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UBB


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Gene DB Home
Symbol:UBB
Name(s):ubiquitin B
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ25987, MGC8385
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17931355 analyse the expression of mutant ubiquitin (UBB+1), in muscle biopsies from patients suffering from myotilinopathy and desminopathy
17237936 UBB+1, a mutant form of ubiquitin was present in the majority of NFTs, whereas co-existence of alpha-synuclein and UBB+1 was found in only a few neurons in cases of combined multiple system atrophy and Alzheimer's disease.
17405812 UBB(+1), at low expression levels, is efficiently degraded by the proteasome, but at high levels, the proteasome failed to degrade UBB(+1), causing its accumulation.
12871580 expression of UBB+1 causes proteasome inhibition and induces expression of heat-shock proteins; although UBB+1-expressing cells have a compromised ubiquitin-proteasome system, they are protected against oxidative stress
12055595 Molecular misreading of the ubiquitin B gene and hepatic mallory body formation.
12893422 The temporal localization of frame-shift ubiquitin-B and amyloid precursor protein, and complement proteins in the brain of non-demented control patients with increasing Alzheimer's disease pathology.
17395554 K63-polyubiquitination guards against chemical carcinogenesis by preventing mutagenesis and thus contributing to genomic stability
15452314 In sporadic inclusion-body myositis, UBB+1 may be pathogenic by inhibiting proteasome, thereby promoting accumulation of cytotoxic misfolded amyloid-beta and phosphorylated-tau.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDbreast cancer 1, early onset isoform 1ubiquitin B precursorBRCA1 interacts with Ub. This interaction was modelled on a demonstrated interaction between human BRCA1 and Ub from an unspecified source.-Pubmed
BINDcyclin-dependent kinase inhibitor 1Bubiquitin B precursorUb interacts with p27.-Pubmed
BINDYamaguchi sarcoma viral oncogene homolog isoform Aubiquitin B precursorLyn interacts with ubiquitin.-Pubmed
HPRDB Mybubiquitin B precursor--Pubmed
HPRDMYB-related protein BUbiquitin B--Pubmed
BINDparkin isoform 1ubiquitin B precursorParkin is S-nitrosylated.-Pubmed
BINDspleen tyrosine kinaseubiquitin B precursorSyk interacts with ubiquitin.-Pubmed
BINDTNF receptor-associated factor 6ubiquitin B precursorTRAF6 interacts with Ub. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and Ub from an unspecified source.-Pubmed
BINDTNF receptor-associated factor 6ubiquitin B precursorTRAF6 interacts with Ub. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and Ub from an unspecified source.-Pubmed
BINDubiquitin B precursorubiquitin specific protease 1USP1 interacts with Ubiquitin.-Pubmed

Recent Publications on UBB:

Pubmed Logo
Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats.
Previous studies have demonstrated that ischemic stroke increases...
22nd October, 2009
Department of Neurobiology, Institute of Biomedical Sciences, State Key J Cereb Blood Flow Metab. 2009 Oct 21.
DOI Direct Link
Ubiquitin B: an essential mediator of trichostatin A-induced tumor-selective killing in human cancer cells.
Although histone deacetylase inhibitors (HDACis) are emerging as a new...
3rd October, 2009
Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Cell Death Differ. 2009 Oct 2.
DOI Direct Link
Optimization of Streptomyces bacteriophage phiC31 integrase system to prevent post integrative gene silencing in pulmonary type II cells.
phiC31 integrase has emerged as a potent tool for achieving long-term gene...
12th September, 2009
Exp Mol Med. 2009 Sep 11.
DOI Direct Link
Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation.
The mechanisms that regulate the ubiquitin (Ub)-proteasome system's own...
26th August, 2009
Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11907-12. Epub 2009 Jul 6.
DOI Direct Link
To bleed or not to bleed. A prediction based on individual gene profiling combined with dose-volume histogram shapes in prostate cancer patients undergoing three-dimensional conformal radiation therapy.
PURPOSE: The main purpose of this work was to try to elucidate why,...
4th August, 2009
Prostate Program, Fondazione IRCCS-Istituto Nazionale dei Tumori, Milano, Int J Radiat Oncol Biol Phys. 2009 Aug 1;74(5):1431-40. Epub 2009 Feb 11.
DOI Direct Link

View more research publications.

BioNews Results for UBB

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BioPortfolio Logo
Hyperion Therapeutics enrolls first patient in HPN-100 phase III clinical trial for urea cycle disorders
News-Medical.Net:  Oct 27 2009 5:04PM Matching: ubb
Ubiquitin B: an essential mediator of trichostatin A-induced tumor-selective killing in human cancer cells
Nature:  Oct 13 2009 10:35AM Matching: ubb

Patents:

Patents logo
US Patent No.Title
6030099 Selected direction lighting device
6725287 Method and system for capturing streaming data by an actionable information engine
6781590 Graphic processing system having bus connection control functions
6789180 Method and apparatus for mask and/or counter address registers readback on the address bus in synchronous single and multi-port memories
6867406 Confocal wafer inspection method and apparatus using fly lens arrangement

View more patents.

UBB results (if any) from reagent suppliers

Google CSE Logo
UBB Antibody / UBB Antibodies
UBB Antibody / UBB Antibodies. ... UBB specific siRNA, sHRNA Plasmid과 shRNA Lentiviral Particles gene silencers 도 제공합니다. ...
http://www.scbt.com/ko/table-ubb.html...

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Antibodies to Ubiquitin, Ubiquitin-like and Proteasome Proteins
human ... UBB(7314), UBC(7316) mouse ... Ubb(22187), Ubc(22190) rat ... Ubb( 192255), Ubc(50522), eukaryotes, prokaryotes, IHC (f), WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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UBB siRNA (h) sc-106654
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: UBB ...
http://www.scbt.com/ja/datasheet-106654-ubb-sirna-h.html...

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Antibody Products - IgG Monoclonal Antibodies - GenWay
RPS27A; UBA80; UBCEP1; UBA52; UBCEP2; UBB; UBC - MAb to Ubiquitin (a.a. 50-65); N/A; Ubiquitin, IgG Monoclonal ELISA, IHC, IP , WB, Source: Mouse ...
http://www.genwaybio.com/all_monoclonal_antibodies.php?fl=U...

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UBB Antibody / UBB Antibodies
UBB Antibody / UBB Antibodies. ... UBB spécifique siARN, shARN Plasmide et shARN Particules Lentivirales Ciblant des Gènes disponible. ...
http://www.scbt.com/fr/table-ubb.html...

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U0508 Monoclonal Anti-Ubiquitin antibody produced in mouse clone ...
UBB(7314), UBC(7316). rat ... Ubb(192255), Ubc(50522). mouse ... Ubb(22187), Ubc (22190). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=U050...

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SCP1 antibody (ab15090) | Abcam
The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol Cell Biol 28:1136-46 (2008). ICC/IF; Mouse. PubMed: 18070917 ...
http://www.abcam.com/SCP1-antibody-ab15090.html...

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