panic disorder (PD) is a debilitating anxiety disorder, characterized by...
11th March, 2009
Department of Psychiatry, Institute for Human Genetics, University of Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):65-73.
DOI Direct Link
NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD.
Abstract Mice with functional genetic ablation of the Tacr1 (substance...
11th February, 2009
Department of Neuroscience, Physiology and Pharmacology, University J Psychopharmacol. 2009 Jun 1.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Effect of LY686017 on Alcohol Craving

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

TACR1 results (if any) from reagent suppliers

Google CSE Logo
S8305 Anti-Substance P Receptor antibody produced in rabbit IgG ...
microarray: suitable. Gene Information, human ... TACR1(6869). rat ... Tacr1( 24807). mouse ... Tacr1(21336). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=S830...

Thumbshot
NK-1R (N-19) Antibody sc-5218
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, TACR1, 6869, 2p13.1, NM_001058, ...
http://www.scbt.com/datasheet-5218-nk-1r-n-19-antibody.html...

Thumbshot
Antibodies to Neurotransmitter Receptors
IgG fraction of antiserum, mouse ... Tacr1(21336) human ... TACR1(6869) rat ... Tacr1(24807), mouse, guinea pig, human, rat, ARR, IHC (f), WB CL, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

Thumbshot
Antibody Products - IgG Polyclonal Antibodies - GenWay
18-202-336284, TACR1 Related Product Names: - TACR1; NK1R; TAC1R - Tachykinin receptor 1 isoform long; N/A, IgG Polyclonal E, WB, Source: Goat ...
http://www.genwaybio.com/all_polyclonal_antibodies.php?fl=T...

Thumbshot
Antibodies available - Antibodies | Imgenex
IMG-30325, TACR1, Purified, Peptide Affinity, H, N/A, WB, 0.1 mg, N/A, View MSDS . IMX-30743, TACR2/Neurokinin 2 receptor, Purified, Peptide Affinity ...
http://www.imgenex.com/alphabetic_antibody_list.php?key=T&do...

Thumbshot
NK Antibody / NK Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. NK-1R (T-20) Antibody, sc-5220, goat IgG, internal (h), WB, IF, ELISA, m, r, h, dog ...
http://www.scbt.com/ko/table-nk.html...

Thumbshot
SelectScreen® Cell-based GPCR Profiling Services
Tachykinin, TACR1, U2OS. Tachykinin, TACR2, NFAT-bla CHO-K1. Tachykinin, TACR3, U2OS. Vasopressin & Oxytocin, AVPR1A, NFAT-bla CHO-K1 ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

Thumbshot

Search Bioportfolio and other Life Science Sites for TACR1, or search for TACR1 on BioPortfolio's antibody search engine.
This page has been viewed 444 times
Recent Search Terms used to find this page:
tachykinin receptor 1 (TACR1) | tachykinin receptor | tachykinin receptor pdf | tachykinin receptor | tachykinin receptor | tachykinin receptor | NK1 receptor gene knockout mouse phenotype | NK1 (TACR1) receptor gene knockout mouse phenotype predicts genetic association with ADHD. | tachykinin 1 isoform 1 | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.