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TRA@


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Symbol:TRA@
Name(s):T cell receptor alpha locus
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ22602, MGC117436, MGC22624, MGC23964, MGC71411, TCRA, TCRD, TRA, TRDD3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
11142503 Observational study of gene-disease association. (HuGE Navigator)
17785774 CD4positive CD25high regulatory T cells showing immunosuppressive functions use a large unrestricted alpha beta T cell receptor repertoire, the size and diversity of which are closely similar to those of CD4-positive CD25negative T cells.
12444131 Self Ag recognition is mediated predominantly by TCR-alpha.
17082594 T cell receptor alpha-chain usage plays a critical role in controlling major histocompatiblity complex (MHC) restriction between closely related allomorphs.
16424183 Data are compatible with an instructive role for the TCR in alphabeta vs gammadelta lineage commitment, with gammadelta development as the default pathway for human thymocyte development.
17015149 different enzymatic activities operate during recombination of TCRA and TCRD genes, although they are located within the same genetic locus
12473666 constitutive pre-TCR down-modulation regulates pre-TCR surface expression levels and hence the extent of ligand-independent signaling through the pre-TCR
11920559 Human T cells potentially recognize through the alpha beta TCR HLA-E molecules that bind to class I- and virus-derived peptides.
17391765 T cell receptor V-J alpha recombination in the thymus is not random but depends on the reciprocal V alpha and J alpha position within the locus.
15128794 Transgenic expression of the natural killer (NK) T cell-specific TCR alpha-chain Valpha14Jalpha18 leads to a complete restoration of NK T cell numbers in tyrosine kinase Fyn-deficient mice.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDcalnexin precursorTRA@ protein--Pubmed
HPRDcalnexin precursorTRA@ protein--Pubmed
HPRDCD3 DeltaTRA@ protein--Pubmed
HPRDCD3D antigen, delta polypeptide isoform A precursorT-cell antigen receptor, alpha--Pubmed
HPRDCD3E antigen, epsilon polypeptide precursorTRA@ protein--Pubmed
HPRDCD3E antigen, epsilon polypeptide precursorTRA@ protein--Pubmed
HPRDCD3 gammaTRA@ protein--Pubmed
HPRDCD3G antigen, gamma polypeptide precursorT-cell antigen receptor, alpha--Pubmed
HPRDT-cell antigen receptor, zetaTRA@ protein--Pubmed
HPRDT-cell receptor zeta chain isoform 1 precursorT cell antigen receptor, alpha--Pubmed

Press Releases on TRA@:

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Schering-Plough Reports Financial Results for 2009 Third Quarter 22nd October, 2009 Schering-Plough Corporation
-- New product launches in Japan, the world's second largest pharmaceutical market, including ASMANEX (mometasone furoate) for asthma and REMERON (mirtazapine) for major
Schering-Plough's Investigational Oral Thrombin Receptor Antagonist Meets Primary Endpoint in a Newly Published Study 12th March, 2009 Schering-Plough Corporation

A Phase II Study Published in The Lancet of Fast-Tracked Antiplatelet Agent Showed No Increase in TIMI Major and Minor Bleeding and was Well Tolerated When Given With Standard

Schering-Plough Highlights R&D Pipeline Progress, Innovation and Breadth of Research Projects 24th November, 2008 Schering-Plough Corporation

KENILWORTH, N.J., Nov. 24 /PRNewswire-FirstCall/ -- Leaders of Schering-Plough Corporation (NYSE: SGP) today provided an update for investors on the company's research pipeline, highlighting

Schering-Plough Reports Financial Results for Second Quarter of 2008 21st July, 2008 Schering-Plough Corporation

KENILWORTH, N.J., July 21 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP) today reported financial results for the second quarter of 2008.

