BioPortfolio - TPM1 - tropomyosin 1 (alpha)

TPM1

Symbol:

TPM1

Name(s):

tropomyosin 1 (alpha)

Type:

protein-coding

Organism:

Homo sapiens

Synonyms:

C15orf13, CMD1Y, HTM-alpha, TMSA

Links:

Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link

Summary of findings

12473556

Observational study of gene-disease association. (HuGE Navigator)

17932326

data illustrate that, in general, dilated cardiomyopathy and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposite effects on the Ca2+ affinity of reconstituted thin filaments

17895359

study reports that DAP kinase promotes in vitro & in vivo phosphorylation of tropomyosin-1 on Ser283 & that this phosphorylation is essential for the H2O2-induced organization of the assembly of actin stress fibers in endothelial cells

15695827

the role of tropomyosin is to facilitate the transmission of structural changes along the F-actin filament so that the monomers within a structural unit are able to interact with myosin

15031138

proposed a hypothesis of pathogenetic changes caused by alpha-tropomyosin mutation Asp(175)Asn in familial hypertrophic cardiomyopathy on basis of changes in Ca(2+) handling as sensitive mechanism to compensate for alterations in sarcomeric structure.

17556170

in hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene, myocardial oxidative metabolism and FFA metabolism are increased and inversely related to LV hypertrophy at both the whole heart and regional level

12527301

identified and demonstrated that the intracellular C terminus of polycystin-2 associates with a core regulatory protein of the actin cytoskeleton system, tropomyosin-1

15000344

A previously described alpha-tropomyosin (TPM1) mutation (Asp175Asn) was found in 11% of cases.

16260624

alternative splicing of alpha-TM may be regulated by the antagonistic splicing regulators RBM4 and PTB

12065096

These data, for the first time, show that hypermethylation of TM1 gene and chromatin remodeling are the predominant mechanisms by which TM1 expression is downregulated in breast cancer cells.

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