Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17975552 |
the potential use of R-Roscovitine as a bitargeted anticancer drug that functions by simultaneously causing p53 activation and NF-kappaB suppression. |
| 18025081 |
DEC1 is induced by the p53 family and DNA damage in a p53-dependent manner. p53 family proteins bind to, and activate, the promoter of the DEC1 gene. |
| 18238895 |
p53-mediated apoptosis occurs by a PIDD- and caspase 2-dependent mechanism, and p53's full transcriptional regulatory functions may be required only for events that are downstream of cytochrome c release |
| 18282133 |
the functions of p53 play substantial roles in many other pathologies as well as in the aging process [review] |
| 17683074 |
results suggest that gene-smoking and gene-gene interactions may impact the prevalence of p53 mutations in breast tumors |
| 17849423 |
p53 codon-249 mutations are associated with X-ray repair cross complementing protein 1 polymorphism Arg399Gln among the Guangxi population of China. |
| 17849424 |
p53 mutations at CpG dinucleotides provide further evidence for a molecular link between chronic inflammation and esophageal malignancy. |
| 17918207 |
among p53 Arg/Arg carriers, HPV infection, smoking, and drinking might further increase the risk of esophageal squamous cell carcinoma development |
| 17970695 |
These data suggest a more complex role for TRIM22 during T lymphocyte activation than merely as an antiproliferative factor. |
| 18038118 |
mutant p53 loses its ability to suppress DNMT1 expression, and thus enhances methylation levels of the p16 ( ink4A ) promoter and subsequently down-regulates p16(ink4A )protein. |
| 17916908 |
compromise of either p53 or Rb pathways during melanocyte transformation leads to up-regulation of survivin expression in melanoma |
| 17984111 |
p53 homolog, p63, may participate in governing global repair instead of p53 in keratinocytes |
| 18161655 |
the presence of both HPV infection and TP53 mutations may define a particular group of tumors with a more aggressive phenotype in advanced oral squamous cell carcinoma |
| 18161662 |
circulating anti-p53 antibodies (anti-p53Ab) in sera of cancer patients may have a role in disease progression |
| 18267949 |
p53 is required for the efficient removal of cross links in human cells; cytotoxic cross links persist in p53-deficient cells. |
| 18334838 |
Changes in p53 expression seen in urothelial and sinonasal inverted papillomas suggest they may share common evolution. |
| 17932466 |
p53 function is not sufficient to suppress glucose uptake in cells and tumors that could theoretically support aerobic glycolysis. |
| 18092951 |
The proliferative activity and p53 overexpression increased with the dedifferentiation of tranitional cell bladder carcinoma. |
| 18197409 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18205229 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18225585 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18226366 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18230179 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18234542 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18240345 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18248785 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18249029 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18256523 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18258602 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18259947 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18262501 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 18265644 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18269649 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18270339 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 18271927 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18280004 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18280645 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18281248 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18288414 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18313915 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18314181 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18314620 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18318116 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18322661 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18332046 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18336951 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18348141 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18355840 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 18357466 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18361427 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18363031 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18223210 |
although HPV16 (human papiloma virus 16) and mutated p53 may coexist in a subset of squamous cell carcinomas of the head and neck, HPV16 and disruptive p53 mutations seem to be nonoverlapping events |
| 18234963 |
These results indicate that in thyroid cancer cells, TAp73alpha is able to increase p53 protein level and function by interfering with Mdm2-mediated p53 degradation. |
| 18234968 |
SS18-SSX1 can negatively regulate p53 tumor-suppressive function by increasing the stability of its negative regulator HDM2. |
| 18000166 |
ability of p53 to down-modulate osteoprotegerin production by endothelial cells may be an additional important mechanism |
| 18022393 |
homeodomain interacting protein kinase 4 phosphorylates p53 at serine 9 is important for p53 mediated transcriptional repression. |
| 18048390 |
p63 exhibits several transcriptional and stress-response properties similar to those of p53 |
| 18172257 |
germ line and somatic alterations of the p53 pathway influence the incidence and survival of ovarian carcinoma |
| 18205229 |
in a Portuguese population, the p53 R72P polymorphism is not associated with an increased susceptibility to squamous intraepithelial lesions or cervical cancer development |
| 18243116 |
that Skp2 controls p300-p53 signaling pathways in cancer cells, making Skp2 a potential molecular target for cancer therapy. |
| 17971485 |
defects in the p53 regulatory cascade do not appear operational in this leukemia |
| 17562177 |
P53 immunohistochemical profile may be useful in detecting colorectal adenomas with a malignant potential. |
| 17636382 |
These findings suggest novel Cdk1/cyclin A phosphorylation sites, which appear to be associated with p53-independent cell death following etoposide treatment. |
| 17728781 |
During fludarabine treatment of Raji and MEC1 cells, proteolytic derivatives of p53 with MW of ~47 and ~40 kDa appeared. There were 8 phosphorylated forms. These could play crucial roles in apoptosis induction. |
| 17676397 |
Study shows that p53 over expression in Crohn's Disease is associated with dysplasia that may progress to a higher grade of neoplasia over time. |
| 17704262 |
p53 mutation was exhibited in pulmonary sclerosing haemangioma. The mutation rate in polygonal cells was higher than that in surface cuboidal cells |
| 18334006 |
p53 is of limited value only, being largely overshadowed by the prognostic capability of FIGO stage and extent of residual disease. |
| 18176677 |
A high proportion of familial microsatellite instability cases and a lower incidence of TP53 mutations were found in Saudi colorectal carcinoma. |
| 18032786 |
The increase of cell membranous phosphatidylcholines containing unsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR. |
| 18230337 |
Our results indicate that nicotinamide treatment attenuates p21WAF1 expression through Sp1 downregulation, and suggest a possible involvement of nicotinamide metabolism in cellular gene expression. |
| 18230339 |
These studies suggest that PARC-interacting peptides are promising candidates for the enhancement of p53-dependent apoptosis in tumors with wt cytoplasmic p53. |
| 18259947 |
p53 codon 72 and intron 3 polymorphisms are associated with non-small cell lung cancer |
| 18172861 |
a network involving signal coactivation of NF-kappaB and STAT3, differentially modified by p53 inactivation or mutation, promotes altered BAX/BCL-XL expression and cell survival in HNSCC. |
| 18088404 |
Distinct rare missense mutations of the TP53 gene were detected in Capi1 (codon 312) and Capi3 (codon 181); the codon 181 mutation is consistent with a previously reported similar finding in a small series of CUP specimens. |
| 18265644 |
The data support that the frequencies and patterns of somatic mutation of the p53 genes in colorectal cancer are variable among populations. |
| 17477370 |
P53 mediated regulation of metallothionein transcription in breast cancer cells is reported. |
| 17638920 |
P53 Arg72Pro and MDM2 T309G polymorphisms contribute to the risk of developing stomach cancer. |
| 18251181 |
Current study showed p53 was associated with induction of apoptosis and cell proliferation in early stage gastric cancers, but not in the subserosa of advanced gastric cancer. |
| 17696741 |
An animo acid substituition is a risk factor for breast cancer. |
| 17690113 |
Isoleucine 31-type p53 may be partly involved in familial gastric cancer because of its low transcriptional activity and low cell proliferation suppressing activity. |
| 17693666 |
Risk for head and neck squamous cell carcinoma may be assocated with single-nucleotide polymorphism in the promoter region. |
| 17724467 |
Some mutant forms can be reactivated by amifostine, mostly in the DNA-binding domain. |
| 18208803 |
a combined expression of survivin and p53 was associated with an increased risk of tumor local progression. |
| 18225585 |
TP53 mutations reduce the prostate cancer (PCa)-free survival time in patients with needle biopsy of the prostate and primary benign diagnosis; Exon 6 mutations enhance the risk of being affected by PCa 32-fold |
| 14741326 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14744727 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 14756543 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14764039 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 14997055 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15023836 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15033824 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15036661 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15036662 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15041222 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15069555 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15099969 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15104366 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15105048 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15120697 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15138483 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15140517 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15145278 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 15158001 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15177663 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15183530 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15183535 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15183536 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15216398 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15230885 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15240512 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15257943 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15263792 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15272143 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15273281 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15291355 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15313891 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15334668 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15355915 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15365822 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15450681 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15523694 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15533911 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15534883 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15554555 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15555357 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 15564800 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15566643 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15573180 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15583690 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15598783 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15608028 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15609317 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16492918 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16499995 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16507123 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16524972 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16525684 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16542834 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 16552814 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16554913 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16569330 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16609366 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16611260 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16625286 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 16629527 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16631474 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16644204 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16646561 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16691626 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 16697770 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16699611 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16710704 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16721749 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16721787 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16739124 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16739339 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16750013 |
Observational study of gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16761419 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16786124 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16788846 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16797751 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16808798 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16818665 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16818855 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16835330 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16835507 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16864176 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16865671 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 16896365 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16912209 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16912210 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16918534 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16930632 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16973168 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 16984108 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16988840 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16989164 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16996204 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16121365 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11597326 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11668523 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 11682637 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 11708408 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11710828 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11746272 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11779589 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11807792 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11814547 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11815410 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 11828992 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11836677 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11844595 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11845987 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11856771 |
Observational study of genotype prevalence, gene-disease association, and gene-environment interaction. (HuGE Navigator) |
| 11872638 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11888672 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11927843 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11983757 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11996107 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12019159 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12036913 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12039466 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12060398 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12065086 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12071291 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12082592 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 12084746 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12115545 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12144687 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12144822 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12161031 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12164325 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 12164929 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12168882 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12170762 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12171773 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12203403 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12221910 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12365037 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 12368717 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12376521 |
Observational study of genetic testing. (HuGE Navigator) |
| 12430182 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12434294 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12445252 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12445680 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12458344 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12470840 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12471629 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12496062 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 12527466 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12530090 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12534455 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12550754 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12556232 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12575207 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12582031 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12635827 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12648751 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 12670525 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12684392 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 12684648 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12708345 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 12796380 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12802680 |
Observational study of gene-environment interaction. (HuGE Navigator) |
| 12818446 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12820330 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12820398 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12824702 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12830514 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12838617 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12840112 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 12875622 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12883749 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12893432 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12911720 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12917199 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 12921568 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12926080 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12935924 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12940438 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 14507241 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14513722 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 14577584 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 14581358 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14617836 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14634508 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14641293 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14644340 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14654539 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 14673037 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14675203 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14678586 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14719475 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14734461 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15623478 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15633234 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15634502 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15639342 |
Observational study of genotype prevalence and gene-environment interaction. (HuGE Navigator) |
| 15651660 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15654624 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 15670080 |
Observational study of gene-environment interaction. (HuGE Navigator) |
| 15704837 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15721419 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15723718 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15734961 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15756275 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15764300 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15774209 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15802278 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15814626 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15837541 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15838728 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15841715 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15844595 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15844633 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15848594 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 15899386 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15905603 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15906354 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15950766 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15958551 |
Observational study of gene-environment interaction. (HuGE Navigator) |
| 15960923 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15966238 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15979781 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15981211 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15987456 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15991278 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16004824 |
Observational study of genetic testing. (HuGE Navigator) |
| 16007417 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16009172 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16014569 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16024113 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16030116 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16033823 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16039051 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16054204 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16061860 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16077965 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16080524 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16103461 |
