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TAF4B


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Symbol:TAF4B
Name(s):TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
Type:protein-coding
Organism:Homo sapiens
Synonyms:TAF2C2, TAFII105
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18206971 TAF4b incorporation into TFIID induces an open conformation at the lobe involved in TFIIA & putative activator interactions, correlating with differential activator-dependent transcription & promoter recognition by 4b/4-IID.
15601843 histone fold domain mediated interaction enhances the DNA binding activity of each of the TAF6-TAF9 and TAF4b-TAF12 pairs and of a histone-like octamer complex composed of the four TAFs
16088961 work suggests that pre-mRNA processing and post-translational modification represent two important regulatory steps for the gonad-specific functions of human TAF(II)105

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDTFIIA alpha, p55 isoform 1Transcription initiation factor TFIID subunit 4B.TAF4B (hTAF12b) interacts with GTF2A1 (TFIIA).-Pubmed
BIND-Transcription initiation factor TFIID subunit 4B.TAF4B (hTAF4b) interacts with an uspecified isoform of TAF1 (hTAF1).-Pubmed
BINDTranscription initiation factor TFIID subunit 4B.Homo sapiens chromosome 6TAF4B (hTAF4b) interacts with TNFAIP3 (A20) promoter.-Pubmed
BINDTranscription initiation factor TFIID subunit 4B.TAF12 RNA polymerase II, TATA box binding protein-associated factor, 20 kDTAF4B (hTAF4b) interacts with TAF12 (hTAF12).-Pubmed

Recent Publications on TAF4B:

Pubmed Logo
Accelerated Ovarian Aging in the Absence of the Transcription Regulator TAF4B in Mice.
The mammalian ovary is unique in that its reproductive lifespan is limited...
18th August, 2009
Biol Reprod. 2009 Aug 26.
DOI Direct Link
TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes.
The major core promoter-binding factor in polymerase II transcription...
29th July, 2009
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot J Biol Chem. 2009 Sep 25;284(39):26286-96. Epub 2009 Jul 27.
DOI Direct Link
Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene.
BACKGROUND: Spontaneous premature ovarian failure (POF) occurs in 1% of...
11th June, 2009
Department of Reproductive Medicine and Gynaecology, University Medical Hum Reprod. 2009 Sep;24(9):2372-8. Epub 2009 Jun 9.
DOI Direct Link
Expression of the TAF4b gene is induced by MYC through a non-canonical, but not canonical, E-box which contributes to its specific response to MYC.
Transcription factor binding sites are short DNA sequences that interact...
3rd February, 2009
Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki Int J Oncol. 2008 Dec;33(6):1271-80.
Regulation of spermatogonial stem cell self-renewal in mammals.
Mammalian spermatogenesis is a classic adult stem cell-dependent process,...
17th December, 2008
Department of Animal Sciences, Center for Reproductive Biology and Health, Annu Rev Cell Dev Biol. 2008;24:263-86.
DOI Direct Link

View more research publications.

TAF4B results (if any) from reagent suppliers

Google CSE Logo
TAF4B antibodies: Chromatin and Nuclear Signaling > Transcription ...
TAF4B antibodies. ... Image Abreview Publication. ab50808 · TAF4B antibody [ TAFAD26A]. WB, ELISA. Images. Mouse monoclonal ...
http://www.abcam.com/index.html?t=204443&pt=1&c=3389&ei=&mu=...

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Antibody Products - IgG Monoclonal Antibodies - GenWay
Mouse monoclonal anti-human TAF4B antibody; Transcription initiation factor TFIID 105 kDa subunit; TAFII-105; TAFII105; PREDICTED: Homo sapiens TAF4b RNA
...
http://www.genwaybio.com/all_monoclonal_antibodies.php?fl=T...

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TAF II p105 siRNA (m) sc-154045
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. マウス, Taf4b, 72504, 18 A1, XP_128905 ...
http://www.scbt.com/ja/datasheet-154045-taf-ii-p105-sirna-m....

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FLAG Literature
The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells, Ongeri, ...
http://www.sigmaaldrich.com/life-science/proteomics/recombin...

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TAF II p105 (TAFAD26A) Antibody sc-81122
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, TAF4B, 6875, 18q11.2, XM_290809 ...
http://www.scbt.com/ja/datasheet-81122-taf-ii-p105-tafad26a-...

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Abcam antibodies and reagents product map
... TAF16 antibodies (2) · TAF1B antibodies (2) · TAF1C antibodies (2) · TAF1L antibodies (1) · TAF40 antibodies (1) · TAF4B antibodies (1) ...
http://www.abcam.com/index.html?c=250...

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TAF II p105 (TAFAD26A) Antibody sc-81122
... Numéro d'accès d´isoforme d´ARNm, Numéro d'accès de la protéine, Numéro OMIM ™. Humain, TAF4B, 6875, 18q11.2, XM_290809 · Q92750 ...
http://www.scbt.com/fr/datasheet-81122-taf-ii-p105-tafad26a-...

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