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UBA1
| Symbol: | UBA1 | | Name(s): | ubiquitin-like modifier activating enzyme 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | A1S9, A1S9T, A1ST, GXP1, MGC4781, UBA1A, UBE1, UBE1X | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 11447495 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18179898 |
Large-scale mutation analysis in genes resulted in detection of 3 rare novel variants in exon 15 of UBE1 that segregate with X-linked infantile spinal muscular atrophy. |
| 17597759 |
Human Uba6 and Ube1 have distinct preferences for E2 charging in vitro, and their specificity depends in part on their C-terminal ubiquitin-fold domains, which recruit E2s |
| 15202508 |
In conclusion, nUBE1L is a novel human E1 like gene highly expressed in adult testis, which plays key role in ubiquitin system, and accordingly influences spermatogenesis and male fertility. |
| 17060614 |
unusual type of regulation at the level of the E1 enzyme is likely to affect numerous cellular processes and may represent a strategy to coordinate multiple phenotypic changes upon differentiation by using E1 as a "master switch." |
| 16595681 |
analysis of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme |
Recent Publications on UBA1: |  |
Inactive X chromosome-specific histone H3 modifications and CpG hypomethylation flank a chromatin boundary between an X-inactivated and an escape gene.
In mammals, the dosage compensation of sex chromosomes between males and... | 22nd October, 2009
| Nuclear Function and Dynamics Unit, Horizontal Medical Research
| Nucleic Acids Res. 2009 Oct 20.
DOI Direct Link |
Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis.
OBJECTIVE: Rheumatoid arthritis (RA) is an inflammatory joint disease with... | 3rd September, 2009
| Institute of Clinical Immunology and Transfusion Medicine/Center for
| J Rheumatol. 2009 Oct;36(10):2149-57. Epub 2009 Sep 1.
DOI Direct Link |
Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila.
Protein ubiquitination has been shown to regulate a wide variety of... | 4th August, 2009
| Massachusetts General Hospital Canter Center, Massachusetts General
| Fly (Austin). 2007 Mar-Apr;1(2):95-105.
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Identification of the chromatin regions coated by non-coding Xist RNA.
Xist non-coding RNA (ncRNA) is essential for X chromosome inactivation... | 31st July, 2009
| Department of Biomedical Science, Regenerative Medicine and Biofunction,
| Cytogenet Genome Res. 2009;125(1):19-25. Epub 2009 Jul 14.
DOI Direct Link |
Ubiquitylation is required for degradation of transmembrane surface proteins in trypanosomes.
The surface of Trypanosoma brucei is dominated by... | 14th January, 2009
| Department of Pathology, University of Cambridge, Cambridge, UK.
| Traffic. 2008 Sep;9(10):1681-97. Epub 2008 Jun 28.
DOI Direct Link |
→View more research publications. |
UBA1 results (if any) from reagent suppliers | 
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E3152 Monoclonal Anti-E1 Ubiquitin Activating Enzyme antibody ...
indirect ELISA: suitable. isotype, IgG1. Gene Information, human ... UBA1(7317). mouse ... Uba1(22201). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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UBE1 (2G2) Antibody sc-53555
Mouse, Uba1, 22201, X A1.3, Q02053, N/A. Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List. UBE1 (2G2), sc-53555, 200 µg/ml, $259
...
http://www.scbt.com/datasheet-53555-ube1-2g2-antibody.html...
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Antibodies to Ubiquitin, Ubiquitin-like and Proteasome Proteins
Uba1(22201) human ... UBA1(7317), mouse, human, rabbit, ELISA (i), WB, pricing. N2786, Monoclonal Anti-Nedd8 antibody produced in mouse, ND23 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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pSAE1 Tubulin pSAE1 Tubulin
resembles the N-terminal half of yeast UBA1; the SAE2 (also called Uba2) subunit corresponds to the ... yeast UBA1 and contains the active site cysteine. ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...
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Product Data Sheet
Figure B: NUB1 UBA1-agarose (UW9700) binding of recombinant FAT10 (lanes g - i) after SDS-PAGE followed by blotting onto PVDF and probing with FAT10 ...
http://www.biomol.com/SiteData/docs/ProductData/UW9700.pdf...
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UBE1 Bethyl Laboratories
Alternate names for UBE1 include A1S9, UBA1, ubiquitin-activating enzyme E1 homolog A, A1S9T and BN75 temperature sensitivity complementing, A1ST, GXP1, ...
http://www.bethyl.com/category/UBE1/Antibody/AAAAAAAABAAEAAN...
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Product Data Sheet
16 Jul 2004 ... ubiquitin-like (UbL), ubiquitin association 1 (UBA1), Xeroderma pigmentosum group C binding, and UBA2 domains. The UBA domains interact with ...
http://www.biomol.com/SiteData/docs/ProductData/UW9440.pdf...
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