Observational study of genetic testing. (HuGE Navigator) |
| 16105905 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16110022 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16111803 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16489069 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17007666 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17574348 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17587242 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17595776 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17597242 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17599946 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17606709 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17607506 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17622940 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17624591 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17624602 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17631738 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17634560 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17638920 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17653713 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17671760 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17683073 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17683074 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 17684142 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17693666 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17696741 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17719241 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17727479 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17767549 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 17785079 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17785557 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17786186 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17849423 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17854663 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17881637 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17908995 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 17909070 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 17912468 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 17918207 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17925548 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17927872 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17931634 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17932356 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17934643 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17949449 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17954263 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17960397 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17970074 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17980001 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 17980096 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17981213 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18006764 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18024870 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17573955 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16122882 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16128105 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16129609 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16131817 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16140998 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16144912 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16161633 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 16168468 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16172235 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16172461 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16174251 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16183105 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16199549 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16200870 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16203772 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16211227 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16229746 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16230424 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 16243804 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16255923 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16258005 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 16271069 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16272802 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16287156 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16289503 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16289646 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16302680 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16314399 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 16318864 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16331344 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16331559 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16353134 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16354872 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16362795 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16364249 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16407418 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16418181 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16434591 |
Observational study of genotype prevalence and genetic testing. (HuGE Navigator) |
| 16434604 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16458962 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16459017 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16465622 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16477330 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16487937 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16488468 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12467072 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18058229 |
Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18058461 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18067229 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18068527 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18076421 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18094375 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18094376 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18159026 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18159160 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18161363 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18161655 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18172257 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18181044 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17018785 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17059853 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 17072987 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17094395 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17096342 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17096406 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17113725 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17118779 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17118968 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 17120592 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17151932 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17171684 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17177838 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17186536 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17208332 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17223878 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17224235 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17259658 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17284368 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17301252 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17306604 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17319790 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17326708 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17341484 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17350822 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17354442 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17369602 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17374954 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17387621 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17390072 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17400331 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17400332 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17403527 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17409195 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17409930 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17428325 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17449902 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17492690 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17495352 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17504512 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17531965 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17535973 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17537232 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17541742 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17546594 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
| 17557246 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17557566 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14740296 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15621215 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11566488 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11002963 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11024482 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11045785 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11097227 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11130248 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11146230 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11165394 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11174479 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11240705 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11255264 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11259085 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11293726 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 11429426 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11458982 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11501650 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11504770 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11507974 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 11519852 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 11535556 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11564578 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17063386 |
Expression of p53 expression was weak or not detected in dental follicles with reduced and stratified squamous epithelium |
| 17938176 |
p53 activity is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes |
| 18061646 |
Examine interaction between TP53 and the C-terminal fragment of p53 (M protein). |
| 18089732 |
HHV-6B induces p53 Ser392 phosphorylation by an atypical pathway independent of casein kinase 2 protein and p38 kinases. |
| 18230179 |
Findings suggest TP53 PIN3 Ins16bp polymorphism as a real risk modifier in breast cancer disease, either in sporadic and familial breast cancer. Furthermore, both TP53 polymorphisms are associated with higher incidence of lymph node metastases. |
| 17593335 |
These data provide evidence that there is a novel signaling pathway from Dishevelled to p53. |
| 18068527 |
In this first assessment of the role of TP53 Arg72Pro polymorphism in a large series of Portuguese glioma tumors, no association was observed with glioma susceptibility or overall survival, except for patients submitted to adjuvant therapy. |
| 18164407 |
Genetic alterations of the p53 tumor suppressor gene were seen in a mixed serous carcinoma of the endometrium. |
| 17497677 |
Pathways of signaling by S100A4, by its interaction with and sequestration of p53, and by Notch also seem differentially operational in the induction of apoptosis |
| 17499344 |
initially p53-negative tumors and initially p63-positive tumors that retain this labeling pattern may follow less aggressive biological courses and present better prognoses |
| 17275163 |
Renal cell carcinoma frequently has p53 mutations, so therapy restoring p53 may markedly improve the response rate of immunochemical therapy combining IFN-alpha and 5-FU. |
| 17721438 |
Data show that knockdown of either p53,but not p16(INK4a) or Rb, allows cells to bypass premature senescence that is induced by BS69 knockdown. |
| 17689819 |
accumulation of VRK1 in tumours with mutant p53 could result in stimulation of other signalling pathways |
| 17881637 |
TP53 DNA-binding mutations were the most significant predictor of poor OS; TRAILreceptor-2 (DR5) was the most differentially underexpressed gene in the TP53 mutated cases |
| 18041310 |
Alterations in the expression of p53, survivn, and bcl-2 take place in a concerted fashion, implying that many of these cases may share common abnormalities. |
| 18084613 |
There is heterogeneity in the requirement for transactivation subdomains 1 and 2 of p53 without any subdomain-specific contribution to p53-induced gene expression. |
| 18084622 |
In etoposide-treated LNCaP cells, p53 bound the AR promoter, which contains a potential p53 DNA-binding consensus sequence. loss of p53 function in prostate cancer cells contributes to increased expression of AR. |
| 18091325 |
this study failed to demonstrate correlation between maspin loss and p53 expression in malignant melanoma using both individual slides and tissue microarray of carcinomas. |
| 18091326 |
Maspin expression is inversely correlated with mutant p53 expression in gastric cancer, which suggests that maspin expression is regulated by the p53 pathway. |
| 17990259 |
Compar. proteome anal.to RNA expr. array showed modest correl. of RNA and protein level = relevance of post-trans. regul. in lymphomagenesis. Data bank search identified 13 out of 17 referenced proteins (76%) as members of a TP53-dependent network. |
| 18184270 |
The expression of iNOS induces oxidative stress in nasopharyngeal carcinoma. p53 mutation was associated with iNOS overexpression. This suggests that the p53 gene is not the direct target of DNA damage by 8-OHdG accumulation. |
| 17066464 |
A new G-to-A transition at position +1 at the invariant G at the exon 8 donor splice site leads to numerous aberrant splicing-products. |
| 17982662 |
study showed higher frequency of p53 mutations in esophageal adenocarcinoma (EAC)than previously reported, but only as a late event in carcinogenesis; 72R allelic polymorphism was of potential significance in the development of Barrett esophagus &/or EAC |
| 17427234 |
R248W may predispose to composite tumors and to neuroblastoma in individuals with Li-Fraumeni syndrome. |
| 17942278 |
Immunohistochemistry localized elevated p53 to a mainly nuclear distribution in neurons and glia in sections from temporal lobe epilepsy hippocampus |
| 17719241 |
The results indicate protective associations of p53 Arg72Pro heterozygous variant with postmenopausal and MDM-2 SNP309G along with p53 Arg72Pro heterozygous variant with premenopausal breast cancer risk. |
| 17919692 |
results of the present study have indicated that p53 mutations occur at the ileovesical anastomosis in patients who have undergone clam ileocystoplasty |
| 18199527 |
An important role for autophagy in tumor suppression via full-length ARF in both p53-dependent and p53-independent manners, depending on cellular context. |
| 17897960 |
There is no association between radon exposure and p53 expression, indicating that maybe the effect of radon is not mediated through p53 alterations. |
| 17709397 |
Results identify cross talk between the p53 and nonsense-mediated mRNA decay pathways that regulates the expression levels of H-ras splice variants. |
| 18060030 |
CP-31398 induced mitochondrial translocation of p53, leading to changes in mitochondrial membrane permeability pore transition (MPT) and consequent cytochrome c release in these cells. |
| 16760300 |
Eighteen mutations (12 missense, one nonsense, two deletions, three nucleotide substitutions at the level of the splice-junctions) and two polymorphisms were detected by FAMA in 17 patients with colorectal cancar. |
| 16760301 |
In 50 of the 66 primitive colorectal tumor cases at least one significant alteration was identified in Ki-Ras and/or TP53 and/or p16(INK4A) genes. |
| 17488404 |
The evaluation of a large number of actinic keratosis specimens have found a low gene mutation rate in low-graded AK lesions. p53 mutations rather than p16(INK4a) and/or Ha-ras mutations may be an early event in the development of AK to cutaneous SCC. |
| 18097574 |
P53 overexpression and changes in phenotypic expression could contribute to the malignant transformation of colorectal precursor lesions. |
| 18097575 |
linear relationship and prognostic role of the p53/p21/PCNA pathway in gastrointestinal stromal tumors. Abnormalities of the p53/p21WAF1 pathway lead to increased proliferating states, thereby triggering the progression of GISTs. |
| 17412337 |
p53 codon 72 polymorphism in Italian women have a minor role in determining genetic susceptibility to endometriosis |
| 17487454 |
A new signaling pathway, DHA-PPAR-gamma-p53, in mediating the apoptotic effect of DHA in Reh cells. |
| 17318340 |
a family with Li-Fraumeni syndrome in which initially a novel germline TP53 intron 5 splice site mutation was found |
| 18067855 |
The culture of cells in the Cl(-)-replaced medium significantly increased expressions of p21 mRNA and protein without any effects on p53. |
| 18050226 |
The increased apoptosis of peripheral blood lymphocytes from adult-onset Still's disease patients may be associated with the effect of IL-18 through up-regulation of FasL and p53 transcripts. |
| 18172499 |
NUMB enters in a tricomplex with p53 and the E3 ubiquitin ligase HDM2 (also known as MDM2), thereby preventing ubiquitination and degradation of p53 |
| 17530187 |
Over expression of H179Y-mutant p53 promoted G1 to S phase transition with enlarged cell size and increased cyclin A1 and Cdk4 expression in HELF cells. |
| 17694537 |
the p53 protein encoded by the 770delT allele is as abundant as the wild-type protein, as removal of the C-terminal p53 domain leads to a stabilized mutant protein, whose abundance is markedly increased when NMD is inhibited. |
| 18088187 |
suggests the unique role of Chk1 in preventing abrogation of the G2 checkpoint in p53+/+ cells |
| 18089646 |
Inactivation of p53 may be associated with the appearance of central consolidation within pure ground-glass opacity (GGO) on HRCT which reflects invasive features and may be useful as a molecular marker. |
| 18160537 |
interplay between TFIIEalpha and the tumor suppressor protein p53 in regulating transcriptional activation that may be modulated by the phosphorylation status of p53 |
| 17525743 |
direct interaction between HAUSP and p53 is not absolutely required for it to antagonize efficiently Mdm2-mediated ubiquitination of p53 |
| 17998337 |
reveal a novel p53 apoptotic pathway in which it initiates apoptosis by transcriptionally repressing ARC |
| 18181044 |
p53 Arg72Pro heterozygous genotype was overall an independent prognostic factor...of lung cancer |
| 17198740 |
By comparing the expression of p53, cyclin D1, p16, hTERT, and TSP-1 in spontaneously regressing keratoacanthoma and squamous cell carcinoma, the changes in the expression of these proteins to specific stages of skin carcinogenesis, is defined. |
| 17533375 |
transcription mediated by p53 is impaired by mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic |
| 17604627 |
a crucial role of p53 in determining p27 upmodulation following HER2 activation |
| 17906639 |
Data suggest that Pin1 is required for efficient loading of p53 on target promoters upon stress, and that after phosphorylation of p53 triggered by cytotoxic stimuli, Pin1 mediates p53's dissociation from iASPP, promoting cell death. |
| 18035504 |
levels of p53/p21waf1 mRNA in blood lymphocytes collected before chemotherapy may predict the chemoresponses of lung cancer patients. |
| 16912210 |
germ-line p53 mutations and sex had significant effects on cancer risk in patients with Li-Fraumeni syndrome |
| 17546594 |
the p53 codon 72 polymorphism may be associated with gastric cancer among Asians, and that difference in genotype distribution may be associated with the location, stage, and histological differentiation of gastric cancer (Review) |
| 17932356 |
Here we report a significant trend toward lower frequency of TP53 mutations with increasing number of Pro72 alleles (P = 0.02). Overall, Pro72 allele carriers had significantly lower frequency of TP53 mutations compared with Arg72 homozygotes (P = 0.02). |
| 17982131 |
TP53 mutations are frequent events in bladder cancer progression and gelsolin relates to TP53 status, tumor staging and clinical outcome. |
| 17762884 |
p53 is a direct transcriptional target gene of hPitx1. This observation is concordant with the recent identification of hPitx1 as a tumor suppressor gene. |
| 17982625 |
Combination of PTEN/p53/PCNA represent an independent prognostic factor for tumor recurrence and disease-specific survival in hepatocellular carcinoma after surgery. |
| 17996705 |
The acetylation of two lysine residues in p53 promotes recruitment of the TFIID subunit TAF1 to the p21 promoter through its bromodomains. |
| 17505880 |
tissue-specific epigenetic regulatory mechanisms might be involved in p53 instability in breast cancer. |
| 17599613 |
Coxsackievirus B3 (CVB3) infection markedly reduced ATF3 expression at mRNA and protein levels in parallel with p53 degradation, and preservation of p53 expression rescued CVB3 infection-induced ATF3 downregulation. |
| 17804819 |
insulin-like growth factor binding protein-5 plays a role in the regulation of cellular senescence via a p53-dependent pathway and in aging-associated vascular diseases |
| 17897950 |
the ectopic expression of IKKalpha into cells silenced for USP11 restores p53 expression, demonstrating that USP11 functions as an upstream regulator of an IKKalpha-p53 signaling pathway. |
| 15923428 |
This meta-analysis produced evidence for interesting tumor site differences in the predictive value of TP53 mutation for survival benefit from 5FU chemotherapy. |
| 15923430 |
Specific TP53 mutations in L3 domain alone (only in DFS) or in combination with specific Ki-ras mutations at codon 13 are associated with a worse prognosis in sporadic Colorectal cancer. |
| 17646389 |
Results suggest that the cross talk between lysine methylation and acetylation is critical for p53 activation in response to DNA damage and that Set7/9 may play an important role in tumor suppression. |
| 17949684 |
p53 plays a role in regulation of replication timing of the human genome through the control of cell-cycle checkpoints. |
| 17982649 |
Human head and neck squamous cell carcinoma cells transfected with mutant TP53 injected subcutaneously into hind legs of nude mice show reduced sensitivity due to repair of radiation-induced damage. |
| 18021719 |
Extent of mutation predicts response to antineoplastic agents. |
| 17909070 |
this large collaborative study did not find an association of MDM2 SNP309 and TP53 R72P, separately or in interaction, with breast cancer |
| 17917588 |
study describes the presence of different p53 gene mutations in astrocytic gliomas in direct correlation to histologic characteristics of dissected tumor areas |
