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UBE2A


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Symbol:UBE2A
Name(s):ubiquitin-conjugating enzyme E2A (RAD6 homolog)
Type:protein-coding
Organism:Homo sapiens
Synonyms:HHR6A, RAD6A, UBC2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
11885984 high resolution backbone structure from nmr
16909393 A single-nucleotide substitution, c.382C-->T in UBE2A, led to a premature UAG stop codon (Q128X). This is the first description of a mutation in a ubiquitin-conjugating enzyme gene as the cause of a human disease.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDp53ubiquitin-conjugating enzyme E2A--Pubmed
HPRDtumor protein p53Ubiquitin conjugating enzyme E2A--Pubmed
HPRDubiquitin-conjugating enzyme E2Apostreplication repair protein hRAD18p--Pubmed
HPRDubiquitin-conjugating enzyme E2Apostreplication repair protein hRAD18p--Pubmed

Recent Publications on UBE2A:

Pubmed Logo
Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing.
Cyclin-dependent kinase-9 (CDK9) was originally characterized as a...
22nd October, 2009
Department of Molecular Oncology, Gottingen Center for Molecular Cell Cycle. 2009 Nov 24;8(22).
Origin and evolution of ubiquitin-conjugating enzymes from Guillardia theta nucleomorph to hominoid.
The origin of eukaryotic ubiquitin-conjugating enzymes (E2s) can be traced...
9th October, 2009
State Key Laboratory of Reproductive Biology, Institute of Zoology, Gene. 2009 Nov 15;447(2):72-85. Epub 2009 Aug 5.
DOI Direct Link
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.
H2B ubiquitylation has been implicated in active transcription but is not...
6th August, 2009
The Rockefeller University, New York, NY 10065, USA. Cell. 2009 May 1;137(3):459-71.
DOI Direct Link
The effect of different zwitterionic buffers and PBS used for out-of-incubator procedures during standard in vitro embryo production on development, morphology and gene expression of bovine embryos.
The effect of the zwitterionic buffers HEPES, TES and MOPS and of PBS used...
4th March, 2009
Ministry of Science and Innovation, Department of Animal Reproduction, Theriogenology. 2008 Dec;70(9):1461-70.
DOI Direct Link
Humans and chimpanzees differ in their cellular response to DNA damage and non-coding sequence elements of DNA repair-associated genes.
Compared to humans, chimpanzees appear to be less susceptible to many...
13th January, 2009
Institute for Human Genetics, Johannes Gutenberg University, Mainz, Cytogenet Genome Res. 2008;122(2):92-102. Epub 2008 Dec 18.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7132234 Methods and compositions for the identification of anti-poxvirus agents
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

UBE2A results (if any) from reagent suppliers

Google CSE Logo
Antibody Products - IgG Monoclonal Antibodies - GenWay
Mouse monoclonal anti-human UBE2A antibody; N/A; N/A; Homo sapiens ubiquitin- conjugating enzyme E2A (RAD6 homolog) (UBE2A) gene, complete cds; N/A ...
http://www.genwaybio.com/all_monoclonal_antibodies.php?fl=U...

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Protein Modification - Ubiquitination Antibody
AP1063a, UBE1C Antibody (N-term), WB, IHC, E, H, M. AT4427aNEW, UBE2A monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H. AP2115b, UBE2B Antibody (C-term) ...
http://www.abgent.com/products/category/protein_modification...

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3C-3E
Monoclonal Anti-UBE2A antibody produced in mouse clone 3D7-E2, purified immunoglobulin, buffered aqueous solution, 3D7-E2 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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HR6A/B (P-12) Antibody sc-27526
Human, UBE2A, 7319, Xq24, NM_003336, NM_181762, NM_181777 · P49459 · 312180. Mouse, Ube2a, 22209, X A3.3, Q9Z255, 없음. Mouse, Ube2b, 22210, 11 B1.3, P63147
...
http://www.scbt.com/ko/datasheet-27526-hr6a-b-p-12-antibody....

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UBC Antibody / UBC Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. UBC2 (2782C5) Antibody, sc-81419, mouse IgG2a, Internal (h), WB, IP, human ...
http://www.scbt.com/ko/table-ubc.html...

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UBC Antibody / UBC Antibodies
製品名, カタログ番号, アイソタイプ, エピトープ, アプリケーション, 動物種. UBC2 ( 2782C5) 抗体, sc-81419, mouse IgG2a, Internal (h), WB, IP, human ...
http://www.scbt.com/ja/table-ubc.html...

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UBC2 (A-18) Antibody sc-10479
Souris, Ube2a, 22209, X A3.3, Q9Z255, Non disponible. Souris, Ube2b, 22210, 11 B1.3, P63147, Non disponible. Produits disponibles. Nom du produit, Référence
...
http://www.scbt.com/fr/datasheet-10479-ubc2-a-18-antibody.ht...

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