Monday November 23 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

TAF4


Suggest Content
Advertise Here
Gene DB Home
Symbol:TAF4
Name(s):TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ41943, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18206971 TAF4b incorporation into TFIID induces an open conformation at the lobe involved in TFIIA & putative activator interactions, correlating with differential activator-dependent transcription & promoter recognition by 4b/4-IID.
12237304 Data present the crystal structure of a complex formed by the interacting domains from two subunits of the general transcription factor TFIID, the human TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20).
12810884 trans-activation of promoters by simian virus 40 small t-antigen may depend on a consensus TATA motif and such promoters recruit the general transcription factor hTAF(II)130/135
11988536 huntingtin interacts with Sp1 and TAFII130; transcriptional activity of SP1 and TAFII130 disrupted in early Huntingtin's Disease

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDaryl hydrocarbon receptorTBP-associated factor 4AHR interacts with TAF4.-Pubmed
HPRDcAMP response element modulatorTBP-associated factor 4--Pubmed
HPRDcAMP responsive element modulator isoform aTBP associated factor 4--Pubmed
HPRDTFIIA alpha, p55 isoform 1TBP-associated factor 4--Pubmed
HPRDgeneral transcription factor IIA, 2, 12kDaTBP-associated factor 4--Pubmed
HPRDhuntingtinTBP-associated factor 4--Pubmed
BINDhuntingtinTBP-associated factor 4TAFII130 interacts with htt.-Pubmed
HPRDTranscription factor Sp1TBP-associated factor 4--Pubmed
HPRDTranscription factor IIDTBP-associated factor 4--Pubmed
HPRDTBP-associated factor 1 isoform 1TBP associated factor 4--Pubmed

Recent Publications on TAF4:

Pubmed Logo
TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes.
The major core promoter-binding factor in polymerase II transcription...
29th July, 2009
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot J Biol Chem. 2009 Sep 25;284(39):26286-96. Epub 2009 Jul 27.
DOI Direct Link
TAF4 takes flight.
The major core promoter-binding factor in polymerase II transcription...
28th February, 2009
Department of Biology and Rosenstiel Basic Medical Sciences Research Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1295-6. Epub 2009 Jan 27.
DOI Direct Link
Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo.
Understanding the diverse activities of the multisubunit core promoter...
14th February, 2009
Howard Hughes Medical Institute, Li Ka-Shing Center for Biomedical and Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):55-60. Epub 2008 Dec 30.
DOI Direct Link
Structural changes in TAF4b-TFIID correlate with promoter selectivity.
Proper ovarian development requires the cell type-specific transcription...
22nd March, 2008
Howard Hughes Medical Institute, Li Ka-Shing Center for Biomedical and Mol Cell. 2008 Jan 18;29(1):81-91.
DOI Direct Link
Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth.
To evaluate the role of murine TFIID subunit TAF4 in activation of...
7th February, 2008
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Oncogene. 2008 Jan 17;27(4):477-89. Epub 2007 Jul 16.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
4704008 Color-corrected prism systems
4761064 Color-corrected lens systems
4762404 Color-corrected lens systems
4765727 Color-corrected lens systems

View more patents.

TAF4 results (if any) from reagent suppliers

Google CSE Logo
Taf4 antibodies: Chromatin and Nuclear Signaling > Transcription ...
Taf4 antibodies. ... Taf4 antibody [305C2a]. WB, Dot. Images. Mouse monoclonal. Reacts with: Hu. Terms and conditions · Legal · Privacy policy ...
http://www.abcam.com/index.html?t=124642&pt=1&c=3579&ei=&mu=...

Thumbshot
TAF II p130 (4A6) Antibody sc-736
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, TAF4, 6874, 20q13.33, NM_003185 ...
http://www.scbt.com/datasheet-736-taf-ii-p130-4a6-antibody.h...

Thumbshot
Yeast research antibodies | Abcam
... SWI2 / SNF2 antibody (ab22012) · SWI2 / SNF2 antibody (ab22013) · TAF10 antibody (ab64061) · TAF11 antibody (ab64066) · Taf4 antibody (ab63910) ...
http://www.abcam.com/index.html?pageconfig=resource&rid=1199...

Thumbshot
TAF II p135 siRNA (h) sc-76626
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, TAF4, 6874, 20q13.33, NM_003185 ...
http://www.scbt.com/ja/datasheet-76626-taf-ii-p135-sirna-h.h...

Thumbshot
Abcam antibodies and reagents product map
... TUSC2 antibodies (1) · TZFP antibodies (2) · TZFP proteins and peptides (1) · Taf4 antibodies (5) · Tbx2 antibodies (6) · Tbx2 proteins and peptides (2) ...
http://www.abcam.com/index.html?c=250...

Thumbshot
TAF II p135 (22) Antibody sc-136093
... Numero de acesso de isoformas de RNA mensageiro, Numero de acesso de proteina, OMIM&trande; Numero. Humano, TAF4, 6874, 20q13.33, O00268 ...
http://www.scbt.com/pt/datasheet-136093-taf-ii-p135-22-antib...

Thumbshot
TAF II p135 (22) Antibody sc-136093
种属, 基因名称, 基因ID, 染色质位置, 亚型(mRNA)即位号码, 蛋白质即位号码, OMIM™ 号码. 人类, TAF4, 6874, 20q13.33, O00268 ...
http://www.scbt.com/zh/datasheet-136093-taf-ii-p135-22-antib...

Thumbshot

Search Bioportfolio and other Life Science Sites for TAF4, or search for TAF4 on BioPortfolio's antibody search engine.
This page has been viewed 96 times
Recent Search Terms used to find this page:
rna polymerase sp1 tata box | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.