| 17979566 |
Results show that p53 seemed to have a significant role in cellular glucose metabolism and G2/M checkpoint, according to beta-irradiation, and could cause a different therapeutic response of (18)F-FDG uptake in cancer cells. |
| 18087040 |
nuclear apoptosis repressor with caspase recruitment domain (ARC)is induced in cancer cells and negatively regulates p53 |
| 18089819 |
p53 status should be taken into account when deciding which therapeutic drug to use in glioblastoma multiforme. |
| 18059557 |
Splicing fidelity is p53 dependent. |
| 17252199 |
Data suggest that cytoplasmic mutant p53 increases Bcl-2 expression in estrogen receptor-positive breast cancer cells. |
| 17913397 |
These data suggest that P1 promoter is the main driving force for transcribing the bcl-2 gene and P1 activity is modulated by M and P2 in a p53-dependent and -independent manner. |
| 16682429 |
Immunohistochemical detection of TP53 expression is a biomarker of malignant progression in Barrett's oesophagus but sensitivity is too low to act as a criterion to inform endoscopic surveillance strategies. |
| 18019675 |
Serum p53 antibodies are expressed in the early stages of colorectal cancer |
| 18019682 |
dThdPase, but not mutant p53, plays an important role in tumor angiogenesis in ductal adenocarcinoma of the pancreas |
| 18089808 |
Hsp27 may play a general role in regulation of cellular senescence by modulating the p53 pathway. |
| 18025460 |
p53 dissociation from some promoters is due to DNA-mediated charge transport through the base-pair stack. Photo-oxidative dissociation, despite being triggered from distance, is sequence-selective. Disulfide bonds are formed. |
| 18040854 |
Activation of p53 mediated pathways in the glia of HIV-associated dementia patients may contribute to neuroinflammatory processes that promote neurodegeneration by inhibiting glial proliferation and/or promoting glial cell dysfunction. |
| 17914225 |
study to identify the common factors governing the DNA-binding loss of p53c upon substitution of Arg 273 to His or Cys,which are abundant in human tumour |
| 18076421 |
The codon72 and IVS7+72C>T polymorphisms of the p53 gene are unlikely to contribute to the pathogenesis of idiopathic male infertility with spermatogenetic failure. |
| 17592964 |
Nutlin-3 abrogates both pre-osteoclastic proliferation and differentiation through a p53-dependent pathway |
| 17662641 |
Downregulation of caveolin-1 expression affects bleomycin-induced cell cycle arrest and subsequent cellular senescence that is driven by p53 and p21. |
| 17942552 |
K-cyclin/Cdk9 interaction greatly enhanced the kinase activity of Cdk9 toward p53. |
| 18042465 |
Based on these results, we conclude that HO activity is involved in the regulation of p53 expression in a ROS-independent mechanism. |
| 17306604 |
The Pro/Pro genotype of the TP53 codon72 polymorphism increases oral cancer risk in non-smokers and worsens their prognosis. |
| 17939878 |
Embryos have varying sensitivity to the stresses of production and culture in vitro, and this resulted in variable expressivity of TRP53. |
| 17964266 |
Active regulator of SIRT1 (AROS) is the first direct SIRT1 regulator to be identified that modulates p53-mediated growth regulation. |
| 17974918 |
The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. |
| 17912468 |
p53 Arg/Arg genotype does not seem to represent a risk marker for the development of cervical lesions in the majority of the European countries analysed. |
| 17981213 |
Single nucleotide polymorphisms within p53 are associated with chronic lymphocytic leukemia. |
| 17221157 |
type of TP53 mutation, especially missense mutation, is a strong prognostic indicator for disease-free survival and disease-specific survival in node-negative breast cancer, particularly in combination with ERBB2 amplification |
| 15933740 |
There is positive role for PI3K in p53 activation by anticancer agents, and suggest that the efficacy of PI3K inhibitors in cancer therapy may be greatly affected by the tumor p53 status. |
| 17716930 |
It is recorded that borealin is a cell cycle regulator, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. |
| 17918160 |
by NF-kappaB activation, Tax elevates the level of the cellular p53 in human T-cells |
| 17954561 |
reveal a direct regulatory connection between p53-responsive stress signaling and Hbo1-dependent chromatin pathways |
| 17967874 |
show an important link between ATM activity and the tumor-suppressive function of B56gamma-protein phosphatase 2A |
| 17984062 |
Mutation of the IP6-binding sites impair oligomerization, reduce interaction with Mdm2, and inhibit p53-dependent antiproliferative effects of beta-arr2 |
| 18036557 |
Furthermore, results indicate that induction of apoptosis in HCT-116 p53(wt) cells after ibuprofen treatment is in part dependent on a signalling pathway including the neutrophin receptor p75(NTR), p53 and Bax. |
| 17957137 |
This review discusses implications of recent studies of the capacity of p53 to control the expression of specific microRNAs which may subsequently become involved in cancer and other critical biological processes. |
| 17957141 |
The ultimate activation status of p53 target genes can be defined at steps downstream of p53 binding to chromatin and p53iated recruitment of histoneifiying activities. |
| 17599045 |
p53 NLS-selective nuclear import pathway and that both soluble and insoluble proteins are involved in its function. |
| 17965547 |
We conclude that the free radical scavenger edaravone suppresses X-ray-induced apoptosis in MOLT-4 cells by inhibiting p53. |
| 17671841 |
our data support the view that patients with P53 overexpression are significantly associated with an unfavorable outcome, whereas |
| 17935714 |
p53 is an indispensable component of cellular signaling system which is regulated by caveolin-1 expression, involving Akt activation and increase in cyclin D1, thereby promoting proliferation of breast cancer cells. |
| 18003932 |
ChIP and expression studies for individual genes indicate that human endogenous retrovirus p53 sites are likely part of the p53 transcriptional program and direct regulation of p53 target genes |
| 17912039 |
p53 is predominantly nuclear and functional in neuroblastoma regardless of differentiation status. |
| 17900613 |
molecular dynamics simulations of wild-type p53 and the R337His mutant at several different pH and salt conditions |
| 18056407 |
In alternative lengthening of telomere cells, TRF2 inactivation/silencing triggers cellular senescence and substantial loss of telomeric DNA upon stable TRF2 knockdown. |
| 18094375 |
Stroma-specific loss of heterozygosity or allelic imbalance is associated with somatic TP53 mutations and regional lymph-node metastases in sporadic breast cancer but not in hereditary breast cancer. |
| 18094376 |
Disruptive TP53 mutations in tumor DNA are associated with reduced survival after surgical treatment of squamous-cell carcinoma of the head and neck. |
| 17823933 |
Paclitaxel has potential for use as a radiosensitizer in the treatment of patients with prostate cancer with either wild-type or mutant p53 genetic status. |
| 17898049 |
Cells expressing mutant forms of E6 that are unable to bind p300/CBP or bind p53 failed to block acetylation of p53 at lysine 382 and were sensitive to growth arrest by interferon. |
| 17900801 |
AG490 enhances UCN-01-induced cytotoxicity in p53 defective cell lines by suppression of BAD phosphorylation and induction of BAX and PARP cleavage |
| 17977211 |
These results indicate that mutations and consequent dysfunction of P53 gene may result in chronic inflammation and hyperplasia in RA (Rheumatoid Arthritis) patients. |
| 17983802 |
Genome-scale chromosomal copy number alteration profiles and mutational statuses of p53 and beta-catenin in 87 hepatocellular carcinoma tumors were clarified. |
| 17855516 |
human papillomavirus 18 E6 protein sensitizes HeLa cells to Herpes simplex virus-dependent apoptosis through hTERT and p53. |
| 17908953 |
rerview of NF-kappaB gene signatures and p53 mutations in head and neck squamous cell carcinoma [review] |
| 17908957 |
NF-kappaB promotes expression of a novel NF-kappaB-related gene signature and cell survival in HNSCC that weakly express TP53, a subset previously associated with inactivated wild-type TP53, greater resistance to chemoradiotherapy, and worse prognosis |
| 17912449 |
MAGED2, a novel protein, is a p53-dissociator. |
| 17079356 |
p53 mutation and human papilloma virus mediated p53 inactivation possibly constitute two independent pathways of head and neck squamous cell carcinoma tumourigenesis |
| 17761206 |
These data implicate a role for p73 in squamous cell carcinoma of the oesophagus and suggest a complex interaction between p53, p73 and HPV in the aetiology of the disease. |
| 17938203 |
These findings provide evidence that activation of TP53 gene transcription by PKCdelta triggers TP53-dependent apoptosis in response to DNA damage. |
| 17471233 |
in addition to growth arrest and induced differentiation, OSM also sensitizes normal and transformed osteoblasts to apoptosis by a mechanism implicating (i) activation and nuclear translocation of STAT5 and p53 and (ii) an increased Bax/Bcl-2 ratio |
| 17535973 |
Tumor suppressor p53 Arg72Pro polymorphism leads to increased longevity, but not to decreased risk of cancer. |
| 17573896 |
data suggest that this tumor suppressor gene plays a critical role in the multistep carcinogenesis process for esophageal squamous cell cancer |
| 17855337 |
provide new insight into a potential role of p53 as a component involved in the dynamic regulation of the major pathway of cytotoxic T-lymphocyte-mediated cell death and may have therapeutic implications |
| 17575320 |
study reveals there are differences in the frequencies & types of K-ras & p53 mutations found in pancreatic adenocarcinomas of patients in high-pollution & low-pollution regions in Egypt & suggests that environmental factors may explain these differences |
| 17692879 |
The apoptogenic activity of BM-ANF1 was mediated through p53 tumor-suppressor gene expression followed by the expression of p21(Cip1) and p27(Kip1)linking it with cell cycle arrest at G1 phase in cancer cells. |
| 17804489 |
The targeted degradation of p53 by E6 may contribute to the invasive phenotype exhibited by cervical cells that contain high-risk HPV types. |
| 17875924 |
Mutant p53 attenuates TGF-beta1 signaling. This was exhibited by a reduction in SMAD2/3 phosphorylation and an inhibition of both the formation of SMAD2/SMAD4 complexes and the translocation of SMAD4 to the cell nucleus. |
| 17908790 |
Mutant and wild-type p53 proteins are ubiquitinated and degraded through overlapping but distinct pathways. |
| 17848574 |
ATP binding function of MDM2 can mediate its chaperone function toward the p53 tumor suppressor |
| 17981542 |
loss of IFI16 activates p53 checkpoint through NBS1-DNA-PKcs pathway |
| 18038880 |
p53 mutation is associated with non-small cell lung carcinoma |
| 17914575 |
Loss of TP53-DNA interaction induced by p.C135R point mutation in lung cancer |
| 17968145 |
High frequency of BRCA1/2 and p53 somatic inactivation in sporadic ovarian cancer. |
| 17910948 |
ZNF307 might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing p53 degradation |
| 17597242 |
We observed that the Pro72/Pro72 genotype of p53 is much less represented in children with nonsyndromic mental retardation than in controls and suggest that subjects carrying the Pro allele are protected from this disease. |
| 17954263 |
Individuals with the Pro/Pro genotype have an increased risk of developing nasopharyngeal carcinoma in Tunisia. |
| 17567834 |
Telomere length in peripheral blood cells of germline TP53 mutation carriers is shorter than that of normal individuals of corresponding age |
| 17653713 |
variant codon 72 p53 genotypes and the absence of the glutathione S transferase 1 (GSTM1) detoxification pathway, act in multiple myeloma disease progression |
| 17671760 |
these preliminary data suggest that polymorphism at codon 72 of the p53 gene influences the clinical course of ulcerative colitis, with continuous disease associated with p53 Pro homozygosity |
| 17848143 |
p53 and Ki-67, but not bcl-2, cyclin D1 or HER-2 may have roles in the process of tumor genesis in non-small cell lung carcinoma |
| 17854663 |
findings suggest no association between oligodendroglial tumors and the SNP in codon 72 of TP53; also no correlation was found among the TP53 codon 72 polymorphism and prognosis, p53 expression, and chromosomes 1p and 19q status |
| 17700068 |
Study reports that p18(Hamlet) can also mediate the cell cycle arrest induced in response to gamma-irradiation, by participating in the p53-dependent upregulation of the cell cycle inhibitor p21(Cip1) (CDKN1A). |
| 17627287 |
HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway. |
| 18006810 |
HPV16/18 E6 is expressed in HPV DNA-positive lung tumors and is involved in p53 inactivation to contributing to HPV-mediated lung tumorigenesis |
| 17936556 |
Discuss how tissue specificity, polymorphisms of genes associated with the p53 pathway, other genetic alterations, or p53 mutant heterogeneity can have a profound impact on the spectrum of p53 mutations (review). |
| 17641416 |
N33, STK11 (19p13) and TP53 might play a role in the development of metastasis in larynx and pharynx squamous cell carcinomas. |
| 17974978 |
Analysis of neuroblastoma cell lines indicated that in contrast to previous reports, wild-type p53 was fully functional in all neuroblastoma lines tested; inactivation of p53 in neuroblastoma cells resulted in establishment of a MDR phenotype. |
| 16912213 |
p53 mutations in plasma DNA from healthy individuals suggest that p53 mutations in plasma DNA may be a marker of carcinogen exposure from tobacco smoke. |
| 17936559 |
Wip1 acts as a gatekeeper in the Mdm2-p53 regulatory loop by stabilizing Mdm2 and promoting Mdm2-mediated proteolysis of p53. |
| 17936562 |
Loss of heterozygosity (LOH) of the hDMP1 gene was detectable in approximately 35% of human lung carcinomas, which was found in mutually exclusive fashion with LOH of INK4a/ARF or that of P53. DMP1 is a pivotal tumor suppressor for human lung cancers. |
| 17574348 |
two p53 haplotypes harboring the intron 3 polymorphic (+16bp) allele are associated with a higher risk of breast cancer in the Turkish population |
| 17721920 |
Activation of AKT, possibly through the PI3K-AKT pathway, is an important component of ASCC tumorigenesis that contributes to MDM2 and TP53 accumulation in the nucleus. |
| 17700029 |
levels of c-myc expression were up-regulated and those of p53 expression were down-regulated by HCV F protein. |
| 17671694 |
pGSK-3beta-ser-9 may confer the cisplatin resistance of ovarian carcinomas through the stabilization of p53 expression |
| 17785449 |
PC4 interacts with the DNA binding and C-terminal domains of p53 through its DNA binding domain, which is essential for the stimulation of p53 DNA binding. |
| 17869221 |
Though not formally excluded, these results do not support models in which p53 binds specific RNA partners in vivo. |
| 16951143 |
p53 preferentially occupied the promoters of growth arrest genes p21 and GADD45 in senescent normal human diploid fibroblasts. |
| 17556661 |
a new role for YY1 as both an inducer of p53 instability in smooth muscle cells, and an indirect repressor of p21WAF1/Cip1 transcription, p21WAF1/Cip1-cdk4-cyclin D1 assembly and intimal thickening. |
| 16818696 |
The rapid shift from a shorter p53 protein form (delta) toward the full-length protein (alpha) underscores the complexity of p53 protein modulation in patients undergoing chemotherapy. |
| 17145812 |
The p53 level was higher than in normal larynxes, whereas laryngeal cancer presented the lowest levels. |
| 17703463 |
Azurin binds to the flexible L(1) and s(7)-s(8) loops of the p53 DBD and stabilizes them through protein-protein tight packing interactions. |
| 17914240 |
This is an overview/review of studies of the p53-protooncogene protein MDM2 module and associated pathways from a systems biology perspective. |
| 17970074 |
Findings may indicate p53 codon 72 polymorphism as a risk factor for HNSCC. |
| 17972508 |
The combination of p53 and p21 expressions in biopsy findings can thus predict the histological effectiveness of hyperthermochemoradiotherapy. |
| 17678892 |
HPV18 E6 oncoprotein contributes to tumor angiogenesis by inducing VEGF transcription from the promoter in a p53-independent manner. |
| 15916722 |
Results indicate that the differential p53-regulated expression of survivin at different stages of the cell cycle results in different cellular outputs under the same apoptosis-inducer. |
| 16951228 |
The p53-positive tumors had more lymph node metastasis, and p53-positive had the worst prognosis with gastric cancer. |
| 17568776 |
phosphorylation of Pirh2 may act as a fine-tuning to maintain the balance of p53-Pirh2 autoregulatory feedback loop, which facilitates the tight regulation of p53 stability and tumor suppression |
| 17767549 |
modulation of p53Pro72Pro-mediated susceptibility to cervical cancer by immunogenetic factors could possibly be mediated through cross talk between HPV16/18-induced immune evasion and cell transformation |
| 17890905 |
In light of current treatment regimens for AIDS-related primary effusion lymphoma, this review discusses the benefits of using reactivation of the p53 pathway as a novel principle for the treatment of this virally induced highly aggressive malignancy. |
| 17593217 |
The combined immunohistochemical and genetic data of carcinoma ex pleomorphic adenoma and intraductal carcinoma showed genetic or morphological evidence of dysfunctional p53, indicating that this is an early event in malignant transformation. |
| 17651038 |
Deletion or mutational inactivation of the p53 gene represents an important step in the tumorigenicity of pancreatic cancer. |
| 17663506 |
KLF6 and p53 mutations are involved in the development of nonpolypoid colorectal carcinoma, whereas K-ras and B-raf mutations are not |
| 17905135 |
A strong correlation was found between the expression of p53 and p130, which was apparent in Stages 1 and 3, but not in Stage 2. These results suggest a novel p53/p130 axis in bladder tumors. |
| 17907599 |
We report the histological and genetic study of two glioblastomas, one case arising de novo and the other case arising 3 years after a previously diagnosed anaplastic astrocytoma, with concurrent EGFR amplification and TP-53 mutation |
| 17582679 |
The phosphorylation of p53 was associated with its transcriptional activity and stability modulated by LMP1 |
| 17616526 |
RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC. |
| 17631895 |
Changes in the intrinsic thermodynamic stability of p53 reduce the level of folded and hence functional p53 substantially in E. coli. |
| 17663418 |
Overexpression of stathmin is an early protumorigenic event in human hepatocarcinogenesis, and its up-regulation can be mediated by gain-of-function mutations in p53. |
| 17656095 |
The data suggest the miRNA34s might be key effectors of p53 tumor-suppressor function, and their inactivation might contribute to certain cancers. |
| 17690688 |
by disrupting the DNA binding activity of E2F1, BTG3 participates in the regulation of E2F1 target gene expression. Therefore, our studies have revealed a previously unidentified pathway through which the activity of E2F1 may be guarded by activated p53. |
| 17727479 |
Alterations in p53 were more commonly observed in localized GISTs at higher risk of relapse, and suggesting that they are significant as an independent, poor prognostic factor. |
| 17390072 |
results indicate an important role of p53 in esophageal squamous cell carcinoma (ESCC) also in low-incidence regions; in combination with the p53 Arg72 variant HPV infection could contribute to risk of ESCC in these cases |
| 17554370 |
KRAS G34A mutation was relatively common to all classes of specimen, whereas TP53 gene C742T and G818C mutations were significantly more frequent in lichen sclerosus than normal genital skin. |
| 17666403 |
CHIP might be a direct chaperone of wild type p53 that helps p53 in maintaining wild type conformation under physiological condition as well as help resurrect p53 mutant phenotype into a folded native state under stress condition. |
| 17684018 |
The up-regulation of PTEN inhibited Akt and MDM2, which enhanced the level of p53, thereby inducing G(2)/M arrest and apoptosis. |
| 17693405 |
TAp73 is a stress-response gene and a downstream effector in the p53 pathway |
| 17763087 |
Data suggest that cylindrospermopsin induces stress responses that result in the activation of the p53 transcription factor. |
| 17909016 |
In breast cancer, bone morphogenetic protein 7 (BMP7) is a novel target gene regulated by the p53 family and mediates the cell survival function of the basal physiologically relevant level of p53. |
| 17018618 |
ANXA7 and p53 can distinctly regulate LOX transcription that is potentially relevant to the arachidonic acid -mediated cell growth control in tumor suppression. |
| 17309603 |
p53 induces monocytic differentiation and the G2-phase cell cycle arrest, but not apoptosis of BM2 monoblasts, implying independence of the p53-driven apoototic and differentiation/proliferation pathways. |
| 17698841 |
HCMV uses a shift from p53 to HDM2 ubiquitination and destabilization to obtain protracted high levels of p53, while promoting cell cycle traverse |
| 17699158 |
Bcl-x(L) interacts with the DNA binding site of p53, but Bak does not interact with this site |
| 17575133 |
study of EGFR, HER2, TP53& KRAS mutations of p14arf expression of non-small cell lung cancers in relation to smoking |
| 17671118 |
p53 mutation is associated with intraductal papillary mucinous neoplasms of the pancreas |
| 17452980 |
p14ARF signals through hAda3 to stimulate p53 acetylation and the induction of cell senescence |
| 17653608 |
The results suggest that p53 expression in gonads of human male fetuses significantly increases in the 20th week. |
| 17676485 |
Alterations in TGF-betaRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 genes of microsatellite instability are rare in urinary bladder carcinoma and they are not associated with microsatellite instability or the presence of p53 mutations. |
| 17369843 |
Radiation-induced somatic mutations were observed in TP53 indicating an early role of TP53 in the radio-sarcomagenesis indicating gene activation in sarcoma. |
| 17650224 |
The expression of p53 was significantly higher in esophogeal squamous cell neoplasm than in non-tumorous tissue. |
| 17400332 |
Lack of evidence that p53 Arg72pro influences lung cancer prognosis: an analysis of survival in 619 female patients. |
| 17449902 |
Common variation in the TP53 gene could modify the risk of invasive breast cancer. |
| 17587242 |
study found that lymphomas harboring p53 missense mutation with/without nonsense mutation had a highly significantly larger nuclear gross area than lymphomas with silent p53 mutation or lacking mutation |
| 17694957 |
no mutation of p53 and RB2/p130 genes was identified in any of the blood samples from Malaysian nasopharyngeal carcinoma; there was an identical G-->4 C nucleotide change at codon 280 of p53 gene in all the NPC cell lines |
| 17360176 |
The researchers found that p53 (-) status was a solid predictor for FR in pre-radiation biopsy specimens. |
| 17611691 |
p53 like other binding partners of cdc25C, regulates entry into mitosis by binding to cdc25C |
| 17531965 |
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of gallbladder cancer among Japanese women and men, respectively. |
| 17569660 |
MEG3 non-coding RNA may function as a tumor suppressor, whose action is mediated by both p53-dependent and p53-independent pathways |
| 17886559 |
Tumors that contained wild-type p53 were significantly more likely to express WT1, and presence of WT1 in glioma support that WT1 expression is important in glioma biology. |
| 17567589 |
In C33-A cells, arsenic treatment leads to a transient increase in p53 followed by a drastic reduction in its nuclear levels and an increase in cell proliferation. |
| 17609875 |
Mutations in exons 5-9 of the p53 gene were screened for using the non-isotopic RNase cleavage assay (NIRCA) and confirmed by direct sequencing, followed by immunohistochemical analysis for p53 protein |
