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TNNI3
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18032382 |
A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin |
| 16157639 |
The crystal structure of troponin suggests that the Ca2+-binding to the regulatory TnC site displaces the N-terminal portion of TnI from actin/tropomyosin, thereby altering mobility/flexibility of the troponin/tropomyosin strand on the actin filament. |
| 16199542 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16754800 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17101185 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18175163 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18092822 |
These results suggest that the perturbations of the N-domain caused by the Trp mutation disturb the interaction between TnC and TnI, which in turn diminishes the activity in fibers. |
| 18042489 |
Modulation of cardiac troponin C function by the cardiac-specific N-terminus of troponin I: influence of PKA phosphorylation and involvement in cardiomyopathies. |
| 17101185 |
spectrum of mutations in cardiac hypertrophy patients |
| 17587709 |
Persistently increased serum concentrations of cardiac troponin (cTn) in patients with acutely decompensated heart failure are predictive of adverse outcomes. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Actin alpha, skeletal muscle 1 | troponin I, cardiac | - | - | Pubmed |
| HPRD | pregnancy-associated plasma protein A preproprotein | troponin I, cardiac | - | - | Pubmed |
| HPRD | polycystin 2 | troponin I, cardiac | - | - | Pubmed |
| HPRD | troponin C, slow | troponin I, cardiac | - | - | Pubmed |
| HPRD | troponin I, cardiac | troponin T1, skeletal, slow | - | - | Pubmed |
| HPRD | troponin I, cardiac | TNNI3 interacting kinase isoform b | - | - | Pubmed |
| HPRD | troponin I, cardiac | TNNI3 interacting kinase isoform b | - | - | Pubmed |
| HPRD | troponin I, cardiac | polycystic kidney disease 2-like 1 | - | - | Pubmed |
| HPRD | troponin I, cardiac | polycystic kidney disease 2-like 1 | - | - | Pubmed |
Recent Publications on TNNI3: |  |
Electrochemiluminescent immunoassay for rat skeletal troponin I (Tnni2) in serum.
INTRODUCTION: The identification of xenobiotic-induced skeletal muscle... | 1st October, 2009
| Investigative Toxicology, Eli Lilly and Company, Lilly Corporate Center,
| J Pharmacol Toxicol Methods. 2009 Sep 26.
DOI Direct Link |
Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy.
RATIONALE: Idiopathic dilated cardiomyopathy (DCM) is inherited in... | 23rd September, 2009
| Department of Cardiovascular Medicine, University of Oxford, Wellcome
| Circ Res. 2009 Aug 14;105(4):375-82. Epub 2009 Jul 9.
DOI Direct Link |
Low prevalence and variable clinical presentation of troponin I and troponin T gene mutations in hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder caused... | 4th August, 2009
| Cardiocenter, Department of Cardiology, 3rd Faculty of Medicine, Charles
| Genet Test Mol Biomarkers. 2009 Oct;13(5):647-50.
DOI Direct Link |
Diagnostic yield, interpretation, and clinical utility of mutation screening of sarcomere encoding genes in Danish hypertrophic cardiomyopathy patients and relatives.
The American Heart Association (AHA) recommends family screening for... | 29th May, 2009
| Department of Clinical Biochemistry, Statens Serum Institute, Copenhagen,
| Hum Mutat. 2009 Mar;30(3):363-70.
DOI Direct Link |
Genetic and clinical profile of Indian patients of idiopathic restrictive cardiomyopathy with and without hypertrophy.
Both idiopathic restrictive cardiomyopathy (IRCM) and hypertrophic... | 19th May, 2009
| Department of Experimental Medicine and Biotechnology, Post Graduate
| Mol Cell Biochem. 2009 Nov;331(1-2):187-92. Epub 2009 May 17.
DOI Direct Link |
→View more research publications. |
TNNI3 results (if any) from reagent suppliers | 
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Troponin I (H-170) Antibody sc-15368
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, TNNI3, 7137, 19q13.42, NM_000363 ...
http://www.scbt.com/datasheet-15368-troponin-i-h-170-antibod...
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Stem Cell Antibodies :: Page 7
TNNI3 Monoclonal Antibody, 49-810, H, M, C, Rb, X, E, WB, IHC, Troponin I, Cardiac Muscle. TNNT2 Monoclonal Antibody, 49-184, H, WB, IHC, IP, Troponin T
...
http://www.prosci-inc.com/shop/catalog1/Stem-Cell-Antibodies...
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cardiac Troponin I antibody [2D5] (ab7829) | Abcam
... by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3). ...
http://www.abcam.com/cardiac-Troponin-I-antibody-2D5-ab7829....
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Abgent - Cell and Structure Antibodies - Cell_structure
AT4291aNEW, TNNC1 monoclonal antibody (M01), ELISA,IHC-P,S-ELISA,WB-Re, H. AT4292aNEW, TNNI3 monoclonal antibody (M04), ELISA,IHC-P,RNAi-Ab,WB-Re, H ...
http://www.abgent.com/products/category/cell_function/cell_s...
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MURF1 antibody (ab4125) | Abcam
Note=Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes. Referenced from Swiss-Prot entry Q969Q1. Research areas ...
http://www.abcam.com/MURF1-antibody-ab4125.html...
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Native Proteins - GenWay Biotech Inc.
TNNI3; TNNC1 - NATIVE HUMAN TROPONIN I; Troponin I, cardiac muscle ... TNNI3; TNNC1 - Troponin I and C-Cardiac >95% Pure; Cardiac troponin I; Troponin I, ...
http://www.genwaybio.com/all_native_proteins.php?fl=T...
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Stem cell product list
Certified LUX™ Primer for Human TNNI3. 463H-01. Isolation. Characterization www. invitrogen.com/stemcell. Page 36. 36. Stem Cell Research. HLA typing ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/pdf.Pa...
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