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TSPO
| Symbol: | TSPO | | Name(s): | translocator protein (18kDa) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | BZRP, DBI, IBP, MBR, PBR, PKBS, PTBR, mDRC, pk18 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18256758 |
Sharp inhibition of apoptosis and changes in the levels of cell proliferation in tumor cells were paralleled by decreased expression of peripheral benzodiazepine receptor in patients with squamous cell carcinoma & skin melanoma. |
| 11304832 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16511838 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18158327 |
These findings reveal a previously unidentified pathway of the membrane integration of MOM proteins with multiple TMSs of the PBR. |
| 17561806 |
TSPO is located in mitochondrial membranes of HT-29 and reveal that its activation induces a rise in cytosolic Ca(2+), leading to the stimulation of Cl(-) secretion. |
| 16919618 |
Our results showed an up-regulation of peripheral-type benzodiazepine receptor (PBR) in platelets of FM patients, and this seems to be related to the severity of fibromyalgic symptoms. |
| 16511838 |
Study provides new and important evidence that variation in the PBR gene influences susceptibility to panic disorder. |
| 16868661 |
the intensity and extent of staining for PBR had a strong direct correlation with the grade of malignancy of the tumor, along with proliferative and apoptotic indices. The highest expression of PBR was in glioblastomas grade IV. |
| 15648546 |
Our results represent first evidence of PBRs in parathyroid glands and suggest for them a role in influencing PTH release. A clear trend of PBR up-regulation in parathyroid adenoma was also found. |
| 15473257 |
our results supported the hypothesis that PBR controls T-cell maturation and suggested mechanisms through which PBR may regulate thymocyte-positive selection. | →View more information from publications. |
Recent Publications on TSPO: |  |
Preservation of TSPO by chronic intermittent hypobaric hypoxia confers antiarrhythmic activity.
Abstract Abnormal activation of mitochondrial translocator protein (TSPO)... | 30th October, 2009
| Key Laboratory of Arrhythmias, Ministry of Education of China, Shanghai
| J Cell Mol Med. 2009 Oct 23.
DOI Direct Link |
TSPO Targeted Dendrimer Imaging Agent: Synthesis, Characterization, and Cellular Internalization.
While it has become common practice for dendrimers to deliver imaging and... | 30th October, 2009
| Department of Chemistry, The Vanderbilt Institute for Chemical Biology and
| Bioconjug Chem. 2009 Oct 28.
DOI Direct Link |
Human biodistribution and radiation dosimetry of (11)C-(R)-PK11195, the prototypic PET ligand to image inflammation.
PURPOSE: The positron emission tomography (PET) radiotracer... | 29th October, 2009
| Turku PET Centre, University of Turku and Turku University Hospital, P.O.
| Eur J Nucl Med Mol Imaging. 2009 Oct 28.
DOI Direct Link |
The Spontaneous Ala147Thr Amino Acid Substitution within the Translocator Protein Influences Pregnenolone Production in Lymphomonocytes of Healthy Individuals.
The de novo production of steroids and neurosteroids begins in... | 23rd October, 2009
| Department of Human Morphology and Applied Biology (B.C.), University of
| Endocrinology. 2009 Oct 21.
DOI Direct Link |
ABA, porphyrins and plant TSPO-related protein.
We have shown that, unexpectedly, AtTSPO (Arabidopsis thaliana... | 20th October, 2009
| Institut des Sciences de la Vie, Molecular Physiology Group (FYMO), Croix
| Plant Signal Behav. 2009 Nov 12;4(11).
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→View more research publications. |
TSPO results (if any) from reagent suppliers | 
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PBR (W-12) Antibody sc-23418
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, TSPO, 706, 22q13.2, NM_000714, ...
http://www.scbt.com/datasheet-23418-pbr-w-12-antibody.html...
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BZRP Antibody (C-term)
Translocator protein; Peripheral-type benzodiazepine receptor; PBR; PKBS; Mitochondrial benzodiazepine receptor; MBR; BZRP; TSPO ...
http://www.abgent.com/products/catalog_no/AP6606b_BZRP_Antib...
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C0424 PK 11195
Gene Information, human ... BZRAP1(9256), TSPO(706). rat ... Gabra2(29706), Tspo (24230). Safety. WGK Germany, 3. RTECS, NW6987000. References ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C042...
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PBR (W-12) Antibody sc-23418
Humano, TSPO, 706, 22q13.2, NM_000714, NM_007311 · P30536 · 109610. camundongo, Tspo, 12257, 15 E1, P50637, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-23418-pbr-w-12-antibody.htm...
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P1-PC
TSPO(706), human, WB, pricing. HPA015629, Anti-PBRM1 antibody produced in rabbit , (polyclonal), affinity isolated antibody, human ... PBRM1(55193) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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PBR (W-12) Antibody sc-23418
种属, 基因名称, 基因ID, 染色质位置, 亚型（mRNA）即位号码, 蛋白质即位号码, OMIM™ 号码. 人类, TSPO, 706, 22q13.2, NM_000714, NM_007311 · P30536 ...
http://www.scbt.com/zh/datasheet-23418-pbr-w-12-antibody.htm...
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D8555 N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
solubility, methanol: 20 mg/mL. H2O: insoluble. Gene Information, human ... BZRAP1(9256). rat ... Tspo(24230). storage temp. 2-8°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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