| 17805299 |
the histone lysine-specific demethylase LSD1 interacts with p53 to repress p53-mediated transcriptional activation and to inhibit the role of p53 in promoting apoptosis |
| 17699779 |
Results unravel a novel mechanism by which ERalpha opposes p53-mediated apoptosis in breast cancer cells. |
| 17404594 |
p53 can form a complex with dephosphorylated Bad thereby converting it to a pro-apoptotic player. |
| 16690525 |
in diffuse large B-cell lymphoma, molecular alterations in ice, bcl-2, c-myc and p53 are present in hematopoietic cells from bone marrow as well as in primitive hematopoietic progenitors |
| 16696307 |
it is concluded that mutation of p53 & deletion of p16 might play important roles in the tumorigenesis of gliomas and it was significantly associated with the grade of tumor differentiation; P53 protein accumulation can indirectly reflect p53 mutation |
| 17224235 |
study indicated only p53 & RNASEL genotypes had significant influence on age of onset of Lynch syndrome in an additive mode of inheritance & that effects of both variants are purely additive supporting the notion that p53 & RNaseL pathways do not interact |
| 17586686 |
In a proteomic screen for p53 interactors the cullin protein Cul7 efficiently associates with p53. |
| 17659731 |
TP53 mutations had low diagnostic accuracy for pancreatic neoplasms. |
| 17786186 |
Wild-type and mutant p53 are shown to differentially regulate MMP-13 expression in malignant peripheral nerve sheath tumors. |
| 17291568 |
The evolutionary perspective in this review indicates that p53 evolved so as to play a subtle but very important role during development, and suggests that p53 was primarily selected for its developmental role and not as a tumor suppressor gene. |
| 16897432 |
Wip1 overexpression abrogates the homeostatic balance maintained through the p38-p53-Wip1 pathway, and contributes to malignant progression by inactivating wild-type p53 and p38 MAPK as well as decreasing p16 protein levels in human breast tissues. |
| 17180249 |
This is the first report showing loss of heterozygosity at the intron 1 region of p53 gene in human brain tumors. |
| 17498291 |
transcription factors p53, NF-kappaB, and AP-1 may be important determinants of the heterogeneous pattern of gene expression, whereas STAT3 and EGR1 may broadly enhance gene expression in head and neck squamous cell carcinomas |
| 17599062 |
These findings support a novel p53 --> CDIP --> TNF-alpha apoptotic pathway that directs apoptosis after exposure of cells to genotoxic stress. |
| 17607506 |
Distribution of a single nucleotide polymorphism in the TP53 codon 72 (Arg/Pro) was studied in Southeast Asia and Oceania where information about this polymorphism was lacking. |
| 17613764 |
interphase Fish on samples from 30 MCL patients revealed p53 deletions in 13 cases |
| 17620186 |
In lung cancer patients, p53 accumulation could be due to a decrease in full-length MDM2 isoform together with an increase of the 57-kDa MDM2 isoform that was unable to stimulate p53 degradation. |
| 17671422 |
abrogation of p53 function in post-selection human mammary epithelial cells inactivates cell cycle checkpoints |
| 17713095 |
p53 expression may have a role in the carcinogenesis of squamous cell cervical carcinoma whereas Bcl-2 expression has no role. Ki-67 expression can not be used in determining the aggressiveness of CIN lesions |
| 16448698 |
No deletions were found in the p53 gene of these MD tumor cell lines, truncations in the p53 ORFs observed in this study might result from alternative splicing of the p53 gene. |
| 17059853 |
Risk of cancer is markedly increased in heavy smokers (>20 pack-years) with squamous-cell carcinoma carrying an amino acid substitution. |
| 17310983 |
S7 binds to MDM2, in vitro and in vivo, and the interaction between MDM2 and S7 leads to modulation of MDM2-p53 binding by forming a ternary complex among MDM2, p53 and S7. |
| 17576382 |
Photodynamic therapy resistant HT29 cell variants are differentially sensitized to UVA compared with UVC due, in part at least, through the altered expression levels of BNip3, Hsp27 and mutant p53. |
| 17406801 |
Non-small cell lung cancer cells with nonfunctional TP53 might be sensitized against radiation by genistein or estradiol. |
| 17628545 |
p53 mediates interstitial cystitis APF-induced growth inhibition of human urothelial cells. |
| 17709727 |
Patients with primary colorectal cancer with low TSP-1 expression, with or without detection of mp53 gene product, are more likely to harbor lymph node metastasis than patients with higher expression. |
| 17549665 |
BAG-1 negativity in association with p53 and c-erbB2 positivity identified a subgroup of tongue cancer patients with an aggressive phenotype |
| 17616578 |
transcription-based stress response involving replication protein A, ATR, and p53 has evolved as a DNA damage-sensing mechanism to safeguard cells against DNA damage-induced mutagenesis |
| 17523278 |
p53 genetic alterations found in gastric stump carcinomas & intestinal-type primary gastric carcinomas could originate from a similar pathway; no association found between p53 gene status & P-gp expression |
| 15756520 |
p53 protein expression in vivo does not correlate with the outcome of patients with primary in primary glioblastoma. |
| 17634554 |
Fluorouracil may show translational regulation and control p53 expression in a colon cancer cell line. |
| 17634560 |
TP53BP1 variants may have protective effects on head and neck cancer risk. |
| 17488735 |
impact of TP53 mutations and codon 72 genotype on survival of ovarian cancer patients |
| 17495352 |
mutations were found mainly in more advanced stages of urinary bladder cancer & at the CIS stage (carcinoma in situ); it cannot be excluded that the observed polymorphism at codon 213 may be a predisposing factor for urinary bladder carcinoma development |
| 17581420 |
Positivity for p53 was strong and diffuse in 5 uterine tumors and in 3 ovarian tumors. p53 expression in 6 of the uterine specimens and 7 of the ovarian specimens was present in fewer tumor cells, of weak intensity, or both. |
| 17581423 |
p53 mutation was observed in 4 of 13 specimens of endometriosis coexisting with ovarian clear cell carcinoma, whereas no mutations were detected in solitary endometriosis or endometriosis coexisting with ovarian endometrioid carcinoma. |
| 17437012 |
No correlation between Pidd expression and the p53 mutation status of oral squamous cell carcinoma, suggesting that Pidd expression may be regulated by p53-independent mechanisms. |
| 17504517 |
TP53 mutation status and gene-expression based groups are important survival markers of breast cancer. |
| 17640893 |
damage-activated switch in Hdm2 ubiquitin ligase preference from P53 to itself and Hdmx is central to P53 activation |
| 17426704 |
Bivariate analysis of p53/BAX proteins possibly may provide further prognostic evidence in colon cancer. |
| 17490723 |
The present study showed elevated expression of topo-I, Ki-67, and mutant p53 in patients with uterine carcinosarcoma suggesting sensitivity to topo-I-targeted drug treatment. |
| 17500067 |
ubiquitination-mediated repression of p53 by Mdm2 acts at least, in part, through inhibiting the sequence-specific DNA binding activity |
| 17537232 |
The Pro/Pro genotype of TP53 codon 72 appears to be an independent prognostic marker in breast cancer patients. |
| 17620598 |
Electron microscopy on the conformationally mobile, unbound p53 selected a minor compact conformation |
| 17390041 |
Comparative genomic hybridization and immunohistochemical assessment of EGFR, PTEN, p53, and MIB-1 expression in 13 oligodendrogliomas, one oligoastrocytoma and 23 high-grade astrocytomas is reported. |
| 17707234 |
This study identifies SET8 as a p53-modifying enzyme, monomethylating p53 at lysine 382(p53K382me1) and identifying (p53K382me1) as a regulatory posttranslational modification of p53. |
| 17701916 |
bcl-2 and p53 expression in neuroblastoma is related to DNA fragmentation |
| 17535811 |
NFBD1 plays an important role in the decision of cell survival and death after DNA damage through the regulation of p53 |
| 17065198 |
p53 mutation spectrum shows that the UV component of sunlight is the major risk factor and modulated DNA repair by immunosuppressive drug treatment may be significant in the skin carcinogenesis of renal transplantation patients. |
| 17465990 |
Te strong nuclear expression of p53 in these and other pediatric GBMs could indicate that p53 dysregulation is important to tumorigenesis. |
| 17606709 |
analysis of the transactivation function of p53 alleles in cancer |
| 17695524 |
Aberrations of the p53, Rb and p27 pathways are associated with aggressive clinical behavior in DLBCL. |
| 17548471 |
These observations demonstrate a novel regulatory role for p53 as a uPAR mRNA binding protein that down-regulates uPAR expression, destabilizes uPAR mRNA, and thereby contributes to the viability of human airway epithelial or lung carcinoma cells. |
| 17554199 |
Regulation of miRNA expression into the transcriptional network regulated by p53. |
| 17598983 |
New gain of function of the common p53 cancer mutants in inducing genetic instability. |
| 17630856 |
Bloom symdrome-independent role for p53 in etoposide-induced, topoisomerase II-mediated DNA damage in human cells. |
| 17426439 |
p53 plays an essential role in the autophagic pathway downstream of the DNA mismatch repair system. |
| 17494866 |
These results demonstrate that, in the cells investigated, the level of NS is regulated by p14(ARF) and the control of the G1/S transition by NS operates in a p53-dependent manner. |
| 17631738 |
In the Italian population there is no association between codon 72-p53 gene polymorphism and the occurrence of rheumatoid arthritis. |
| 17186536 |
Results describe four novel single nucleotide polymorphisms within the promoter region of the p53 gene and their associations with uterine leiomyoma. |
| 17652955 |
There is strong evidence that low grade dysplasia is a neoplastic lesion and that p53 point mutation is deeply involved in esophageal carcinogenesis. |
| 12270344 |
Immunohistochemical expression of this protein in squamous cell carcinomas from immunosuppressed renal transplant recipients and immunocompetent individuals |
| 12446780 |
Results suggest that intrinsic DNA binding affinity and p53 protein levels are important contributors to p53-induced differential transactivation. |
| 11755471 |
New mutations of p53 identified by SSCP in acute myeloid leukemia cell lines. Loss of p53 is not the decisive event causing tumor cells to proliferate in vitro without externally added growth factors. |
| 11923872 |
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization |
| 12392301 |
insulin inhibits TNF-alpha-dependent cell killing, induction of p53, p21 and apoptosis in a human cervical carcinoma cell line |
| 14749371 |
v-Fos-stimulated invasion is independent of the pRb/p16(INK4a) and p53 tumor suppressor pathways and telomerase |
| 15696860 |
This study focused on the expression levels of Bcl-2 family regulators (anti-apoptotic Bcl-2 and Bcl-XL, pro-apoptotic Bcl-Xs and Bax), p53, and PCNA as a marker of proliferation, together with the evaluation of the level of apoptosis in human embryos. |
| 15772596 |
higher expression in atrophic oral lichen planus and patients with areca quid chewing |
| 15806145 |
data suggest that p53pSer15 plays a dual role in the functional interactions with early complexes of Rad51-dependent recombination and with BLM-associated surveillance and signalling complexes within distinct nuclear subcompartments |
| 16055707 |
initiation of DNA replication is regulated by p53 through Cdc6 protein stability |
| 16151725 |
findings suggest that overexpression of EGFR in glioblastomas in Chinese patients may be associated closely with the patients age but not with the tumors' pathological pathway |
| 16243804 |
Results suggests that analysis of p53 codon 72 polymorphism may provide a simple predictive marker for selecting the right breast cancer patients to anthracycline-based neoadjuvant chemotherapy in clinical setting. |
| 16243918 |
In summary, the p53/p21 pathway is mainly responsible for GC-induced apoptosis, but the coordinated activation of the p53/p21 and p16 pathway is responsible for GC-induced endothelial cell senescence through a Rb-dependent mechanism. |
| 16436515 |
Beta-interferon-induced senescence was more efficient in cells expressing either, p53, or constitutive allele of ERK2 or RasV12. |
| 11844595 |
A link between the p53 germ line polymorphisms and white blood cells apoptosis in lung cancer patients |
| 11844788 |
role in regulating growth-promoting gene IEX-1 |
| 11844800 |
Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis. |
| 11844810 |
aberrent expresion correlates with VEGF and IL-8 mRNA expression and neoangiogenesis in non-small-cell lung cancer |
| 12568865 |
mutation analysis of this gene in a case of familial endometriosis |
| 12818446 |
study showed that polymorphism at codon 72 of TP53 gene is not associated with an increased susceptibility to cervical disease and/or HPV infection in the Argentine women population |
| 12972634 |
inactivation of p53 in osteosarcomas directly by mutation versus indirectly by HDM2 amplification may have different cellular consequences with respect to the stability of the genome |
| 14559824 |
PTEN inhibits MDM2 and protects p53 through both p13k/Akt-dependent and -independent pathways in ALL. |
| 14640983 |
Crucial role of p53 C-terminal phosphorylation in the regulation of its DNA-binding activity. |
| 16033918 |
The TP53 R337H mutation dramatically increases predisposition to childhood adrenocortical carcinoma (ACT) but not to other cancers, and explains the increased frequency of ACT observed in this geographic region. |
| 15456759 |
PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation |
| 15456784 |
survivin can reduce the cell growth inhibition and apoptosis, and p53 elevates the p21 level, which may attenuate the cell death in the quercetin-treated human lung carcinoma cells |
| 15498930 |
low-dose radiation hypersensitivity is associated with p53-dependent apoptosis. |
| 15659650 |
possible interplay between p53 C-terminal phosphorylation and acetylation, and they provide an additional mechanism for the control of the activity of p53 by Checkpoint kinase 1 and Checkpoint kinase 2 |
| 15917304 |
The human gene in transgenic mice behaves like its murine ortholog in mouse hepatocarcinogenesis. |
| 12637159 |
ING1 expression is frequently associated with Adenocarcinoma of the esophagogastric junction tumorigenesis, further supporting its role as a tumor suppressor gene, and ING1 expression is independent of p53 status |
| 14517211 |
identification of defect in response pathway induced by de novo purine synthesis inhibition |
| 14517280 |
VHL-mediated p53 upregulation may contribute to pVHL's tumor suppressive functions in renal cell carcinoma |
| 16492679 |
analysis of TP53 mutation pattern in radiation-induced sarcomas |
| 16740634 |
presence of p53 in a transcription complex of NPM and Sp1 or NF-kappaB at the promoter of the MnSOD gene was verified. p53 interacts with Sp1 to suppress expression of the MnSOD gene. |
| 16905769 |
Hdmx is an important determinant of the outcome of P53 activation |
| 16963839 |
p53 directly regulatescarboxylesterase 2expression in a colonic cancer cell line. |
| 17113101 |
analysis of the human p53 tetramerization domain |
| 17121821 |
p53-dependent staurosporine-induced caspase-3 activation is affected by the C-terminal products of cellular prion protein processing, C1 and C2 |
| 17383050 |
Taurolidine induces apoptosis and necrosis, activates p53 and sensitizes cells to cisplatin, whereas PVP-I inhibits cell growth via necrosis. |
| 17409384 |
LSD1 has a pro-oncogenic function by modulating pro-survival gene expression and p53 transcriptional activity |
| 17452332 |
nuclear IKK-alpha-mediated accumulation of p73alpha is one of the novel molecular mechanisms to induce apoptotic cell death in response to CDDP, which may be particularly important in killing tumor cells with p53 mutation |
| 11854266 |
effect of phosphorylation on structure and fold of transactivation domain |
| 12084347 |
A cytoplasmic accumulation of wild-type p53 in human primary glioblastomas correlates with GFAP and vimentin expression. Cytoplasmic p53 is inactive in growth suppression. |
| 12105992 |
persistence of induced levels of ROS in normal diploid human cells for 1 month after X-ray exposure and the role of TP53 in this oxidant response |
| 12704785 |
central and carboxy-terminal regions are essential for interaction and complex formation with PARP-1 |
| 12821780 |
Inhibition of p53 causes ubiquitination and down-regulation, through increased degradation, of the IGF-1R in human malignant melanoma cells. By sequestering Mdm2 in the cell nuclei, the level of p53 may indirectly influence the expression of IGF-1R. |
| 12821781 |
The 3' UTR of p53 was found to be a target of the RNA-binding protein HuR in a UVC-dependent manner in vitro and in vivo. |
| 12821945 |
molecular interactions of p53 within the N-terminal domain are not required to restrain DNA recombination, but might contribute to the genome stabilizing function |
| 12823440 |
low incidence for actinic damage, basal cell and squamous cell carcinoma as documented in vitiligo could well reside in a protective function of up-regulated wild-type p53. |
| 12888634 |
Zinc deficiency caused an increase in p53 protein expression. |
| 12894226 |
Epigallocatechin-3-gallate-induced stabilization of p53 caused an upregulation in its transcriptional activity, thereby resulting in activation of its downstream targets p21/WAF1 and Bax. |
| 12944468 |
colocalization of a nonshuttling p53 with MDM2 either in the nucleus or in the cytoplasm is sufficient for MDM2-induced p53 polyubiquitination but not degradation. |
| 14562055 |
Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation |
| 14586398 |
p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1. |
| 14719105 |
p53 mutations are common among oral cavity cancers in the Brazilian population |
| 14719118 |
trp53 has a role in activation of the Fas/CD95 pathway |
| 14961077 |
p53 disruption has a dramatic effect on how glioblastoma cells process topoisomerase I inhibitor-mediated DNA damage. |
| 15492790 |
Decreased level of the phosphorylation is associated with basal cell carcinomas of skin |
| 17434128 |
Our results suggest that phosphorylation of CBP by IKKalpha regulates the CBP-mediated crosstalk between NF-kappaB and p53 and thus may be a critical factor in the promotion of cell proliferation and tumor growth. |
| 17545525 |
SNP309 of HDM2 is a frequent event in bladder cancer, related to earlier onset of superficial disease and TP53 mutation status |
| 17545546 |
nutlin-3A stabilized p53 by preventing MDM2-mediated p53 degradation in and Reed-Sternberg (HRS) cells of Hodgkin's lymphoma (HL) |
| 11859970 |
Immunostaining of p53 accumulation in families with multiple glioma pts showed that p53 alterations are as common in familial as in sporadic gliomas.Germline p53 mutations in exons 4-10 were not found. |
| 11900859 |
review on mutations in brain neoplasms |
| 12138209 |
These data indicate a novel p53-dependent mechanism in which cell stress mobilizes nucleolin for transient replication inhibition and DNA repair. |
| 12429911 |
p53 as a sensor of transcriptional integrity |
| 12610779 |
Germline mutations of this protein exist in a cohort with childhood sarcoma: sex differences in cancer risk. |
| 12851404 |
TP53INP1s and HIPK2 could be partners in regulating p53 activity. |
| 12909720 |
Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity. |
| 15149862 |
WRN and TP53 perform different functions in a shared DNA damage response pathway. |
| 15664194 |
Data show that human papillomavirus E6 oncoprotein does not prevent p53 or p300 recruitment to the chromatin but inhibits p300-mediated acetylation on p53 and nucleosomal core histones. |
| 15671551 |
Rb and p53 have roles in progression of primary non-small cell lung carcinoma |
| 15750621 |
WR1065 specifically modulates a subset of p53 target genes in a colon carcinoma cell line, consistent with the observation that this agent elicits essentially p53-dependent, cell cycle arrest responses. |
| 15848166 |
RB18A plays a central role to control p53wt and p53mut protein content and functions in cells through a loop of regulation, which involves MDM2 |
| 15850555 |
Analysis of expression levels of p21(waf1), as well as the activity of caspase-3 and caspase-8, allowed us to characterize some aspects of the arrest of PC-3 cells in G2 and the apoptotic response to oxidative stress in the absence of functional p53 |
| 15943410 |
The sequential accumulation of mutations in p53 drives the transition from normal epithelium through increasing adenomatous dysplasia to colorectal cancer. |
| 15961390 |
TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism |
| 16142332 |
in nasopharyngeal carcinoma cells, SarCNU-induced apoptosis is p53-dependent while SarCNU-induced G2/M arrest is mediated by the cyclin B1-cdc-2 complex |
| 16142358 |
the p14ARF-p53-MDM2 pathway has a role in development of oral squamous cell carcinoma |
| 16203772 |
the p53 and MDM2 promoter polymorphisms do not appear to play a role on age of colorectal cancer onset in Lynch syndrome |
| 16203773 |
loss of nuclear p53 signal may have a role in cisplatin resistance in head and neck squamous cell carcinoma |
| 16246896 |
Copper alters the conformation and transcriptional activity of TP53 in Hep G2 cells. |
| 16247442 |
Functional p53 can promote the adenovirus (Ad) lytic cycle |
| 16287156 |
Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 contribute to the risk of developing lung cancer. |
| 11799106 |
IkappaBalpha x p53 complex plays an important role in responses involving growth regulation, apoptosis, and hypoxic stress |
| 11881786 |
The first direct demonstration of p53 mutations in pleuropulmonary blastomas (PPB)suggests p53 inactivation can occur as a nonrandom genetic change involving the pathogenesis and outcome of PPB. |
| 12048243 |
reacts with glycogen synthase kinase-3beta after DNA damage |
| 12372430 |
p53 activates ATF3 in human tumor cells |
| 12499093 |
The relationships and interactions between p53, Rb and bcl-2 immunostaining, clinical parameters and response to cisplatin-based chemotherapy were evaluated in the present study. |
| 12670866 |
Bcl-2 constitutively suppresses aptoptosis dependent on this protein in colorectal cancer cells. |
| 12670900 |
Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143. |
| 14682374 |
Review outlines uses of adenoviruses in brain tumor therapy by examining clinical trials of adenovirus-mediated p53 gene therapy and by reviewing the application of two conditionally replicative adenoviruses (CRAds) ONYX-015 and Delta 24 in brain tumors. |
| 14729628 |
Upregulation of p14ARF paralleled with MDM2 inhibition contributes to p53 accumulation in the nucleus in radiation-treated breast cancer cells. |
| 15133049 |
the N-terminal domain of PIAS1 interacts with DNA as well as p53 |
| 15500550 |
increased expression is not an indicator of the presence of p53 gene mutations at exons 4-8 in hepatocellular carcinoma |
| 16682816 |
Data suggest that dose-dependent UV stabilization of p53 in cultured human cells undergoing apoptosis is mediated by poly(ADP-ribosyl)ation. |
| 16875676 |
p53 plays a role in regulation of cullin 7 activity |
| 17438265 |
A complex between tetrameric p53 and p300 in which four domains of p300 wrap around the four transactivation domains of p53. |
| 12080066 |
recombinant p53 binds to BLM and WRN helicases and attenuates their ability to unwind synthetic Holliday junctions in vitro |
| 12958068 |
the greater severity of TP53-mutant B-CLLs compared with ATM-mutant B-CLLs is consistent with the additive effect of defective apoptotic and elevated survival responses after DNA damage in these tumors |
| 15299072 |
p53 activation is not necessary for up-regulation of NOXA in melanoma cells |
| 15882981 |
NLS domain of ING4 is essential for the binding of ING4 to p53 and the function of ING4 associated with p53 |
| 16012716 |