"We are very

BioNews Results for TRA@

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Merck Announces Completion of Patient Enrollment in Phase III TRA-2P-TIMI 50 Trial of SCH 530348, a Novel, Oral Antiplatelet PAR-1 Inhibitor
Business Wire UK:  Nov 13 2009 1:41PM Matching: tra
Merck Announces Completion of Patient Enrollment in Phase III TRA-2P-TIMI 50 Trial of SCH 530348, a Novel, O
Business Wire:  Nov 13 2009 1:41PM Matching: tra
Merck Announces Completion of Patient Enrollment in Phase III TRA-2P-TIMI 50 Trial of SCH 530348, a Novel, Oral Antiplatelet PAR-1 Inhibitor
FinanzNachrichten.de:  Nov 13 2009 1:41PM Matching: tra
Merck Announces Completion of Patient Enrollment in Phase III TRA-2P-TIMI 50 Trial of SCH 530348, a Novel, Oral Antiplatelet PAR-1 Inhibitor
Stockwatch:  Nov 13 2009 1:40PM Matching: tra
Merck Announces Completion of Patient Enrollment in Phase III TRA-2P-TIMI 50 Trial of SCH 530348, a Novel, Oral Antiplatelet PAR-1 Inhibitor
Yahoo! Canada:  Nov 13 2009 5:02PM Matching: tra
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Patents:

Patents logo
US Patent No.Title
7574580 Intelligent caching scheme for streaming file systems
7586361 Semiconductor device comprising a charge pump operated by clock signals
7586366 Complex filter circuit
7587291 Focusing of broadband acoustic signals using time-reversed acoustics
7588774 Molecules enhancing dermal delivery of influenza vaccines

View more patents.

TRA@ results (if any) from reagent suppliers

Google CSE Logo
Tra-2 Antibody / Tra-2 Antibodies
Tra-2 Antibody / Tra-2 Antibodies. ... Tra-2 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-tra-2.html...

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TRA-1-81 antibody [TRA-1-81] - Embryonic Stem Cell Marker (ab16289 ...
The monoclonal antibody TRA-1-81 is a marker of Human Embryonic Stem, Germ and Carcinoma Cells but Not Mouse Embryonic Stem, Germ or Carcinoma Cells. ...
http://www.abcam.com/TRA-1-81-antibody-TRA-1-81-Embryonic-St...

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TNAP (TRA-2-54) Antibody sc-21707
See how others have used TNAP (TRA-2-54): sc-21707 antibody and or TNAP ... D1 cells stained with TNAP (TRA-2-54), followed by FITC-conjugated goat ...
http://www.scbt.com/datasheet-21707-TNAP-tra-2-54-antibody.h...

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Biotin Anti-human TRA-1-81 Antibody Anti-TRA-1-81 - BioLegend
Biotin Anti-human TRA-1-81 Antibody Anti-TRA-1-81 - The TRA-1-81 antibody reacts with a 200-240 kD cell surface antigen expressed by human embryonic stem ...
http://www.biolegend.com/biotin-anti-human-tra-1-81-antibody...

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Alkaline Phosphatase, Tissue Non-Specific antibody [3H414 (TRA-2 ...
Mouse monoclonal [3H414 (TRA-2-49)] to Alkaline Phosphatase, Tissue Non-Specific . Alkaline Phosphatase is a hydrolase enzyme responsible for removing ...
http://www.abcam.com/Alkaline-Phosphatase-Tissue-Non-Specifi...

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TRA-1-60 (TRA-1-60) Antibody sc-21705
See how others have used TRA-1-60 (TRA-1-60): sc-21705 antibody and or ... Western blot analysis of TRA-1-81 (A) and TRA-1-60 (B) expression in NTERA-2 cl.
...
http://www.scbt.com/datasheet-21705-tra-1-60-tra-1-60-antibo...

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human TRA-1-81 antibody, Phycoerythrin (PE) conjugate
eBioscience technical data sheet for product 12-8883 Phycoerythrin (PE) anti- human TRA-1-81 (podocalyxin) TRA-1-81 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_12/12-...

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