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BUB1B
| Symbol: | BUB1B | | Name(s): | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | BUB1beta, BUBR1, Bub1A, MAD3L, SSK1, hBUBR1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17210994 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17268814 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17498870 |
BUB1B mRNA levels but not MAD2L1 levels correlate with intrachromosomal insttability in ductal breast carcinomas. |
| 11907259 |
BubR1 and Mad2 act cooperatively to prevent premature separation of sister chromatids by directly inhibiting the anaphase-promoting complex |
| 16411201 |
Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint is associated with premature chromatid separation syndrome |
| 14576821 |
we identified the mitotic checkpoint protein BubR1 as a novel binding partner of BCSG1 |
| 15475955 |
n five families with mosaic variegated aneuploidy, including two with embryonal rhabdomyosarcoma, we identified truncating and missense mutations of BUB1B, which encodes BUBR1, a key protein in the mitotic spindle checkpoint. |
| 15190214 |
Taken together, our study suggests that Plk3 and Aurora A kinases may lie in the same regulatory pathway and that Plk3 and Aurora A as well as BubR1 may play an important role in polyploidization and megakaryocytic differentiation. |
| 17478512 |
Identification of promoter regions that are involved in the transcriptional regulation of the BUB1 gene. |
| 11792804 |
As part of a common complex in checkpoint-activated cells, BubR1 monitors different spindle events compared to Bub1 and integrates different signals into a single signal that is then relayed to the downstream cell cycle machinery. | →View more information from publications. |
Recent Publications on BUB1B: |  |
Identification of genes associated with progression and metastasis of advanced cervical cancers after radiotherapy by cDNA microarray analysis.
PURPOSE: To identify a set of genes related to the progression and... | 28th October, 2009
| Department of Radiology, Takii Hospital, Kansai Medical University,
| Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):1232-9.
DOI Direct Link |
Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase.
Polyploid endothelial cells are found in aged and atherosclerotic... | 23rd October, 2009
| 1The University of Western Ontario.
| Am J Physiol Cell Physiol. 2009 Oct 21.
DOI Direct Link |
BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells.
BubR1 is a critical component of the mitotic checkpoint that delays the... | 17th September, 2009
| Department of Radiation Biology, Research Institute for Radiation Biology
| Oncogene. 2009 Aug 6;28(31):2806-20. Epub 2009 Jun 8.
DOI Direct Link |
Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice.
Aneuploidy is defined as numerical abnormalities of chromosomes and is... | 16th September, 2009
| Department of Medicine, Hematology/Oncology Section, University of
| Carcinogenesis. 2009 Sep;30(9):1469-74. Epub 2009 Apr 16.
DOI Direct Link |
Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.
In order to identify new genes with differential expression in early... | 17th July, 2009
| Molecular and Population Genetics Laboratory, London Research Institute,
| Hum Mol Genet. 2008 Dec 15;17(24):3864-75. Epub 2008 Sep 9.
DOI Direct Link |
→View more research publications. |
BUB1B results (if any) from reagent suppliers | 
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Bub1b Antibody
Specificity/Sensitivity: Bub1b Antibody detects endog- enous levels of total Bub1b protein. ... Lys370 of human Bub1b. Antibodies are purified by Protein ...
http://www.cellsignal.com/pdf/4116.pdf...
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Bub1b-CT. Sheep Polyclonal Antibody , Mouse
30 Aug 2007 ... named Bub1b. The yeast mitotic checkpoint pathway is ... Antibody detects Bub1b in mitotic cells seperated from NIH/3T3 cells by IP/Westen ...
http://www.exalpha.com/pdfs/X1161P.pdf...
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Bub3 Antibody
which contains Bub1, Bub1b, Bub3, Mad2 and Cdc20, con- trols chromosome segregation and ... in Bub1b have been found in mosaic variegated aneuploidy ...
http://www.cellsignal.com/pdf/3049.pdf...
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Abgent - Phosphorylation Antibodies - Phosphorylation
AT1320a, BUB1B monoclonal antibody (M01), ELISA,IF,IHC-P,WB-Re, H. AP8059a, BUBR1 (BUB1B) Antibody (N-term), WB, IHC, E, H ...
http://www.abgent.com/products/category/protein_modification...
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Bub3 Antibody #3049
The Mitotic Checkpoint Complex (MCC) , which contains Bub1, Bub1b, Bub3, ... Bub3 binds both Bub1 and Bub1b, facilitating their recruitment to kinetochores
...
http://www.cellsignal.com/products/3049.html...
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BUBR1 (N-20) Antibody sc-16193
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, BUB1B, 701, 15q15.1, NM_001211 ...
http://www.scbt.com/datasheet-16193-bubr1-n-20-antibody.html...
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Cell Cycle/Checkpoint Control
4116 Bub1b Antibody. New. 3049 Bub3 Antibody. 2543 Phospho-cdc2 (Thr14) Antibody . 4539 Phospho-cdc2 (Tyr15) (10A11) Rabbit mAb ...
http://www.cellsignal.com/about/marketing/pdfs/cellcycle_100...
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