Results suggested that the loss of p53 expression in conjunction with the overexpression of p21(WAF1/CIP1) was a stronger predictor of survival benefit than either molecule alone in Japanese serous-type advanced ovarian cancer. |
| 16043423 |
Differentiating human keratinocytes are deficient in p53 but they preserve global nucleotide excision repair as well as expression of genes encoding key DNA damage recognition proteins |
| 16412606 |
Tumours with FGFR3+/p53- phenotype seem to have a distinctive pathway in bladder tumorigenesis. |
| 16418486 |
BTG2 expression was found to be significantly reduced in a large proportion of human kidney and breast carcinomas, suggesting that BTG2 is a tumor suppressor that links p53 and Rb pathways in human tumorigenesis. |
| 16501611 |
Protein phoaphatase-1 directly dephosphorylates p53. This has as important an impact on its functions as phosphorylation does. One way PP-1 promotes cell survival is to dephosphorylate p53, & thus negatively regulate the p53-dependent death pathway. |
| 16504179 |
p53 inhibits protein synthesis in human lung carcinoma cells;The mechanism involves dephosphorylation and accumulation of the translational inhibitor 4E-BP1, and increased association of 4E-BP1 with initiation factor eIF4E. |
| 16600182 |
A Small Ras-like GTPase protein Ray was indicated to modulate p53 transcriptional activity of PRPK. |
| 16728565 |
The present paper aims to provide updated information on p53 regulation and function, with specific interest on its role in breast cancer. |
| 16728594 |
findings show that p53 modulates the balance between the utilization of respiratory and glycolytic pathways; identifed Synthesis of Cytochrome c Oxidase 2 (SCO2) as the downstream mediator of this effect |
| 16778203 |
ECT2 is negatively regulated by wild-type p53 but not tumor-derived mutant p53 or other p53 family members. |
| 16778209 |
Increased GEF-H1 expression contributes to the tumor progression phenotype associated with the p53 mutation. |
| 16782868 |
As the amount of p53 protein increases, there is a downregulation of the VRK1 protein level independent of its promoter. |
| 16943578 |
Antisense ODN to p53 impairs secretion of VEGF in the undifferentiated thyroid cancer cell line FTC-133. |
| 16959223 |
The results obtained demonstrated that, at least in vitro, the p53 family members tested (TAp63alpha, TAp73alpha, DeltaNp63alpha, but not DeltaNp73alpha) were able to drive transcription from the PKCdelta promoter. |
| 17116689 |
Cancer-associated missense mutations targeting MDM2's central zinc finger disrupt the interaction of MDM2 with L5 and L11. |
| 17135243 |
BCCIP in maintaining the transactivation activity of wild type p53; down-regulation of BCCIP as a novel mechanism to impair the p53 function in cells harboring wild type p53 |
| 12750368 |
p53 is regulated by hGTSE-1 during apoptosis control after DNA damage in S and G2 phases |
| 12750388 |
p53 and p73alpha have roles in cell migration |
| 14586402 |
Histone deacetylase inhibitors can induce Gadd45 through its promoter without the need for functional p53, and Oct-1 and NF-Y concertedly participate in Trichostatin A-induced activation of the gadd45 promoter. |
| 14680293 |
The p21 upregulation followed the p53 phosphorylation process in irradiated MOLT-4 ce |
| 14680497 |
Study indicate that the coexistence of p53 protein accumulation and HER2 overexpression is a strong prognostic molecular marker in breast cancer. |
| 14724564 |
O(6)MeG-triggered apoptosis in proliferating lymphocytes was preceded by a wave of double stranded breaks, which coincided with p53 and Fas receptor upregulation |
| 17227108 |
We showed that renal cell carcinoma with rhabdoid features is a very aggressive neoplasm with a poor prognosis. We observed an overexpression of p53 in the rhabdoid component that may be implicated in the tumor dedifferentiation. |
| 17349958 |
These findings indicate that DYRK2 regulates p53 to induce apoptosis in response to DNA damage. |
| 17536310 |
immunoreactivity of p53, MDM2, WAF1, and BCL-2 were measured in soft tissue sarcomas cases consisting of 54 low-grade, 40 intermediate-grade, and 58 high-grade sarcomas |
| 12447653 |
TP53 mutations could be a useful prognostic indicator in precancerous oral lesions. |
| 12748190 |
expression of p21/CDKN1A is necessary and sufficient for the negative regulation of gene expression by p53 |
| 14991543 |
results suggest that microsatellite instability and p53 mutations are involved in tumor progression of dermatofibrosarcoma protuberans to fibrosarcoma as early and late events, respectively |
| 15295102 |
YY1 regulates the transcriptional activity, acetylation, ubiquitination, and stability of p53 by inhibiting its interaction with the coactivator p300 and by enhancing its interaction with the negative regulator Mdm2. |
| 15550400 |
COX-2-positive prostate cancer cells can have impaired p53 function even in the presence of wild-type p53 and that p53 activity can be restored in these cells via inhibition of COX-2 activity. |
| 15574785 |
The ability of p53 to bind and inactivate JNK, together with the activation of the p53 target genes related to cell cycle arrest and DNA damage repair, is responsible for its protection of cells against UV-induced apoptosis. |
| 15633234 |
Homozygosity for Pro of p53 Arg72Pro is potentially one of the genetic risk factors for hepatocarcinoma in a Chinese population. |
| 15741235 |
DeltaNp73alpha not only acts as an inhibitor of p53/TAp73 functions in neuroblastoma tumors, but also cooperates with wt-p53 in playing a physiological role through the activation of BTG2TIS21/PC3 gene expression |
| 15943041 |
besides P53 alterations, mouse double minute 2 gene deregulation seems to be an important event in hepatocarcinogenesis |
| 16039051 |
Haplotype analysis also showed a significant association between TP53 and schizophrenia. These results provide further evidence that TP53 may play a role in the pathogenesis of schizophrenia. |
| 16481301 |
Logistic regression analysis showed p53 and COX-2 as dependent predictors in pancreatic carcinogenesis, and a reciprocal relationship to neoplastic progression between p53 and COX-2. |
| 16494995 |
Results show that the TP53 R337H germline mutation predisposes to a larger spectrum of tumours. |
| 16531411 |
Caspase-dependent cleavage of p53 resulting in the generation of four fragments, two of which lack a nuclear localization signal and consequently localize to cytosol; these translocate to mitochondria and induce membrane depolarization. |
| 16569765 |
While ATL patients carrying a wild-type p53 enter remission following treatment with AZT, those with a mutated p53 did not respond, and patients' disease relapse was associated with the selection of a tumor clone carrying mutated inactive p53. |
| 16721787 |
p53 Arg72Pro may play a role in the early stages of colorectal neoplasia and possibly in progression to invasive disease, depending on site and sex |
| 16937443 |
The alterations of the p53 gene evaluated by DNA sequence analysis is relatively accurate. Expression of P53 protein could not act as an independent index to estimate the prognosis of cholangiocarcinoma. |
| 16941491 |
Data suggest that the TP53 and CHEK2 mutations can substitute each other in at least 25% (21/84) of prostate cancers and that DNA damage-signaling pathway plays an important role in prostate cancer tumorigenesis. |
| 17028100 |
Results show that the p53beta isoform is the only p53 species to be endogenously expressed in the neuroblastoma (NB)cell line SK-N-AS, suggesting that the C-terminus truncated p53 isoforms may play an important role in NB tumor development. |
| 17105820 |
Bcl-2 inhibition might therefore improve the efficacy of existing acute myeloid leukemia therapies by inactivating this suppression of wild-type p53 activity |
| 17107393 |
p53 mutation is not an important mechanism for beta-catenin activation in primary cutaneous T-cell lymphoma; p53 codon 72 polymorphism may influence negative feedback control involving beta-catenin and p53. |
| 11804688 |
nuclear mutant p53 protein is expressed in early precancerous stages suggesting this is an early change in NSCLC tumorigenesis; may be a potential marker for development of NSCLC |
| 17186020 |
Notch signaling downregulated p53-dependent apoptosis induced by ultraviolet irradiation. |
| 17200338 |
somatic alterations in p53 and EGFR have roles in progression of primary lung cancer |
| 17216584 |
These data demonstrate the importance of Noxa induction in determining the apoptotic response to fenretinide and emphasise the role of Noxa in p53-independent apoptosis. |
| 12136132 |
p53 status is an important modulator of nitric oxide-induced mutagenesis and apoptosis, and suggest that level of the Apaf-1 ans XIAP proteins are regulated by p53 |
| 12875991 |
Data describe the correlation between inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 activities and p53 gene status in head and neck squamous cell carcinomas in vivo and in vitro. |
| 14645574 |
cytoplasmic sequestration of p53 by the E1B 55-kDa protein plays an important role in restricting p53 activities in human osteosarcoma cells |
| 15042092 |
identification of one known and five new modulators of p53-dependent proliferation arrest, using an RNA interference library |
| 15808506 |
l structure of the p53 binding domain of USP7 alone and bound to an EBNA1 peptide |
| 11692157 |
differentiation status of the tumor was found for the p53 aberration but not for CD95 expression. |
| 12874009 |
p53 has a differential role in effecting G(2) arrest in response to topoisomerase II inhibitors, depending upon the mechanisms of action of the inhibitors tested. |
| 15381368 |
germline mutations in the TP53 gene in five index cases of German and Swiss origin with cancers typical of Li-Fraumeni syndrome |
| 15950944 |
These results suggest that Chk2 regulates the transcription-independent mechanism of p53-mediated apoptosis by inducing stabilization of p53 in response to IR. |
| 16177659 |
TP53 abnormalities are early and frequent events in the pathogenesis of gallbladder carcinoma, starting from chronic cholecystitis. |
| 16377624 |
These findings indicate that PKCdelta regulates p53 to induce apoptotic cell death in the cellular response to DNA damage. |
| 14519637 |
The poor prognosis associated with p53-null mutation is independent of the mutation mechanism in ovarian cancer survival. |
| 15099937 |
TP53 mutation is common in early stage ovarian carcinomas of serous histology, with a mutation frequency comparable to that reported for advanced-stage ovarian tumors. |
| 15262986 |
p53 acts upstream of Bax to promote antineoplastics mediated cell death in a proline-rich domain-dependent manner through both transcription-dependent and -independent mechanisms in human colon cancer HCT116 cells. |
| 15466207 |
Down-regulation of Cdc7 by small interfering RNA in a variety of tumor cell lines causes an abortive S phase, leading to cell death by either p53-independent apoptosis or aberrant mitosis. |
| 15770529 |
TP53 deletion significantly associated with malignant transformation of breast papilloma, pointing to p53 role as a progression factor |
| 15940268 |
p53 not only can provide proapoptotic signals but also regulates a survival pathway influencing Mcl-1 and Bcl-x(L) levels |
| 12370812 |
These findings suggest that impairment of transcriptionally active p53 in response to replication blockade is not a general phenomenon. |
| 15095978 |
results establish a direct functional link between p53 and human Rad51, and reveal that one of p53's functions in genome stabilization may be to prevent detrimental genome rearrangements promoted by Rad51 |
| 15334064 |
role in regulating survivin 2B |
| 15334668 |
Individuals carrying Arg allele compared to those with Pro allele have an increased risk for esophageal squamous cell carcinoma. |
| 15798209 |
p53 is an effective repressor of snRNA gene transcription by RNA polymerases II and III. |
| 16125276 |
an aberrant p53 status was related to IL-8 expression in patients with non-small cell lung carcinoma |
| 16397624 |
Results illustrate a novel mechanism of the alteration of p53 function that is mediated by a cutaneous HPV type and support the role of HPV38 and deltaNp73 in human carcinogenesis. |
| 16516153 |
We suggest that p53 has a role in RAD51 clearance post DSB repair and that nucleoli might be sites of RAD51 protein degradation. |
| 16621805 |
p90Rsk-mediated modulation of Hdm2 nuclear is linked to cytoplasmic shuttling with the diminished ability of p53 to regulate cell cycle checkpoints that ultimately leads to transformation |
| 16799873 |
The data implicate cyclin A1 as a downstream player in p53-dependent apoptosis and G2 arrest. |
| 11788906 |
Telomerase activity in microdissected human breast cancer tissues: association with p53, p21 and outcome |
| 14663467 |
a correlation between focal p53 immunostaining in primary primary prostate cancers and cancer recurrence after radical prostatectomy |
| 16797751 |
Polymorphism in the p53 gene at codon 72 revealed no significant association with the development of CAD or diabetes in Kuwait. |
| 17139261 |
p53 mediates the suppression of TR3 on MDM2 at both transcriptional and post-transcriptional level and suggest TR3 as a potential target to develop new anticancer agents that restrict MDM2-induced tumor progression. |
| 17360541 |
expression of hTERT reduces the number of foci and the level of active p53, thereby decreasing sensitivity to growth factor depletion |
| 17461446 |
H pylori-associated chronic gastritis expressed the mutant-type p53, which was significantly associated with more severe atrophic and metaplastic changes. |
| 12474051 |
Expression or this protein does not predict outcome in colorectal cancer patients. |
| 12496062 |
A selective growth advantage for cells carrying a type of TP53 mutation seen in breast carcinomas when the mutation resides on Arg72 allele. These are not seen in colorectal neoplasms. |
| 15059885 |
Results identify a novel mechanism of p53-dependent apoptosis in which p53-mediated up-regulation of MnSOD and GPx, but not CAT, produces an imbalance in antioxidant enzymes and oxidative stress. |
| 15539839 |
Data suggest that certain p53 mutations may have prognostic value in superficial bladder transitional cell carcinoma, even though they were not associated with other classic recurrence and tumor progression parameters. |
| 15539956 |
We propose that a major mechanism by which p53 maintains genome stability is the prevention of DSB accumulation at long-lived ssDNA regions in stalled-replication forks. |
| 15709766 |
Phosphorylation of p53 plays a crucial role in detection and interaction with sites of DNA damage and unusual DNA structures. |
| 15710230 |
TP53 pathway is invslved in the carcinogenesis ofHepatic undifferentiated (embryonal) sarcoma. |
| 15710329 |
MUC1 regulates p53-responsive genes and thereby cell fate in the genotoxic stress response |
| 15719270 |
Atypical meningioma showed TP53 mutations and a 22q loss of heterozygosity (LOH), while glioblastoma showed epidermal growth factor receptor (EGFR) amplification and TP53 mutations. |
| 15720412 |
Expression of p53 is associated with NIH risk category, various pathological features, and clinical outcome, and may be independently prognostic for gastrointestinal stromal tumours. |
| 15900046 |
Many p53-defective tumors retain activity of the apoptosome, which is therefore a potential target for cancer chemotherapy. Inhibition of ACS may be a novel strategy to induce the death of p53-defective tumor cells |
| 16007153 |
p53-induced apoptosis may be important for efficient cell lysis and viral spread and that E1B-19K may neutralize the apoptotic activity of p53 at multiple levels |
| 16007163 |
inhibition in HTLV-1-transformed cells is regulated by activated AKT |
| 16283431 |
Results describe the opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity. |
| 16313886 |
transglutaminase 2 (TG2) modification of p53 could be an additional mechanism whereby TG2 could facilitate apoptosis |
| 16416221 |
TP53 gene mutations alone are not likely to represent a widely useful prognostic marker of the risk of progression to malignancy, at least not in Barrett's esophagus without dysplasia. |
| 16432196 |
identification of a second binding site helps stabilize the interaction between HDM2 and p53 during p53 degradation |
| 16432214 |
the VEGF system is integrated into the p53 transcriptional network by an SNP in the flt-1 promoter |
| 16432227 |
Myc overexpression causes DNA damage in vivo and the ATM-dependent response to this damage is critical for p53 activation, apoptosis, and the suppression of tumor development |
| 16651519 |
p53 as a determinant of the response to oncogene inhibition |
| 16686942 |
p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer |
| 16687402 |
Hghly modular role for the L1 loop in the recognition of specific DNA sequences, target transactivation, and apoptotic signaling by p53. |
| 16741917 |
The DU145 cell line harbors a TS mutant of p53 and, in addition to being a widely used model of human prostate carcinoma, may also reveal new insights into p53 function due to the unique transcriptional properties of its TS phenotype. |
| 16785993 |
data indicate that a mutant p53 can contribute to the suppression of apoptosis in a human breast cancer cell line and suggest a rationale for the selection of p53 mutations early in tumorigenesis to suppress apoptosis in an emerging tumor |
| 16786124 |
the TP53 codon 72 polymorphism could be associated with susceptibility for adrenocortical cancer |
| 16909101 |
Epigenetic alteration of XAF1 is frequent in human urogenital cancers and may contribute to the malignant progression of tumors by rendering tumor cells a survival advantage partially through the attenuated p53 response. |
| 16912307 |
Our results provide evidence of how poliovirus counteracts p53 antiviral activity by regulating PML and NBs, thus leading to p53 degradation. |
| 17012841 |
p53 family proteins are potent therapeutic agents for human papilomavirus-associated uterine cervical cancers. |
| 11925449 |
description of a novel MDM2 binding interface in p53 that plays a regulatory role in MDM2-dependent ubiquitination of p53 |
| 11953857 |
p53 mutational pathway may favor selection for ErbB2 gene amplification during tumor progression in breast cancer |
| 11953859 |
high level of p53 protein in cPNETs measured by immunostaining intensity associated with poor patient survival |
| 12162806 |
MDMX-mediated regulation of p53 activity during development. |
| 12171773 |
Mutations in exons 4-10 of the p53 gene in acute myeloid leukemia patients screened in an epidemiologic study in Brazil were found to correlate with poor prognosis and to occur at frequencies similar to those reported for Northern America and Europe. |
| 12606585 |
These results indicate that p53 and BLM functionally interact during resolution of stalled DNA replication forks and provide insight into the mechanism of genomic fidelity maintenance by these nuclear proteins. |
| 11872638 |
We investigated three common sequence variants in TP53 and p21 for possible associations with the risk of breast cancer and with various phenotypic features of this disease |
| 12082636 |
Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. |
| 12532420 |
The presence of E-cadherin mutations can significantly alter the accumulation of the apoptosis-regulating p53 protein, whereas no correlation with the p53 mutation status or with Ki-67 staining was observed. |
| 14576823 |
DeltaN-p63-alpha mediates the silencing of its own promoter thereby altering the pattern of p53-target gene expression. |
| 15367885 |
p53 mutations were found in 70% of pancreatic adenocarcinoma cell lines and 33% of primary tumors. p53 missense mutations correlated with more frequenct metastases to all sites. |
| 15489903 |
sequestration of replication protein A by p53 at the sites of recombination is one means by which p53 can inhibit homologous recombination processes |
| 12034444 |
Refolding and structural characterization of the human p53 tumor suppressor protein. |
| 12082526 |
RNA polymerase III transcription can be derepressed by mutations that compromise p53 function in tumours and Li-Fraumeni syndrome. Substitution R175H, the most common mutation in cancers, converts p53 from a pol III repressor to an activator. |
| 12082529 |
UV-induced DNA damage in epidermal KCs triggers p53 activation and apoptosis. Lack of activation in aging KCs and psoriatic Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes |
| 12569576 |
Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets. |
| 14576150 |
Nitric oxide depletion reduces the presence of p53-DNA complexes after cisplatin treatment. |
| 15650224 |
a productive human herpesvirus 6B infection suppresses T-cell proliferation concomitant with the phosphorylation and accumulation of p53 |
| 15816455 |
Colorectal cancers not expressing hMLH1 or hMSH2 may have distinct features from those expressing these mismatch repair proteins. p53 expression appears to be implicated in a compensatory pathway with mismatch repair proteins. |
| 15816541 |
Constitutive dephosphorylation at Ser 376 correlated with the nuclear accumulation of p53, but not with the transcriptional activity of the protein in glioma. |
| 11751853 |
We show a novel alternative pathway of apoptosis in human primary cells that is mediated by transcriptionally dependent decreases in p53 and c-Myc and decreases in p21. |
| 11960374 |
P53 mediates ceramide-induced apoptosis in SKN-SH cells |
| 12032659 |
p53 protein transport in hepatoma cells with VP22 |
| 12045262 |
p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling |
| 12046064 |
Changes of NF-kB, p53, Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells: role of reactive oxygen species. |
| 12046074 |
The point mutation of p53 gene exon7 in hepatocellular carcinoma from Anhui Province, a non HCC prevalent area in China. |
| 12388812 |
hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53 |
| 12931731 |
HSU94788 may not be the wild-type p53 sequence. AF136270 and AF135120 may be the correct wild-type intron 7 sequences. |
| 14572637 |
ING1 has a subtle antiproliferative effect even in the absence of p53, and ING1b enhances the DNA damage responses through p53-dependent and -independent mechanisms. |
| 14607337 |
High p53 protein level is associated with advanced TNM stage and positive nodal status of squamous cell carcinoma of hypopharyngeal cancer |
| 15334053 |
SCN3B mediates a p53-dependent apoptotic pathway and may be a candidate for gene therapy combined with anticancer drugs. |
| 15902285 |
TP53 mutation has only a limited role in the transformation of lymphoma to diffuse large B-cell lymphoma, exerting a heterogeneous influence upon phenotypic change. In contrast, dysregulation of MDM2 is frequent. |
| 15902745 |
p53 gene mutation may be an early event in esophageal carcinogenesis |
| 16440000 |
indicate a novel translational control of p53 gene expression and activity |
| 16446369 |
some isoforms of p63 serve as a pro-survival factor by up-regulating GPX2 to reduce the p53-dependent oxidative stress-induced apoptotic response |
| 16446403 |
These data provide evidence that in addition to the COOH-terminal residues, p53 may also be ubiquitinated at sites in the DNA-binding domain. |
| 16482544 |
E6AP is extensively involved in the ubiquitin-mediated degradation of p53 (an HPV E6-dependent substrate) as a cellular E3 ubiquitin-protein ligase. |
| 16625286 |
Alleles and smoking play a significant role in modified prostate cancer risk in this study population. |
| 16681440 |
serum p53 protein may have a role in hepatocellular carcinoma |
| 16685387 |
We demonstrated that p53 wild-type protein nuclei accumulation is associated with GEP protein expression in human HCC specimens, and GEP modulates p53 wild-type protein levels in vitro. |
| 16810754 |
Somatic chromosomal mutations, especially in exon 6 of Tp53 gene, among esophageal cancer patients of an ethnically homogenous population of Kashmir valley are closely related to continued exposure to various common dietary risk factors. |
| 16924240 |
hHR23B thus plays a critical role in the activation and function of p53 after specific genotoxic exposures. |
| 17069461 |
In transfected cells and KSHV-infected B lymphoma cells, KSHV-encoded latency-associated nuclear antigen (LANA) expression stimulates degradation of tumor suppressors von Hippel-Lindau and p53. |
