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TP53


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Gene DB Home
Symbol:TP53
Name(s):tumor protein p53
Type:protein-coding
Organism:Homo sapiens
Synonyms:LFS1, TRP53, p53
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17975552 the potential use of R-Roscovitine as a bitargeted anticancer drug that functions by simultaneously causing p53 activation and NF-kappaB suppression.
18025081 DEC1 is induced by the p53 family and DNA damage in a p53-dependent manner. p53 family proteins bind to, and activate, the promoter of the DEC1 gene.
18238895 p53-mediated apoptosis occurs by a PIDD- and caspase 2-dependent mechanism, and p53's full transcriptional regulatory functions may be required only for events that are downstream of cytochrome c release
18282133 the functions of p53 play substantial roles in many other pathologies as well as in the aging process [review]
17683074 results suggest that gene-smoking and gene-gene interactions may impact the prevalence of p53 mutations in breast tumors
17849423 p53 codon-249 mutations are associated with X-ray repair cross complementing protein 1 polymorphism Arg399Gln among the Guangxi population of China.
17849424 p53 mutations at CpG dinucleotides provide further evidence for a molecular link between chronic inflammation and esophageal malignancy.
17918207 among p53 Arg/Arg carriers, HPV infection, smoking, and drinking might further increase the risk of esophageal squamous cell carcinoma development
17970695 These data suggest a more complex role for TRIM22 during T lymphocyte activation than merely as an antiproliferative factor.
18038118 mutant p53 loses its ability to suppress DNMT1 expression, and thus enhances methylation levels of the p16 ( ink4A ) promoter and subsequently down-regulates p16(ink4A )protein.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDABLtumor protein p53--Pubmed
HPRDv-abl Abelson murine leukemia viral oncogene homolog 1 isoform ap53--Pubmed
HPRDADP ribosyl transferasetumor protein p53--Pubmed
HPRDApex nucleasetumor protein p53--Pubmed
BINDAPEX nucleasetumor protein p53p53 interacts with Ref-1.-Pubmed
HPRDAPEX nucleasep53--Pubmed
HPRDactivating transcription factor 3 isoform 1tumor protein p53--Pubmed
HPRDactivating transcription factor 3 isoform 1tumor protein p53--Pubmed
BINDactivating transcription factor 3 isoform 1tumor protein p53An unspecified isoform of ATF3 interacts with p53.-Pubmed
HPRDATMtumor protein p53--Pubmed

Recent Publications on TP53:

Pubmed Logo
The emerging role of the distal Fallopian tube and p53 in pelvic serous carcinogenesis.
In their paper in this issue of the Journal, Xian et al have analysed in...
3rd November, 2009
Bute Medical School, University of St Andrews and Department of Pathology, J Pathol. 2009 Sep 25.
DOI Direct Link
Detailed haplotype analysis at the TP53 locus in p.R337H mutation carriers in the population of Southern Brazil: evidence for a founder effect.
Due to patterns of migration, selection, and population expansion, founder...
31st October, 2009
International Agency for Research on Cancer (IARC), Lyon, Rhone, 69372, Hum Mutat. 2009 Oct 29.
DOI Direct Link
Concurrent sequence variation of TP53 and TP73 genes in anaplastic astrocytoma.
Disruption or loss of tumor suppressor gene TP53 is implicated in the...
31st October, 2009
Departamento de Genetica, Laboratorio de Oncogenetica, Faculdade de Genet Mol Res. 2009 Oct 20;8(4):1257-63.
DOI Direct Link
p53 expression by immunohistochemistry is an important determinant of survival in patients with chronic lymphocytic leukemia receiving frontline chemo-immunotherapy.
Although chromosome 17p abnormalities and TP53 mutations have been...
30th October, 2009
Department of Hematopathology. Leuk Lymphoma. 2009 Oct;50(10):1597-605.
Benzene-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the functional analysis of separated alleles in yeast, in human lung cells.
Recent concern has centred on the effects of continuous exposure to low...
29th October, 2009
LCE EA2598, Toxicologie Industrielle et Environnementale, Universite du Arch Toxicol. 2009 Oct 28.
DOI Direct Link

View more research publications.

BioNews Results for TP53

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TP53 PIN3 and MDM2 SNP309 polymorphisms as genetic modifiers in the Li-Fraumeni syndrome: impact on age at fir
Journal of Medical Genetics:  Oct 30 2009 5:54PM Matching: tp53
TP53 PIN3 and MDM2 SNP309 polymorphisms as genetic modifiers in the LiFraumeni syndrome: impact on age at firs
Journal of Medical Genetics:  Oct 30 2009 5:09PM Matching: tp53

Clinical Trials:

Clinical Trials Logo
rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors

Patents:

Patents logo
US Patent No.Title
7452727 Method for increasing clinical specificity when detecting tumors and their precursor stages by simultaneously measuring at least two different molecular markers
7504225 Reagents and methods for use in cancer diagnosis, classification and therapy
7510881 Method and kit for the quantitative and/or qualitative detection of components in a sample
7517650 Method of diagnosing breast cancer and compositions therefor
7521446 Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith

View more patents.

TP53 results (if any) from reagent suppliers

Google CSE Logo
TP53 Antibody
Specific antibody for the gene product of TP53, the protein Tumor protein p53. Validated for specificity by gene-silencing with siRNA followed by Western ...
http://www.piercenet.com/products/Browse.cfm?fldID=1F59907A-...

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Polyclonal Antibody to TIGAR (TP53-induced glycolysis and ...
Polyclonal Antibody to TIGAR (TP53-induced glycolysis and apoptosis regulator). Catalog No : IMG-5910A. Formulation : 100 ug in 200 ul PBS containing 0.2% ...
http://www.imgenex.com/tds/IMG-5910A.pdf...

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TP53 protein, p53 Human recombinant protein
Buy quality TP53 protein (e. coli), TP53, p53 Human recombinant protein, (n/an/a ). p53 Protein Human Recombinant; Tumor suppressor p53; Phosphoprotein p53; ...
http://www.genwaybio.com/product_info.php?products_id=45596...

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Antibodies to p53 and Related Proteins
rat ... Tp53(24842) human ... TP53(7157), rat, human, mouse, IHC (p), IP, WB, pricing ... human ... TP53(7157), human, ELISA (i), ICC, IHC, IP, WB, pricing
...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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P53 antibody, p53 (Phospho-Ser46) Antibody, Rabbit Polyclonal Antibody
Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). Binds DNA as a homotetramer. Interacts with histone acetyltransferases EP300 ...
http://www.genwaybio.com/product_info.php?products_id=210332...

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iASPP antibody (ab34898) | Abcam
This protein also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the
...
http://www.abcam.com/iASPP-antibody-ab34898.html...

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p53 antibody, p53 [DO-1] Antibody, Mouse Monoclonal Antibody
Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). ... TP53 is frequently mutated or inactivated in about 60% of cancers. ...
http://www.genwaybio.com/product_info.php?products_id=193756...

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