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TTR


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Gene DB Home
Symbol:TTR
Name(s):transthyretin (prealbumin, amyloidosis type I)
Type:protein-coding
Organism:Homo sapiens
Synonyms:HsT2651, PALB, TBPA
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15649951 Observational study of gene-disease association. (HuGE Navigator)
16011990 Observational study of genotype prevalence. (HuGE Navigator)
16194875 A Swedish family is reported with rare Phe33Leu transthyretin mutation; the phenotype is characterized by familial amyloidotic polyneuropathy and carpal tunnel syndrome.
17176092 Transthyretin preferentially binds to aggregated rather than monomeric beta-amyloid and arrests further growth of the aggregates.
17957146 Serum RBP4 and TTR showed no differences between controls/type 1 diabetic children.
17466336 Thus, there was considerable phenotypic heterogeneity among family members with FAP despite the identical TTR genotype.
17873539 First described case of a TTR-Phenylalanine-64-serine mutation in an African-American family with profound gastrointestinal symptoms.
17980738 Elevated IOP (intraocular pressure) may develop in patients with vitreous amyloidosis due to a TTR Val30Gly mutation in the transthyretin gene.
17683281 proposed for TTR fibrillogenesis inhibitor screens avoids not only lengthy and cumbersome large-scale protein isolation steps but also artefacts associated with most current in vitro first-line screening methods
17683510 Reduced transthyretin expression is associated with lung cancer

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDheparan sulfate proteoglycan 2Transthyretin--Pubmed
HPRDlow density lipoprotein-related protein 2Transthyretin--Pubmed
HPRDRBP4 gene productTransthyretin--Pubmed

Recent Publications on TTR:

Pubmed Logo
Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease.
The diagnostic performance of several candidate cerebrospinal fluid (CSF)...
30th October, 2009
The Longtine Center for Molecular Biology and Genetics, Sun Health Biomarkers. 2009 Nov;14(7):493-501.
DOI Direct Link
Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity.
More than 100 transthyretin (TTR) variants are associated with hereditary...
29th October, 2009
Grupo de Neurobiologia Molecular, IBMC - Instituto de Biologia Molecular e FEBS Lett. 2009 Oct 25.
DOI Direct Link
Alcohol, Cocaine, and Brain Stimulation-Reward in C57Bl6/J and DBA2/J Mice.
Background: Pleasure and reward are critical features of alcohol drinking...
29th October, 2009
From the Department of Neurology (EWF, TTR, MMM, CJM); Bowles Center for Alcohol Clin Exp Res. 2009 Oct 23.
DOI Direct Link
Vitreous amyloidosis in two sisters as the indication of transthyretin-related familial form of systemic amyloidosis among liver transplantation candidates.
Vitreous amyloidosis, a rare condition characteristic of the familial form...
28th October, 2009
Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland. Transplant Proc. 2009 Oct;41(8):3085-7.
DOI Direct Link
Proteome analysis reveals candidate markers of disease progression in amyotrophic lateral sclerosis (ALS).
Objectives: In amyotrophic lateral sclerosis (ALS) the pathological...
27th October, 2009
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Neurosci Lett. 2009 Oct 22.
DOI Direct Link

View more research publications.

BioNews Results for TTR

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Alnylam Pharmaceuticals (ALNY) Provides Update on RNAi Pipeline, Platform, and Technology at Its R&D Day
BioSpace:  Nov 13 2009 3:44PM Matching: ttr
Alnylam Provides Update on RNAi Pipeline, Platform, and Technology at Its R&D Day
Pharma Live:  Nov 13 2009 3:50AM Matching: ttr
Alnylam Provides Update on RNAi Pipeline, Platform, and Technology at Its R&D Day
Therapeutics Daily:  Nov 12 2009 1:32PM Matching: ttr
Update on Alnylam Pharmaceuticals' RNAi pipeline, platform, and technology
News-Medical.Net:  Nov 12 2009 3:19PM Matching: ttr
Alnylam Provides Update on RNAi Pipeline, Platform, and Technology at Its R&D Day
Genetic Engineering News:  Nov 12 2009 2:37PM Matching: ttr
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
The Effects of Fx-1006A on Transthyretin Stabilization and Clinical Outcome Measures in Patients With V122I or Wild-Type (Transthyretin) TTR Amyloid Cardiomyopathy

Patents:

Patents logo
US Patent No.Title
7492659 Integrated circuit device and electronic instrument
7537922 Proteases and variants thereof
7542472 Data transmission
7544491 TANGO 240 nucleic acids and uses thereof
7544795 Recombinant hexose oxidase, a method of producing same and use of such enzyme

View more patents.

TTR results (if any) from reagent suppliers

Google CSE Logo
Anti-TTR Polyclonal Antibody
Polyclonal Antibody against TTR for use in Immunohistochemistry, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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TTR Antibody (Center)
TTR Antibody (Center) Cell Function, TTR Antibody (Center) Cancer.
http://www.abgent.com/products/catalog_no/AP6698c...

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TTR antibody, Transthyretin Antibody, Chicken IgY Polyclonal ...
This product is temporary unavailable. Continue. Exact | Advanced Search. Specific Categories. Antibodies · Secondary Antibodies ...
http://www.genwaybio.com/product_info.php?products_id=660...

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Prealbumin (N-19) Antibody sc-8105
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, TTR, 7276, 18q12.1, NM_000371 ...
http://www.scbt.com/datasheet-8105-prealbumin-n-19-antibody....

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RBP4 antibody (ab57622) | Abcam
Under physiological conditions, RBP binds transthyretin (TTR) to prevent ... The RBP/TTR molar ration provides an indirect way to indicate marginal vitamin ...
http://www.abcam.com/RBP4-antibody-ab57622.html...

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Transthyretin Antibody a tetrameric carrier protein
Additional Names. Transthyretin,TTR, PALB, TBPA, HsT2651. Transthyretin Antibody . Description. Left: Western blot analysis of Transthyretin in human lung ...
http://www.prosci-inc.com/shop/catalog1/Transthyretin-Antibo...

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ADAMTS13 antibody - Metalloproteinase domain (ab28274) | Abcam
A thrombocytopenic disorder called thrombic thrombocytopenic purpura (TTR) was shown to be due to a deficiency in the cleavage of von Willebrands factor, ...
http://www.abcam.com/ADAMTS13-antibody-Metalloproteinase-dom...

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