| 17151828 |
Our results imply that HERV-I LTR, while under negative control by its LTR cis-elements and by wild type p53, may become active upon p53 mutation |
| 17151932 |
study found associations of risk haplotypes and protective haplotypes in p53 for glioblastoma and in ATM for meningioma; study provides new data that could add to our understanding of brain tumour susceptibility |
| 17436385 |
p53 expression in gastric cancer was associated with poorer survival and was an independent predictor of tumor behavior and patient response to therapy. |
| 17447881 |
Mutations of p53 were associated with lymph node metastases and III/IV stage of tumors that are signs of unfavorable prognosis in colorectal cancer. |
| 17488820 |
Bub1 compromise triggers p53-dependent senescence, which limits the production of aneuploid and potentially cancerous cells. |
| 11971958 |
These results demonstrate direct activation of the human DDB2 gene by p53. The corresponding region in the mouse DDB2 gene shared significant sequence identity with the human gene but was deficient for p53 binding and transcriptional activation. |
| 11971968 |
Identification of a novel mouse gene, mRTVP-1, as a p53 target gene. The mRTVP-1 protein has 255 amino acids and differs from the human RTVP-1 protein by two short in-frame deletions of two and nine amino acids. (mRTVP-1) |
| 12175902 |
Efficient repair of bulky anti-BPDE DNA adducts from non-transcribed DNA strand requires functional p53 but not p21(waf1/cip1) and pRb. |
| 15964625 |
NPM inhibits ionizing irradiation-induced p53 transactivation, and interacts with p53 in hematopoietic cells. |
| 15967108 |
SAK repression by p53 is likely mediated through the recruitment of HDAC repressors, and SAK repression contributes to p53-induced apoptosis |
| 16246554 |
the p53-HDM2 interaction can be inhibited by a newly isolated hexylitaconic acid from the marine-derived fungus, Arthrinium |
| 17302414 |
Both kinetics and free energy landscape analyses indicate that bound MDM2 unfolds in the order of p53 unbinding, tertiary unfolding, and finally secondary structure unfolding. |
| 11953423 |
MDMX, when exceedingly overexpressed, inhibits MDM2-mediated p53 degradation by competing with MDM2 for p53 binding |
| 11953436 |
Mutation of human thioredoxin reductase 1 promotes p53-dependent gene expression |
| 12217802 |
bcl-2/Jh lymphomas show molecular heterogeneity and that bcl-6 and p53 mutations may be acquired during the evolution of such lymphomas |
| 12482984 |
Thus, the accumulation of mutant p53 in tumor cells may contribute to tumorigenesis by inhibiting stress-inducible kinase pathways. |
| 12687275 |
p53 and c-fos are significantly overexpressed in thyroid cancer patients, indicating their role in the genetic mechanisms leading to thyroid tumorigenesis |
| 12687276 |
the expression of p53 is very probably involved in the regulation of leukemic hematopoiesis and that the inhibition of p53 expression could modulate the proliferation of leukemic cells. |
| 12821135 |
p53 must be dephosphorylated on serine residues during N-alpha-tosyl-L-phenylalanyl chloromethyl ketone-induced apoptosis |
| 13678722 |
p53 gene mutations might be a main causal factor for carcinogenesis for gynecological neoplasms. |
| 13679039 |
p53-induced transcription is inhibited by SINK-homologous serine-threonine kinase |
| 14704000 |
expression of iNOS, P53 and Bax in the gallbladder wall |
| 15178678 |
when p53 protein levels increase, it contributes to its own demise by up-regulating the transcription of S100B protein as part of a negative feedback loop |
| 15764300 |
association between genetic polymorphisms of GSTT1, p53 codon 72 and bladder cancer in southern Taiwan |
| 16122737 |
Data show that Topors enhances the conjugation of the small ubiquitin-like modifier 1 (SUMO-1) to p53 in vivo and in a reconstituted in vitro system. |
| 11948632 |
Evaluation of relationship between chromosome 22 and p53 gene alterations and the subtype of meningiomas by the interphase-FISH technique. |
| 11949842 |
expression of apoptosis-regulating proteins p53, Bcl-2, and Bax in primary resected esophageal squamous cell carcinoma |
| 11949843 |
Expression of p53 and bcl-2 proteins in acute leukemias: an immunocytochemical study |
| 12501250 |
investigated whether Tat might alter p53 acetylation and p53-responsive transcription; results allude to mechanism where the HIV-1 trans-activator might impair tumor suppressor functions favoring establishment of neoplasia in AIDS |
| 12514180 |
p53 plays an important role in PP2C alpha-directed cell cycle arrest and apoptosis |
| 15037740 |
identified a global suppressor motif involving codons 235, 239, and 240 |
| 15199150 |
p53 is associated with the telomeric complex in alternative lengthening of telomeres (ALT) cells; inhibition of DNA synthesis in ALT cells by p53 requires intact specific DNA binding and suppression of recombination functions. |
| 15226443 |
observations identify hMutL proteins as regulators of p53 response and demonstrate for the first time a function of hMLH1-hPMS1 complex in controlling the DNA damage response |
| 16299809 |
age dependent phosphorylation of p53 protein and deregulation of p53 gene has a role in the development of human vestibular schwannomas |
| 11960904 |
summarize the current understanding of post-translational modifications and their effect on conformation-based functional relationship between Mdm2 and p53 |
| 11960918 |
Genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus: the CDKN2A (p16(INK4a) and p14(ARF) ) and p53 genes are major targets for inactivation. |
| 12119414 |
mutations in rheumatoid arthritis synovium |
| 12154087 |
CARF is co-regulated with ARF and cooperates with it in activating p53 |
| 12165799 |
p53 is acetylated by tumor necrosis factor alpha, then p53 attenuates its trans-activation by depleting CREB binding protein in rheumatoid synoviocytes |
| 12592393 |
Methylation of CpG and CCWGG motifs in the promoter of TP53 could represent a novel mechanism leading to functional impairment of this tumor suppressor gene in ALL. |
| 12660163 |
activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner |
| 12669312 |
this gene regulates the matastasis suppressor gene Nm23 in cultured tumor cells. |
| 12768030 |
p53-induced apoptosis inhibited by activated Notch1 |
| 12811820 |
Caffeine induces cell cycle arrest and apoptosis in association with activation of p53 by a novel pathway to phosphorylate the Ser-15 residue and induction of phosphorylation of cdc 2 in leukemic cells with normal p53. |
| 14744935 |
inactivation of p53 is a protective mechanism utilized by cells to adapt to ER stress. |
| 15358769 |
Hsp90 chaperone activity is important for the transcriptional activity of genotypically wild-type p53 |
| 15358771 |
Hsp90 is required to maintain the folded, active state of p53 by a reversible interaction |
| 15509555 |
p53 antagonizes c-Myb by recruiting mSin3A to down-regulate specific Myb target genes |
| 15557124 |
Integrin alphav controls melanoma cell survival in 3D-collagen through a pathway involving p53 regulation of MEK1 signaling. |
| 15713654 |
Activation domain 2 of p53 is required for induction of the proapoptotic target gene insulin-like growth factor binding protein 3 (IGFBP3) and p53 basic domain inhibits induction of this gene. |
| 12403781 |
Data suggest that securin is a p53 target gene and may play a role in p53-mediated cellular response to DNA damage. |
| 12679912 |
Codon 249 mutation in exon 7 of this gene in plasma DNA may be a new early diagnostic marker of hepatocellular carcinoma in Qidong risk area, China. |
| 15448009 |
TP53 does not have a role in the histologic response to chemotherapy in patients with osteosarcoma, but its mutation may be associated with disease progression |
| 15448010 |
p53 expression may have a role in progression of inflammatory breast cancer |
| 15680394 |
decreased cell-surface expression of Fas and resistance to Fas-mediated apoptosis may occur independently of loss of wt p53 expression in esophageal adenocarcinoma |
| 15734290 |
an apoptosis-deficient Pro allele of the p53 gene may be related to psoriasis resistance to UV-based therapy |
| 15925988 |
Study reports the first unequivocal case of a ganglioglioma harboring aberrant TP53 product that was expressed predominantly in the neuronal component. |
| 15993843 |
We propose that induction of NQO2 may relate to the observed increased expression of p53 that, in turn, contributes to the observed suppression of cell growth in both melanoma cell lines. |
| 16051302 |
A proteasome inhibitor, lactacystin, enhances TNFalpha cytotoxicity in p53-positive and -negative cells. |
| 16251187 |
4-oxo-2-nonenal, a lipid peroxidation product is a potential trigger of the p53 pathway |
| 16485142 |
an independent prognostic marker in stage III colrectal carcinoma |
| 16738336 |
HIPK2 cooperates with p53 in Gal-3 repression and that this cooperation requires HIPK2 kinase activity. |
| 16778101 |
Expressions of p53 proteins should be useful for determining the tumor properties, including prognosis, in patients with esophageal squamous cell carcinoma. |
| 16827804 |
The p53-46F mutant with enchanced ability to induce p53-dependent apoptosis was reported. |
| 16867217 |
p53 is functional in the absence of p14(ARF) in malignant pleural mesothelioma |
| 12163498 |
p53 represses TauT and is involved in renal development and apoptosis. |
| 12854888 |
potential improvement of the International Prognostic Scoring System by the addition of molecular analysis to the system, with particular reference to the configuration of the TP53 gene |
| 17014845 |
transcriptional activation of the IGF-IR gene by Cav-1 requires an intact p53 signaling pathway |
| 17014852 |
Klotho normally regulates cellular senescence by repressing the p53/cyclin-dependent kinase inhibitor 1A pathway |
| 17170702 |
the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin' destroys p53 |
| 17170736 |
1,25 dihydroxyvitamin D3 photoprotection is associated with an increase in p53 and a decrease in nitric oxide products |
| 17289842 |
modified LDL results in an increased transfer of mitochondria-derived superoxide anion to p53, which stimulates a conformational change in Bax favoring its translocation to the mitochondria with resultant apoptosis of progenitor cells |
| 17289876 |
a genetic instability of the 17p13 region, occurring early in adrenocortical cancer development, involves various genes located in this region, including TP53 |
| 17363555 |
Cancer-associated mutant p53 can augment the induction of nuclear factor kappaB (NFkappaB) transcriptional activity in response to the cytokine tumor necrosis factor alpha (TNFalpha). |
| 17372198 |
this study reveals protein targets of p53 and highlights the role of transcription-independent effects for the p53-induced biological response |
| 17515610 |
The ability of mutant p53 to prevent arrest induced by replicational stress per se is primarily dependent on preventing p21CIP1 up-regulation. |
| 12077306 |
use of p53MH algorithm in detection of p53-responsive genes |
| 12716906 |
deacetylated p53 can transactivate the p21Waf1 gene |
| 12826609 |
Comprehensive site-directed mutagenesis technique & a yeast-based functional assay were used to construct, express, & evaluate 2,314 p53 mutants representing all possible AA substitutions caused by a point mutation throughout the protein. |
| 14675665 |
Abnormality of the p53 pathway was detected in cervix cancer and in CINs. |
| 14981901 |
Loss of p21 and/or p53 might not predict for prognosis in oropharnyggeal squamous cell carcinoma. |
| 15018706 |
the expression of DAP kinase, p19ARF, p53, and p21WAF1 was significantly down-regulated in the chronically HIV-1SF2-infected HUT78 T cells |
| 15297421 |
Cyclin D1, p53, and p21Waf1/Cip1 have roles in progression of serous epithelial ovarian cancer |
| 15297424 |
the inhibitory protein c-FLIP(L) is involved in resistance to CD95-mediated apoptosis in ovarian carcinoma cells with wild-type p53 |
| 15331608 |
Data show that squamous cell carcinoma cells escape suspension-induced, p53-mediated anoikis by forming multicellular aggregates that use fibronectin survival signals mediated by integrin alpha(v) and focal adhesion kinase. |
| 11875500 |
The low-molecular-weight compound PRIMA-1 restored sequence-specific DNA binding and the active conformation to mutant p53 proteins in vitro and in living cells. |
| 11997498 |
mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53. |
| 12138177 |
Data suggest a model in which p53 directly recruits a TRRAP/acetyltransferase complex to the mdm2 gene to activate transcription. In addition, this study defines a novel mechanism utilized by the p53 tumor suppressor to regulate gene expression. |
| 12535653 |
Data show that aspirin decreases endothelial cell proliferation through cell cycle arrest mediated by enhanced p53 expression. |
| 15778501 |
p53 participates in a feedback mechanism with JNK to regulate the apoptotic process and is oppositely regulated by JNK1 and JNK2. |
| 15964795 |
Mutations in proline 82 of p53 impair its activation by PIN1 and CHK2 in response to DNA damage. |
| 16082197 |
p53 undergoes ubiquitin-independent degradation by the 20S proteasomes and that this process is regulated by NAD(P)H quinone oxidoreductase 1 (NQO1) together with NADH [review] |
| 16082221 |
ATM directly activates p53 while activating a safe-lock mechanism to inactivate the negative regulators of p53, Mdm2, and Mdmx [review] |
| 16364249 |
Our results indicate that the TP53 P allele is associated with a worse prognosis (P=0.011) while P21 polymorphism genotypes did not reveal any statistically significant result (P>0.05). |
| 16449651 |
PolH has a novel role in the DNA damage checkpoint, and a p53 target can modulate the DNA damage response and subsequently regulate p53 activation. |
| 16830793 |
The results indicate that overexpressed ER-beta may induce LoVo cell apoptosis and anti-proliferation by increasing p53 signaling in a ligand-dependent manner, and without hTNF-alpha involvement. |
| 12386810 |
role in regulating expression of 67-kDa laminin receptor precursor 37LRP |
| 14511408 |
p53 is not required for LKB1-induced apoptosis in pancreatic neoplasms |
| 14990579 |
p53 induced by ionizing radiation requires IFI16 |
| 16869745 |
whereas exogenous p73 exhibits similar transcriptional activity to p53 in H1299 cells, the endogenous p73 that accumulates upon DNA damage in HCT116 cells is unable to compensate for p53 function |
| 16918502 |
Caspase 7 promoter was found to have p53-binding sites and prohibitin activated this promoter through p53. |
| 16918534 |
presence of a codon 72 of p53 germline variant genotype increased the risk for HHV6 infection more than five times after kidney transplant |
| 16919027 |
In this study, the p53 protein immunoreactivity was not a marker of malignant transformation of chronic actinic cheilitis to squamous cell carcinoma. |
| 17478762 |
Expression of c-erbB-2 and p53 has no prognostic value in patients with early-stage breast cancer in which axillary lymph node metastasis is absent. |
| 17538794 |
hypoxia may decrease tumor cell radiosensitivity through the suppression of p53 activity in some tumor cell lines |
| 11756653 |
To determine whether genotoxic stress regulates DNA binding by p53 in vivo, we have performed quantitative chromatin immunoprecipitation (ChIP) assays on tumor and normal cell lines containing wild-type p53 |
| 12036943 |
Induction of gene amplification is a gain-of-function phenotype of mutant p53 proteins. |
| 12459877 |
TP53 has a role in aortal endothelial cell aging |
| 12062821 |
Perturbations of chromosome 17 in general and the p53 locus in particular occur frequently in severe/late stage endometriosis. |
| 12124396 |
two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53 |
| 12374798 |
role in enhancing MUC2 mRNA expression |
| 12609716 |
Mutation of p53 gene endows gliomas with an angiogenic phenotype by reducing thrombospondin-1 production as well as enhancing the angiogenesis inducers in the early phase of malignant progression. |
| 12642870 |
mutations induce loss of DNA methylation and amplification of the TROP1 gene |
| 12642871 |
modulation of level by cyclin G via a negative feedback reglation |
| 12700230 |
half-life (t(1/2)) of the unfolding of highly destabilized mutants |
| 12804595 |
p53-dependent apoptosis triggered by fast neutrons in lymphoid cells requires caspase 8-mediated BID cleavage |
| 12823592 |
P-53 over-expression can occur in initial stages of HCV-related liver disease. |
| 12713809 |
tp53 has a role in recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage |
| 12773566 |
p53 is inactivated by leukemic protein MLL-ELL |
| 14534749 |
p53 inactivation caused by HPV infection may play a role in the pathogenesis of colon cancer |
| 14689061 |
The frequency of p53-positive patients is relatively low in T-ALL (29%) and B-CLL (16%). B-ALL, AML and CML patients revealed higher frequency of p53 protein. |
| 14757278 |
The levels of p53 protein elevated in keloid, hypertrophic scar and white and hard hypertrophic scar |
| 14612499 |
p53 is an important mediators of chemoresistance in ovarian cancer cells. |
| 14612511 |
Tumor cells with wild-type p53 activity exhibited up-regulation of surface CD95 after ionizing irradiation. |
| 14612513 |
The presence of wild-type p53 increased survival of prostate carcinoma cells after fractionated exposure to radiation. |
| 14644318 |
MNNG induces apoptosis in lymphoblastoid cells by activating the p53-dependent Fas receptor-driven pathway. |
| 15102863 |
p53-dependent apoptosis requires BOK and NOXA |
| 15039530 |
HHV-6 has a mechanism for retaining p53 within the cytoplasm and protects the infected cells from apoptosis. |
| 15256442 |
Results demonstrated a novel function of Ser(392) phosphorylation in regulating the oncogenic function of mutant p53. |
| 15256449 |
Regulation of cyclin E expression plays a role underlying numeral homeostasis of centrosomes in human bladder cancer cells and that deregulation of cyclin E expression, together with inactivation of p53, results in centrosome amplification. |
| 15292938 |
Tumorigenesis pathway independent of p53 dysfunction appears to exist in association with ulcerative colitis. |
| 15371445 |
eIF5A may be a regulator of p53, and syntenin might regulate p53 by balancing the regulation of eIF5A signaling to p53 for apoptosis |
| 15341441 |
p53 gen mutation analysis may be useful in the follow-up of at-risk patients, and introduces new possibilities to analyse molecular markers before malignant lesions are clinically apparent. |
| 15304330 |
Serine 392 exerts important effects upon p53 stability via the inhibition of its nuclear export mechanism. |
| 15340061 |
mechanism of p53 regulation originating through alternative splicing of the human p53 gene resulting in the expression of a novel p53 mRNA |
| 15351976 |
MDR functional phenotype could be associated with p53 mutation in the advanced stage of leukemias |
| 15367600 |
herpesvirus saimiri (HVS) ORF73 binds both p53 and pRb in vitro and in vivo, colocalizes with p53 in T cells infected with HVS, and in cells overexpressing both ORF73 and p53, and adversely influences pRB/E2F and p53 transcriptional regulation |
| 15583825 |
TP53 function closely influences the decision between apoptosis and growth arrest following Fatty acid synthase blockade |
| 15582998 |
in tumor cells lacking functional p53 and/or p21, p14(ARF) impaired mitotic entry and enforced a primarily cytoplasmic localization of p34(cdc2) that was associated with a decrease in p34(cdc2) kinase activity and reduced p34(cdc2) protein expression |
| 15793143 |
Excision of nucleoside analogs from DNA by p53 protein suggests a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase |
| 15838728 |
Nuclear genetic polymorphisms related to oxidative stress or apoptosis may modify the age at onset of Leber's hereditary optic neuropathy (LHON). |
| 15878620 |
The Aberrant expression of p53 Genes were determined in bone marrow samples of children with de novo B-lineage (n=170) and T-lineage (n=25) acute lymphoblastic leukemia (ALL). |
| 16055726 |
GSK3-dependent phosphorylation of Mdm2 regulates p53 abundance |
| 11859195 |
the presence or absence of wild-type p53, may be an important determinant of response to antiangiogenic therapy |
| 16142387 |
P53 is probably involved in the development of conjunctival and eyelid tumors due to its high rate of presence in both benign and malignant neoplasms of these organs. |
| 12161427 |
These results demonstrate that overexpression of Activating transcription factor 3 (ATF3) suppresses tumor necrosis factor-alpha-induced cell death of HUVECs, at least in part, through down-regulating the transcription of p53 gene. |
| 12698195 |
p53 mutations reflected histological progression in Barrett's patients with p53 mutations found in 30% of metaplasia patients (P=0.4) and low-grade dysplasia patients (P=0.33). |
| 12698197 |
This additivism, where doxorubicin acts via p53 expression and vinorelbine through p38 MAP KINASE activation, may contribute to the high clinical response rate when the two drugs are used together in the treatment of breast cancer. |
| 12743423 |
p53 accumulation and loss of bax expression influence the acquisition of a malignant phenotype but seem to have no further impact on tumor progression. |
| 12743601 |
This protein is required for the Nuclear localization of Y-box factor YB1. |
| 12772781 |
The detection of mutant p53 protein in hepatocellular cancer is corellated with clinicopathologic parameters and incidence of the liver neoplasms in Turkey. |
| 14534696 |
there may be a p53-dependent regulatory pathway of the maspin protein in human cancer |
| 14612423 |
proline-directed acetylation of p53 is a post-DNA binding event |
| 14612427 |
L11 functions as a negative regulator of HDM2 and there might exist in vivo an L11-HDM2-p53 pathway for monitoring ribosomal integrity |
| 15123817 |
p53-dependent cell fate is determined by E1A-binding p300 nucleoprotein |
| 15254240 |
in sensitive organs mitochondrial p53 accumulation in vivo occurs soon after a death stimulus |
| 15629713 |
The HIF-1alpha ODD domain binds weakly to the isolated p53 core domain but tightly to full-length p53 to give a complex of one HIF-1alpha ODD domain with a p53 dimer. |
| 15671037 |
Plk3 is a RelA-NF-kappaB-regulated gene that induces apoptosis in both p53-dependent and -independent signaling pathways |
| 15998523 |
Expression of p53 in renal carcinoma cells is independent of VHL. |
| 15998635 |
mutant p53 is reactivated and apoptosis is induced by maleimide analogs in human tumor cells |
| 16088313 |
analysis of the role of HTLV I Tax in p53 inhibition in leukemia [review] |
| 16131611 |
p53 isoforms can regulate p53 transcriptional activity. |
| 16163384 |
Tumor suppressor molecule p53 maintains mitochondrial genetic stability through its ability to translocate to mitochondria and interact with mtDNA polymerase gamma (pol gamma) in response to mtDNA damage. |
| 16301995 |
induction of transcription is mediated by HIC1 p53-responsive element |
| 16327987 |
expression of p53 is essential for cytotoxic effect of cisplatin in human malignant glioblastoma cells, A172 and T98G, and introduction of apoptotic signal molecules, such as p53, will be beneficial to achieve chemosensitivity in malignant glioma |
| 16328005 |
DNA hypermethylation of p53 was detected in a quarter of the low-grade, low-stage transitional cell carcinomas(TCC) and undifferentiated small cell carcinomas, but only sporadically in squamous cell carcinomas, and was absent in high-grade, high-stage TCC |
| 12419825 |
The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a mutational hotspot in hepatocellular carcinoma. 4-HNE may cause human cancers with mutations at codon 249 of p53 gene. |
| 16318864 |
p53 overexpression in esophageal cancer tissue is positively associated with the presence of the Arg allele of the p53 codon 72 polymorphism |
| 16360120 |
Our results indicate that chromatin alteration in interstitial chromosomal regions is the most likely cause of continuous activation of p53, which results in the induction of SLGA by ionizing radiation. |
| 11733360 |
Mutations of p53 gene were present in 24% (5 of 21) of the evaluable cases, all of them overexpressing p53 in the majority of tumor cells. |
