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BTK
| Symbol: | BTK | | Name(s): | Bruton agammaglobulinemia tyrosine kinase | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AGMX1, AT, ATK, BPK, IMD1, MGC126261, MGC126262, PSCTK1, XLA | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16159644 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18022864 |
Plasmacytoid dendritic cells express a signalosome consisting of Lyn, Syk, Btk, Slp65 (Blnk) and PLCgamma2. |
| 17932028 |
Btk as a key signaling molecule that interacts with and acts downstream of TLR8 and TLR9. |
| 18051214 |
Of 9 CVID patients from a single Taiwanese tertiary care hospital, we identified 2 cousins with decreased Btk expression who had a mutated (Asp521Val) kinase domain of Btk (1694A>T in exon 15) |
| 17707910 |
A first report of an X-linked Agammaglobulinemia patient with a polymorphism in Btk SH3 domain has been identified after sequencing of the entire gene. |
| 12437073 |
CD40 is a surface receptor through which the activity of Btk can be stimulated in human B cells. |
| 15082835 |
Conservation and covariance in mutations of BTK domain sequences causing agammaglobulinemia were studied. |
| 11877742 |
Interaction between Btk TH and SH3 domain |
| 16751014 |
Btk is not essential for early lipopolysaccharide signaling in human monocytes. |
| 16141323 |
lack of BTK expression or expression of dominant-negative splice variants in B cell precursor leukemia cells can (i) inhibit differentiation beyond the pre-B cell stage and (ii) protect from radiation-induced apoptosis | →View more information from publications. |
Recent Publications on BTK: |  |
[Shopping addiction--the new face of Mammon]
The cooperation of stem cell factor (SCF) and erythropoietin (Epo) is... | 24th October, 2009
| Pecsi Tudomanyegyetem, BTK, Szocialis Munka es Szocialpolitika Tanszek,
| Lege Artis Med. 2009 May;19(4-5):354-7.
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Absence of mature peripheral B cell populations in mice with concomitant defects in B cell receptor and BAFF-R signaling.
Generation of mature B lymphocytes from early (T1) and late transitional... | 22nd October, 2009
| Department of Microbiology and Immunology, Vanderbilt University School of
| J Immunol. 2009 Nov 1;183(9):5630-43.
DOI Direct Link |
NF-kappaB regulates the transcription of protein tyrosine kinase Tec.
The tyrosine kinase expressed in hepatocellular carcinoma (Tec) is a... | 22nd October, 2009
| Department of Laboratory Medicine, Clinical Research Center, Karolinska
| FEBS J. 2009 Oct 16.
DOI Direct Link |
Reduced Diabetes in btk-Deficient Nonobese Diabetic Mice and Restoration of Diabetes with Provision of an Anti-insulin IgH Chain Transgene.
Type 1 diabetes results from T cell-mediated destruction of... | 21st October, 2009
| Departments of *Medicine.
| J Immunol. 2009 Oct 19.
DOI Direct Link |
IL-5- and eosinophil-mediated inflammation: from discovery to therapy.
IL-5 was originally defined as a T-cell-derived cytokine that triggers... | 13th October, 2009
| Laboratory of Immune Modulation, National Institute of Biomedical
| Int Immunol. 2009 Oct 9.
DOI Direct Link |
→View more research publications. |
Press Releases on BTK:
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| Pharmacyclics Announces Poster Presentations and Clinical Update at the 51st Annual Meeting of the American Society of Hematology |
12th November, 2009 |
Pharmacyclics, Inc. |
SUNNYVALE, Calif., Nov. 12 /PRNewswire-FirstCall/ -- Pharmacyclics, Inc. (Nasdaq: PCYC) today announced that posters related to PCI-24781 and PCI-32765 have been selected for presentation at
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| New Options for Treatment of RA and Lupus are Focus of Rheumatology Thought Leader Panel |
6th November, 2009 |
MedPredict |
-- Role of other mechanisms, including CTLA4, IL-6, IL-17, JAK, Syk,
TNF/PDE4, BTK, MEK, and S1P.
Companies/Partnerships mentioned in this report include: Abbott
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| BioTech Stock Report - Summer Doldrums |
1st August, 2003 |
Biotechsage |
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BTK results (if any) from reagent suppliers | 
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