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U2AF1
| Symbol: | U2AF1 | | Name(s): | U2 small nuclear RNA auxiliary factor 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | DKFZp313J1712, FP793, RN, RNU2AF1, U2AF35, U2AFBP | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15950937 |
Binding assays revealed that IpaH9.8 has a specific affinity to U2AF(35), a mammalian splicing factor, which interferes with U2AF(35)-dependent splicing as assayed for IgM pre-mRNA |
| 11830556 |
A misspliced form of the cholecystokinin-B/gastrin receptor in pancreatic carcinoma: role of reduced sellular U2AF35 and a suboptimal 3'-splicing site leading to retention of the fourth intron. |
| 15096518 |
U2AF1 gene expression may provide a mechanism by which the relative cellular concentration and availability of U2AF(35) protein isoforms are modulated, thus contributing to the finely tuned control of splicing events in different tissues. |
| 16855028 |
Taken together our results demonstrate that U2AF35a is essential for HeLa cell division and suggest a novel role for both U2AF35 protein isoforms as regulators of alternative splicing of a specific subset of genes. |
| 16940179 |
Results describe the roles of the two subunits of U2AF, U2AF65 and 35, in the selection between alternative 3' splice sites associated with polypyrimidine tracts of different strengths. |
| 12297299 |
U2AF35 RRM is unstructured in solution but its tertiary structure is induced upon binding to U2AF65. |
| 16043505 |
identified and spatially localized sites of direct interaction between U2AF35 and U2AF65 in vivo in live cell nuclei. |
| 16809543 |
DEK enforces 3' splice site discrimination by U2AF; DEK phosphorylated at serines 19 and 32 associates with U2AF35, facilitates the U2AF35-AG interaction and prevents binding of U2AF65 to pyrimidine tracts not followed by AG |
| 15899895 |
U2AF35 appears to be completely dispensable for splicing in nuclear extracts prepared from adenovirus late-infected cells |
Recent Publications on U2AF1: |  |
Interactome for auxiliary splicing factor U2AF(65) suggests diverse roles.
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) is an essential... | 31st October, 2009
| Department of Veterinary Molecular Biology, Montana State University,
| Biochim Biophys Acta. 2009 Jun-Aug;1789(6-8):487-92. Epub 2009 Jun 18.
DOI Direct Link |
A NEW MOUSE MODEL FOR THE TRISOMY OF THE ABCG1-U2AF1 REGION REVEALS THE COMPLEXITY OF THE COMBINATORIAL GENETIC CODE OF DOWN SYNDROME.
Mental retardation in Down syndrome (DS), the most frequent trisomy in... | 29th September, 2009
| Universite d'Orleans, UMR6218, Molecular Embryology and Immunology,
| Hum Mol Genet. 2009 Sep 26.
DOI Direct Link |
Antisense transcription occurs at the promoter of a mouse imprinted gene, Commd1, on the repressed paternal allele.
The Commd1 gene is imprinted in the adult mouse brain and is predominantly... | 19th September, 2009
| Division of Molecular Genetics and Epigenetics, Department of Biomolecular
| J Biochem. 2009 Sep 17.
DOI Direct Link |
Reproductive and epigenetic outcomes associated with aging mouse oocytes.
Female aging entails a decline in fertility in mammals, manifested by... | 31st July, 2009
| Department of Human Genetics, McGill University and Montreal Children's
| Hum Mol Genet. 2009 Jun 1;18(11):2032-44. Epub 2009 Mar 17.
DOI Direct Link |
Correlation of expression and methylation of imprinted genes with pluripotency of parthenogenetic embryonic stem cells.
Mammalian parthenogenetic embryos (pE) are not viable due to placental... | 9th July, 2009
| School of Life Science, Sun Yat-Sen University, Guangzhou 510275, China.
| Hum Mol Genet. 2009 Jun 15;18(12):2177-87. Epub 2009 Mar 26.
DOI Direct Link |
→View more research publications. |
U2AF1 results (if any) from reagent suppliers | 
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Abgent - Stem Cell
AP2843aNEW, TRIP13 Antibody (N-term), WB, E, H. AP2802cNEW, U2AF1 Antibody ( Center S70), WB, IHC, E, H. AP2802dNEW, U2AF1 Antibody (Center Y114), WB, E, H
...
http://www.abgent.com/products/category/stem_cell...
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HNRNP C1/C2 antibody, HNRNP C1/C2 [4F4] Antibody, Mouse Monoclonal ...
... SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. ...
http://www.genwaybio.com/product_info.php?products_id=190171...
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U2AF35 (N-16) Antibody sc-19961
Humain, U2AF1, 7307, 21q22.3, NM_001025203, NM_001025204, NM_006758 · Q01081 · 191317. Souris, U2af1, 108121, 17 B1, Q9D883, Non disponible ...
http://www.scbt.com/fr/datasheet-19961-u2af35-n-16-antibody....
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U2AF35 (C-12) Antibody sc-19663
Humano, U2AF1, 7307, 21q22.3, NM_001025203, NM_001025204, NM_006758 · Q01081 · 191317. camundongo, U2af1, 108121, 17 B1, Q9D883 ...
http://www.scbt.com/pt/product.php?datasheet=19663...
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U2AF35 siRNA (m) sc-37666
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, U2af1, 108121, 17 B1, Q9D883 ...
http://www.scbt.com/ko/datasheet-37666-u2af35-sirna-m.html...
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U2AF35 Antibody / U2AF35 Antibodies
製品名, カタログ番号, アイソタイプ, エピトープ, アプリケーション, 動物種. U2AF35 (C-12) 抗体, sc-19663, goat IgG, internal (h), WB, IF, ELISA, m, r, h ...
http://www.scbt.com/ja/table-u2af35.html...
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