| 11911244 |
Interaction between bcl-2 and P53 in neoplastic progression of basal cell carcinoma of the head and neck |
| 12584563 |
TP53 rearrangements in families with the Li-Fraumeni syndrome reveals a complete deletion of the TP53 gene |
| 12756585 |
The detected pattern of the p53/ bcl-2 ratio in hypertrophic actinic keratosis suggests important role for another gene: the proapoptotic gene bax. |
| 12901798 |
p53 mutation [p53(R273H)], is frequently found in human cancers. |
| 15705871 |
The homeodomain of Msx1 functions as a protein-protein interacting motif rather than a DNA-binding domain and is essential for stabilization, nuclear accumulation, and apoptotic function of wild-type p53. |
| 11779500 |
acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases |
| 11779855 |
role in inducing CD95 gene expression in endothelial cells exposed to doxorubicin |
| 11923280 |
Akt enhances Mdm2-mediated ubiquitination and degradation of p53. |
| 11979459 |
pathogenesis of nasopharyngeal carcinoma in children may involve EBV infection leading to LMP-1 expression and p53 overexpression |
| 16226255 |
The data was obtained that establishes the contribution of the transcription-independent mitochondrial p53 pathway to apoptosis of primary cells in response to deregulated oncogenes. |
| 16260623 |
mutants of p53 may induce loss of drug sensitivity is via the NF-kappaB2 pathway |
| 16325212 |
p33ING1b prominently enhances etoposide-induced apoptosis through p53-dependent pathways in human osteosarcoma cells. |
| 12351827 |
Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor |
| 12885235 |
Fibrillar aggregates of the p53 core domain contribute to the loss of function of p53 and seed the accumulation of conformationally altered protein in some cancerous cells. |
| 14627345 |
p53 gene mutation is an independent predictor of poor prognosis in colorectal cancers |
| 15081425 |
role of pathway in regulating G1-S transition and apoptosis along with RFT |
| 15359011 |
Emerging evidence in this review discusses a key survival/death checkpoint in both peripheral and central neurons that involves the p53 tumor suppressor and its newly discovered family members, p73 and p63. |
| 15291355 |
analyses of statistical interactions between polymorphisms (p73 G4A, p53 Arg72Pro and p21 Ser31Arg polymorphisms) revealed the marginally significant risk of non-Hodgkin's lymphoma for interaction between p53 Arg72Pro and p73 G4A polymorphisms |
| 11883440 |
minor role of exon 5-9 among Sudanese breast cancer patients |
| 11934017 |
inverse relationship seen between HPV infection and p53 positivity suggests loss of p53 function in cervical cancer, either by binding to E6 oncoprotein of HPV or by mutation in p53 |
| 11948395 |
Characterization of the p53-rescue drug CP-31398 in vitro and in living cells |
| 11948396 |
p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation. |
| 12007715 |
Mutations for basal cell carcinoma (BCC), were screened in 15 cases of sporadic BCCs that developed in sun-exposed skin region in a Korean population |
| 12145320 |
enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics |
| 12438652 |
Many genes are affected by TP53 gene dosage for their expression. We report several candidate genes as potential downstream targets of p53 in nonstressed cells. Among them, CSPG2 is validated as being directly transactivated by p53. |
| 14504475 |
Results identify a 22-mer peptide derived from the p53 core domain (peptide 14), which inhibits p53-specific DNA binding, and may prevent inappropriately-triggered apoptosis in normal tissues. |
| 12032848 |
DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest. |
| 12145207 |
Syncytia from cells expressing the HIV-1 Env gene fused with cells expressing CD4/CXCR4 undergo apoptosis after nuclear translocation of mTOR, mTOR-mediated p53 phosphorylation, p53-dependent Bax upregulation & mitochondrial death pathway activation. |
| 15279793 |
activation of the DNA DSB checkpoint provides the selective pressure for the high frequency of p53 inactivation in human cancer [review] |
| 15337531 |
Ras appears to attenuate p53 in SW480 cells by two independent regulatory mechanisms, the one leading to increased Mdm2-dependent p53 degradation and the other leading to a decrease in p53 transcription. |
| 12468914 |
expressed in biopsies from children with Langerhans cell histiocytosis |
| 12782597 |
Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells. |
| 14669308 |
Aberrant HPLC chromatographies were found in tumor tissues, while their normal-adjacent counterparts running in parallel showed a normal shape. |
| 14670539 |
both HPV infection and p53 gene abnormalities may contribute to Bilharzial bladder carcinogenesis in an independent way |
| 15378004 |
describes that lactoferrin specifically transactivates the p53 tumor suppressor gene through the activation of nuclear factor-kappaB and consequently regulates p53-responsive oncogenes |
| 15378026 |
results suggest that SAP contributes to the execution of some p53 functions |
| 15474092 |
The p53 codon 72 gene polymorphism is not associated with the susceptibility of leiomyomas. |
| 15670751 |
The results suggest that I3C represses cell proliferation through up-regulation of NAG-1 and that ATF3 may play a pivotal role in DIM-induced NAG-1 expression in human colorectal cancer cells. |
| 15713979 |
Two cases of lymphomatoid palulosis with mutated p53 gene in biopsy showed no progression of disease in 5 yr follow up. May not play any significant role in the pathogenesis, progression or transformation of cutaneous CD30(+) lymphoproliferative diseases. |
| 11867628 |
NO induces the accumulation of transcriptionally active p53 in a variety of cell types and NO signaling to p53 does not require ataxia telangiectasia-mutated (ATM), poly(ADP-ribose) polymerase 1, or the ARF tumor suppressor protein |
| 11920528 |
expression has an independent effect on prediction of survival, progression, and development of metastasis in transitional cell bladder carcinoma |
| 12782576 |
P53-negative AsPC-1 cells are resistant to p53-mediated apoptosis. |
| 12444079 |
Interacts with WT1 in insulin-like growth factor-I receptor gene regulation |
| 14654549 |
p53 protein was estimated by immunohistochemistry of beta-catenin and p53 proteins in colorecta mucinous carcinoma. |
| 15064727 |
p53 interacts with RNA via its C-terminal domain; oligomerization of p53 is significantly enhanced by disrupting this. Binding of RNA to p53 is involved in the mechanism of p53 latency. |
| 15064747 |
Phosphorylation of p53 on N-terminal serine residues is not required for increased transcription of most p53-responsive genes. Induction of p53 by p14ARF, with little phosphorylation, leads to substantial repression of genes with roles in proliferation. |
| 15377670 |
NDRG1 is necessary but not sufficient for p53-mediated caspase activation and apoptosis |
| 15601585 |
p53 is an essential effector of PKCdelta in human colon cancer cells |
| 15814626 |
The p53 Pro allele is associated with an increased frequency of p53 mutations in non-small cell lung cancer. |
| 15958617 |
Data show that the status of codon 72 polymorphism and p53 mutations can be used as a means for prediction of treatment response, although variables for each cancer type requires detailed evaluation. |
| 16107691 |
p53 represses myelocytomatosis oncogene c-myc transcription through a mechanism that involves histone deacetylation |
| 11751390 |
different genotype combinations of p53 and GSTM1 increase the risk of developing specific histological subtypes of NSCLC. |
| 11751391 |
DNA-PK and p53 may form a sensor complex that detects the disruption of DNA replication caused by nucleoside analogue incorporation and may subsequently signal for apoptosis. |
| 11751402 |
Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. |
| 12080348 |
Nucleophosmin (NPM) interacts directly with p53, regulates the increase in stability and transcriptional activation of p53 after different types of stress, and induces p53-dependent premature senescence on overexpression in diploid fibroblasts |
| 12234998 |
p53 controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblasts. |
| 14517281 |
p53 activity is regulated by 14-3-3 sigma |
| 14654539 |
Association association between lack of response to 5-fluorouracil and mitomycin and mutations affecting the L2/L3 domains of the p53 protein. |
| 11919562 |
binding and activation of PIG3 promotoer via a pentanucleotide microsatellite sequence |
| 14637168 |
We thus identified ik3-2 as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. |
| 15111320 |
activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 are induced during tumor cell differentiation by beta-catenin |
| 15159397 |
BRCA1-BARD1 complexes act as an adaptor to mediate phosphorylation of p53, influencing G(1)/S cell cycle progression after DNA damage. |
| 12794118 |
The restoration of wild-type p53 expression and function in human autologous lung carcinoma IGR-Heu cells results in a significant potentiation of target cell susceptibility to cytotoxic T cell-mediated lysis. |
| 14557644 |
small airway epithelial cells expressing a p53 mutant alleles were able to inhibit endogenous p53 activity; only one allele, 248W demonstrated a markedly increased ability to facilitate E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) replication |
| 14557665 |
Daxx significantly augmented p53-mediated transcription and the Adenovirus E1B 55-kDa protein eliminated this effect. |
| 14623878 |
cloned and characterized a p53 consensus element located within the first intron of the TRAIL-R3 gene |
| 14743210 |
Downregulation of p16(INK4a) and loss of wild-type p53 expression occurs after escape from cell immortalization. |
| 14995078 |
combined expression of p53 and metallothionein did not improve the predictive value for recurrence compared to MT alone |
| 15358195 |
Protein tyrosine phosphatase 1-B levels increased with introduction of wt p53 and may be involved in the dephosphorylation of Janus kinase 2 |
| 15509522 |
mutations in TP53 do not have a role in formation of human cerebral vascular malformations |
| 15358177 |
estimation of the sensitive positions to mutations in human p53 protein |
| 15701968 |
p14ARF induces p53-dependent cell cycle arrest but not apoptosis |
| 15701975 |
p53 might play a similar role in certain tissue stem cells and suppress the development of cancer stem cells [review] |
| 15703170 |
R273H removes an arginine involved in DNA binding, H168R and R249S induce substantial structural perturbation around the site |
| 15781620 |
Transactivation-dependent apoptosis does not always play a major role in p53-dependent apoptosis, indirectly supporting the importance role of the transactivation-independent mechanism. |
| 15927816 |
p53-specific serum antibodies are not associated with a history of skin carcinoma in renal transplant recipients and immunocompetent individuals. |
| 15945132 |
that wt-tumor protein p53 gene transfer inhibits interleukin 8 production and NF-kappaB transcription activity in cancer cells |
| 15937335 |
p53 is induced by urokinase in lung epithelial cells |
| 16158057 |
Transcriptionally active p53 is required for nuclear localization of Y-box-binding protein (YB1). |
| 16199549 |
p53 codon 72 genotypes are associated with the age of onset of colorectal carcinoma in a mismatch repair deficient background in a dose dependent manner |
| 16289694 |
IFN-alpha plus IFN-gamma triggers apoptosis independent of p53 in HaCaT cells, and also demonstrate an unexpected survival role for p53 in human KCs as regards apoptotic responsiveness to cytokines |
| 16430884 |
P53 interferes with the TAD-truncated p73alpha-mediated activation of NFkappaB. |
| 16458330 |
Mutations do not confer a growth advantage to somatic heterozygous clusters or maintenance turnover units. |
| 16474133 |
results indicate that KSHV vIRF1 comprehensively compromises an ATM/p53-mediated DNA damage response checkpoint by targeting both upstream ATM kinase and downstream p53 tumor suppressor |
| 16487937 |
p53 gene alterations may be involved in Balkan endemic nephropathy genetic pathways. |
| 16518869 |
caspase-6 and its cleavage of lamin A are critical in apoptotic signaling triggered by resveratrol in the colon carcinoma cells, which can be activated in the absence of Bax or p53 |
| 16525651 |
Data suggest that detection of mutated p53 could be a useful serological marker for diagnostic purposes. |
| 16525665 |
Findings support the hypothesis that p53 mutations are homogeneous throughout a tumor and may thus be a more useful diagnostic and prognostic indicator. |
| 16525684 |
Findings suggest TP53 allele combinations other than Arg/Arg may contribute to the risk of development of papillary thyroid cancer in individuals exposed to radiation during their late childhood, adolescence or in young adulthood. |
| 16598767 |
Our data indicated that in MTX M cells, p53 is sequestered in the cytoplasm by a novel mechanism that abrogates p53 residual function. |
| 16552814 |
findings of the present study indicate that p53 codon 72 arginine homozygous genotype may represent a genetic predisposing factor for colon cancer development |
| 16601838 |
angiostatins K1-3, K1-4 and K1-4.5 mediate anti-angiogenesis in a process involvingp53, FasL, AKT and mRNA deregulation |
| 16611260 |
Variations in TP53 and BAX alleles are unrelated to the development of pemphigus foliaceus. |
| 16690937 |
NS3 plays an important role in the hepatocarcinogenesis of Hepatitis C virus by interacting differentially with p53 in an NS3 sequence-dependent manner. |
| 16714289 |
PGE(2)-stimulated phosphoserine p53 abrogated DNA binding of c/EBPbeta dimers and c/EBPbeta/NF-kappaB p65 heterodimers. |
| 16741250 |
CD154 can sensitize leukemia cells to apoptosis via the c-Abl-dependent activation of p73 and mitigate the resistance of p53-deficient CLL cells to anticancer drug therapy. |
| 16777982 |
Metabolic activation of hormones can generate endogenous mutagens, and we demonstrate that estrone-quinone attenuates p53 function in human breast cancer cells. |
| 16777989 |
alteration of both p53 and PTCH genes is likely to play a role in radiation-induced basal cell carcinogenesis |
| 16777994 |
analysis of novel mechanisms for apoptosis induction by silibinin involving p53-caspase 2 activation and caspase-mediated cleavage of Cip1/p21 |
| 16798743 |
p53-induced cell cycle arrest is a function of not only the transactivation of cell cycle inhibitors but also the repression of targets that regulate proliferation at several distinct phases of the cell cycle |
| 16799632 |
p53 not only plays a key role in the regulation of the topoisomerase I response to UV-C irradiation but also to treatment with colcemid |
| 16855398 |
genomic instability is an early event that occurs at precancerous stages prior to changes in tumor suppressor genes (p53 and adenomatosis polyposis coli) in Barrett's esophagus-associated tumorigenesis in patients |
| 16839413 |
The Bcl-2 protein expression has a close correlation with p27 and p53 protein expressions and the proliferation activity determined by MIB-1 counts in invasive ductal carcinoma of the breast. |
| 16865671 |
identification of polymorphisms in lung carcinoma of never smokers |
| 16872365 |
Tumour protein p53 plays a role in facilitating histone H2AX phosphorylation, an important step in the mobilization of the DNA repair machinery at the site of DNA double-strand breaks. |
| 16924229 |
these findings identify the first instance of a ubiquitin ligase that causes stabilization of p53 while inactivating its transcriptional activities. |
| 16982033 |
The functional consequences of the identified PIDD/nucleolin interaction remain to be elucidated, but may be related to a recently discovered new role for PIDD in the activation of NF-kappaB upon genotoxic stress. |
| 16988840 |
Interval between the onset of rheumatoid arthritis and lymphoproliferative disorders development was significantly longer in patiets with p53 gene mutations and had more advanced diseases and an unfavorable prognosis |
| 17010455 |
Phosphorylation of specific serine and/or threonine residues reduces the affinity of the S100B-p53 interaction. |
| 17055453 |
ZNF415 isoforms in COS-7 cells inhibits the transcriptional activities of AP-1 and p53, suggesting that the ZNF415 protein may be involved in AP-1- and p53-mediated transcriptional activity. |
| 17093398 |
Although pterygium has limited local invasion and ainability to metastasize, concomitant presence of altered p53 in 8-OHdG-immunoreactive cells could provide evidence of apparent genetic instability, which is in contrast to its benign clinical course. |
| 17101792 |
Inhibition of KSP induces apoptosis independently of p53 and that p53 is dispensable for spindle checkpoint function. Thus, KSP inhibitors should be active in p53-deficient tumors. |
| 17108107 |
Chromatin immunoprecipitation analyses show that LKB1 is recruited directly to the p21/WAF1 promoter, as well as to other p53 activated promoters, in a p53-dependent fashion. |
| 17143016 |
In an analysis of breast cancer-specific survival up to 5 years, high Ki-67, high p53, and negative ER as well as aneuploidy of the tumour were significant prognostic factors. |
| 17149973 |
Moreover, these M6P/IGF2R 3'UTR mutations and the TP53 mutations detected previously were mutually exclusive in most of the tumors, suggesting two independent pathways to HCC development. |
| 17150106 |
The differential ability of p53 and p73 to inhibit glucocorticoid receptor transcription activity is due, in part, to differences in their N-terminal and C-terminal sequences. |
| 17132229 |
p53 to NF-kappaB signaling has a role in chemotherapy responsiveness of neuroblastoma |
| 17158927 |
While the DNA replication checkpoint is unlikely to regulate the assembly of a p21 promoter initiation complex, it signals to one or more factors involved in the process of transcriptional elongation. |
| 17198188 |
There are different immunohistochemical expression patterns of p16INK4A and p53 between intraductal papillary-mucinous neoplasm and pancreatic intraepithelial neoplasm |
| 17214516 |
individual variations in radiosensitivity and in the level of induction of TP53 (and consequently CDKN1A) are congruent, irrespective of the genetic background of the nontransformed fibroblasts |
| 17214517 |
the gene encoding Ku86 (XRCC5) is an essential gene in human somatic cells, and its absence cannot be suppressed by the loss of p53 function |
| 17230496 |
Overexpression of p53 is associated with pancreatic cancer |
| 17264218 |
p53 binds to and positively regulates BLIMP1. |
| 17264673 |
Review of ongoing work on biological functions of p53 tumor suppressor in different cell types and under various physiological conditions will help to unravel the complexity of molecular circuits that orchestrate the biological response to p53 activation. |
| 17272277 |
human Ada3 has an essential role in p53 acetylation |
| 17280505 |
Most non-small cell lung cancers (NSCLCs) have mutations of p53.[Review] |
| 17290307 |
Cytoplasmic relocalization of HIPK2 induced by HMGA1 overexpression is a mechanism of inactivation of p53 apoptotic function. |
| 17294448 |
result combined with our two previous analyses indicates that the p53 Y220C mutation was expressed in 6/50 HLA-A2+ squamous cell carcinomas of the head and neck tumors tested |
| 17349959 |
These findings establish HIPK2 as an MDM2 target and support a model in which, upon nonsevere DNA damage, p53 represses its own phosphorylation at Ser46 due to HIPK2 degradation. |
| 17360476 |
the binding of nuclear p53 to the specific sites within the PUMA promoter is essential for its ability to induce apoptosis and is likely to be required for its tumor suppressive capacity |
| 17364023 |
Nutlin-3a shows antitumor activity in vivo in a mouse xenograft model, exploiting new options for exploiting reactivation of p53 as treatment for virally-induced lymphoma. |
| 17387044 |
p53 modulates DNA DSB repair by, in part, inducing hnRNP G |
| 17387280 |
The delay in traversing S phase was reduced by the presence of p53 in HCT 116 cells exposed to cytotoxic drugs. |
| 17387621 |
The Arg72Pro polymorphism of p53 alters the transcription of p53 target genes and modifies the apoptotic potential of cells but there are inconclusive results with respect to breast cancer risk |
| 17393088 |
p53 upregulates restin transcription through an indirect mechanism rather than by direct interaction with the cis-activating element of the restin promoter. |
| 17409824 |
high and low P-glycoprotein, glutathione S-transferase pi expression, excision repair cross-complementing 1 alterations, and tumor suppressor p53 mutation were candidates for future clinical trials of chemosensitivity tests in lung cancer patients. |
| 17460193 |
CARF may exert a vital control on p53-HDM2-p21(WAF1) pathway that is central to the cell cycle control, senescence, and DNA damage response of human cells |
| 17460194 |
stress-induced premature senescence (SIPS) from hydrogen peroxide is associated with a transient increase in DNA-binding activity of p53 and an increased expression of p21(WAF-1) in human hTERT fibroblasts |
| 17499812 |
theaflavins induce apoptosis in human prostate cancer cells through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways |
| 17511743 |
A microtubule-facilitated nuclear import pathway for p53 is described. |
| 11718557 |
interactions with DNA in solution using time lapse atomic force microscopy |
| 16533178 |
p53 protein appears only in sporadic cases (6.6%) of severe colonic dysplasia |
| 17555331 |
shielding of reactive cysteines contributes to a negative regulation for human p53 and imply that such an inactivation of the transcription factor may represent an acute defensive response with significant consequences for oncogenesis. |
| 17616682 |
analysis of the p53-Mdm2 feedback loop using protein lysate microarrays |
| 17642181 |
correlation between p53 gene deletion and mammary gland carcinoma |
| 11840332 |
MDMX post-translational processing may be regulated by p53 |
| 11957139 |
the lack of correlation between p73 or p63 and p53 expression in head and neck squamous carcinoma suggests an independent and/or compensatory functional role |
| 12190289 |
p53 was detected more frequently in CIN I compared with CIN II/III and invasive carcinoma |
| 11518545 |
A loss of wild-type p53 gene function and consequent p53 overexpression in gastric carcinomas may be involved in early stages of tumor progression. |
| 12388558 |
regulation of function by Pin1 during DNA damage |
| 12519780 |
basal expression of p53 plays a functional role in a glucocorticoid receptor-mediated response regulating the expression of p21(Waf1/Cip1) via a mechanism that is suppressed by PP5 and associated with the phosphorylation of p53 at Ser-15 |
| 12553064 |
The complement inhibitor CD59 and the lymphocyte function-associated antigen-3 (LFA-3, CD58) genes possess functional binding sites for the p53 tumor suppressor protein. |
| 12668287 |
Patients with tumors who also showed overexpression of p53 had a significantly inferior response to chemotherapy compared with the patients with p53-negative tumors |
| 12692266 |
a transcriptional switch from P(0)-/P(2)- to P(1)-initiated p53 mRNA could be an important mechanism by which cells regulate p53 expression |
| 12839966 |
This protein interacts with TFAM and helps regulate DNA damage. |
| 12841598 |
Expression of apoptosis-inductive genes were increased by X-ray irradiation in squamous cell carcinoma cells(SAS) with wild-type p53, but not in SAS cells expressing mutated p53. Radiation sensitivity may come from expression of apoptosis-related genes. |
| 12926050 |
Ligase dead mutants of Mdm2 did not act in a dominant negative manner to reactivate p53 and they are not oncogenes in human mammary epithelial cells. |
| 12926080 |
A shift from one p53 intron 2 genotype in the blood to another genotype in the tissue may be a prognostic factor in ovarian cancer patients. |
| 12926093 |
P53 mutation predicts the failure of intravesical adriamycin instillation in transitional cell carcinoma of the bladder. |
| 12926120 |
p53 alteration is an independent and significant indicator to predict unfavorable prognosis in patients with unresectable non-small cell lung cancer. |
| 12926130 |
