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TARBP2


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Symbol:TARBP2
Name(s):TAR (HIV-1) RNA binding protein 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:TRBP, TRBP1, TRBP2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18178619 Ago2, Dicer, and TRBP comprise the RISC-loading complex (RLC) and assembles spontaneously in vitro from purified components
17452327 Results indicate that human TRBP and PACT directly interact with each other and associate with Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA.
16343534 Data suggest that the cell specifity of HIV-1 expression and replication may be regulated, in part, through the control of TRBP1 expression by NF-Y factors.
15123692 binds to merlin, which inhibits its oncogenic activity; results provide the first clue to the functional interaction between TRBP and merlin and suggest a novel mechanism for the tumor suppressor function of merlin both in vitro and in vivo
17360756 These results suggest that, in the context of HIV replication, TRBP contributes mainly to the enhancement of virus production and that Dicer does not mediate HIV restriction by RNAi.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDneurofibromin 2 isoform 1TAR RNA binding protein 2 isoform aMerlin interacts with TRBP.-Pubmed
HPRDPKRTAR RNA binding protein 2 isoform a--Pubmed
BINDTAR RNA binding protein 2 isoform bTNF receptor-associated factor 4TRAF4 interacts with TARBP2.-Pubmed
HPRDTAR RNA binding protein 2 isoform aRNA binding motif protein 14--Pubmed
HPRDTAR RNA binding protein 2 isoform aTAR RNA binding protein 2 isoform a--Pubmed

Recent Publications on TARBP2:

Pubmed Logo
Characterization of the TRBP domain required for dicer interaction and function in RNA interference.
BACKGROUND: Dicer, Ago2 and TRBP are the minimum components of the human...
16th July, 2009
Virus-Cell Interactions Laboratory, Lady Davis Institute for Medical BMC Mol Biol. 2009 May 7;10:38.
DOI Direct Link
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression...
3rd April, 2009
Cancer Epigenetics Laboratory, Spanish National Cancer Research Centre Nat Genet. 2009 Mar;41(3):365-70. Epub 2009 Feb 15.
DOI Direct Link
Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.
PURPOSE: MicroRNAs (miRNA) are a class of small noncoding RNA molecules...
6th February, 2009
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Clin Cancer Res. 2008 Dec 1;14(23):7956-62.
DOI Direct Link
TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.
The TAR RNA binding Protein, TRBP, inhibits the activity of the...
15th January, 2009
Virus-Cell Interactions Laboratory, Lady Davis Institute for Medical Mol Cell Biol. 2009 Jan;29(1):254-65. Epub 2008 Oct 20.
DOI Direct Link
Characterization of the two genes differentially expressed during development in human fetal astrocytes.
Astrocytes are ubiquitous in the brain and have multiple functions. It is...
10th February, 2004
Department of Neurology, Yonsei University Wonju College of Medicine, Yonsei Med J. 2003 Dec 30;44(6):1059-68.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7595159 Prediction of Parkinson's disease using gene expression levels of peripheral blood samples
6723534 Purified and isolated PIWI family genes and gene products and therapeutic and screening methods using same
6706867 DNA array sequence selection

TARBP2 results (if any) from reagent suppliers

Google CSE Logo
TRBP2 (E-25) Antibody sc-134110
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, TARBP2, 6895, 12q13.13, Q15633 ...
http://www.scbt.com/datasheet-134110-trbp2-e-25-antibody.htm...

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Abgent - Transcription and Regulation Antibodies ...
AT4152aNEW, TARBP2 monoclonal antibody (M01), ELISA,IF,RNAi-Ab,WB-Ce,WB-Re, H. AT4153aNEW, TARBP2 monoclonal antibody (M04), ELISA,WB-Ce, H ...
http://www.abgent.com/products/category/nuclear_signaling/tr...

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Dicer (H-212) Antibody sc-30226
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat. Genet. 41: 365-370. View PubMed Entry. Cheever, A. et al. 2009.
...
http://www.scbt.com/datasheet-30226-dicer-h-212-antibody.htm...

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Dicer (H-212) Antibody sc-30226
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat. Genet. 41: 365-370. PubMed Entry 보기. Rybak, A. et al. 2008. ...
http://www.scbt.com/ko/datasheet-30226-dicer-h-212-antibody....

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< 전 5 논문 >
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat. Genet. 41: 365-370. PubMed Entry 보기. Cheever, A. et al. 2009.
...
http://www.scbt.com/ko/product.php?datasheet=30226&page=1&to...

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