The p53 tumor suppressor pathway is disrupted in most oral squamous cell carcinomas at the cellular levels, due to either an abnormality in p53 itself or loss of expression of p53 regulatory factors. |
| 12955365 |
Radiation induced increased expression of p53. Ionizing radiation induces p53-dependent cell apoptosis in bladder cancer cells with wt- p53 but not in those with mutated p53. |
| 14500711 |
tp53 has a role in apoptosis along with noxa protein in human tumor cells |
| 14500729 |
TP53-mediated transcription is induced by prohibitin in human tumor cells through enhanced recruitment to promoters |
| 14529662 |
The immunodetection of both p53 and bcl-2 proteins in squamous cell carcinoma of the uterine cervix can be used as an independent diagnostic marker for cervical cancer associated with HPV infection. |
| 14527689 |
adenovirus 2 E1B-55K protein blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters |
| 14634213 |
p53 mutants showed increased binding to NQO1, which can explain their resistance to dicoumarol-induced degradation, as NQO1 has an important role in stabilizing hot-spot p53 mutant proteins in cancer |
| 14676844 |
Adenovirus-p53 induces the expression of a variety of proapoptotic genes and that lack of induction in one of these genes does not block Ad/p53-mediated cell killing in human lung cancer cells. |
| 14764457 |
p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells |
| 14966292 |
Results suggest that p53 degradation and inhibition of p14(ARF) signaling are independent functions of HPV16 E6, and that long-term proliferation of mammary epithelial cells requires inactivation of the p14(ARF)-p53 pathway. |
| 14967026 |
The ability to form unique amphipathic structures in both an aqueous cytosolic-like and a mixed organic membrane-mimetic solution environment may allow a p53 peptide from the mdm-2 binding domain to selectively and rapidly disrupt cancer cell membranes. |
| 14982997 |
Acetylation of p53 in vivo may contribute, at least in part, to its transcriptional activation functions. |
| 14676802 |
TP53 mutations develop in non-neoplastic epithelial lesions of the vulva, lichen sclerosus and squamous hyperplasia and are intrinsic to the clonal evolution that leads to squamous cell carcinoma of the vulva. |
| 11328884 |
Binding to the p53 binding sites of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation. |
| 11999565 |
p53 protein overexpression was noted in 59% of T-cell ltymphoblastic lymphoma cases and was correlaed with higher rate of relapse |
| 12174591 |
In response to irradiation, the amount of p53 protein synthesized in patients with AT and NBS was significantly lower than that in normal cells. |
| 12174820 |
Wild-type p53 protein conformation is stabilized upon CP-31398 exposure. |
| 12370303 |
p53 activation is inhibited by MDMX, which is transported to the cell nucleus with or without p53 upon DNA damage |
| 12690203 |
generation of the polyubiquitinated forms of p53 that are targeted for proteasome degradation requires the intrinsic ubiquitin ligase activities of MDM2 and p300 |
| 12789271 |
Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant cytosine methylation of their promoters |
| 12789273 |
Here we showed that 361 out of 1501 p53 responsive genes contained p53 consensus DNA-binding sequence(s) in their regulatory region, approximately 80% of which were repressed by p53 |
| 12839924 |
Hepatitis B virus X protein in liver cells down-regulates the expression of PTEN and activates AKT and affects p53-mediated transcription of PTEN. |
| 12893432 |
the p53 gene polymorphism may associate with NPC susceptibility in Thai population, particularly the Pro/Pro genotype carriers with age of >40 years. |
| 14584049 |
Data show that growth arrested keratinocytes may resist ultraviolet-light induced apoptosis by inactivating the pro-apoptotic function of p53. |
| 14965474 |
TIAF1 and p53 functionally interact in regulating apoptosis, and TIAF1 is likely to participate in the nuclear translocation of activated p53. |
| 15016620 |
examination of expression of p53, p21, and phosphorylated p42/44 mitogen-activated protein kinase in human pulmonary arterial smooth muscle cells |
| 15073170 |
p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1 |
| 11838964 |
The temperature sensitive mutant p53-143ala extends in vitro life span, promotes errors in DNA replication and impairs DNA repair in normal human oral keratinocytes. |
| 11838966 |
TSG101 expression in gynecological tumors: relationship to cyclin D1, cyclin E, p53 and p16 proteins. |
| 11839095 |
inhibition by TP53 of G2 phase checkpoint abrogation and radiosensitization induced by PD0166285 |
| 11890931 |
SN2 DNA-alkylating agent-induced phosphorylation of p53 increases its DNA-binding properties to cause an increased expression of p21 that may play a role in cell cycle arrest and/or apoptosis of human colon cancer cells HCT-116. |
| 15073118 |
p16INK4A, p14ARF, p53, and PCNA have roles in the progression of cervical neoplasia |
| 15120697 |
findings suggest that the tumor protein p53 codon 72 polymorphism is unlikely to be associated with endometriosis in Japanese women |
| 15321712 |
Data show that the fundamental active unit of p53 appears to be the tetramer, which is induced by DNA binding. |
| 12014634 |
Resistance to p53-mediated growth suppression in human ovarian cancer cells retain endogenous wild-type p53. |
| 12065086 |
polymorphism in codon 72 and risk of head and neck neoplasms |
| 12127401 |
An identical single nucleotide deletion within the C/EBP-like site of the promoter in 2 OF 18 Li-Fraumeni families. This site is not utilized in the wild type TP53 promoter and mutation of this site in LFS/LFL does not have a functional effect. |
| 12433927 |
description of the role of ionic interactions in the stability of the p53 tetramer and of heterotetramers of the protein scaffold |
| 12518062 |
pivotal role of NO in the induction of cellular stress and the activation of a p53 response pathway during chronic inflammation |
| 12552135 |
role of binding to mdm2 protein in p53 regulation |
| 12824925 |
types of mutations in sinonasal NK/T cell lymphoma in northeast district of China |
| 14583449 |
Activation of p53 reduces binding and relieves transcriptional repression of the Dnmt1gene, whereas loss of p53, a frequent, early event in tumorigenesis, may significantly contribute to aberrant genomic methylation. |
| 14583450 |
UV-induced activation of p53R2 transcription and binding of p53R2 to hRRM1 to form RR holoenzyme are impaired in the p53-mutant cell line PC3. |
| 14583461 |
Loss of p53, directly or indirectly, perturbs the normal regulation of phosphorylation of serine 10 in histone H3. |
| 14759115 |
There was no correlation between human papillomavirus status and p53 overexpression in human oropharyngeal squamous cell carcinoma. |
| 15140942 |
new roles for several DNA damage response factors by demonstrating that they also participate in the oncogenic stress signaling pathway between E2F1 and p53 |
| 15320716 |
Review focuses on potency of p53 as an inducer of apoptosis and reasons for extraordinarily high frequency of p53 inactivation in tumors, and mechanisms of tumor cell sensitization to p53-induced apoptosis. |
| 15247280 |
TP53 is ubiquitinated by topors |
| 15272143 |
A significant association between p53 gene Bam HI RFLP polymorphism and the infarction volume was found in patients with carotid atherothrombotic stroke from Moscow population. |
| 11805092 |
biogenesis in vitro to determine how wild type and mutant forms form hetero-oligomers |
| 12039466 |
were not able to confirm that the TP53 polymorphism at exon 4 increases the susceptibility to be infected by HPV or to develop high-grade intra-epithelial lesion of the cervix |
| 12085209 |
A new germline p53 mutation was found associated with a choroid plexus papilloma. The 7-BP insertion in exon 5 causes a frameshift from 161-182 and affected transactivation but not apoptosis induction. |
| 12386819 |
role in mediating cell cycle arrest in Rb(-/-) Saos2 cells |
| 12507556 |
Ubiquitination and degradation of p53 are largely controlled by Mdm2, an oncogenic E3 ligase. |
| 12824702 |
findings suggest that the Pro/Pro genotype of p53 codon 72 played a role in prostate cancer susceptibility in a Japanese population; the Pro allele did not appear to worsen such clinical parameters as clinical stage or pathological grade |
| 14737103 |
complete loss of p53 is a prerequisite for collaborating with activated Ha-ras to promote bladder tumorigenesis |
| 15058298 |
the net deubiquitination of the various targets of HAUSP determines the steady-state level of p53 |
| 15218947 |
No association between p53 status and overall survival in human glioma. |
| 15469940 |
phosphorylation of p53 at Ser-215 by Aurora-A is a major mechanism to inactivate p53 |
| 15753095 |
blockade of pol II-mediated transcription induces p53 accumulation in mitochondria and is the critical factor for eliciting p53-dependent but transcription-independent apoptosis |
| 15830705 |
Proliferative inhibition of breast cancer cells by Velcade is associated with stabilization of p53. |
| 15865924 |
review of current knowledge about association of aneuploidy and p53 |
| 15865925 |
role of p53 as a major pro-apoptotic factor in the pathogenesis of AIDS [review] |
| 15865935 |
review of the evidence for p53 as a participant in the responses of multiple CNS cell types to the presence of HIV and propose the hypothesis that HIV induced alterations in the CNS extracellular milieu converge at neuronal p53 activation |
| 15866118 |
expression of p53, MDM2, and p21Waf1 suggests a role for these oncoproteins in the regulation of endometrioma cell growth, but not in adenomyosis |
| 15765147 |
Data show that latent infection with Kaposi sarcoma-associated herpesvirus in B lymphocytes can be terminated by glycyrrhizic acid. |
| 15911628 |
CHIP-induced degradation was observed for mutant and wild-type p53, which transiently associate with molecular chaperones Hsc70 and Hsp90 and can be diverted onto a degradation pathway through this association |
| 16082224 |
p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1 |
| 16082226 |
Ser15 phosphorylation is important in regulating the oncogenic function of mutant p53 apoptosis induction in the context of the NF-kappaB/IkappaB signaling pathway |
| 16273653 |
Transient transfection of hepatitis B virus into the SMMU-7721 cell line can enhance p53 expression and its effects on development of hepatocarcinoma |
| 16230356 |
p53 may act as a DNA topology-modulating factor |
| 16255765 |
p53 expression in HBV or HCV cirrhotic liver are a rather late event in carcinogenesis and related to hepatocellular carcinoma grade |
| 16256294 |
overexpression of c-myc (p=0.038) related to poor survival whereas increased positivity for p53 predicted better survival (p=0.013). |
| 16273189 |
Both p53 and c-erbB-2 proteins appear to be involved at an early stage of malignization of pleomorphic adenoma |
| 16273227 |
Results demonstrate that p53 base mutations in combination with allelic imbalance do not predict survival or progression of colorectal cancer. |
| 16273238 |
TP53 expression may be a useful biomarker for assessing the risk of developing esophageal cancer. |
| 16297369 |
The current data collectively indicate that BaP induces apoptosis of Hepa1c1c7 cells via activation of p53-related signaling, which was, in part, regulated by p38 kinase. |
| 16293709 |
Loss of p53 function can lead to decreased hOgg1 repair activity. |
| 16354677 |
Although SIRT1 deacetylates p53, this does not play a role in cell survival following DNA damage in certain cell lines and primary human mammary epithelial cells. |
| 16449974 |
molecular analysis of p53 haplo-insufficiency |
| 16506220 |
TP53 G-->T transversions associated with tobacco smoke carcinogens were most frequent (50%) in the intermediate location. |
| 16552184 |
Cyclin dependent kinase 9, whose well-known substrate is RNA polymerase II, can also phosphorylate p53. |
| 16582589 |
Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis [review] |
| 16582625 |
Fatty acid synthase (FAS) gene, encoding for a key enzyme involved in the biogenesis of membrane lipids in rapidly proliferating cells, is a conserved target of the p53 family throughout the evolution. |
| 16611991 |
This study defines a new role for residues 53 and 54 of p53 in regulating transrepression and demonstrates that 25-26 and 53-54 work in the same pathway to induce apoptosis through gene repression. |
| 16569330 |
p53 codon 72 polymorphisms do not serve as a susceptibility factor affecting the chances of miscarriage in an unselected population. |
| 16611888 |
binding of p53 serves to modify simian virus 40 large T antigen (SV40 LT) by targeting CREB binding protein and p300 binding to direct the acetylation of SV40 LT |
| 16620878 |
distribution of methylation sites and repetitive elements in silent and nonsense p53 mutations in cancers |
| 16697957 |
NKX3.1 engages cell cycle and cell death machinery via association with HDAC1, leading to increased p53 acetylation and half-life through MDM2-dependent mechanisms. |
| 16684540 |
NF-kappaB-dependency of the platelet-activating factor -induced increase in VEGF expression is due to decreased p53 activity, which is reciprocally regulated by increased NF-kappaB activity. |
| 16729031 |
Moreover, in the absence of overt apoptotic signals, the constitutive induction of AIF by p53 may underpin a cytoprotective maintenance role, based on the role of AIF in ensuring proper mitochondrial function. |
| 16870621 |
p53 binding to the central domain of Mdm2 is regulated by phosphorylation |
| 16897187 |
These results suggest that DFNA5 plays a role in the p53-regulated cellular response to genotoxic stress probably by cooperating with p53. |
| 16917063 |
results show that p53 transcriptionally activates the alpha(II) collagen prolyl-4-hydroxylase [alpha(II)PH] gene, resulting in the extracellular release of antiangiogenic fragments of collagen type 4 and 18 |
| 16996204 |
high frequency of somatic TP53 gene mutations implicates TP53 as a predominant factor for breast carcinogenesis in moderate risk ethnic Kashmiri population |
| 17009393 |
Alkyl resorcinol exerts its cytotoxic effect in both hepatocellular cell lines through apoptotic cell death. For Hep3B, cells with mutated p53 and Fas, apoptosis would proceed by p53- or Fas-independent pathways. |
| 17012228 |
p53 and pRB can be sumoylated by SUMO-2/3 in vivo, and such modification of p53 and pRB may play roles in premature senescence and stress response |
| 17072987 |
The Pro/Pro genotype of the p53 codon 72 polymorphism carries a higher risk for gastric cancer in general and is also associated with a much higher risk for early gastric cancer than advanced gastric cancer. |
| 17041757 |
Although p53 is a main regulator of apoptosis in mammalian cells, the Tfpt induced apoptosis appears p53-independent. |
| 17050670 |
Our findings show that p53 is a transcriptional regulator of ECK in mediating apoptosis.The discovery of the novel p53-binding motif in the promoter may lead to the identification of a new class of p53 target genes. |
| 17050675 |
RNPC1a is required to maintain the stability of p21 transcript induced by p53. |
| 17050687 |
Stimulation of macrophage inhibitory cytokine 1-dependent S phase arrest in normal gut epithelial cells might help to revitalize the clinical use of N-phosphonacetyl-l-aspartate, which has been limited by gut toxicity |
| 17077087 |
Negative control by p53 on Nrf2 transactivation appears to be aimed to prevent the generation of a strong anti-oxidant intracellular environment that could hinder the induction of apoptosis. |
| 17174923 |
Study demonstrates that the p53-mediated induction of RhoE in response to DNA damage favors cell survival partly through inhibition of ROCK I-mediated apoptosis. |
| 17208332 |
study reveals that the TP53 Arg allele, active smoking and human papillomavirus infection infection are the important risk factors in lung cancer development in the north part of Iran, Mazandaran province |
| 17237848 |
no specific pattern for p53 mutations was observed in HCV genotype 4-associated hepatocellular carcinoma and no significant relation between p53 mutations, HCV-NS3 expressions or any HCV sub-genotype-4 sequence in Egyptian patients |
| 17310847 |
No siatistically significant value in assocation with survival or event-free survival in head and neck squamous cell carcinoma. |
| 17310850 |
Mutant p53 may contribute to its 'gain of function' effects which accelerate the oncogenesis and promotion of lung adenocarcinoma. |
| 17332323 |
Critical role of subcellular localization in the dominant-negative action of p53. |
| 17374954 |
Our finding that two different p53 haplotypes are associated with colorectal adenoma and cancer, respectively, suggests that each of these haplotypes may independently impact on p53 function within different genetic pathways of colorectal carcinogenesis. |
| 17374967 |
xeroderma pigmentosum group C protein polymorphism might affect p53 alteration and the molecular pathway defined by the p53 alteration in the development of muscle-invasive bladder cancer |
| 17380154 |
This study strengthens the rationale for targeting p53 deubiquitylation by drugs like Nutlin as a promising new strategy in Neuroblastoma therapy. |
| 17383977 |
findings point to the calpain pathway as a key player to maintain steady state levels of p53 in resting cells without affecting its activity. |
| 17390010 |
results suggest that some cells from head and neck cancer may contain the oncogenic mutation of the p53 gene, and the oncogenic p53 protein prevents cancer cells from undergoing apoptosis after DNA damage |
| 17401423 |
The central domain of the p53 protein targeted by 80% of p53 mutations is associated with the DNA-binding activity of the p53 protein;it is the binding site for proteins that play a key role in p53 regulation such as ASPP proteins or BclxL. |
| 17426708 |
The negative role played by the WTH3 gene in MDR development is through its proapoptotic potential that is regulated by multiple mechanisms at the transcription level, and one of these mechanisms is linked to the p53 gene. |
| 17428325 |
common polymorphisms in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are not shown to increase breast cancer risk |
| 11861393 |
Targeted inactivation of p53 in human cells does not result in aneuploidy. |
| 11861400 |
Human tumor suppressor ARF impedes S-phase progression independent of p53. |
| 11914273 |
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling |
| 14645705 |
p53 is required for sensitization to TRAIL |
| 17518987 |
alteration and/or a modulation of the p53-p21 pathway in response to UV could be determinant for human papillomavirus 16-infected keratinocyte survival and HPV-associated carcinogenic process |
| 12939400 |
findings suggest a novel mechanism of MLH1 in the induction p53 and apoptosis by inhibiting RNA polymerase II-dependent transcription on damaged DNA templates |
| 12051912 |
Recognition of DNA by p53 core domain and location of intermolecular contacts of cooperative binding. |
| 12093899 |
Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. The most common combination of mutations was p53 and APC (27.1%), whereas mutations in both p53 and K-ras were extremely rare. |
| 12534345 |
This protein and p73 interact with CTF2 and regulate HMG1 gene expression. |
| 12759537 |
results demonstrated significant positive staining of p53 in the salivary tumorigenic tissue but not in the surrounding non-tumorigenic tissue, pointing to a biological role in the tumorigenic process |
| 12890671 |
tp53 may negatively control the MAKP pathway via MKP1 |
| 12673251 |
During apoptosis, p53 activates transcription of PAC1 by binding to a palindromic site in the PAC1 promoter |
| 12712134 |
Mutations in PTEN/MMAC1 gene correlated inversely with an altered p53 status. |
| 12759240 |
Results showed that mutations in the p53 gene were frequently detected in in recurrent hepatocellular carcinoma. |
| 12860918 |
P53 protein expression in quiescent vascular smooth muscle cells [VSMCs] is paradoxically increased by application of a growth stimulus. Through mediation of p21WAF1/CIP1 and Bax, induced p53 protein negatively regulates the growth of dividing VSMCs |
| 12905527 |
role of p53 gene in the biophysics and biology in murine erythroleukemia cell line with the goal of understanding the influence of this tumor suppressor gene on the deformability and metastasis of tumor cells |
| 14523002 |
role of glycogen synthase kinase-3beta in binding and promoting action of p53 |
| 14735465 |
p53 induced apoptosis is inhibited by Bcl-xL in head and neck neoplasms |
| 14755251 |
ATR-p53 pathway is suppressed in noncycling lymphocytes via ATR downregulation. |
| 14756543 |
Probably no association between TP53 polymorphism at codon 72, HPV infection and the etiology of cervical cancer in this population sample. |
| 14756544 |
Correlation between p53 accumulation and survival in bilharziasis associated bladder squamous cell carcinoma. |
| 15029243 |
Data reveal that controlled MDM2 degradation is an important new step in p53 regulation. |
| 15069555 |
p53 codon 72 polymorphism may contribute to gastric cancer susceptibility |
| 15069711 |
The expression of p21 protein depends on p53 protein largely in normal gastric mucosa and dysplasia, but not in gastric carcinoma. |
| 15192123 |
suppression of p53-C277Y by RNAi reduced pig3 promoter activity, RNA, and protein expression |
| 15342377 |
Cyclin A1 methylation was inversely related to p53 mutational status in primary tumors, and forced expression of cyclin A1 resulted in robust induction of wild-type p53 in HNSCC cell lines. |
| 15201954 |
Disruption of p53-p21/WAF1 cell cycle pathways contributes to tumor progression and worse clinical outcome of hepataocellular hepatoma. |
| 15201971 |
Glioma cells with functional p53 were relatively resistant to gamma-radiation, and ceramide may play an important role in caspase activation during gamma-radiation-induced apoptosis of glioma cells lacking functional p53. |
| 15201979 |
Relation between expression, DNA ploidy and human papillomavirus infection in cervical carcinoma. |
| 15202001 |
Results link p53 status with POLkappa expression and suggest that loss of p53 function may in part contribute to the observed POLkappa upregulation in human lung cancers. |
| 15342238 |
examined the binding of DNA in solution to a series of unmodified p53 constructs that lack various domains, and identified the residues of the C terminus that interact with the non-specific DNA |
| 15314287 |
Radiation treatment in the presence of p53 C-terminal peptides is more effective for inducing p53 -mediated apoptosis than radiation treatment alone or p53 C-terminal peptide treatment alone in cancer cells. |
| 15327968 |
interaction of Ubc9 with p53 was regulated by phosphorylation of p53 |
| 15339933 |
Results describe the role of Daxx in modulating the apoptotic threshold and identify it as a possible integrating factor that coordinates the response of p53 family members. |
| 15386362 |
The finding of different p53 gene mutations among multiple esophageal carcinoma lesions suggest further evidence of multicentric or field carcinogenesis of the human esophagus |
| 15386430 |
We conclude that overexpression of PKCdelta in human colon cancer cells induces multiple antineoplastic effects that depend on the activities of p21(Waf1/Cip1) and p53. |
| 15469934 |
proximal 5'-flanking region of the IKKalpha gene contains a functional promoter reciprocally regulated by p53 and ETS-1 |
| 15548678 |
role of Cul4A in the MDM2-mediated proteolysis of p53 |
| 15548685 |
mutant p53s are likely to be distinct in terms of the extent to which each mechanism contributes to their gain-of-function phenotypes |
| 15537749 |
P53 is induced by Aluminum in neuron-like cells suggesting that the p53-dependent intrinsic pathway may be responsible for Aluminum-induced apoptosis. |
| 15592418 |
p53-dependent loss of Fbxw7 leads to genetic instability by mechanisms that might involve the activation of Aurora-A, providing a rationale for the early occurrence of these mutations in human cancers |
| 15608028 |
an over-representation of the Pro allele of the p53 gene in women with idiopathic recurrent miscarriage gives support to the theory that p53 has a potential role during pregnancy. |
|
